Page last updated: 2024-10-29

imipramine and Nocturnal Enuresis

imipramine has been researched along with Nocturnal Enuresis in 28 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Nocturnal Enuresis: Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.

Research Excerpts

ExcerptRelevanceReference
"The combination treatment of solifenacin and imipramine is a useful and safe treatment for nocturnal enuresis after failure of everything else."9.41Can the combined treatment of solifenacin and imipramine has a role in desmopressin refractory monosymptomatic nocturnal enuresis? A prospective double-blind randomized placebo-controlled study. ( Elawady, H; Mahmoud, MA; Samir, M, 2021)
"Nocturnal enuresis is a condition, which can affectthe quality of life in children."6.90Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial. ( Azarfar, A; Esmaeeli, M; Mostafavian, Z; Ravanshad, S; Ravanshad, Y; Zahabi, E, 2019)
"The combination treatment of solifenacin and imipramine is a useful and safe treatment for nocturnal enuresis after failure of everything else."5.41Can the combined treatment of solifenacin and imipramine has a role in desmopressin refractory monosymptomatic nocturnal enuresis? A prospective double-blind randomized placebo-controlled study. ( Elawady, H; Mahmoud, MA; Samir, M, 2021)
"The additive pharmacologic effects of imipramine with pseudoephedrine for the treatment of monosymptomatic nocturnal enuresis in children were well tolerated, and gave significantly faster results than single drug therapy using imipramine."5.15Comparison between imipramine and imipramine combined with pseudoephedrine in 5-12-year-old children with uncomplicated enuresis: a double-blind clinical trial. ( Abedin Zadeh, M; Kholaseh Zadeh, G; Moslemi, MK, 2011)
"Imipramine has been used for over four decades (early reports in 1960s) for the treatment of nocturnal enuresis, although the reason for its effect is not clear."3.75Synthesis of a quaternary bis derivative of imipramine as a novel compound with potential anti-enuretic effect. ( Faizi, M; Jamali, B; Kobarfard, F; Roodsari, MS; Shafaghi, B; Soleymani, Z, 2009)
"Nocturnal enuresis is a condition, which can affectthe quality of life in children."2.90Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial. ( Azarfar, A; Esmaeeli, M; Mostafavian, Z; Ravanshad, S; Ravanshad, Y; Zahabi, E, 2019)
"Imipramine has a proven efficiency in unselected enuretic patients, but due to its side-effect profile it is only indicated, if at all, in therapy-resistant cases."2.73Tolterodine and imipramine in refractory enuresis; a placebo-controlled crossover study. ( Nevéus, T; Tullus, K, 2008)
"Nocturnal enuresis affects 15-20% of 5-year-old children, 5% of 10 year-old-children and 1-2% of people aged 15 years and over."2.44Nocturnal enuresis. ( Kiddoo, D, 2007)
"Bed wetting or nocturnal enuresis is a common problem among children."1.39Bed wetting - silent suffering: an approach to enuresis and voiding disorders in children. ( Kanitkar, M; Ramamurthy, HR, 2013)
"We examined whether the existence of spina bifida occulta or ultrasonographic bladder abnormalities was related to the outcome of treatment for primary nocturnal enuresis in children."1.34Location of spina bifida occulta and ultrasonographic bladder abnormalities predict the outcome of treatment for primary nocturnal enuresis in children. ( Miyazato, M; Nishijima, S; Ogawa, Y; Owan, T; Sugaya, K, 2007)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19909 (32.14)18.7374
1990's0 (0.00)18.2507
2000's6 (21.43)29.6817
2010's8 (28.57)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Moretti, E1
Barbosa, L1
da Silva, IB1
de Lima, AMJ1
Lemos, A1
Mello, MF2
Locali, RF1
Araujo, RM1
Reis, JN1
Saiovici, S1
Mello, LF1
Trigo Rocha, FE1
Dai, R1
Deng, C1
Ravanshad, Y1
Azarfar, A1
Esmaeeli, M1
Mostafavian, Z1
Zahabi, E1
Ravanshad, S1
Samir, M1
Mahmoud, MA1
Elawady, H1
Rittig, N1
Hagstroem, S1
Mahler, B1
Kamperis, K1
Siggaard, C1
Mikkelsen, MM1
Bower, WF1
Djurhuus, JC1
Rittig, S1
Kanitkar, M1
Ramamurthy, HR1
Caldwell, PH2
Deshpande, AV2
Von Gontard, A1
Tuncel, A1
Mavituna, I1
Nalcacioglu, V1
Tekdogan, U1
Uzun, B1
Atan, A1
Kiddoo, D1
Jamali, B1
Roodsari, MS1
Soleymani, Z1
Faizi, M1
Shafaghi, B1
Kobarfard, F1
Abedin Zadeh, M1
Moslemi, MK1
Kholaseh Zadeh, G1
Hergüner, S1
Hergüner, A1
Küçükapan, HU1
Eggert, P1
Freischmidt, S1
Bismarck, PV1
Schulz-Jürgensen, S1
MEUSERT, W1
FISHER, GW1
MURRAY, F1
WALLEY, MR1
KILOH, LG1
CERNY, L1
KULE, J1
DESTOUNIS, N1
EPSTEIN, SJ1
GUILFOYLE, FM1
ALDERTON, HR1
MEIJER, A1
HAEGGLUND, TB1
PARKKULAINEN, KV1
Miyazato, M1
Sugaya, K1
Nishijima, S1
Owan, T1
Ogawa, Y1
Volkers, AC1
Heerdink, ER1
van Dijk, L1
Nevéus, T1
Tullus, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Relationship Between Nocturnal Enuresis And Spina Bifida Occulta: A Prospective Controlled Trial[NCT03543995]330 participants (Actual)Observational [Patient Registry]2017-01-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for imipramine and Nocturnal Enuresis

ArticleYear
What do cochrane systematic reviews say about interventions for enuresis in children and adolescents? An overview of systematic reviews.
    Journal of pediatric urology, 2022, Volume: 18, Issue:4

    Topics: Adolescent; Child; Deamino Arginine Vasopressin; Enuresis; Humans; Imipramine; Nocturnal Enuresis; S

2022
Management of nocturnal enuresis.
    BMJ (Clinical research ed.), 2013, Oct-29, Volume: 347

    Topics: Adult; Antidepressive Agents, Tricyclic; Antidiuretic Agents; Behavior Therapy; Child; Child, Presch

2013
Nocturnal enuresis.
    BMJ clinical evidence, 2007, Oct-01, Volume: 2007

    Topics: Acupuncture Therapy; Age Factors; Antidepressive Agents, Tricyclic; Desipramine; Genetic Linkage; Hu

2007
Medical management of nocturnal enuresis.
    Paediatric drugs, 2012, Apr-01, Volume: 14, Issue:2

    Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Antidiuretic

2012

Trials

8 trials available for imipramine and Nocturnal Enuresis

ArticleYear
A prospective and randomized study comparing the use of alarms, desmopressin and imipramine in the treatment of monosymptomatic nocturnal enuresis.
    Journal of pediatric urology, 2023, Volume: 19, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Deamino Arginine Vasopressin; Enuresis; Female; Humans; Imipram

2023
Re: A prospective and randomized study comparing the use of alarms, desmopressin and imipramine in the treatment of monosymptomatic nocturnal enuresis.
    Journal of pediatric urology, 2023, Volume: 19, Issue:4

    Topics: Antidiuretic Agents; Deamino Arginine Vasopressin; Enuresis; Humans; Imipramine; Nocturnal Enuresis;

2023
Response to letter to the editor re a prospective and randomized study comparing the use of alarms, desmopressin and imipramine in the treatment of monosymptomatic nocturnal enuresis.
    Journal of pediatric urology, 2023, Volume: 19, Issue:4

    Topics: Antidiuretic Agents; Deamino Arginine Vasopressin; Humans; Imipramine; Nocturnal Enuresis; Prospecti

2023
Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial.
    Iranian journal of kidney diseases, 2019, Volume: 13, Issue:4

    Topics: Antidiuretic Agents; Child; Child, Preschool; Deamino Arginine Vasopressin; Drug Therapy, Combinatio

2019
Can the combined treatment of solifenacin and imipramine has a role in desmopressin refractory monosymptomatic nocturnal enuresis? A prospective double-blind randomized placebo-controlled study.
    Urologia, 2021, Volume: 88, Issue:4

    Topics: Child; Deamino Arginine Vasopressin; Humans; Imipramine; Nocturnal Enuresis; Prospective Studies; So

2021
Comparison between imipramine and imipramine combined with pseudoephedrine in 5-12-year-old children with uncomplicated enuresis: a double-blind clinical trial.
    Journal of pediatric urology, 2011, Volume: 7, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Child; Child, Preschool; Double-Blind Method; Drug Administration

2011
Differentiation of subgroups of monosymptomatic enuresis according to prepulse inhibition of the startle reflex.
    Acta paediatrica (Oslo, Norway : 1992), 2012, Volume: 101, Issue:7

    Topics: Acoustic Stimulation; Adolescent; Adrenergic Uptake Inhibitors; Antidiuretic Agents; Child; Clinical

2012
Tolterodine and imipramine in refractory enuresis; a placebo-controlled crossover study.
    Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:2

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Child; Cresols; Cross-Over Studi

2008

Other Studies

16 other studies available for imipramine and Nocturnal Enuresis

ArticleYear
Outcome of a standardized approach to childhood urinary symptoms-long-term follow-up of 720 patients.
    Neurourology and urodynamics, 2014, Volume: 33, Issue:5

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Antidiuretic Agents; Biofeedback, Psychology; Child; Child

2014
Bed wetting - silent suffering: an approach to enuresis and voiding disorders in children.
    Indian journal of pediatrics, 2013, Volume: 80, Issue:9

    Topics: Adolescent; Algorithms; Behavior Therapy; Child; Child, Preschool; Cholinergic Antagonists; Deamino

2013
Long-term follow-up of enuretic alarm treatment in enuresis nocturna.
    Scandinavian journal of urology and nephrology, 2008, Volume: 42, Issue:5

    Topics: Adolescent; Behavior Therapy; Child; Child, Preschool; Combined Modality Therapy; Deamino Arginine V

2008
Synthesis of a quaternary bis derivative of imipramine as a novel compound with potential anti-enuretic effect.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:9

    Topics: Acetylcholine; Animals; Chemistry, Pharmaceutical; Cholinergic Antagonists; Drug Evaluation, Preclin

2009
Imipramine for enuresis associated with risperidone.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:6

    Topics: Adrenergic Uptake Inhibitors; Antipsychotic Agents; Child; Humans; Imipramine; Male; Nocturnal Enure

2011
[Treatment of enuresis with tofranil].
    Die Medizinische Welt, 1961, Feb-04, Volume: 5

    Topics: Enuresis; Humans; Imipramine; Nocturnal Enuresis; Psychopharmacology

1961
A controlled trial of imipramine in the treatment of nocturnal enuresis in mentally subnormal patients.
    American journal of mental deficiency, 1963, Volume: 67

    Topics: Enuresis; Humans; Imipramine; Mental Disorders; Nocturnal Enuresis

1963
[NOCTURNAL ENURESIS IN CHILDREN--IMIPRAMINE THERAPY AND ITS COMPLICATIONS].
    Activitas nervosa superior, 1963, Volume: 5

    Topics: Adolescent; Child; Drug Hypersensitivity; Enuresis; Humans; Imipramine; Mental Disorders; Nocturnal

1963
[AMBULATORY TREATMENT OF NOCTURNAL ENURESIS WITH IMIPRAMINE].
    Ceskoslovenska psychiatrie, 1963, Volume: 59

    Topics: Enuresis; Humans; Imipramine; Nocturnal Enuresis

1963
IMIPRAMINE IN THE TREATMENT OF MENTALLY ILL ADULT ENURETICS.
    Psychiatric communications, 1964, Volume: 7

    Topics: Adult; Drug Therapy; Enuresis; Humans; Imipramine; Mental Disorders; Mentally Ill Persons; Nocturnal

1964
IMIPRAMINE (TOFRANIL) IN THE CONTROL OF ENURESIS.
    American journal of diseases of children (1960), 1965, Volume: 109

    Topics: Child; Drug Therapy; Enuresis; Humans; Imipramine; Nocturnal Enuresis; Toxicology

1965
IMIPRAMINE IN THE TREATMENT OF NOCTURNAL ENURESIS OF CHILDHOOD.
    Canadian Psychiatric Association journal, 1965, Volume: 10

    Topics: Biomedical Research; Child; Child Behavior Disorders; Drug Therapy; Enuresis; Humans; Imipramine; No

1965
VALUE OF IMIPRAMINE FOR BEDWETTING CHILDREN.
    Diseases of the nervous system, 1965, Volume: 26

    Topics: Child; Diagnosis; Drug Therapy; Enuresis; Humans; Imipramine; Nocturnal Enuresis; Placebos

1965
ENURETIC CHILDREN TREATED WITH IMIPRAMINE (TOFRANIL): A CYSTOMETRIC STUDY.
    Annales paediatriae Fenniae, 1965, Volume: 11

    Topics: Adolescent; Child; Drug Therapy; Enuresis; Humans; Imipramine; Manometry; Nocturnal Enuresis; Physio

1965
Location of spina bifida occulta and ultrasonographic bladder abnormalities predict the outcome of treatment for primary nocturnal enuresis in children.
    International journal of urology : official journal of the Japanese Urological Association, 2007, Volume: 14, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Imipramine; Male; Nocturnal Enuresis; Risk Fact

2007
Antidepressant use and off-label prescribing in children and adolescents in Dutch general practice (2001-2005).
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:9

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Antidepressive Agents, Second-Generation; Antidepressive A

2007