imipramine has been researched along with Niemann-Pick Disease, Type C in 2 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Imipramine was found to affect both the fusion and replication steps of the viral life cycle." | 1.46 | Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking. ( Bernard, E; Briant, L; Choumet, V; Diop, F; Ekchariyawat, P; Ferraris, P; Hamel, R; Liegeois, F; Luplertlop, N; Merits, A; Missé, D; Roques, P; Surasombatpattana, P; Talignani, L; Thomas, F; Wichit, S; Yssel, H, 2017) |
| "Cataplexy is a brief episode of bilateral loss of muscle tone with intact consciousness, triggered by a variety of strong emotions such as anger, laugh, humor or surprise and it is considered to represent the physiologic atonia of rapid eye movement sleep." | 1.40 | Successful treatment of cataplexy in patients with early-infantile Niemann-Pick disease type C: use of tricyclic antidepressants. ( Cak, HT; Düzgün, G; Haliloğlu, G; Topçu, M; Yüce, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wichit, S | 1 |
| Hamel, R | 1 |
| Bernard, E | 1 |
| Talignani, L | 1 |
| Diop, F | 1 |
| Ferraris, P | 1 |
| Liegeois, F | 1 |
| Ekchariyawat, P | 1 |
| Luplertlop, N | 1 |
| Surasombatpattana, P | 1 |
| Thomas, F | 1 |
| Merits, A | 1 |
| Choumet, V | 1 |
| Roques, P | 1 |
| Yssel, H | 1 |
| Briant, L | 1 |
| Missé, D | 1 |
| Cak, HT | 1 |
| Haliloğlu, G | 1 |
| Düzgün, G | 1 |
| Yüce, A | 1 |
| Topçu, M | 1 |
2 other studies available for imipramine and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking.
Topics: Androstenes; Biological Transport; Cells, Cultured; Chikungunya virus; Cholesterol; Fibroblasts; Hum | 2017 |
Successful treatment of cataplexy in patients with early-infantile Niemann-Pick disease type C: use of tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Cataplexy; Child; Female; Humans; Imipramine; Niemann-Pick Disease | 2014 |