imipramine has been researched along with Multiple Sclerosis in 9 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colombo, F | 1 |
| Bastoni, M | 1 |
| Nigro, A | 1 |
| Podini, P | 1 |
| Finardi, A | 1 |
| Casella, G | 1 |
| Ramesh, M | 1 |
| Farina, C | 1 |
| Verderio, C | 1 |
| Furlan, R | 1 |
| Pollak, Y | 1 |
| Orion, E | 1 |
| Goshen, I | 1 |
| Ovadia, H | 1 |
| Yirmiya, R | 1 |
| McGuire, EJ | 1 |
| Savastano, JA | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Rabey, JM | 1 |
| Moriel, EZ | 1 |
| Farkas, A | 1 |
| Firstater, M | 1 |
| Vardi, I | 1 |
| Streifler, M | 1 |
| Cendrowski, W | 1 |
| Jameson, RM | 1 |
| Dean, G | 1 |
| Gottschalk, LA | 1 |
| Gleser, GC | 1 |
| Wylie, HW | 1 |
| Kaplan, SM | 1 |
2 reviews available for imipramine and Multiple Sclerosis
| Article | Year |
|---|---|
Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'.
Topics: Animals; Antidepressive Agents, Tricyclic; Cytokines; Depressive Disorder; Disease Models, Animal; E | 2002 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
2 trials available for imipramine and Multiple Sclerosis
| Article | Year |
|---|---|
A double-blind trial with an antidepressant drug, imipramine, in multiple sclerosis.
Topics: Clinical Trials as Topic; Depression; Humans; Imipramine; Multiple Sclerosis; Placebos; Spasm | 1969 |
Effects of imipramine on anxiety and hostility levels.
Topics: Adult; Anxiety; Clinical Trials as Topic; Fear; Guilt; Hate; Humans; Hypochondriasis; Imipramine; Ma | 1965 |
5 other studies available for imipramine and Multiple Sclerosis
| Article | Year |
|---|---|
Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell-Derived Microparticles; Cytokines; Encephalomyeliti | 2018 |
Urodynamic findings and long-term outcome management of patients with multiple sclerosis-induced lower urinary tract dysfunction.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Female; Humans; Imipramine; Male; Mandelic Acids; M | 1984 |
Detrusor hyperreflexia in multiple sclerosis. Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study.
Topics: Adult; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Mu | 1979 |
[Attempts at pharmacological and surgical treatment of intentional and postural tremor in patients with disseminated sclerosis (authors transl)].
Topics: Adult; Amitriptyline; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Mu | 1976 |
Management of the bladder in non-traumatic paraplegia.
Topics: Amitriptyline; Female; Humans; Imipramine; Male; Multiple Sclerosis; Myelitis; Neoplasm Metastasis; | 1974 |