imipramine has been researched along with Obsessive-Compulsive Disorder in 53 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-three outpatients with primary obsessive-compulsive disorder (OCD) were started in a 12-week double-blind clinical trial of clomipramine (CLI) (n = 11) and imipramine (IMI) (n = 12)." | 9.05 | Clomipramine and imipramine in obsessive-compulsive disorder. ( Neziroglu, F; Volavka, J; Yaryura-Tobias, JA, 1985) |
| "[3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects." | 7.68 | Decreased platelet imipramine binding in Tourette syndrome children with obsessive-compulsive disorder. ( Barber, Y; Cohen, A; Mandel, A; Mester, R; Rehavi, M; Weitz, R; Weizman, A, 1992) |
| "14C-Serotonin (5-HT) uptake and 3H-imipramine binding (IB) were studied in the blood platelets of 20 obsessive-compulsive disorder (OCD) patients, 53 normal controls (5-HT uptake) and 32 normal controls (IB binding)." | 7.68 | Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients. ( Arora, RC; Bastani, B; Meltzer, HY, 1991) |
| "Trichotillomania is seen in normal children with a variety of psychiatric conditions (Krishnan, 1985)." | 5.28 | Imipramine treatment of trichotillomania and coexisting depression in a seven-year-old. ( Carr, S; Weller, EB; Weller, RA, 1989) |
| "The authors evaluated platelet tritiated imipramine binding in 22 outpatients with obsessive-compulsive disorder (OCD) and 22 psychiatrically normal controls matched for age and gender." | 5.06 | Tritiated imipramine binding in obsessive-compulsive volunteers and psychiatrically normal controls. ( Black, DW; Kelly, M; Myers, C; Noyes, R, 1990) |
| "Most of the controlled studies on the efficacy of medical treatments of obsessive-compulsive disorder (OCD) have involved clomipramine, a tricyclic antidepressant reputed to have anti-obsessional properties." | 5.06 | Effects of imipramine on depression and obsessive-compulsive symptoms. ( Dugger, D; Foa, EB; Kozak, MJ; Steketee, G, 1987) |
| "Twenty-three outpatients with primary obsessive-compulsive disorder (OCD) were started in a 12-week double-blind clinical trial of clomipramine (CLI) (n = 11) and imipramine (IMI) (n = 12)." | 5.05 | Clomipramine and imipramine in obsessive-compulsive disorder. ( Neziroglu, F; Volavka, J; Yaryura-Tobias, JA, 1985) |
| " To investigate this phenomenon as a possible animal model of obsessive-compulsive disorder (OCD), rats were treated for 5 weeks with fluoxetine, an antidepressant that relieves OCD symptoms in humans (5 mg/kg, 2." | 3.69 | Effects of serotonergic agents on food-restriction-induced hyperactivity. ( Altemus, M; Galliven, E; Glowa, JR; Leong, YM; Murphy, DL, 1996) |
| "[3H]Imipramine binding to blood platelets was assessed in eight untreated Tourette syndrome (TS) children, nine drug-free TS children with obsessive-compulsive disorder (OCD), and nine age-matched and gender-matched control subjects." | 3.68 | Decreased platelet imipramine binding in Tourette syndrome children with obsessive-compulsive disorder. ( Barber, Y; Cohen, A; Mandel, A; Mester, R; Rehavi, M; Weitz, R; Weizman, A, 1992) |
| "In an attempt to clarify the possible role of a serotonergic and dopaminergic dysfunction in obsessive-compulsive disorder (OCD), we measured platelet 3H-imipramine (3H-IMI) binding, serotonin uptake, and platelet sulfotransferase activity in 17 drug-free OCD patients and an equal number of healthy controls." | 3.68 | Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder. ( Cassano, GB; Hollander, E; Lensi, P; Marazziti, D; Ravagli, S, 1992) |
| "14C-Serotonin (5-HT) uptake and 3H-imipramine binding (IB) were studied in the blood platelets of 20 obsessive-compulsive disorder (OCD) patients, 53 normal controls (5-HT uptake) and 32 normal controls (IB binding)." | 3.68 | Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients. ( Arora, RC; Bastani, B; Meltzer, HY, 1991) |
| "Platelet imipramine binding was measured in 16 drug-free nondepressed patients (aged 20-61 years, mean +/- SD 35 +/- 8) suffering from obsessive-compulsive disorder (OCD) and in 16 sex-, race- and age-matched healthy controls." | 3.68 | Platelet imipramine binding and serotonin uptake in obsessive-compulsive patients. ( Behar, D; Bridger, WH; Friedman, E; Shimon, H; Stoff, D; Vitiello, B, 1991) |
| "The authors evaluated high-affinity [3H]imipramine binding and [3H]serotonin uptake to platelets in eight adolescent and 10 adult patients who met DSM-III criteria for obsessive-compulsive disorder in comparison with those of normal control subjects of similar ages." | 3.67 | High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients. ( Apter, A; Carmi, M; Hermesh, H; Rehavi, M; Shahar, A; Tyano, S; Weizman, A, 1986) |
| "Clomipramine has been found superior to placebo or other psychoactive drugs in 5 controlled studies." | 2.37 | Antidepressant drugs in anxiety disorders. ( Modigh, K, 1987) |
| "Trichotillomania is seen in normal children with a variety of psychiatric conditions (Krishnan, 1985)." | 1.28 | Imipramine treatment of trichotillomania and coexisting depression in a seven-year-old. ( Carr, S; Weller, EB; Weller, RA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (67.92) | 18.7374 |
| 1990's | 14 (26.42) | 18.2507 |
| 2000's | 3 (5.66) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DELAY, J | 1 |
| DENIKER, P | 1 |
| LEMPERIERE, T | 1 |
| GINESTET, D | 1 |
| GUYOTAT, J | 1 |
| ELLISON, RM | 1 |
| VOLTERRA, V | 1 |
| GUERMANI, M | 1 |
| TELLENBACH, H | 1 |
| SEGERS, J | 1 |
| NUYTS, JA | 1 |
| TIMOFEEVA, AN | 1 |
| LIPSKAIA, LA | 1 |
| GILLINGHAM, FJ | 1 |
| SMYTHIES, JR | 1 |
| PAKESCH, E | 1 |
| Delorme, R | 2 |
| Chabane, N | 2 |
| Callebert, J | 2 |
| Falissard, B | 1 |
| Mouren-Siméoni, MC | 2 |
| Rouillon, F | 1 |
| Launay, JM | 2 |
| Leboyer, M | 2 |
| Joel, D | 1 |
| Doljansky, J | 1 |
| Roz, N | 1 |
| Rehavi, M | 3 |
| Betancur, C | 1 |
| Laplanche, JL | 1 |
| Herbert, ME | 1 |
| Jacobson, S | 1 |
| Uhlenhuth, EH | 1 |
| Cobb, J | 1 |
| Prasad, A | 1 |
| Mavissakalian, M | 2 |
| Michelson, L | 2 |
| Insel, TR | 1 |
| Mueller, EA | 1 |
| Gillin, JC | 1 |
| Siever, LJ | 1 |
| Murphy, DL | 2 |
| Davis, JM | 2 |
| Nasr, S | 1 |
| Spira, N | 1 |
| Vogel, C | 1 |
| Isberg, RS | 1 |
| Turner, SM | 2 |
| Hersen, M | 1 |
| Bellack, AS | 1 |
| Andrasik, F | 1 |
| Capparell, HV | 1 |
| Campbell, M | 1 |
| Cueva, JE | 1 |
| Altemus, M | 1 |
| Glowa, JR | 1 |
| Galliven, E | 1 |
| Leong, YM | 1 |
| Kutin, VP | 1 |
| Kutin, GV | 1 |
| Weizman, A | 2 |
| Mandel, A | 1 |
| Barber, Y | 1 |
| Weitz, R | 1 |
| Cohen, A | 1 |
| Mester, R | 1 |
| Foa, EB | 4 |
| Kozak, MJ | 4 |
| Steketee, GS | 1 |
| McCarthy, PR | 2 |
| Marazziti, D | 1 |
| Hollander, E | 1 |
| Lensi, P | 1 |
| Ravagli, S | 1 |
| Cassano, GB | 1 |
| Bastani, B | 1 |
| Arora, RC | 1 |
| Meltzer, HY | 1 |
| Kim, SW | 1 |
| Dysken, MW | 1 |
| Pandey, GN | 1 |
| Vitiello, B | 1 |
| Shimon, H | 1 |
| Behar, D | 1 |
| Stoff, D | 1 |
| Bridger, WH | 1 |
| Friedman, E | 1 |
| Chalfin, RM | 1 |
| Altieri, J | 1 |
| Stokes, PE | 1 |
| Black, DW | 1 |
| Kelly, M | 1 |
| Myers, C | 1 |
| Noyes, R | 2 |
| Pfohl, B | 1 |
| Black, D | 1 |
| Kelley, M | 1 |
| Blum, N | 1 |
| Friman, PC | 1 |
| Rostain, A | 1 |
| Parrish, JM | 1 |
| Carey, WB | 1 |
| Schreier, HA | 1 |
| Rossi, M | 1 |
| Weller, EB | 1 |
| Weller, RA | 1 |
| Carr, S | 1 |
| Carmi, M | 1 |
| Hermesh, H | 1 |
| Shahar, A | 1 |
| Apter, A | 1 |
| Tyano, S | 1 |
| Marks, I | 1 |
| O'Sullivan, G | 1 |
| Modigh, K | 1 |
| Ananth, J | 1 |
| Lei, BS | 1 |
| Steketee, G | 2 |
| Dugger, D | 2 |
| Jacob, R | 1 |
| Volavka, J | 1 |
| Neziroglu, F | 1 |
| Yaryura-Tobias, JA | 1 |
| Ciani, N | 2 |
| Silipo, P | 1 |
| Rose, JT | 1 |
| Maxwell, C | 1 |
| Hussain, MZ | 1 |
| Ahad, A | 1 |
| Lingjaerde, O | 1 |
| Naviau, J | 1 |
| Ruyffelaere, J | 1 |
| Lehembre, C | 1 |
6 reviews available for imipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Behaviour therapy in phobic and obsessional disorders.
Topics: Agoraphobia; Arousal; Behavior Therapy; Clomipramine; Cognition; Combined Modality Therapy; Desensit | 1983 |
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder | 1995 |
The changing horizon in the treatment of depression: scientific/clinical publication overview.
Topics: Adolescent; Ambulatory Care; Antidepressive Agents; Anxiety Disorders; Clinical Trials as Topic; Dep | 1991 |
Drugs and psychological treatments for agoraphobia/panic and obsessive-compulsive disorders: a review.
Topics: Agoraphobia; Antidepressive Agents; Fear; Habituation, Psychophysiologic; Humans; Imipramine; Obsess | 1988 |
Antidepressant drugs in anxiety disorders.
Topics: Antidepressive Agents; Anxiety Disorders; Clomipramine; Humans; Imipramine; Monoamine Oxidase Inhibi | 1987 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
17 trials available for imipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder.
Topics: Adolescent; Adult; Binding Sites; Biomarkers; Blood Platelets; Carrier Proteins; Cell Membrane; Chil | 2004 |
Specific anxiety syndromes: current therapeutic options.
Topics: Agoraphobia; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepin | 1981 |
A double blind study of imipramine versus zimelidine in treatment of obsessive compulsive neurosis.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Imipramine; Male; Obsessive-Co | 1984 |
Tricyclic antidepressants in obsessive-compulsive disorder. Antiobsessional or antidepressant agents?
Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Female; Humans | 1983 |
Anxiety: differential diagnosis and treatment from a biologic perspective.
Topics: Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Diagnosis, Differential; Diazepam; Double- | 1981 |
Treatment of depressive and obsessive-compulsive symptoms in OCD by imipramine and behaviour therapy.
Topics: Adult; Behavior Therapy; Combined Modality Therapy; Depressive Disorder; Double-Blind Method; Female | 1992 |
Platelet 3H-imipramine binding sites in obsessive-compulsive behavior.
Topics: Adult; Blood Platelets; Carrier Proteins; Clomipramine; Female; Humans; Imipramine; Male; Middle Age | 1991 |
Tritiated imipramine binding in obsessive-compulsive volunteers and psychiatrically normal controls.
Topics: Adult; Blood Platelets; Carrier Proteins; Clinical Trials as Topic; Clomipramine; Double-Blind Metho | 1990 |
Effects of imipramine on the autonomic responses of obsessive-compulsives to auditory tones.
Topics: Acoustic Stimulation; Adult; Arousal; Female; Galvanic Skin Response; Heart Rate; Humans; Imipramine | 1989 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
[A cross-over treatment of obsessive-compulsive neurosis with imipramine and chlorimipramine].
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Female; Humans; Imip | 1986 |
Imipramine and placebo in the treatment of obsessive-compulsives: their effect on depression and on obsessional symptoms.
Topics: Adult; Depression; Female; Humans; Imipramine; Male; Obsessive-Compulsive Disorder; Time Factors | 1987 |
Effects of imipramine on depression and obsessive-compulsive symptoms.
Topics: Adolescent; Adult; Aged; Clomipramine; Depressive Disorder; Humans; Imipramine; Middle Aged; Obsessi | 1987 |
Tricyclic antidepressants in obsessive-compulsive disorder: antiobsessional or antidepressant agents? II.
Topics: Adult; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Hum | 1985 |
Clomipramine and imipramine in obsessive-compulsive disorder.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Female; Humans; | 1985 |
[First observations on the association of imipramine and butyrrilperazine in the treatment of obsessive-phobic psychoneuroses].
Topics: Adult; Clinical Trials as Topic; Humans; Imipramine; Middle Aged; Obsessive-Compulsive Disorder; Phe | 1964 |
Depression: prognosis and drug treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Clinical Trials as Topic; Depression; Desipramine; Female; Hum | 1969 |
31 other studies available for imipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
[2 years of experience with imipramine].
Topics: Depression; Depressive Disorder; Humans; Imipramine; Neurotic Disorders; Obsessive-Compulsive Disord | 1961 |
[Imipramine treatment in other than depressive states].
Topics: Depression; Humans; Imipramine; Neurotic Disorders; Obsessive-Compulsive Disorder; Psychopharmacolog | 1960 |
GILLES DE LA TOURETTE'S SYNDROME.
Topics: Chlorpromazine; Chorea; Geriatrics; Humans; Imipramine; Intelligence Tests; Neurotic Disorders; Obse | 1964 |
[PRELIMINARY OBSERVATIONS ON THE CLINICAL USE OF A METABOLITE OF IMIPRAMINE: DESMETHYLIMIPRAMINE (G 35020)].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Mental Diso | 1963 |
[ON THE TREATMENT OF PHOBIC AND ANANCASTIC STATES WITH IMIPRAMINE].
Topics: Humans; Imipramine; Neurotic Disorders; Obsessive-Compulsive Disorder; Phobic Disorders | 1963 |
[ACTION OF DESMETHYL-IMIPRAMINE (PERTOFRAN) IN DEPRESSIVE SYNDROMES].
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Imipramine; Neuro | 1964 |
[BARBAMYL-TOFRANIL TEST IN THE EVALUATION OF THE DEPRESSIVE STATE].
Topics: Amobarbital; Anxiety; Anxiety Disorders; Bipolar Disorder; Delirium; Delusions; Depression; Depressi | 1963 |
A CASE OF POSTENCEPHALITIC PARKINSONISM RESPONDING TO COMBINED SURGICAL AND MEDICINAL TREATMENT.
Topics: Amitriptyline; Chlordiazepoxide; Depression; Depressive Disorder; Drug Therapy; Encephalitis; Eye Mo | 1965 |
[On the medical treatment of compulsive diseases].
Topics: Humans; Imipramine; Neurotic Disorders; Obsessive-Compulsive Disorder | 1961 |
Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dos | 2005 |
Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Biomarkers; Blood Platelets; Case-Control Studies; | 2005 |
Late paraphrenia.
Topics: Aged; Chlorpromazine; Dementia; Diagnosis, Differential; Electroconvulsive Therapy; Female; Hearing | 1967 |
Biological markers in obsessive-compulsive and affective disorders.
Topics: Blood Platelets; Clomipramine; Clonidine; Depressive Disorder; Dexamethasone; Electroencephalography | 1984 |
A comparison of phenelzine and imipramine in an obsessive-compulsive patient.
Topics: Female; Humans; Imipramine; Middle Aged; Obsessive-Compulsive Disorder; Phenelzine | 1981 |
Behavioral and pharmacological treatment of obsessive-compulsive disorders.
Topics: Adolescent; Adult; Behavior Therapy; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Imip | 1980 |
Effects of serotonergic agents on food-restriction-induced hyperactivity.
Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Disease Models, Animal; Eating; Female; Fenc | 1996 |
[Complex treatment of obsessive states of different etiology].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Benactyzine; Diazepam; Drug Therapy, Combination; | 1978 |
Decreased platelet imipramine binding in Tourette syndrome children with obsessive-compulsive disorder.
Topics: Adolescent; Blood Platelets; Carrier Proteins; Child; Female; Humans; Imipramine; Male; Obsessive-Co | 1992 |
Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder.
Topics: Adult; Blood Platelets; Dopamine; Female; Humans; Imipramine; Male; Obsessive-Compulsive Disorder; R | 1992 |
Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients.
Topics: Adult; Blood Platelets; Carrier Proteins; Female; Humans; Imipramine; Male; Obsessive-Compulsive Dis | 1991 |
Platelet imipramine binding and serotonin uptake in obsessive-compulsive patients.
Topics: Adult; Age Factors; Blood Platelets; Female; Humans; Imipramine; Male; Middle Aged; Obsessive-Compul | 1991 |
Supervised treatment of an obsessional patient by a psychiatric resident utilizing psychotherapy and pharmacotherapy.
Topics: Adult; Combined Modality Therapy; Empathy; Humans; Imipramine; Internship and Residency; Interprofes | 1991 |
A test of the tridimensional personality theory: association with diagnosis and platelet imipramine binding in obsessive-compulsive disorder.
Topics: Arousal; Blood Platelets; Carrier Proteins; Dependency, Psychological; Humans; Imipramine; Motivatio | 1990 |
Hair pulling.
Topics: Child; Depressive Disorder; Humans; Imipramine; Obsessive-Compulsive Disorder; Trichotillomania | 1990 |
OCD and tricyclics.
Topics: Child; Dose-Response Relationship, Drug; Humans; Imipramine; Male; Obsessive-Compulsive Disorder | 1990 |
Imipramine treatment of trichotillomania and coexisting depression in a seven-year-old.
Topics: Child; Depressive Disorder; Female; Humans; Imipramine; Obsessive-Compulsive Disorder; Trichotilloma | 1989 |
High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients.
Topics: Adolescent; Adult; Age Factors; Blood Platelets; Carrier Proteins; Chronic Disease; Female; Humans; | 1986 |
Treatment of obsessive-compulsive neurosis.
Topics: Amitriptyline; Chlordiazepoxide; Chlorprothixene; Haloperidol; Humans; Imipramine; Obsessive-Compuls | 1970 |
[Tricyclic antidepressive agents in compulsive neuroses].
Topics: Adult; Amitriptyline; Antidepressive Agents; Humans; Imipramine; Male; Obsessive-Compulsive Disorder | 1968 |
[Clinical experiences with butyrylperazine].
Topics: Female; Humans; Imipramine; Obsessive-Compulsive Disorder; Schizophrenia; Tranquilizing Agents | 1965 |
[Apropos of 2 cases of obsessive neurosis].
Topics: Adult; Female; Humans; Imipramine; Obsessive-Compulsive Disorder; Psychosurgery | 1966 |