imipramine has been researched along with Lipidoses in 13 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As the dosage of imipramine (a cationic amphiphilic drug) increased, both the PP and cellular phospholipid content increased." | 1.40 | Putative biomarker for phospholipid accumulation in cultured cells treated with phospholipidosis-inducing drugs: alteration of the phosphatidylinositol composition detected using high-performance liquid chromatography-tandem mass spectrometry. ( Hamaguchi, R; Kuroda, Y; Tanimoto, T, 2014) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "to drug-induced lipidosis." | 1.25 | Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. ( Lüllmann-Rauch, R; Scheid, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Tomida, T | 1 |
| Ishimura, M | 1 |
| Iwaki, M | 1 |
| Hamaguchi, R | 1 |
| Tanimoto, T | 1 |
| Kuroda, Y | 1 |
| Lüllmann-Rauch, R | 5 |
| Hostetler, KY | 1 |
| Matsuzawa, Y | 1 |
| Geist, SH | 1 |
| Xia, Z | 1 |
| Appelkvist, EL | 1 |
| DePierre, JW | 1 |
| Nässberger, L | 1 |
| Lüllmann-Rauch, B | 1 |
| Scheid, D | 1 |
| Joshi, UM | 1 |
| Kodavanti, PR | 1 |
| Coudert, B | 1 |
| Dwyer, TM | 1 |
| Mehendale, HM | 1 |
1 review available for imipramine and Lipidoses
| Article | Year |
|---|---|
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Per | 1981 |
12 other studies available for imipramine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans; | 2017 |
Putative biomarker for phospholipid accumulation in cultured cells treated with phospholipidosis-inducing drugs: alteration of the phosphatidylinositol composition detected using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Animals; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationshi | 2014 |
Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C.
Topics: Amantadine; Aniline Compounds; Animals; Chlorphentermine; Chlorpromazine; Heptanes; Imipramine; Lipi | 1981 |
Experimentally induced lipidosis in uterine and vaginal epithelium of rats.
Topics: Animals; Chlorphentermine; Dose-Response Relationship, Drug; Epithelium; Estrus; Female; Imipramine; | 1994 |
Tricyclic antidepressant-induced lipidosis in human peripheral monocytes in vitro, as well as in a monocyte-derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red.
Topics: Antidepressive Agents, Tricyclic; Cell Line; Citalopram; Clomipramine; Flow Cytometry; Fluorescent D | 1997 |
Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Chlorphentermine; Female; Imipramine; Inclusion Bodies; I | 1975 |
Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1975 |
Types of interaction of amphiphilic drugs with phospholipid vesicles.
Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazi | 1988 |
Retinal lesions in rat after treatment with chlorphentermine or with tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Appetite Depressants; Chlorphentermine; Cytoplasm; Di | 1974 |
Lipidosis-like ultrastructural alterations in rat lymph nodes after treatment with tricyclic antidepressants or neuroleptics.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1974 |