imipramine has been researched along with Long QT Syndrome in 6 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Milnacipran is a specific serotonin and norepinephrine reuptake inhibitor, which has been widely used against major depressive episodes." | 1.36 | In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine. ( Adachi-Akahane, S; Hoshiai, K; Koizumi, S; Matsumoto, M; Mitsumori, Y; Nagayama, Y; Nakamura, Y; Sugiyama, A, 2010) |
| "Fluoxetine is a potent inhibitor of CYP2D6, and imipramine is metabolized by CYP2D6." | 1.33 | QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. ( Blackmon, CL; Nykamp, DL; Roberson, AG; Schmidt, PE, 2005) |
| "No significant arrhythmias or tachycardias were observed." | 1.29 | ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine. ( Giuffre, RM; Johnson, A; O'Malley, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Mitsumori, Y | 1 |
| Nakamura, Y | 1 |
| Hoshiai, K | 1 |
| Nagayama, Y | 1 |
| Adachi-Akahane, S | 1 |
| Koizumi, S | 1 |
| Matsumoto, M | 1 |
| Sugiyama, A | 1 |
| Nykamp, DL | 1 |
| Blackmon, CL | 1 |
| Schmidt, PE | 1 |
| Roberson, AG | 1 |
| Roy, J | 1 |
| Vantol, B | 1 |
| Cowley, EA | 1 |
| Blay, J | 1 |
| Linsdell, P | 1 |
| Alderton, HR | 1 |
| Johnson, A | 1 |
| Giuffre, RM | 1 |
| O'Malley, K | 1 |
1 review available for imipramine and Long QT Syndrome
| Article | Year |
|---|---|
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Chil | 1995 |
5 other studies available for imipramine and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Cyclopropanes; Dogs; Dose-R | 2010 |
QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine.
Topics: Anti-Infective Agents, Urinary; Antidepressive Agents; Cytochrome P-450 CYP2D6 Inhibitors; Drug Syne | 2005 |
Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7.
Topics: Adenocarcinoma; Anti-Allergic Agents; Anti-Arrhythmia Agents; Astemizole; Breast Neoplasms; Cell Pro | 2008 |
ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine.
Topics: Adolescent; Alberta; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disor | 1996 |