imipramine has been researched along with Inadequate Sleep in 21 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Amphetamine and L-dopa pretreatment attenuated the increases in apomorphine-induced stereotypy and aggression in REMSD rats, but ECS selectively reduced apomorphine-induced aggression." | 7.67 | Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments. ( Braz, S; Ferreira, TM; Silveira Filho, NG; Troncone, LR; Tufik, S, 1988) |
| " The antidepressant imipramine, which shows pro-manic properties in patients with bipolar disorder (BPD), also enhanced phospho-MARCKS in prefrontal cortex in vivo." | 3.75 | Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. ( Cirelli, C; Du, J; Falke, C; Machado-Vieira, R; Manji, HK; Szabo, ST; Tononi, G; Wang, Y; Wei, Y; Yuan, P, 2009) |
| " Amphetamine and L-dopa pretreatment attenuated the increases in apomorphine-induced stereotypy and aggression in REMSD rats, but ECS selectively reduced apomorphine-induced aggression." | 3.67 | Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments. ( Braz, S; Ferreira, TM; Silveira Filho, NG; Troncone, LR; Tufik, S, 1988) |
| "Several non-pharmacological treatments of depression upregulate adenosine concentration and/or adenosine A1 receptors (A1R) in the brain." | 1.42 | Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. ( Biber, K; Clement, HW; de Bartolomeis, A; Iasevoli, F; Idzko, M; Jacobson, KA; Normann, C; Schwarz, MK; Serchov, T; Tosh, DK; van Calker, D, 2015) |
| "Astrocytes regulate responses to sleep deprivation, raising the possibility that glial signaling mediates antidepressive-like actions of sleep deprivation." | 1.39 | Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. ( Haydon, PG; Hines, DJ; Hines, RM; Moss, SJ; Schmitt, LI, 2013) |
| " Chronic administration of the antidepressant drugs imipramine and clorgyline delays the timing of the peak number of many receptors." | 1.27 | Circadian rhythms in rat brain neurotransmitter receptors. ( Benedito, MA; Kafka, MS; Moore, RY; Naber, D; Wirz-Justice, A, 1983) |
| "In the treatment of endogenous depression REM sleep deprivation and imipramine have similar efficacy." | 1.27 | Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs. ( Vogel, GW, 1983) |
| "Imipramine treatment decreased the peak value of 5-HT concentration at 1000 to about 65% and appears to abolish the rhythm of 5-HT concentration." | 1.27 | Circadian rhythm of serotonin binding in rat brain--II. Influence of sleep deprivation and imipramine. ( Rotsch, M; Schulz, E; Wesemann, W; Zöfel, P, 1986) |
| "The influence of sleep deprivation on 3H imipramine binding was investigated in blood platelets of 32 depressed patients and 15 healthy subjects." | 1.27 | Sleep deprivation and imipramine binding sites in depressed patients and healthy subjects. ( Fähndrich, E; Haug, HJ; Rommelspacher, H; Strauss, S, 1988) |
| "Forty-six patients with various forms of endogenous depression were treated by night sleep deprivation (NSD) which was used as the cardinal method of treatment." | 1.27 | [Sleep deprivation as a method of treating endogenous depression]. ( Fakturovich, AIa; Vovin, RIa, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Serchov, T | 1 |
| Clement, HW | 1 |
| Schwarz, MK | 1 |
| Iasevoli, F | 1 |
| Tosh, DK | 1 |
| Idzko, M | 1 |
| Jacobson, KA | 1 |
| de Bartolomeis, A | 1 |
| Normann, C | 1 |
| Biber, K | 1 |
| van Calker, D | 1 |
| Szabo, ST | 1 |
| Machado-Vieira, R | 1 |
| Yuan, P | 1 |
| Wang, Y | 1 |
| Wei, Y | 1 |
| Falke, C | 1 |
| Cirelli, C | 1 |
| Tononi, G | 1 |
| Manji, HK | 1 |
| Du, J | 1 |
| Hines, DJ | 1 |
| Schmitt, LI | 1 |
| Hines, RM | 1 |
| Moss, SJ | 1 |
| Haydon, PG | 1 |
| Kafka, MS | 1 |
| Wirz-Justice, A | 2 |
| Naber, D | 1 |
| Moore, RY | 1 |
| Benedito, MA | 1 |
| Tannhauser, SL | 1 |
| Tannhauser, M | 1 |
| Barros, HM | 1 |
| Corso, CO | 1 |
| Pinto-Netto, LM | 1 |
| Chuman, MA | 1 |
| Vogel, GW | 2 |
| Pearlman, CA | 2 |
| Harris, PF | 1 |
| Overstreet, DH | 1 |
| Orbach, J | 1 |
| Asakura, W | 1 |
| Matsumoto, K | 1 |
| Ohta, H | 1 |
| Watanabe, H | 1 |
| Thurmond, A | 1 |
| Gibbons, P | 1 |
| Sloan, K | 1 |
| Walker, M | 1 |
| Porsolt, RD | 1 |
| Anton, G | 1 |
| Blavet, N | 1 |
| Jalfre, M | 1 |
| Pühringer, W | 1 |
| Hole, G | 1 |
| Wesemann, W | 1 |
| Rotsch, M | 1 |
| Schulz, E | 1 |
| Zöfel, P | 1 |
| Haug, HJ | 1 |
| Fähndrich, E | 1 |
| Strauss, S | 1 |
| Rommelspacher, H | 1 |
| Troncone, LR | 1 |
| Ferreira, TM | 1 |
| Braz, S | 1 |
| Silveira Filho, NG | 1 |
| Tufik, S | 1 |
| Vovin, RIa | 1 |
| Fakturovich, AIa | 1 |
| Stern, WC | 1 |
| Morgane, PJ | 1 |
| Greenberg, R | 2 |
| Pearlman, C | 1 |
| Pflug, B | 1 |
| Tölle, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjunctive Triple Chronotherapy in the Acute Treatment of Depression and Suicidality in the Adolescent Population: A Randomized Controlled Trial[NCT03679962] | 64 participants (Actual) | Interventional | 2019-01-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for imipramine and Inadequate Sleep
| Article | Year |
|---|---|
Theoretical view of REM sleep function: maintenance of catecholamine systems in the central nervous system.
Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Brain Chemistry; Catecholamines; Cats; Electroen | 1974 |
Cutting the REM nerve: an approach to the adaptive role of REM sleep.
Topics: Adaptation, Psychological; Animals; Anxiety; Avoidance Learning; Defense Mechanisms; Depression; Ele | 1974 |
Medical-psychological implications of recent sleep research.
Topics: Adaptation, Psychological; Amphetamine; Barbiturates; Central Nervous System Stimulants; Chloral Hyd | 1970 |
2 trials available for imipramine and Inadequate Sleep
| Article | Year |
|---|---|
REM sleep reduction effects on depression syndromes.
Topics: Adjustment Disorders; Adult; Clinical Trials as Topic; Depression; Electroconvulsive Therapy; Electr | 1975 |
Disturbance of the 24-hour rhythm in endogenous depression and the treatment of endogenous depression by sleep deprivation.
Topics: Adjustment Disorders; Adult; Age Factors; Amitriptyline; Antidepressive Agents; Blood Pressure; Circ | 1971 |
16 other studies available for imipramine and Inadequate Sleep
| Article | Year |
|---|---|
Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.
Topics: Animals; Carrier Proteins; Depression; Homer Scaffolding Proteins; Humans; Imipramine; Ketamine; Mic | 2015 |
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Bipolar Disorder; Cell Membrane; Central Ner | 2009 |
Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling.
Topics: Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Depression; Hippocampus; Imipramine; Im | 2013 |
Circadian rhythms in rat brain neurotransmitter receptors.
Topics: Animals; Circadian Rhythm; Clorgyline; Imipramine; Lithium; Male; Neurotransmitter Agents; Rats; Rec | 1983 |
Effects of carbamazepine or imipramine alone or in association with amphetamine on the fighting time of REM sleep-deprived rats.
Topics: Aggression; Animals; Carbamazepine; Dextroamphetamine; Humans; Imipramine; Male; Rats; Rats, Inbred | 1984 |
The neurological basis of sleep.
Topics: Brain Stem; Electroencephalography; Eye Movements; Humans; Hypothalamus; Imipramine; Narcolepsy; Nor | 1983 |
Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Humans; Imipra | 1983 |
Negative transfer abolished by REM sleep deprivation in rats.
Topics: Animals; Avoidance Learning; Female; Imipramine; Inhibition, Psychological; Memory; Muridae; Retenti | 1982 |
Disruption of passive avoidance memory by REM sleep deprivation: methodological and pharmacological considerations.
Topics: Animals; Avoidance Learning; Discrimination Learning; Imipramine; Male; Memory; Mental Recall; Physo | 1982 |
REM sleep deprivation potentiates the effects of imipramine and desipramine but not that of clomipramine in the forced swimming test.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Brain; Clomipramine; | 1993 |
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Electroshock; Humans; Imipramine | 1978 |
Response to sleep deprivation as a predictor of therapeutic results with antidepressant drugs.
Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Female; Humans; Imipramine; Male; Maprot | 1979 |
Circadian rhythm of serotonin binding in rat brain--II. Influence of sleep deprivation and imipramine.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Circadian Rhythm; Corticosterone; Imipramine; Male; Rat | 1986 |
Sleep deprivation and imipramine binding sites in depressed patients and healthy subjects.
Topics: Adult; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Male; Mid | 1988 |
Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Bromocriptine; Carbidopa; Dopamine; Imipramine; Levod | 1988 |
[Sleep deprivation as a method of treating endogenous depression].
Topics: Adult; Amitriptyline; Anxiety; Depersonalization; Depressive Disorder; Diazepam; Female; Humans; Imi | 1985 |