imipramine has been researched along with Idiopathic Parkinson Disease in 43 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with Parkinson's syndrome whose major symptoms are akinesis, rigidity, inertia, depression, irritability and failure of adaptation rather than tremor appear to benefit in a global way from therapy with imipramine." | 7.64 | Parkinson's syndrome, depression and imipramine. A preliminary report. ( FOWLER, W; MANDELL, AJ; MARKHAM, C, 1961) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 5.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "Tritiated imipramine binding in platelets has been used to evaluate serotonin activity in depression in previous studies." | 3.68 | Tritiated imipramine binding. A peripheral marker for serotonin in Parkinson's disease. ( Coté, L; Lawton, A; Marder, K; Mayeux, R; Sano, M; Stanley, M; Stern, Y; Williams, J, 1991) |
| "Patients with Parkinson's syndrome whose major symptoms are akinesis, rigidity, inertia, depression, irritability and failure of adaptation rather than tremor appear to benefit in a global way from therapy with imipramine." | 3.64 | Parkinson's syndrome, depression and imipramine. A preliminary report. ( FOWLER, W; MANDELL, AJ; MARKHAM, C, 1961) |
| "The most common features of Parkinson's disease (PD) are motor impairments, but many patients also present depression and memory impairment." | 1.62 | Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease. ( Andreatini, R; Da Cunha, C; Hocayen, PAS; Kanazawa, LKS; Miyoshi, E; Takahashi, RN; Vecchia, DD; Vital, MABF; Wendler, E, 2021) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 1.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| " The present study indicates that already a moderate lesion of dopaminergic neurons induces "depressive-like" behaviour in animals which is reversed by chronic administration of the antiparkinsonian drug, pramipexole." | 1.40 | Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease. ( Berghauzen-Maciejewska, K; Dziubina, A; Głowacka, U; Kolasiewicz, W; Kuter, K; Ossowska, K; Wardas, J, 2014) |
| "Nine patients 55 to 74 years old with Parkinson's disease were tested before and after treatment with 50 to 225 mg dimepramine fumarate (CIBA G-31406) for about three weeks daily in order to determine the drug's effects on electrodermal responsiveness to a series of unpredictably occurring loud sounds." | 1.26 | Effects of dimepramine fumarate on physiological and cognitive behaviors of Parkinson patients. ( Feldman, RG; Gade, A; Oscar-Berman, M; Saavedra, MA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (88.37) | 18.7374 |
| 1990's | 1 (2.33) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 2 (4.65) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Vecchia, DD | 2 |
| Kanazawa, LKS | 2 |
| Wendler, E | 2 |
| Hocayen, PAS | 1 |
| Vital, MABF | 2 |
| Takahashi, RN | 1 |
| Da Cunha, C | 1 |
| Miyoshi, E | 2 |
| Andreatini, R | 2 |
| de Almeida Soares Hocayen, P | 1 |
| Bruginski, E | 1 |
| Campos, FR | 1 |
| Stern, CAJ | 1 |
| Wöhr, M | 1 |
| Schwarting, RKW | 1 |
| Berghauzen-Maciejewska, K | 1 |
| Kuter, K | 1 |
| Kolasiewicz, W | 1 |
| Głowacka, U | 1 |
| Dziubina, A | 1 |
| Ossowska, K | 1 |
| Wardas, J | 1 |
| GAL, JC | 1 |
| DENMARK, JC | 1 |
| DAVID, JD | 1 |
| McCOMB, SG | 1 |
| MANDELL, AJ | 1 |
| MARKHAM, C | 1 |
| FOWLER, W | 1 |
| SIGWALD, J | 1 |
| PAKKENBERG, H | 1 |
| GILLHESPY, RO | 1 |
| MUSTARD, DM | 1 |
| GILLINGHAM, FJ | 1 |
| KALYANARAMAN, S | 1 |
| POROT, M | 1 |
| PASCALIS, G | 1 |
| LIM, H | 1 |
| TAN, K | 1 |
| Winer, JA | 1 |
| Bahn, S | 1 |
| Edwards, M | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Oscar-Berman, M | 1 |
| Gade, A | 1 |
| Feldman, RG | 1 |
| Saavedra, MA | 1 |
| Bhaskar, PA | 1 |
| Bhaskar, EA | 1 |
| Jagannathan, K | 1 |
| Sano, M | 1 |
| Stanley, M | 1 |
| Lawton, A | 1 |
| Coté, L | 1 |
| Williams, J | 1 |
| Stern, Y | 1 |
| Marder, K | 1 |
| Mayeux, R | 2 |
| Schneider, LS | 1 |
| Chui, HC | 1 |
| Severson, JA | 1 |
| Sloane, RB | 1 |
| Raisman, R | 1 |
| Cash, R | 1 |
| Agid, Y | 1 |
| Suranyi-Cadotte, BE | 1 |
| Gauthier, S | 1 |
| Lafaille, F | 1 |
| DeFlores, S | 1 |
| Dam, TV | 1 |
| Nair, NP | 1 |
| Quirion, R | 1 |
| D'Amato, RJ | 1 |
| Zweig, RM | 1 |
| Whitehouse, PJ | 1 |
| Wenk, GL | 1 |
| Singer, HS | 1 |
| Price, DL | 1 |
| Snyder, SH | 1 |
| Klawans, HL | 1 |
| Carvey, PM | 1 |
| Tanner, CM | 1 |
| Goetz, CG | 1 |
| Jenkins, RB | 2 |
| Groh, RH | 2 |
| Chase, TN | 1 |
| Nelson, SR | 1 |
| Walaszek, EJ | 1 |
| Roos, BE | 1 |
| Shibasaki, H | 1 |
| Shibazaki, H | 1 |
| Debus, G | 1 |
| Markham, CH | 1 |
| Giroud, M | 1 |
| Flandrois, R | 1 |
| Calamai, M | 1 |
| Buffat, JJ | 1 |
| Quiviger, P | 1 |
| Mouret, JR | 1 |
| Fisher, C | 1 |
| Yahr, MD | 1 |
| Duvoisin, RC | 1 |
| Tolosa, E | 1 |
| Presthus, J | 1 |
| Schmidt, P | 1 |
| Castaigne, P | 1 |
| Laplane, D | 1 |
| Dordain, G | 1 |
| Birkmayer, W | 1 |
| Kirow, K | 1 |
| Dandiya, PC | 1 |
| Bhargava, LP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kinetic Studies in Whole Body and Brain of [11C]DASB PET Imaging of Serotonin Transporters[NCT00059046] | 20 participants | Observational | 2003-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for imipramine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
Pharmacology of the central nervous system.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Adrenocorticotropic Hormone; Amphetamine; Anger; Angiote | 1968 |
Parkinson's syndrome. Recent progress in the medical treatment and its pharmacological basis.
Topics: Amantadine; Atropine; Catecholamines; Dihydroxyphenylalanine; Histamine H1 Antagonists; Humans; Imip | 1971 |
[Recent advances and pharmacological basis of the medical treatment of Parkinson's syndrome].
Topics: Amantadine; Catecholamines; Dihydroxyphenylalanine; Histamine H1 Antagonists; Humans; Imipramine; Pa | 1971 |
Drug therapy of parkinsonism.
Topics: Amantadine; Amitriptyline; Amphetamine; Antiparkinson Agents; Dihydroxyphenylalanine; Drug Antagonis | 1972 |
Parkinson's disease; modern treatment.
Topics: Amantadine; Amphetamine; Antidepressive Agents; Antiparkinson Agents; Aromatic Amino Acid Decarboxyl | 1973 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
[Therapy of Parkinsonism. II].
Topics: Amantadine; Amitriptyline; Humans; Imipramine; Levodopa; Parkinson Disease; Physical Therapy Modalit | 1974 |
[On the antagonism between neuroleptic and thymoleptic drugs in psychiatry and neurology].
Topics: Drug Synergism; Humans; Imipramine; Mental Disorders; Parkinson Disease; Tranquilizing Agents | 1965 |
33 other studies available for imipramine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Imipramine; Ketamine; Male; Memory, S | 2021 |
Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Gait; Imipramine; Ketamine; Male; Nerve Dege | 2018 |
Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Depression; Disease Models, Animal; Dopamine Agonist | 2014 |
[Study of the action of imipramine on parkinsonian akinesia].
Topics: Apraxias; Imipramine; Parkinson Disease; Psychopharmacology | 1960 |
Imipramine hydrochloride (Tofranil) in Parkinsonism. A preliminary report.
Topics: Imipramine; Parkinson Disease; Parkinsonian Disorders; Psychopharmacology | 1961 |
Parkinson's syndrome, depression and imipramine. A preliminary report.
Topics: Depression; Depressive Disorder; Humans; Imipramine; Irritable Mood; Motivation; Muscle Rigidity; Pa | 1961 |
[Treatment of parkinsonian akinesia].
Topics: Apraxias; Humans; Imipramine; Iproniazid; Monoamine Oxidase Inhibitors; Parkinson Disease | 1961 |
[Pathogenesis and medical treatment of parkinsonism].
Topics: Humans; Imipramine; Parkinson Disease; Parkinsonian Disorders; Piperidines; Trihexyphenidyl | 1963 |
The evaluation of imipramine in the treatment of Parkinson's disease.
Topics: Humans; Imipramine; Parasympatholytics; Parkinson Disease | 1963 |
PARKINSON'S DISEASE.
Topics: Amitriptyline; Dextroamphetamine; Humans; Imipramine; Muscle Relaxants, Central; Neurosurgery; Orphe | 1963 |
[Neurological complications during imipramine therapy].
Topics: Basal Ganglia Diseases; Disease; Extrapyramidal Tracts; Imipramine; Nervous System Diseases; Parkins | 1959 |
[Treatment of Parkinson syndroms with tofranil].
Topics: Humans; Imipramine; Parkinson Disease; Parkinsonian Disorders | 1961 |
Loss of teeth with antidepressant drug therapy.
Topics: Dental Caries; Diphenhydramine; Humans; Imipramine; Male; Middle Aged; Parkinson Disease; Psychophar | 1967 |
Adverse interaction of levodopa with tricyclic antidepressants.
Topics: Aged; Amitriptyline; Carbidopa; Drug Combinations; Drug Interactions; Female; Humans; Imipramine; Le | 1982 |
Effects of dimepramine fumarate on physiological and cognitive behaviors of Parkinson patients.
Topics: Aged; Antiparkinson Agents; Cognition; Female; Galvanic Skin Response; Habituation, Psychophysiologi | 1979 |
Augmenting procedures during L-dopa therapy for Parkinsonism.
Topics: Antacids; Dextroamphetamine; Drug Synergism; Female; Humans; Imipramine; Levodopa; Male; Middle Aged | 1975 |
Tritiated imipramine binding. A peripheral marker for serotonin in Parkinson's disease.
Topics: Aged; Biomarkers; Blood Platelets; Depression; Humans; Hydroxyindoleacetic Acid; Imipramine; Middle | 1991 |
Decreased platelet 3H-imipramine binding in Parkinson's disease.
Topics: Aged; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Male; Park | 1988 |
Parkinson's disease: decreased density of 3H-imipramine and 3H-paroxetine binding sites in putamen.
Topics: Aged; Binding Sites; Humans; Imipramine; Middle Aged; Parkinson Disease; Paroxetine; Piperidines; Pu | 1986 |
Platelet 3H-imipramine binding distinguishes depression from Alzheimer dementia.
Topics: Age Factors; Aged; Alzheimer Disease; Blood Platelets; Carrier Proteins; Depressive Disorder; Diagno | 1985 |
Aminergic systems in Alzheimer's disease and Parkinson's disease.
Topics: Alzheimer Disease; Biogenic Amines; Brain; Choline O-Acetyltransferase; Citalopram; Humans; Imiprami | 1987 |
Drug-induced myoclonus.
Topics: 5-Hydroxytryptophan; Anesthetics; Animals; Anti-Bacterial Agents; Antidepressive Agents; Bismuth; Ca | 1986 |
Mental symptoms in Parkinsonian patients treated with L-dopa.
Topics: Aged; Behavior; Depression; Dihydroxyphenylalanine; Dreams; Female; Humans; Imipramine; Male; Memory | 1970 |
[Parkinson's syndrome. 10. Effects of psychopharmacological agents on central monoamine neurons].
Topics: Amitriptyline; Humans; Imipramine; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Reserpi | 1970 |
[Self- and foreign placements of current condition in psychopharmacological longitudinal studies].
Topics: Adolescent; Aggression; Alcoholism; Antiparkinson Agents; Anxiety; Depression; Drug Evaluation; Extr | 1974 |
The "on-off" side effect of L-DOPA.
Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Cate | 1974 |
[Primary alveolar hypoventilation, Ondine's curse. New aspects of functional exploration. Study of ventilatory regulation and disorders of wakefulness].
Topics: Adult; Carbon Dioxide; Diabetes Insipidus; Electrocardiography; Encephalitis; Feeding and Eating Dis | 1974 |
[Imipramine in parkinsonism].
Topics: Aged; Drug Evaluation; Female; Humans; Imipramine; Male; Middle Aged; Parkinson Disease | 1973 |
[Amantadine. Prolonged clinical trial in 50 parkinsonian patients].
Topics: Adult; Aged; Amantadine; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Imipramine; Male; M | 1972 |
[Conservative therapy in the Parkinson syndrome].
Topics: Amantadine; Antidepressive Agents; Dihydroxyphenylalanine; Humans; Imipramine; Injections, Intraveno | 1971 |
Psychic effects in patients treated with levodopa.
Topics: Aged; Depression; Dihydroxyphenylalanine; Female; Humans; Imipramine; Middle Aged; Parkinson Disease | 1970 |
[Treatment of Parkinsonian syndromes with two derivates of iminodibenzil: imipramine (tofranil) and desipramine (pertrofana)].
Topics: Aged; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Parkinson Disease | 1967 |
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine | 1968 |