Page last updated: 2024-10-29

imipramine and Neoplasms

imipramine has been researched along with Neoplasms in 26 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Fifty-two cancer patients diagnosed as having neuropathic pain were allocated into four groups: G400-I group took gabapentin 200 mg and imipramine 10 mg every 12 h orally; G400 group took gabapentin 200 mg every 12 h orally; G800 group took gabapentin 400 mg every 12 h orally; I group took imipramine 10 mg every 12 h orally."9.14Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. ( Arai, YC; Arakawa, M; Hayashi, R; Kinoshita, A; Kobayashi, K; Kondo, M; Matsubara, S; Matsubara, T; Nishida, K; Nishihara, M; Shimo, K; Suetomi, K; Suzuki, C; Tohyama, Y; Ushida, T, 2010)
"A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q."9.08Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998)
"Burkitt lymphoma is a rare malignancy arising from B cells."5.40The NADPH oxidase inhibitor imipramine-blue in the treatment of Burkitt lymphoma. ( Becker, J; Eberth, S; Klingenberg, M; Kube, D; Wilting, J, 2014)
"Fifty-two cancer patients diagnosed as having neuropathic pain were allocated into four groups: G400-I group took gabapentin 200 mg and imipramine 10 mg every 12 h orally; G400 group took gabapentin 200 mg every 12 h orally; G800 group took gabapentin 400 mg every 12 h orally; I group took imipramine 10 mg every 12 h orally."5.14Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. ( Arai, YC; Arakawa, M; Hayashi, R; Kinoshita, A; Kobayashi, K; Kondo, M; Matsubara, S; Matsubara, T; Nishida, K; Nishihara, M; Shimo, K; Suetomi, K; Suzuki, C; Tohyama, Y; Ushida, T, 2010)
"This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms."5.13Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008)
"A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q."5.08Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998)
" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome."4.80Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000)
"Burkitt lymphoma is a rare malignancy arising from B cells."1.40The NADPH oxidase inhibitor imipramine-blue in the treatment of Burkitt lymphoma. ( Becker, J; Eberth, S; Klingenberg, M; Kube, D; Wilting, J, 2014)
"Eight depressed children with cancer had a rapid clinical response to low doses of imipramine or amitriptyline."1.27Tricyclic antidepressants for children with cancer. ( Cangir, A; Choroszy, M; Kumor, K; Pfefferbaum-Levine, B; Roseberry, EA, 1983)
" A dosing strategy for the combbination of clomipramine and haloperidol is described."1.26[The treatment of chronic pain symptoms with psychotropic drugs (author's transl)]. ( Kocher, R, 1976)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199018 (69.23)18.7374
1990's1 (3.85)18.2507
2000's2 (7.69)29.6817
2010's5 (19.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tukey, RH1
Strassburg, CP1
Dolusić, E1
Larrieu, P1
Moineaux, L1
Stroobant, V1
Pilotte, L1
Colau, D1
Pochet, L1
Van den Eynde, B1
Masereel, B1
Wouters, J1
Frédérick, R1
Unzue, A1
Lafleur, K1
Zhao, H1
Zhou, T1
Dong, J1
Kolb, P1
Liebl, J1
Zahler, S1
Caflisch, A1
Nevado, C1
Service, RF1
Klingenberg, M1
Becker, J1
Eberth, S1
Kube, D1
Wilting, J1
Arai, YC1
Matsubara, T1
Shimo, K1
Suetomi, K1
Nishihara, M1
Ushida, T1
Kobayashi, K1
Suzuki, C1
Kinoshita, A1
Kondo, M1
Matsubara, S1
Hayashi, R1
Tohyama, Y1
Nishida, K1
Arakawa, M1
HUGUES, A2
CHAUVERGNE, J2
LISSILOUR, J1
LAGARDE, C2
KRAMER, M1
LACHAPELE, A1
DAY, M1
STOCKBRIDGE, A1
STENDARDO, B1
Cankurtaran, ES1
Ozalp, E1
Soygur, H1
Akbiyik, DI1
Turhan, L1
Alkis, N1
Pfefferbaum-Levine, B1
Kumor, K1
Cangir, A1
Choroszy, M1
Roseberry, EA1
Ziebarth, D1
Schulz, P1
Luttrell, S1
Minotti, V1
De Angelis, V1
Righetti, E1
Celani, MG1
Rossetti, R1
Lupatelli, M1
Tonato, M1
Pisati, R1
Monza, G1
Fumi, G1
Del Favero, A1
Kocher, R2
Purohit, DR1
Navlakha, PL1
Modi, RS1
Eshpumiyani, R1
Evans, DL1
McCartney, CF1
Nemeroff, CB1
Haggerty, JJ1
Simon, JS1
Pedersen, CA1
Holmes, V1
Droba, M1
Mason, GA1
Raft, D1
Deutschmann, W1
Buttaro, CA1
Silvestri, D1
Turchetti, A1
Rohrer, G1
Miliani, P1
Viallet, M1
Viallet, JF1
Isnard, A1
Lapalus, B1
Gimbergues, H1
Adjan, M1
Bortz, W1

Reviews

3 reviews available for imipramine and Neoplasms

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia;

2000
Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.
    European journal of medicinal chemistry, 2016, Apr-13, Volume: 112

    Topics: Animals; Computer Simulation; Drug Design; Humans; Isoquinolines; Neoplasms; Protein Kinase Inhibito

2016
Depression in cancer patients. Diagnostic and treatment considerations.
    North Carolina medical journal, 1988, Volume: 49, Issue:10

    Topics: Depressive Disorder; Dexamethasone; Female; Genital Neoplasms, Female; Imipramine; Neoplasms; Pilot

1988

Trials

4 trials available for imipramine and Neoplasms

ArticleYear
Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine.
    Journal of anesthesia, 2010, Volume: 24, Issue:3

    Topics: Aged; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal;

2010
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008, Volume: 16, Issue:11

    Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive

2008
Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain.
    Pain, 1998, Volume: 74, Issue:2-3

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti

1998
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1974, Dec-31, Volume: 63, Issue:52

    Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug

1974

Other Studies

19 other studies available for imipramine and Neoplasms

ArticleYear
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
    Journal of medicinal chemistry, 2011, Aug-11, Volume: 54, Issue:15

    Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line; Drug Design; Enzyme Inhibitors;

2011
Biology's dry future.
    Science (New York, N.Y.), 2013, Oct-11, Volume: 342, Issue:6155

    Topics: Access to Information; Antidepressive Agents; Data Mining; Databases, Genetic; Disease; Genome, Huma

2013
The NADPH oxidase inhibitor imipramine-blue in the treatment of Burkitt lymphoma.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:4

    Topics: Animals; Antineoplastic Agents; Burkitt Lymphoma; Cell Line, Tumor; Cell Proliferation; Cell Surviva

2014
[Imipramine used as major analgesic in carcinology. Study of 118 cases].
    La Presse medicale, 1963, Apr-27, Volume: 71

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Humans; Imipramine; Neoplasms

1963
DELIRIUM AS A COMPLICATION OF IMIPRAMINE THERAPY IN THE AGED.
    The American journal of psychiatry, 1963, Volume: 120

    Topics: Astrocytoma; Brain Neoplasms; Delirium; Geriatrics; Imipramine; Neoplasms; Temporal Lobe; Toxicology

1963
[NEW MAJOR ANALGESICS IN CARCINOLOGY].
    Journal de medecine de Bordeaux et du Sud-Ouest, 1964, Volume: 141

    Topics: Analgesics; Antidepressive Agents; Humans; Imipramine; Neoplasms; Palliative Care

1964
THE EFFECTS OF DRUGS ON THE UPTAKE OF AMINES BY MAST CELLS.
    British journal of pharmacology and chemotherapy, 1964, Volume: 23

    Topics: Amines; Animals; Chlorpromazine; Cocaine; Ethanolamines; Guanethidine; Hallucinogens; Histamine; Imi

1964
[ON ANTALGIC PROPERTIES OF IMIPRAMINE IN ONCOLOGY].
    La Riforma medica, 1964, Oct-31, Volume: 78

    Topics: Imipramine; Internal Medicine; Neoplasms; Toxicology

1964
Tricyclic antidepressants for children with cancer.
    The American journal of psychiatry, 1983, Volume: 140, Issue:8

    Topics: Adolescent; Amitriptyline; Child; Child, Preschool; Depressive Disorder; Female; Humans; Imipramine;

1983
[Comparative studies of the nitrosation behavior of drugs by constant pH value and under simulated stomach conditions].
    Archiv fur Geschwulstforschung, 1982, Volume: 52, Issue:6

    Topics: Aminopyrine; Ampicillin; Biotransformation; Clomipramine; Desipramine; Dipyrone; Ethambutol; Gastric

1982
Increased plasma protein binding of imipramine in cancer patients.
    Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:6

    Topics: Adult; Aged; Erythrocytes; Female; Humans; Imipramine; Male; Middle Aged; Neoplasms; Protein Binding

1982
[The treatment of chronic pain symptoms with psychotropic drugs (author's transl)].
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:6

    Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bone Diseases; Clomipramine; Drug Therapy, C

1976
The role antidepressants in hospitalised cancer patients. (A pilot study).
    The Journal of the Association of Physicians of India, 1978, Volume: 26, Issue:4

    Topics: Adult; Depression; Female; Humans; Imipramine; Male; Middle Aged; Neoplasms

1978
[Tofranil in pain therapy of cancer patients].
    Die Medizinische Welt, 1971, Aug-28, Volume: 35

    Topics: Humans; Imipramine; Neoplasms; Pain; Palliative Care

1971
[On the antalgic action of imipramine in oncology].
    Minerva medica, 1970, Feb-17, Volume: 61, Issue:11

    Topics: Humans; Imipramine; Neoplasms; Palliative Care

1970
[Use of tofranil as antalgic in surgery].
    Marseille medical, 1969, Volume: 106, Issue:9

    Topics: Aged; Analgesics; Female; Humans; Imipramine; Male; Middle Aged; Neoplasms; Postoperative Care; Preo

1969
[Value of a thymoleptic agent combined with local therapy in practical carcinology].
    Journal de radiologie, d'electrologie, et de medecine nucleaire, 1969, Volume: 50, Issue:5

    Topics: Humans; Imipramine; Mental Disorders; Neoplasms; Skin Neoplasms

1969
[Therapeutic influence of pain symptoms in incurable tumor patients].
    Therapie der Gegenwart, 1970, Volume: 109, Issue:11

    Topics: Humans; Imipramine; Neoplasms; Pain

1970
[Treatment of severe pain in patients with carcinoma].
    Die Medizinische Welt, 1967, Sep-09, Volume: 36

    Topics: Humans; Imipramine; Neoplasms; Pain

1967