imipramine has been researched along with Hypothermia in 32 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice were studied." | 7.72 | Influence of alpha-adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice. ( Sadeghi, S; Sahebgharani, M; Zarrindast, MR, 2003) |
| "The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)(1A)-receptor full agonist, -induced hypothermia was examined in rats." | 7.72 | Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats. ( Araki, H; Gomita, Y; Kitamura, Y; Shibata, K; Tanizaki, Y, 2003) |
| "Effects of adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice were studied." | 3.72 | Influence of alpha-adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice. ( Sadeghi, S; Sahebgharani, M; Zarrindast, MR, 2003) |
| "The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)(1A)-receptor full agonist, -induced hypothermia was examined in rats." | 3.72 | Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats. ( Araki, H; Gomita, Y; Kitamura, Y; Shibata, K; Tanizaki, Y, 2003) |
| " Maternal exposure to imipramine in a dose equivalent to the therapeutic dose per unit body weight induced hyperthermic response to chlorpromazine in the male offspring, while normal control rats showed a marked hypothermia." | 3.69 | Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring. ( Fujii, T, 1997) |
| " Potential antidepressant activity in this subset was assayed in three rodent models--the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland." | 3.68 | 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. ( Andree, T; Bicksler, J; Butch, J; Fletcher, H; Husbands, GE; James, MN; Moyer, JA; Muth, EA; Stack, G; Yardley, JP, 1990) |
| "5-32 mg kg-1, ip) fully prevented apomorphine (16 mg kg-1, sc)- and partly reversed reserpine- and oxotremorine-induced hypothermia." | 3.68 | Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice. ( Assous, E; Duteil, J; Mangiameli, P; Pointeau, AM; Rambert, FA, 1991) |
| "A series of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols was prepared and evaluated for potential antidepressant activity in the reserpine-induced hypothermia model and selected central nervous system and autonomic activity tests." | 3.66 | Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols. ( Gogerty, JH; Houlihan, WJ; Parrino, VA; Ryan, E, 1983) |
| " Proadifen antagonized the action of IMI when investigated in reserpine hypothermia and ptosis and in the behavioral despair test." | 3.66 | Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats. ( Daniel, W; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H, 1981) |
| "Hypothermia was the only effect observed in all animals exposed to the FST when using this standard protocol." | 1.91 | Evidence-based severity assessment of the forced swim test in the rat. ( Becker, L; Bleich, A; Brandwein, C; Gass, P; Mallien, AS; Palme, R; Pfeiffer, N; Potschka, H; Talbot, SR, 2023) |
| "The effects of psychotropic drugs on brain inflammation may contribute to their therapeutic mechanism but also to their toxicological profile." | 1.43 | Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats. ( Azab, AN; Nassar, A; Sharon-Granit, Y, 2016) |
| " Intraventricular injection of phenylephrine produced a dose-dependent hypothermia, whereas no dose-response relationship was obtained by isoproterenol." | 1.25 | [Role of brain biogenic amines in the central thermoregulatory mechanism of the rat (author's transl)]. ( Fukushima, N, 1975) |
| " Increasing doses of nortriptyline produced a parallel shift of the hypothermic log dose-response curve for intraventricular injections of noradnamine to the right." | 1.25 | The interactions of noradnamine and imipramine-like antidepressant drugs. ( Cowell, P, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (65.63) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Crooks, PA | 1 |
| Rosenberg, HE | 1 |
| Yardley, JP | 1 |
| Husbands, GE | 1 |
| Stack, G | 1 |
| Butch, J | 1 |
| Bicksler, J | 1 |
| Moyer, JA | 1 |
| Muth, EA | 1 |
| Andree, T | 1 |
| Fletcher, H | 1 |
| James, MN | 1 |
| Houlihan, WJ | 1 |
| Gogerty, JH | 1 |
| Parrino, VA | 1 |
| Ryan, E | 1 |
| Becker, L | 1 |
| Mallien, AS | 1 |
| Pfeiffer, N | 1 |
| Brandwein, C | 1 |
| Talbot, SR | 1 |
| Bleich, A | 1 |
| Palme, R | 1 |
| Potschka, H | 1 |
| Gass, P | 1 |
| Nassar, A | 1 |
| Sharon-Granit, Y | 1 |
| Azab, AN | 1 |
| Zarrindast, MR | 1 |
| Sadeghi, S | 1 |
| Sahebgharani, M | 1 |
| MCGRATH, MD | 1 |
| PALEY, RG | 1 |
| METYSOVA, J | 2 |
| METYS, J | 2 |
| ASKEW, BM | 1 |
| MORPURGO, C | 1 |
| THEOBALD, W | 1 |
| LETTAU, HF | 1 |
| SELLERS, EA | 1 |
| SCHOENBAUM, E | 1 |
| Kitamura, Y | 1 |
| Araki, H | 1 |
| Shibata, K | 1 |
| Gomita, Y | 1 |
| Tanizaki, Y | 1 |
| Maj, J | 1 |
| Daniel, W | 1 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Rubat, C | 1 |
| Coudert, P | 1 |
| Bastide, P | 1 |
| Tronche, P | 1 |
| Tanra, AJ | 1 |
| Kagaya, A | 1 |
| Motohashi, N | 1 |
| Uchitomi, Y | 1 |
| Yamawaki, S | 1 |
| Fujii, T | 1 |
| Corral, C | 1 |
| Lissavetzky, J | 1 |
| Manzanares, I | 1 |
| Darias, V | 1 |
| Expósito-Orta, MA | 1 |
| Martïn Conde, JA | 1 |
| Sánchez-Mateo, CC | 1 |
| Bruins Slot, LA | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Ribet, JP | 1 |
| Colpaert, FC | 1 |
| Hissa, R | 1 |
| Rautenberg, W | 1 |
| Rajtar, G | 1 |
| Fukushima, N | 1 |
| Duteil, J | 1 |
| Rambert, FA | 1 |
| Pointeau, AM | 1 |
| Mangiameli, P | 1 |
| Assous, E | 1 |
| Okiyama, M | 1 |
| Ueno, K | 1 |
| Ohmori, S | 1 |
| Igarashi, T | 1 |
| Kitagawa, H | 1 |
| Kurihara, A | 1 |
| Suzuki, H | 1 |
| Sawada, Y | 1 |
| Sugiyama, Y | 1 |
| Iga, T | 1 |
| Hanano, M | 1 |
| Ahtee, L | 1 |
| Jounela, AJ | 1 |
| Saarnivaara, L | 1 |
| Simola, I | 1 |
| Srimal, RC | 1 |
| Singh, HK | 1 |
| Dhawan, BN | 1 |
| Lapin, IP | 1 |
| Suchowsky, GK | 1 |
| Pegrassi, L | 1 |
| Bruinvels, J | 1 |
| Zetler, G | 1 |
| Cowell, P | 1 |
32 other studies available for imipramine and Hypothermia
| Article | Year |
|---|---|
Synthesis of spiro[tetralin-2,2'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives as potential analgesics.
Topics: Acetates; Analgesics; Animals; Antidepressive Agents; Hypothermia; Indans; Indenes; Mice; Naphthalen | 1978 |
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Binding, Competitive; Biological Assay; | 1990 |
Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Hypothermia; Imi | 1983 |
Evidence-based severity assessment of the forced swim test in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Hypothermia; Imipramine; Prospective Studies; Rats | 2023 |
Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats.
Topics: Animals; Carbamazepine; Dinoprostone; Encephalitis; Haloperidol; Hypothalamus; Hypothermia; Imiprami | 2016 |
Influence of alpha-adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; | 2003 |
Hypothermia induced in a myxoedematous patient by imipramine hydrochloride.
Topics: Humans; Hypothermia; Imipramine; Myxedema; Psychopharmacology | 1960 |
[CONTRIBUTION TO THE DIFFERENTIATION OF THYMOLEPTICS AND NEUROLEPTICS].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Chlorprothixene; Hypothe | 1963 |
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS.
Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Beme | 1963 |
INFLUENCE OF IMPIRAMINE-LIKE COMPOUNDS AND CHLORPROMAZINE ON THE RESERPINE-HYPOTHERMIA IN MICE AND THE AMPHETAMINE-HYPERTHERMIA IN RATS.
Topics: Amphetamine; Amphetamines; Animals; Chlorpromazine; Fever; Hypothermia; Hypothermia, Induced; Imipra | 1965 |
MODIFICATION OF DRUG-INDUCED HYPOTHERMIA.
Topics: Adrenocorticotropic Hormone; Body Temperature Regulation; Chlorpromazine; Hydrocortisone; Hypothermi | 1964 |
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Indu | 1965 |
Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Drug Synergism; H | 2003 |
Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats.
Topics: Animals; Blepharoptosis; Desipramine; Hypothermia; Imipramine; Male; Motor Activity; Proadifen; Rats | 1981 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Bleph | 1995 |
TJS-010, a new prescription of Kampo medicine with putative antidepressive and anxiolytic properties.--A behavioral study using experimental models for depression and anxiety.
Topics: Administration, Oral; Animals; Anxiety; Depression; Disease Models, Animal; Drugs, Chinese Herbal; H | 1994 |
Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring.
Topics: Aggression; Aminobutyrates; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplast | 1997 |
Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Apomorphine; Blepharoptosis; Dose-Response Rela | 1999 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
Thermoregulatory effects of intrahypothalamic injections of neurotransmitters and their inhibitors in the pigeon.
Topics: Acetylcholine; Animals; Body Temperature Regulation; Columbidae; Dopamine; Dose-Response Relationshi | 1975 |
The influence of chlorpromazine, diazepam and imipramine on the central action of ethanol.
Topics: Animals; Chlorpromazine; Diazepam; Drug Synergism; Ethanol; Hypothermia; Imipramine; Lethal Dose 50; | 1977 |
[Role of brain biogenic amines in the central thermoregulatory mechanism of the rat (author's transl)].
Topics: Adaptation, Physiological; Animals; Biogenic Amines; Blood Glucose; Body Temperature Regulation; Cer | 1975 |
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.
Topics: Adrenergic beta-Agonists; Albuterol; Analysis of Variance; Animals; Antidepressive Agents; Apomorphi | 1991 |
Drug interactions between imipramine and benzodiazepines in rats.
Topics: Animals; Anti-Anxiety Agents; Blood Proteins; Brain; Chromatography, High Pressure Liquid; Desiprami | 1988 |
Uptake of propranolol by microvessels isolated from bovine brain.
Topics: 2,4-Dinitrophenol; Adsorption; Animals; Brain; Capillaries; Cattle; Dinitrophenols; Glutamine; Hypot | 1987 |
Interactions of some analgesics and antidepressants with phenelzine or reserpine in the mouse.
Topics: Alphaprodine; Analgesics; Animals; Antidepressive Agents; Body Temperature; Drug Interactions; Fencl | 1974 |
Experimental evidence for imipramine like activity of fenfluramine.
Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru | 1970 |
Proceedings: Antagonism of nicotinic acid and other kynurenines to antidepressants: one of the probable reasons of the therapy-resistance in depression?
Topics: Allopurinol; Amitriptyline; Animals; Depression; Drug Interactions; Humans; Hypnotics and Sedatives; | 1974 |
The pharmacology of 4H-3-methylcarboxyamide-1,3-benzoxazine-2-one (F.I. 6654), a compound acting on the central nervous system.
Topics: Anesthesia; Animals; Atropine; Barbiturates; Behavior, Animal; Cats; Central Nervous System; Depress | 1969 |
Effect of noradrenaline, dopamine and 5-hydroxytryptamine on body temperature in the rat after intracisternal administration.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cisterna Magna; Cocaine; Dopamine; Hypothala | 1970 |
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compo | 1968 |
The interactions of noradnamine and imipramine-like antidepressant drugs.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Cerebral Ventricles; Dibenzocycloheptenes; Hypother | 1969 |