imipramine has been researched along with Nerve Degeneration in 7 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was aimed to determine whether imipramine chronic treatment promotes neurogenesis in the dentate gyrus (DG) and interferes with neuronal death in the CA1 subfield of the hippocampus after transient global cerebral ischemia (TGCI) in rats." | 7.76 | Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats. ( Castro, OW; de Oliveira, RM; Foresti, ML; Garcia-Cairasco, N; Milani, H; Romanini, CV; Schiavon, AP, 2010) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 5.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| " Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravation of anhedonia spontaneously occurred especially after 20 weeks of MCAO, and it was prevented by chronic antidepressants treatment (imipramine or fluvoxamine)." | 3.83 | Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats. ( Kasahara, J; Oka, N; Tezuka, K; Uchida, H, 2016) |
| "This study was aimed to determine whether imipramine chronic treatment promotes neurogenesis in the dentate gyrus (DG) and interferes with neuronal death in the CA1 subfield of the hippocampus after transient global cerebral ischemia (TGCI) in rats." | 3.76 | Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats. ( Castro, OW; de Oliveira, RM; Foresti, ML; Garcia-Cairasco, N; Milani, H; Romanini, CV; Schiavon, AP, 2010) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 1.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vecchia, DD | 1 |
| Kanazawa, LKS | 1 |
| Wendler, E | 1 |
| de Almeida Soares Hocayen, P | 1 |
| Bruginski, E | 1 |
| Campos, FR | 1 |
| Stern, CAJ | 1 |
| Vital, MABF | 1 |
| Miyoshi, E | 1 |
| Wöhr, M | 1 |
| Schwarting, RKW | 1 |
| Andreatini, R | 1 |
| Kasahara, J | 1 |
| Uchida, H | 1 |
| Tezuka, K | 1 |
| Oka, N | 1 |
| Schiavon, AP | 1 |
| Milani, H | 1 |
| Romanini, CV | 1 |
| Foresti, ML | 1 |
| Castro, OW | 1 |
| Garcia-Cairasco, N | 1 |
| de Oliveira, RM | 1 |
| Hitoshi, S | 1 |
| Maruta, N | 1 |
| Higashi, M | 1 |
| Kumar, A | 1 |
| Kato, N | 1 |
| Ikenaka, K | 1 |
| Kitayama, I | 2 |
| Nakamura, S | 1 |
| Yaga, T | 2 |
| Murase, S | 2 |
| Nomura, J | 2 |
| Kayahara, T | 2 |
| Nakano, K | 2 |
| Otani, M | 1 |
| Clineschmidt, BV | 1 |
7 other studies available for imipramine and Nerve Degeneration
| Article | Year |
|---|---|
Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Gait; Imipramine; Ketamine; Male; Nerve Dege | 2018 |
Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Cell Proliferation; Dentate Gyrus; Diseas | 2016 |
Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Cell Proliferation; Dentate Gyrus; Dou | 2010 |
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
Topics: Animals; Antidepressive Agents; Biological Assay; Cell Death; Cells, Cultured; Chronic Disease; Cort | 2007 |
Degeneration of locus coeruleus axons in stress-induced depression model.
Topics: Animals; Axons; Depressive Disorder; Electrophysiology; Female; Horseradish Peroxidase; Imipramine; | 1994 |
Long-term stress degenerates, but imipramine regenerates, noradrenergic axons in the rat cerebral cortex.
Topics: Adrenergic Uptake Inhibitors; Animals; Arousal; Axons; Cerebral Cortex; Depressive Disorder; Disease | 1997 |
Spinal monoamines and the toxic interaction between monoamine oxidase inhibitors and tricyclic antidepressants.
Topics: Animals; Antidepressive Agents; Cats; Drug Interactions; Female; Hydrazines; Imipramine; Male; Monoa | 1972 |