imipramine has been researched along with Neuroblastoma in 23 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of our work was to study effect of antidepressant imipramine on both thapsigargin- and tunicamycin-induced ER stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells." | 8.02 | Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. ( Brodnanova, M; Cibulka, M; Evinova, A; Hatokova, Z; Racay, P, 2021) |
| " Thus, this work was designed to study the possible neuroprotective properties of mirtazapine and imipramine, two commercially available antidepressants with different primary mechanisms of action, in human neuroblastoma SH-SY5Y cells against an oxidative insult." | 7.96 | Neuroprotective effects of mirtazapine and imipramine and their effect in pro- and anti-apoptotic gene expression in human neuroblastoma cells. ( Engel, D; Gabilan, NH; Lieberknecht, V; Rodrigues, ALS, 2020) |
| "Imipramine and some of its analogs (trimipramine, 3-chlorimipramine, desipramine, 3-chloro-2-hydroxyimipramine, 2-hydroxyimipramine, and didesmethylimipramine), were assayed for their potencies as antimuscarinic agents by their abilities to antagonize muscarinic receptor-mediated cyclic guanosine monophosphate (GMP) formation by cultured mouse neuroblastoma cells." | 7.66 | Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells. ( Petersen, RC; Richelson, E, 1982) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 5.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| "Hypertension is a well-known finding in some patients with neuroblastoma." | 5.27 | Hypertension in neuroblastoma induced by imipramine. ( Beach, B; Feusner, J; O'Leary, M, 1987) |
| "The aim of our work was to study effect of antidepressant imipramine on both thapsigargin- and tunicamycin-induced ER stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells." | 4.02 | Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. ( Brodnanova, M; Cibulka, M; Evinova, A; Hatokova, Z; Racay, P, 2021) |
| "We have examined how fentanyl modulates [3H]noradrenaline uptake in two cultured neuronal cell preparations, the human neuroblastoma SH-SY5Y and the rat phaeochromocytoma PC12." | 3.68 | Fentanyl inhibits the uptake of [3H]noradrenaline in cultured neuronal cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1993) |
| "NCB-20 cells (neuroblastoma X fetal Chinese hamster brain hybrids) are equipped with a [3H]5-hydroxytryptamine [( 3H]5-HT) uptake system and [3H]imipramine recognition sites." | 3.67 | 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. ( Chuang, DM; Costa, E; Nakaki, T; Roth, BL, 1985) |
| "Imipramine and some of its analogs (trimipramine, 3-chlorimipramine, desipramine, 3-chloro-2-hydroxyimipramine, 2-hydroxyimipramine, and didesmethylimipramine), were assayed for their potencies as antimuscarinic agents by their abilities to antagonize muscarinic receptor-mediated cyclic guanosine monophosphate (GMP) formation by cultured mouse neuroblastoma cells." | 3.66 | Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells. ( Petersen, RC; Richelson, E, 1982) |
| "Tricyclic antidepressants (imipramine and desipramine) gave rise to an important decrease of sphingomyelinase activity in murine neuroblastoma and human fibroblast cell cultures." | 3.66 | Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. ( Albouz, S; Baumann, N; Berwald-Netter, Y; Bourdon, R; Boutry, JM; Hauw, JJ, 1981) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 1.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| "Hypertension is a well-known finding in some patients with neuroblastoma." | 1.27 | Hypertension in neuroblastoma induced by imipramine. ( Beach, B; Feusner, J; O'Leary, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lieberknecht, V | 1 |
| Engel, D | 1 |
| Rodrigues, ALS | 1 |
| Gabilan, NH | 1 |
| Brodnanova, M | 1 |
| Hatokova, Z | 1 |
| Evinova, A | 1 |
| Cibulka, M | 1 |
| Racay, P | 1 |
| Elliott, E | 1 |
| Ezra-Nevo, G | 1 |
| Regev, L | 1 |
| Neufeld-Cohen, A | 1 |
| Chen, A | 1 |
| Seo, JS | 1 |
| Park, JY | 1 |
| Choi, J | 1 |
| Kim, TK | 1 |
| Shin, JH | 1 |
| Lee, JK | 1 |
| Han, PL | 1 |
| Brink, CB | 1 |
| Viljoen, SL | 1 |
| de Kock, SE | 1 |
| Stein, DJ | 1 |
| Harvey, BH | 1 |
| Basta-Kaim, A | 1 |
| Budziszewska, B | 1 |
| Jaworska-Feil, L | 1 |
| Tetich, M | 1 |
| Kubera, M | 1 |
| Leśkiewicz, M | 1 |
| Lasoń, W | 1 |
| Petersen, RC | 1 |
| Richelson, E | 2 |
| Albouz, S | 1 |
| Hauw, JJ | 1 |
| Berwald-Netter, Y | 1 |
| Boutry, JM | 1 |
| Bourdon, R | 1 |
| Baumann, N | 1 |
| Kinnier, WJ | 1 |
| Chuang, DM | 2 |
| Gwynn, G | 1 |
| Costa, E | 2 |
| Rana, B | 1 |
| McMorn, SO | 1 |
| Reeve, HL | 1 |
| Wyatt, CN | 1 |
| Vaughan, PF | 1 |
| Peers, C | 1 |
| Servidei, T | 3 |
| Iavarone, A | 2 |
| Lasorella, A | 2 |
| Mastrangelo, S | 1 |
| Riccardi, R | 3 |
| Willets, JM | 2 |
| Lambert, DG | 3 |
| Griffiths, HR | 2 |
| Atcheson, R | 1 |
| Rowbotham, DJ | 1 |
| Mastrangelo, R | 1 |
| Lunec, J | 1 |
| Franceschini, R | 1 |
| Pecorale, A | 1 |
| Chinol, M | 1 |
| Calcagni, ML | 1 |
| Troncone, L | 1 |
| Cornelissen, J | 1 |
| Tytgat, GA | 1 |
| van den Brug, M | 1 |
| van Kuilenburg, AB | 1 |
| Voûte, PA | 1 |
| van Gennip, AH | 1 |
| Storch, A | 1 |
| Kaftan, A | 1 |
| Burkhardt, K | 1 |
| Schwarz, J | 1 |
| Zwiller, J | 1 |
| Treska-Ciesielski, J | 1 |
| Mack, G | 1 |
| Mandel, P | 1 |
| Smets, LA | 1 |
| Loesberg, C | 1 |
| Janssen, M | 1 |
| Metwally, EA | 1 |
| Huiskamp, R | 1 |
| Feusner, J | 1 |
| O'Leary, M | 1 |
| Beach, B | 1 |
| Nakaki, T | 1 |
| Roth, BL | 1 |
23 other studies available for imipramine and Neuroblastoma
| Article | Year |
|---|---|
Neuroprotective effects of mirtazapine and imipramine and their effect in pro- and anti-apoptotic gene expression in human neuroblastoma cells.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Line, Tumor; Cell Survival; Humans; Imipramine; Mirtaz | 2020 |
Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells.
Topics: Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Endoribonucleases; Humans | 2021 |
Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Azacitidine; Ce | 2010 |
NADPH oxidase mediates depressive behavior induced by chronic stress in mice.
Topics: Acetophenones; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Ascorb | 2012 |
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Topics: Adrenergic Uptake Inhibitors; Androstadienes; Atropine; Cell Line, Tumor; Enzyme Inhibitors; Estrene | 2004 |
Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Cell Line, Tumor; Chloramphenicol O-Acetyl | 2005 |
Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells.
Topics: Animals; Clone Cells; Cyclic GMP; Imipramine; Mice; Neuroblastoma; Receptors, Cholinergic; Receptors | 1982 |
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
Topics: Animals; Cells, Cultured; Desipramine; Fibroblasts; Humans; Imipramine; Mice; Neuroblastoma; Phospho | 1981 |
Characteristics and regulation of high affinity [3H] imipramine binding to rat hippocampal membranes.
Topics: Animals; Carrier Proteins; Cell Line; Cell Membrane; Hippocampus; Imipramine; In Vitro Techniques; K | 1981 |
Inhibition of neuronal nicotinic acetylcholine receptors by imipramine and desipramine.
Topics: Desipramine; Dimethylphenylpiperazinium Iodide; Electrophysiology; Humans; Imipramine; Ion Channels; | 1993 |
Release mechanisms of [125I]meta-iodobenzylguanidine in neuroblastoma cells: evidence of a carrier-mediated efflux.
Topics: 3-Iodobenzylguanidine; Biological Transport, Active; Carrier Proteins; Humans; Imipramine; Iodobenze | 1995 |
Suitability of B65 and SH-SY5Y neuroblastoma cells as models for 'in vitro' neurotoxicity testing.
Topics: Animals; Biological Transport; Carbachol; Cell Line; Dopamine; Drug Evaluation, Preclinical; Humans; | 1993 |
Fentanyl inhibits the uptake of [3H]noradrenaline in cultured neuronal cells.
Topics: Adrenal Gland Neoplasms; Animals; Dose-Response Relationship, Drug; Fentanyl; Humans; Imipramine; Mo | 1993 |
Uptake and storage of m-iodobenzylguanidine are frequent neuronal functions of human neuroblastoma cell lines.
Topics: 3-Iodobenzylguanidine; Biological Transport; Cell Differentiation; Imipramine; In Vitro Techniques; | 1993 |
Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.
Topics: Adenylyl Cyclases; Adrenergic Uptake Inhibitors; Catecholamines; Cell Death; Clorgyline; Dose-Respon | 1995 |
In vitro and in vivo studies with no-carrier added radioiodinated MIBG.
Topics: 3-Iodobenzylguanidine; Adrenal Glands; Adrenergic Uptake Inhibitors; Animals; Benzoates; Chromatogra | 1995 |
Menadione inhibits MIBG uptake in two neuroendocrine cell lines.
Topics: 3-Iodobenzylguanidine; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Cytoplasmic Gra | 1997 |
6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism.
Topics: 1-Methyl-4-phenylpyridinium; Adrenergic Uptake Inhibitors; Antioxidants; Catecholamines; Cell Surviv | 2000 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Cl | 1979 |
Uptake of noradrenaline by an adrenergic clone of neuroblastoma cells.
Topics: Amphetamine; Clone Cells; Desipramine; Imipramine; Kinetics; Neuroblastoma; Norepinephrine; Ouabain | 1975 |
Active uptake and extravesicular storage of m-iodobenzylguanidine in human neuroblastoma SK-N-SH cells.
Topics: 3-Iodobenzylguanidine; Humans; Imipramine; Iodine Radioisotopes; Iodobenzenes; Neuroblastoma; Norepi | 1989 |
Hypertension in neuroblastoma induced by imipramine.
Topics: Adrenal Gland Neoplasms; Catecholamines; Child Behavior Disorders; Child, Preschool; Female; Humans; | 1987 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid | 1985 |