Page last updated: 2024-10-29

imipramine and Innate Inflammatory Response

imipramine has been researched along with Innate Inflammatory Response in 18 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Research Excerpts

ExcerptRelevanceReference
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine."7.83Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016)
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine."3.83Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016)
" The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation."3.72Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003)
"The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat."3.72Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004)
"Depression is a chronic recurrent neuropsychiatric disorder associated with inflammation."1.72Methanolic Extract of ( Ahmad, FU; Arshad, HM; Lodhi, AH, 2022)
"On 14th day of the treatment, depression-like behaviour was induced by LPS (0."1.48Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus. ( Barua, CC; Haloi, P; Pathak, DC; Ren, X; Rizavi, H; Saikia, B; Sulakhiya, K; Tamuli, S, 2018)
"Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market."1.46Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. ( Honda, H; Ito, Y; Kawamoto, T; Morita, O, 2017)
"Imipramine was administered chronically to LEW/N, outbred and F344/N rats which were then exposed to the aseptic irritant carrageenin in order to determine whether the decreased hypothalamic expression of CRH m-RNA previously shown to be associated with imipramine affects peripheral immune processes."1.29Imipramine reduces the local inflammatory response to carrageenin. ( Gold, PW; Michelson, D; Misiewicz-Poltorak, B; Raybourne, RB; Sternberg, EM, 1994)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's1 (5.56)18.2507
2000's5 (27.78)29.6817
2010's7 (38.89)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Blaess, M1
Bibak, N1
Claus, RA1
Kohl, M1
Bonaterra, GA1
Kinscherf, R1
Laufer, S1
Deigner, HP1
Yamawaki, Y1
So, H1
Oue, K1
Asano, S1
Furusho, H1
Miyauchi, M1
Tanimoto, K1
Kanematsu, T1
Arshad, HM2
Ahmad, FU2
Lodhi, AH2
Wei, KC1
Wei, WJ1
Liao, CL1
Chang, TH1
Lu, Z1
Li, Y1
Chowdhury, N1
Yu, H1
Syn, WK1
Lopes-Virella, M1
Yilmaz, Ö1
Huang, Y1
Kawamoto, T1
Ito, Y1
Morita, O1
Honda, H1
Barua, CC1
Haloi, P1
Saikia, B1
Sulakhiya, K1
Pathak, DC1
Tamuli, S1
Rizavi, H1
Ren, X1
de la Garza, AL1
Garza-Cuellar, MA1
Silva-Hernandez, IA1
Cardenas-Perez, RE1
Reyes-Castro, LA1
Zambrano, E1
Gonzalez-Hernandez, B1
Garza-Ocañas, L1
Fuentes-Mera, L1
Camacho, A1
Ramirez, K1
Sheridan, JF1
Tallerova, AV1
Kovalenko, LP1
Durnev, AD1
Seredenin, SB1
Ulrich-Merzenich, G1
Kelber, O1
Koptina, A1
Freischmidt, A1
Heilmann, J1
Müller, J1
Zeitler, H1
Seidel, MF1
Ludwig, M1
Heinrich, EU1
Winterhoff, H1
Pollak, Y1
Orion, E1
Goshen, I1
Ovadia, H1
Yirmiya, R1
Abdel-Salam, OM2
Nofal, SM1
El-Shenawy, SM1
Baiuomy, AR1
Arbid, MS1
Kubera, M1
Kenis, G1
Bosmans, E1
Kajta, M1
Basta-Kaim, A1
Scharpe, S1
Budziszewska, B1
Maes, M1
Michelson, D1
Misiewicz-Poltorak, B1
Raybourne, RB1
Gold, PW1
Sternberg, EM1
Fioramonti, J1
Bueno, L1
Delvaux, M1
Frexinos, J1
Floersheim, GL1
Bucher, K1

Reviews

2 reviews available for imipramine and Innate Inflammatory Response

ArticleYear
Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'.
    Brain, behavior, and immunity, 2002, Volume: 16, Issue:5

    Topics: Animals; Antidepressive Agents, Tricyclic; Cytokines; Depressive Disorder; Disease Models, Animal; E

2002
[Old and new physiopathological concepts of irritable bowel syndrome].
    Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:2 Pt 2

    Topics: Adult; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agen

2001

Other Studies

16 other studies available for imipramine and Innate Inflammatory Response

ArticleYear
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation.
    European journal of medicinal chemistry, 2018, Jun-10, Volume: 153

    Topics: Apoptosis; Cell Line; Cells, Cultured; Ceramides; Enzyme Inhibitors; Humans; Inflammation; Lipopolys

2018
Imipramine prevents Porphyromonas gingivalis lipopolysaccharide-induced microglial neurotoxicity.
    Biochemical and biophysical research communications, 2022, 12-17, Volume: 634

    Topics: Animals; Imipramine; Inflammation; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Periodontal Dis

2022
Methanolic Extract of
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor;

2022
Methanolic Extract of
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor;

2022
Methanolic Extract of
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor;

2022
Methanolic Extract of
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor;

2022
Discrepant Activation Pattern of Inflammation and Pyroptosis Induced in Dermal Fibroblasts in Response to Dengue Virus Serotypes 1 and 2 and Nonstructural Protein 1.
    Microbiology spectrum, 2023, 02-14, Volume: 11, Issue:1

    Topics: Caspase 1; Dengue; Dengue Virus; Fibroblasts; Humans; Imipramine; Inflammation; Insect Bites and Sti

2023
The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome.
    International journal of molecular sciences, 2023, May-05, Volume: 24, Issue:9

    Topics: Animals; Ceramides; Diet, High-Fat; Imipramine; Inflammation; Insulin Resistance; Lipopolysaccharide

2023
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:4

    Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; D

2017
Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus.
    Pharmaceutical biology, 2018, Volume: 56, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Bra

2018
Maternal Flavonoids Intake Reverts Depression-Like Behaviour in Rat Female Offspring.
    Nutrients, 2019, Mar-07, Volume: 11, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Diet; Disaccharides; Drug Interactions

2019
Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.
    Brain, behavior, and immunity, 2016, Volume: 57

    Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Corticosterone; Depression; Im

2016
[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:11

    Topics: Adamantane; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Depression; Disease

2011
Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Jul-15, Volume: 19, Issue:10

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzyl Alcohols; Brain; Cytokines;

2012
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
    Pharmacological research, 2003, Volume: 48, Issue:2

    Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise

2003
Studies on the anti-inflammatory effect of fluoxetine in the rat.
    Pharmacological research, 2004, Volume: 49, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc

2004
Stimulatory effect of antidepressants on the production of IL-6.
    International immunopharmacology, 2004, Volume: 4, Issue:2

    Topics: 5-Hydroxytryptophan; Adult; Age Factors; Aging; Antidepressive Agents; Blood Cells; Cyclohexanols; D

2004
Imipramine reduces the local inflammatory response to carrageenin.
    Agents and actions, 1994, Volume: 42, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Exudates and Transudates; Female; Gra

1994
Effects of thyroxine, oxyphenbutazone and imipramine on an inflammatory graft-versus-host reaction in chicks.
    Agents and actions, 1972, Volume: 2, Issue:4

    Topics: Animals; Atropine; Chickens; Gold; Graft vs Host Reaction; Hydralazine; Imipramine; Inflammation; Ly

1972