imipramine has been researched along with Narcolepsy in 46 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The course of the patient's symptomatology and the favourable response of his symptoms to stimulants and imipramine support the theory that his intermittent loss of sphincter control is part of his narcolepsy-cataplexy." | 3.69 | Narcolepsy-cataplexy and loss of sphincter control. ( Bixler, EO; Kales, A; Sollenberger, SE; Vela-Bueno, A; Vgontzas, AN, 1996) |
| "Narcolepsy is a disorder of sleep with uncontrolled sleepiness and cataplexy." | 2.40 | [Narcolepsy]. ( Shimizu, T, 1998) |
| "Saudi patients with narcolepsy have the same clinical presentation as reported in the Western literature." | 1.33 | Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder. ( Alenezi, AM; BaHammam, AS, 2006) |
| " The serum concentration-versus-time curve for each horse was analyzed separately to estimate pharmacokinetic values." | 1.31 | Pharmacokinetics of imipramine in narcoleptic horses. ( Hines, MT; Mealey, KL; Mealey, RH; Peck, KE, 2001) |
| "Narcolepsy may affect as many as 250,000 Americans." | 1.26 | The treatment of narcolepsy and cataplexy. ( Campbell, RK, 1981) |
| "Narcolepsy may affect as many as 200,000 Americans." | 1.26 | Narcolepsy. Diagnosis and treatment. ( Carskadon, MA; Dement, WC; Guilleminault, C; Zarcone, VP, 1976) |
| " Side effects were common and almost half these patients became tolerant, needing higher dosage to control symptoms." | 1.25 | Natural history, symptoms and treatment of the narcoleptic syndrome. ( Asselman, P; Baraitser, M; Marsden, CD; Parkes, JD, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (78.26) | 18.7374 |
| 1990's | 7 (15.22) | 18.2507 |
| 2000's | 3 (6.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parkes, JD | 1 |
| Baraitser, M | 1 |
| Marsden, CD | 1 |
| Asselman, P | 1 |
| Tonokura, M | 1 |
| Fujita, K | 1 |
| Morozumi, M | 1 |
| Yoshida, Y | 1 |
| Kanbayashi, T | 1 |
| Nishino, S | 1 |
| PECK, RE | 1 |
| MOUSSONG-KOVACS, E | 2 |
| TAKACS, L | 2 |
| BaHammam, AS | 1 |
| Alenezi, AM | 1 |
| Suzuki, J | 1 |
| Hess, CW | 1 |
| Strain, GM | 1 |
| Olcott, BM | 1 |
| Archer, RM | 2 |
| McClintock, BK | 1 |
| Chuman, MA | 1 |
| Sweeney, CR | 1 |
| Hendricks, JC | 2 |
| Beech, J | 1 |
| Morrison, AR | 1 |
| Soldatos, CR | 1 |
| Kales, A | 2 |
| Cadieux, RJ | 1 |
| Hagel, K | 1 |
| Campbell, RK | 1 |
| Linnoila, M | 1 |
| Simpson, D | 1 |
| Skinner, T | 1 |
| Parkes, D | 1 |
| Lunn, DP | 1 |
| Cuddon, PA | 1 |
| Shaftoe, S | 1 |
| Helbing-Zwanenburg, B | 1 |
| Kamphuisen, HA | 1 |
| Mourtazaev, MS | 1 |
| Vgontzas, AN | 1 |
| Sollenberger, SE | 1 |
| Bixler, EO | 1 |
| Vela-Bueno, A | 1 |
| Shimizu, T | 1 |
| Peck, KE | 1 |
| Hines, MT | 1 |
| Mealey, KL | 1 |
| Mealey, RH | 1 |
| Autret, A | 1 |
| Minz, M | 1 |
| Beillevaire, T | 1 |
| Degos, C | 1 |
| Cathala, HP | 1 |
| Dement, WC | 4 |
| Darke, PG | 1 |
| Jessen, V | 1 |
| Montplaisir, J | 1 |
| Pfefferbaum, A | 1 |
| Berger, PA | 1 |
| Mitler, MM | 1 |
| Soave, O | 1 |
| Carskadon, MA | 1 |
| Guilleminault, C | 2 |
| Zarcone, VP | 1 |
| Lange, KW | 1 |
| Egeler-Peerdeman, SM | 1 |
| Visscher, F | 1 |
| Taphoorn, MJ | 1 |
| Hughes, C | 1 |
| Karacan, I | 1 |
| Cunha, UV | 1 |
| Roth, B | 4 |
| Faber, J | 4 |
| Nevsímalová, S | 4 |
| Tosovský, J | 3 |
| Kuhlo, W | 1 |
| Zarcone, V | 1 |
| Kendel, K | 1 |
| Rüther, E | 1 |
| Beck, U | 1 |
| Meier-Ewert, K | 1 |
| Carskadon, M | 1 |
| Sigwald, J | 1 |
| Julou, L | 1 |
| Bouttier, D | 1 |
| Thomas, J | 1 |
| Pearlman, CA | 1 |
| Greenberg, R | 1 |
| Gottschalk, LA | 1 |
| Gleser, GC | 1 |
| Wylie, HW | 1 |
| Kaplan, SM | 1 |
| Passouant, P | 1 |
| Baldy-Moulinier, M | 1 |
| Aussilloux, C | 1 |
| Bourdillon, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for imipramine and Narcolepsy
| Article | Year |
|---|---|
Introduction to the mechanism of action of different treatments of narcolepsy.
Topics: Amphetamine; Brain; Clomipramine; Drug Therapy, Combination; Humans; Imipramine; Narcolepsy | 1994 |
[Narcolepsy].
Topics: Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Clomipramine; Diagnosis, Differ | 1998 |
[Narcolepsy].
Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Clomipramine; Diagnosis, Differential; Female; Hum | 1990 |
[Nacolepsy an its therapy].
Topics: Amphetamine; Barbiturates; Cataplexy; Drug Tolerance; Electroencephalography; Humans; Imipramine; Mo | 1971 |
Narcolepsy.
Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Diagnosis, Differential; Female; Hallucinations; H | 1973 |
Medical-psychological implications of recent sleep research.
Topics: Adaptation, Psychological; Amphetamine; Barbiturates; Central Nervous System Stimulants; Chloral Hyd | 1970 |
2 trials available for imipramine and Narcolepsy
| Article | Year |
|---|---|
Clinical and polygraphic effects of d.1 5 HTP on narcolepsy-cataplexy.
Topics: 5-Hydroxytryptophan; Cataplexy; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Fema | 1977 |
Effects of imipramine on anxiety and hostility levels.
Topics: Adult; Anxiety; Clinical Trials as Topic; Fear; Guilt; Hate; Humans; Hypochondriasis; Imipramine; Ma | 1965 |
38 other studies available for imipramine and Narcolepsy
| Article | Year |
|---|---|
Natural history, symptoms and treatment of the narcoleptic syndrome.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Clomipr | 1975 |
Narcolepsy in a hypocretin/orexin-deficient chihuahua.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Dog Diseases; Dogs; Imipramine; Intracellul | 2003 |
Imipramine hydrochloride in the treatment of narcolepsy--a case report.
Topics: Health Services; Humans; Imipramine; Narcolepsy; Psychopharmacology; Sleep Wake Disorders | 1961 |
Treatment of narcolepsy with imipramin.
Topics: Humans; Imipramine; Narcolepsy; Sleep Wake Disorders | 1963 |
[Imipramine in the treatment of narcolepsy. (Preliminary communication)].
Topics: Communication; Health Services; Humans; Imipramine; Narcolepsy; Sleep Wake Disorders | 1962 |
Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Antidepressive Agents, Second-Generation; Ant | 2006 |
Narcoleptic syndrome and paradoxical sleep.
Topics: Adolescent; Adult; Child; Chlorpromazine; Electroencephalography; Eye Movements; Female; Humans; Imi | 1966 |
[Narcolepsy--epilepsy. Differential diagnosis].
Topics: Amnesia; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Epilepsy; Halluci | 1984 |
Narcolepsy in a Brahman bull.
Topics: Animals; Cattle; Cattle Diseases; Electroencephalography; Electromyography; Electrooculography; Huma | 1984 |
The neurological basis of sleep.
Topics: Brain Stem; Electroencephalography; Eye Movements; Humans; Hypothalamus; Imipramine; Narcolepsy; Nor | 1983 |
Narcolepsy in a horse.
Topics: Animals; Atropine; Cataplexy; Female; Horse Diseases; Horses; Humans; Imipramine; Narcolepsy; Neosti | 1983 |
Treatment of sleep disorders II: narcolepsy.
Topics: Cataplexy; Female; Humans; Imipramine; Male; Methylphenidate; Narcolepsy | 1983 |
[Narcolepsy (morbus Gélineau) (author's transl)].
Topics: Electroencephalography; Female; Hallucinations; Humans; Imipramine; Male; Methylphenidate; Narcoleps | 1980 |
The treatment of narcolepsy and cataplexy.
Topics: Cataplexy; Female; Humans; Imipramine; Methylphenidate; Middle Aged; Narcolepsy; Pharmacists; Sleep | 1981 |
Characteristics of therapeutic response to imipramine in cataplectic men.
Topics: Cataplexy; Drug Tolerance; Humans; Imipramine; Male; Middle Aged; Narcolepsy; Pilot Projects | 1980 |
Familial occurrence of narcolepsy in miniature horses.
Topics: Animals; Atropine; Breeding; Electroencephalography; Female; Horse Diseases; Horses; Imipramine; Mal | 1993 |
The origin of excessive daytime sleepiness in the Prader-Willi syndrome.
Topics: Adolescent; Adult; Catalepsy; Clomipramine; Female; Humans; Hypoventilation; Imipramine; Male; Middl | 1993 |
Narcolepsy-cataplexy and loss of sphincter control.
Topics: Adult; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Fecal Inconti | 1996 |
Pharmacokinetics of imipramine in narcoleptic horses.
Topics: Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Chromatography, High Pressure Liquid; F | 2001 |
Narcolepsy--not as rare as we believed!
Topics: Adult; Child; Humans; Imipramine; Methamphetamine; Methylphenidate; Narcolepsy | 1979 |
Narcolepsy in a dog.
Topics: Animals; Dog Diseases; Dogs; Humans; Imipramine; Male; Narcolepsy | 1977 |
[Hypersomnias. 1. Narcolepsy].
Topics: Amphetamines; Clomipramine; Humans; Imipramine; Methylphenidate; Monoamine Oxidase Inhibitors; Narco | 1977 |
Narcolepsy, paranoid psychosis, and tardive dyskinesia: a pharmacological dilemma.
Topics: Chlorpromazine; Dyskinesia, Drug-Induced; Fluphenazine; Humans; Imipramine; Male; Middle Aged; Narco | 1977 |
Narcolepsy in seven dogs.
Topics: Animals; Catalepsy; Dog Diseases; Dogs; Eating; Female; Humans; Imipramine; Male; Narcolepsy; Play a | 1976 |
Narcolepsy. Diagnosis and treatment.
Topics: Adolescent; Adult; Behavior; Cataplexy; Child; Diagnosis, Differential; Female; Humans; Hypoglycemia | 1976 |
[Too weak with laughing].
Topics: Adult; Cataplexy; Clomipramine; Emotions; Female; Humans; Imipramine; Male; Methylphenidate; Middle | 1990 |
Treatment of cataplexy in a dog with narcolepsy.
Topics: Animals; Cataplexy; Dog Diseases; Dogs; Electrocardiography; Female; Imipramine; Narcolepsy; Parasym | 1989 |
Erectile dysfunction in narcoleptic patients.
Topics: Adult; Cataplexy; Erectile Dysfunction; Humans; Imipramine; Male; Methylphenidate; Middle Aged; Narc | 1986 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
[Effect of imipramine, dexphenmetrazine and amphetamine sulfate on synchronous and paradoxical sleep in narcolepsy-cataplexy. A polygraphic study].
Topics: Amphetamine; Cataplexy; Electroencephalography; Humans; Imipramine; Narcolepsy; Phenmetrazine; Sleep | 1970 |
The influence of imipramine, dexphenmetrazine and amphetaminsulphate upon the clinical and polygraphic picture of narcolepsy-cataplexy.
Topics: Amphetamine; Cataplexy; Electrocardiography; Electroencephalography; Electromyography; Electrooculog | 1971 |
A clinical and polygraphic study of the effect of a new imidazo-quinazoline derivative in narcolepsy-cataplexy. The relationship between the antidepressant and anticataplectic effects of the drug.
Topics: Antidepressive Agents; Cataplexy; Humans; Imipramine; Narcolepsy; Quinazolines; Sleep, REM | 1972 |
[L-dopa therapy of narcolepsy. Observation of clinical course and polygraphic EEG night sleep and day leads].
Topics: Adult; Brain; Dihydroxyphenylalanine; Drug Combinations; Electroencephalography; Female; Humans; Imi | 1973 |
On the treatment of rapid eye movement narcolepsy.
Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalograph | 1974 |
[Therapy of hypersomnia].
Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Centra | 1967 |
The influence of imipramine, dexphenmetrazine and amphetamine-sulphate on the composition of diurnal sleep of narcoleptics.
Topics: Amphetamine; Humans; Imipramine; Narcolepsy; Phenmetrazine; Sleep Stages; Time Factors | 1974 |
[Cataplexy associated with Gélineau's disease; effect of clomipramine].
Topics: Cataplexy; Hallucinations; Humans; Hypnosis; Imipramine; Male; Middle Aged; Narcolepsy; Paralysis; S | 1970 |
Treatment of narcolepsy.
Topics: Adult; Cataplexy; Humans; Imipramine; Male; Narcolepsy | 1971 |