Page last updated: 2024-10-29

imipramine and Memory Disorders

imipramine has been researched along with Memory Disorders in 16 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Sweroside is a secoiridoid glycoside and belongs to a large group of naturally occurring monoterpenes with glucose sugar attached to C-1 in the pyran ring."1.72Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish ( ( Brinza, I; El-Kashak, W; Eldahshan, OA; Hritcu, L; Raey, MAE, 2022)
"Imipramine is a kind of tricyclic antidepressant with reported anti-inflammatory and anti-oxidant effects in the brain."1.62Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. ( Ahmadiani, A; Askari, S; Dargahi, L; Ghasemi, R; Javadpour, P; Rashidi, FS, 2021)
"Imipramine has been widely used as an antidepressant in the clinic over the years."1.56NS398, a cyclooxygenase-2 inhibitor, reverses memory performance disrupted by imipramine in C57Bl/6J mice. ( Bobula, B; Stachowicz, K; Tokarski, K, 2020)
"Imipramine significantly prevented memory deficits caused by Abeta25-35 in the water-maze and Y-maze tests, and inhibited the TNF-alpha increase in the frontal cortex."1.36Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease. ( Chavant, F; Deguil, J; Fauconneau, B; Ingrand, I; Lafay-Chebassier, C; Milin, S; Pain, S; Pérault-Pochat, MC, 2010)
"The results showed that memory deficits were reversed with curcumin in a dose dependent manner, as were stress-induced increases in serum corticosterone levels."1.35Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. ( Barish, PA; Li, G; Li, S; Lin, D; Ogle, WO; Pan, J; Shyamala, SG; Vernon, MM; Xu, Y, 2009)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19904 (25.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's6 (37.50)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Sang, Z2
Pan, W1
Wang, K2
Ma, Q1
Yu, L1
Yang, Y1
Bai, P2
Leng, C1
Xu, Q1
Li, X1
Tan, Z1
Liu, W1
Zhang, P1
Shi, J1
Cheng, X1
Zhang, Q1
Zheng, C1
Cheng, Y1
Yang, J1
Lu, X1
Brinza, I1
Raey, MAE1
El-Kashak, W1
Eldahshan, OA1
Hritcu, L1
Stachowicz, K1
Bobula, B1
Tokarski, K1
Javadpour, P1
Askari, S1
Rashidi, FS1
Dargahi, L1
Ahmadiani, A1
Ghasemi, R1
de Rezende, VB1
Rosa, DV1
Comim, CM1
Magno, LA1
Rodrigues, AL1
Vidigal, P1
Jeromin, A1
Quevedo, J1
Romano-Silva, MA1
Marszalek-Grabska, M1
Gibula-Bruzda, E1
Jenda, M1
Gawel, K1
Kotlinska, JH1
Xu, Y1
Lin, D1
Li, S1
Li, G1
Shyamala, SG1
Barish, PA1
Vernon, MM1
Pan, J1
Ogle, WO1
Chavant, F1
Deguil, J1
Pain, S1
Ingrand, I1
Milin, S1
Fauconneau, B1
Pérault-Pochat, MC1
Lafay-Chebassier, C1
Cline, BH1
Steinbusch, HW1
Malin, D1
Revishchin, AV1
Pavlova, GV1
Cespuglio, R1
Strekalova, T1
Garcia-Toro, M1
Talavera, JA1
Gonzalez, E1
Tejada, P1
Blanco, C1
Gonzalez, A1
Saiz-Ruiz, J1
Zarrindast, MR1
Shamsi, T1
Azarmina, P1
Rostami, P1
Shafaghi, B1
Crowe, RR1
Glass, RM1
Uhlenhuth, EH1
Hartel, FW1
Matuzas, W1
Fischman, MW1
Sternberg, DE1
Jarvik, ME1
Jenkins, RB1
Groh, RH1

Reviews

1 review available for imipramine and Memory Disorders

ArticleYear
Current concepts. Electroconvulsive therapy--a current perspective.
    The New England journal of medicine, 1984, Jul-19, Volume: 311, Issue:3

    Topics: Depression; Electroconvulsive Therapy; Humans; Imipramine; Memory Disorders; Methods; Patient Accept

1984

Trials

1 trial available for imipramine and Memory Disorders

ArticleYear
Cognitive dysfunction and imipramine in outpatient depressive.
    Archives of general psychiatry, 1981, Volume: 38, Issue:9

    Topics: Adult; Attention; Clinical Trials as Topic; Cognition Disorders; Depressive Disorder; Double-Blind M

1981

Other Studies

14 other studies available for imipramine and Memory Disorders

ArticleYear
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholine

2017
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Tr

2019
Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (
    Molecules (Basel, Switzerland), 2022, Sep-11, Volume: 27, Issue:18

    Topics: Acetylcholinesterase; Animals; Anti-Bacterial Agents; Antifungal Agents; Antioxidants; Brain; Cholin

2022
NS398, a cyclooxygenase-2 inhibitor, reverses memory performance disrupted by imipramine in C57Bl/6J mice.
    Brain research, 2020, 05-01, Volume: 1734

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cyclooxygenase 2 Inhibitors; Imipramine; Maze Lear

2020
Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling.
    Behavioural brain research, 2021, 06-25, Volume: 408

    Topics: Adrenergic Uptake Inhibitors; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Behavior, Ani

2021
NCS-1 deficiency causes anxiety and depressive-like behavior with impaired non-aversive memory in mice.
    Physiology & behavior, 2014, May-10, Volume: 130

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Avoidance Learnin

2014
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antidepressive Agents; Central Nervous System S

2016
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.
    Neuropharmacology, 2009, Volume: 57, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells

2009
Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition; Diseas

2010
The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2.
    BMC neuroscience, 2012, Sep-18, Volume: 13

    Topics: Animals; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Hippocampus; Imipramine

2012
Audioverbal cognitive dysfunction in depression. Factors involved.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Attention; Cognition Dis

2003
GABAergic system and imipramine-induced impairment of memory retention in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2004, Volume: 14, Issue:1

    Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA

2004
Memory functions in depression.
    Archives of general psychiatry, 1976, Volume: 33, Issue:2

    Topics: Amitriptyline; Depression; Female; Humans; Imipramine; Male; Memory Disorders; Memory, Short-Term

1976
Mental symptoms in Parkinsonian patients treated with L-dopa.
    Lancet (London, England), 1970, Jul-25, Volume: 2, Issue:7665

    Topics: Aged; Behavior; Depression; Dihydroxyphenylalanine; Dreams; Female; Humans; Imipramine; Male; Memory

1970