imipramine and Hypertension studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate whether imipramine and quinidine, inhibitors of the Na /Mg exchanger, influence development of hypertension in rats infused with angiotensin (Ang) II."	7.72	Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. ( Touyz, RM; Yao, G, 2003)
"A pheochromocytoma was diagnosed in a 14-year-old boy developing hypertension after treatment with imipramine for primary nocturnal enuresis."	7.67	Pheochromocytoma diagnosed in an enuretic boy after imipramine-induced hypertension. ( Birkebaek, NH; Perrild, BD, 1986)
"Hypertension is a well-known finding in some patients with neuroblastoma."	5.27	Hypertension in neuroblastoma induced by imipramine. ( Beach, B; Feusner, J; O'Leary, M, 1987)
"To investigate whether imipramine and quinidine, inhibitors of the Na /Mg exchanger, influence development of hypertension in rats infused with angiotensin (Ang) II."	3.72	Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. ( Touyz, RM; Yao, G, 2003)
"In the present in vivo study, we have investigated whether inhibitors of the Na(+)/Mg(2+) exchanger quinidine and imipramine influence the development of hypertension and whether this is associated with modulation of mitogen-activated protein (MAP) kinase activation in arteries and kidneys of hypertensive rats."	3.72	Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. ( Touyz, RM; Yao, G, 2003)
"The uptake of 3H-serotonin, endogenous serotonin content and 3H-imipramine binding were measured in platelets of subjects with essential hypertension and matched control volunteers."	3.67	Reduced Vmax of 3H-serotonin uptake but unchanged 3H-imipramine binding in the platelets of untreated hypertensive subjects. ( Kamal, LA; Langer, SZ; Meyer, P; Raisman, R, 1984)
"A pheochromocytoma was diagnosed in a 14-year-old boy developing hypertension after treatment with imipramine for primary nocturnal enuresis."	3.67	Pheochromocytoma diagnosed in an enuretic boy after imipramine-induced hypertension. ( Birkebaek, NH; Perrild, BD, 1986)
"In the course of investigations on experimental arterial hypertension in rats, it has been stated, that imipramine prevents the development of hypertension and that is simultaneously causes an accumulation of cAMP in the vessel walls."	3.65	The role of cyclic adenosine 3',5'-monophosphate (cAMP) in the mechanism of action of tricyclic antiderpressants. ( Bobkiewicz, T; Chodera, A; Czekalski, S; Hladoń, B, 1977)
"The tricyclic antidepressant drugs: imipramine, opipramol, amitryptiline and nortryptiline inhibit development of experimental arterial hypertension in rats."	3.65	Influence of tricyclic antidepressant drugs on experimental arterial hypertension. ( Bobkiewicz, T; Chodera, A; Nowakowska, E; Okulicz-Kozaryn, I, 1975)
"Hypertension is a well-known finding in some patients with neuroblastoma."	1.27	Hypertension in neuroblastoma induced by imipramine. ( Beach, B; Feusner, J; O'Leary, M, 1987)
" The urinary excretion kinetics of bethanidine during and after repetive oral dosing was also studied."	1.25	Pharmacokinetics of bethanidine in hypertensive patients. ( Bellward, G; Cunningham, R; Dayton, P; Gibaldi, M; Israili, A; McNay, J; Shen, D; Throne, M, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (84.00)	18.7374
1990's	4 (8.00)	18.2507
2000's	3 (6.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.00)	2.80

Authors	Studies
Malhotra, V	1
Vats, M	1
Nath, R	1
Mehta, S	1
Kumar, R	1
Bhalla, M	1
Sinha, JN	1
Shanker, K	1
Pathak, SR	1
Touyz, RM	2
Yao, G	2
Brown, K	1
Ratner, M	1
Stoll, M	1
CAIRNCROSS, KD	1
GERSHON, S	1
SIGG, EB	1
OSBORNE, M	1
KOROL, B	1
NATOFF, IL	1
SAINTJEAN, A	1
DONALD, MW	1
BAN, TA	1
HORWITZ, D	1
LOVENBERG, W	1
ENGELMAN, K	1
SJOERDSMA, A	1
MCCURDY, RL	1
KAN, FJ	1
BETHUNE, HC	1
BURRELL, RH	1
CULPAN, RH	1
OGG, GJ	1
Schmitt, H	2
Kamal, LA	1
Raisman, R	1
Meyer, P	1
Langer, SZ	1
Hui, KK	1
Adler, L	1
Angrist, B	1
Lautin, A	1
Rotrosen, J	1
McNeil, GN	1
Shaw, PK	1
Dock, DS	1
Gulati, A	1
Arora, RC	1
Crayton, J	1
Evenden, J	1
Meyerson, B	1
Dadkar, NK	1
Dohadwalla, AN	1
Bhattacharya, BK	1
Chodera, A	4
Bobkiewicz, T	2
Czekalski, S	1
Hladoń, B	1
Konkiewicz, B	2
Nowakowska, E	3
Godlewski, J	1
Szczawiński, R	1
Kozaryn, I	1
Johnson, ER	1
Jones, MD	1
Stewart, JN	1
Spiker, DG	1
Pugh, DD	1
Shen, D	1
Gibaldi, M	1
Israili, A	1
Bellward, G	1
Cunningham, R	1
Throne, M	1
Dayton, P	1
McNay, J	1
Okulicz-Kozaryn, I	1
García Rodríguez, M	1
Krivonkin, KIu	1
Belousov, IuB	1
Brusov, OS	1
Katasonov, AB	1
Zlobina, GP	1
Faktor, MI	1
Buckley, M	1
Feely, J	1
Birkebaek, NH	1
Perrild, BD	1
Feusner, J	1
O'Leary, M	1
Beach, B	1
Blackwell, B	1
Rabkin, JG	1
Quitkin, FM	1
McGrath, P	1
Harrison, W	1
Tricamo, E	1
Ogura, C	1
Kimishima, K	1
Goodwin, FK	1
Bunney, WE	1
Rumack, BH	1
Anderson, RJ	1
Wolfe, R	1
Fletcher, EC	1
Vestal, BK	1
Hessov, I	1
Kaufmann, JS	1
Lajeunesse, BS	1
Guilleminault, C	1
Carskadon, M	1
Dement, WC	1
Turkington, RW	1
Chien, CP	1
Kaplan, RM	1
Lagrue, G	2
Barkan, DV	1
Hessov, IB	1
Amery, A	1
Deruyttere, M	1
Fagard, R	1
Koninckx, P	1
Lewis, WH	1
Schuckit, M	1
Robins, E	1
Feighner, J	1
Iwaki, R	1
Kudo, Y	1
Ishiko, J	1
Irikura, T	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?[NCT01623297]				52 participants (Anticipated)	Observational	2012-01-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Archives of internal medicine, 1972, Volume: 130, Issue:3 Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Clinical Trials as Topic; Fluphenazine; Humans	1972
Clinical trial of imidazoline (DH-524) as an anti-depressant. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:6 Topics: Antidepressive Agents; Chronic Disease; Depression; Humans; Hypertension; Imidazoles; Imipramine	1971

Article	Year
Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents. Bioorganic & medicinal chemistry letters, 2020, 12-01, Volume: 30, Issue:23 Topics: Animals; Antihypertensive Agents; Central Nervous System Agents; Depression; Female; Hypertension; I	2020
Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats. Journal of hypertension, 2003, Volume: 21, Issue:2 Topics: Angiotensin II; Animals; Antiporters; Biological Transport; Blood Platelets; Blood Pressure; Body We	2003
Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger. Clinical science (London, England : 1979), 2003, Volume: 105, Issue:2 Topics: Angiotensin II; Animals; Antiporters; Blood Pressure; Body Weight; Hypertension; Imipramine; Kidney	2003
Pheochromocytoma unmasked by imipramine in an 8-year-old girl. Pediatric emergency care, 2003, Volume: 19, Issue:3 Topics: Catecholamines; Child; Emergencies; Enuresis; Female; Heart Murmurs; Humans; Hypertension; Hypertrop	2003
A pharmacological basis for the cardiovascular complications of imipramine medication. The Medical journal of Australia, 1962, Sep-08, Volume: 49(2) Topics: Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Humans; Hypertension; Imipram	1962
CARDIOVASCULAR EFFECTS OF IMIPRAMINE. The Journal of pharmacology and experimental therapeutics, 1963, Volume: 141 Topics: Blood Pressure; Cardiovascular System; Cats; Coronary Vessels; Dogs; Heart; Hypertension; Hypertensi	1963
CHEESE AND MONOAMINE OXIDASE INHIBITORS. INTERACTION IN ANAESTHETISED CATS. Lancet (London, England), 1964, Mar-07, Volume: 1, Issue:7332 Topics: Cheese; Hydrazines; Hypertension; Imipramine; Iproniazid; Monoamine Oxidase Inhibitors; Nialamide; P	1964
[THE PSYCHOPHYSIOLOGICAL EFFECTS OF METHYLDOPA]. L'union medicale du Canada, 1963, Volume: 92 Topics: Blood Pressure; Blood Pressure Determination; Depression; Depressive Disorder; Dihydroxyphenylalanin	1963
MONOAMINE OXIDASE INHIBITORS, TYRAMINE, AND CHESSE. JAMA, 1964, Jun-29, Volume: 188 Topics: Cheese; Food Analysis; Hypertension; Imipramine; Meperidine; Monoamine Oxidase Inhibitors; Nialamide	1964
TRANSIENT BRAIN SYNDROME AS A NON-FATAL REACTION TO COMBINED PARGYLINE-IMIPRAMINE TREATMENT. The American journal of psychiatry, 1964, Volume: 121 Topics: Brain; Depression; Depressive Disorder; Drug Therapy; Geriatrics; Hypertension; Imipramine; Mental D	1964
VASCULAR CRISES ASSOCIATED WITH MONOAMINE-OXIDASE INHIBITORS. The American journal of psychiatry, 1964, Volume: 121 Topics: Amphetamine; Amphetamines; Beer; Cheese; Dairy Products; Drug Therapy; Headache; Hypertension; Imipr	1964
[Restraining action of antidepressive agents of the imipramine group on the cardiovascular centers]. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 165, Issue:2 Topics: Action Potentials; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Blood Pressure; Carotid	1967
Reduced Vmax of 3H-serotonin uptake but unchanged 3H-imipramine binding in the platelets of untreated hypertensive subjects. Life sciences, 1984, May-21, Volume: 34, Issue:21 Topics: Biological Transport; Blood Platelets; Carrier Proteins; Humans; Hypertension; Imipramine; Kinetics;	1984
Hypertensive crisis induced by interaction of clonidine with imipramine. Journal of the American Geriatrics Society, 1983, Volume: 31, Issue:3 Topics: Aged; Clonidine; Drug Interactions; Emergencies; Female; Humans; Hypertension; Imipramine; Time Fact	1983
Differential effects of tricyclic antidepressants on mean arterial pressure in a hypertensive patient. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2 Topics: Blood Pressure; Depressive Disorder; Humans; Hypertension; Hypotension, Orthostatic; Imipramine; Mal	1983
Substitution of atenolol for propranolol in a case of propranolol-related depression. The American journal of psychiatry, 1982, Volume: 139, Issue:9 Topics: Angina Pectoris; Atenolol; Depressive Disorder; Female; Humans; Hypertension; Imipramine; Middle Age	1982
Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin. European journal of pharmacology, 1993, Feb-09, Volume: 231, Issue:2 Topics: Animals; Binding, Competitive; Blood Pressure; Brain Chemistry; Brain Stem; Cell Membrane; Cerebral	1993
The behavior of spontaneously hypertensive and Wistar Kyoto rats under a paced fixed consecutive number schedule of reinforcement. Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Chlordiazepoxide; Conditioning, Opera	1999
Role of peripheral vascular resistance and reactivity in the interaction between clonidine and imipramine in spontaneously hypertensive rats. The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:1 Topics: Animals; Blood Pressure; Clonidine; Hypertension; Imipramine; Male; Rats; Vascular Resistance	1978
The role of cyclic adenosine 3',5'-monophosphate (cAMP) in the mechanism of action of tricyclic antiderpressants. Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:2 Topics: Animals; Aorta; Blood Pressure; Blood Vessels; Cyclic AMP; Female; Hypertension; Imipramine; Ischemi	1977
The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension. International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:7 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Catecholamines; Hemodynamics; Humans; Hypertension;	1979
The influence of imipramine on the circulatory system and some other parameters of arterial hypertension. Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:6 Topics: Adult; Catecholamines; Eosinophils; Fundus Oculi; Humans; Hypertension; Imipramine; Middle Aged	1977
Occurrence of a pheochromocytoma after ingestion of imipramine. The Journal of the American Osteopathic Association, 1979, Volume: 78, Issue:5 Topics: Abdominal Neoplasms; Adult; Humans; Hypertension; Imipramine; Male; Neoplasms, Multiple Primary; Phe	1979
Combining tricyclic and monoamine oxidase inhibitor antidepressants. Archives of general psychiatry, 1976, Volume: 33, Issue:7 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Humans; Hype	1976
Pharmacokinetics of bethanidine in hypertensive patients. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:3 Topics: Administration, Oral; Adult; Benzyl Compounds; Depression, Chemical; Feces; Guanidines; Half-Life; H	1975
Influence of tricyclic antidepressant drugs on experimental arterial hypertension. Archivum immunologiae et therapiae experimentalis, 1975, Volume: 23, Issue:4 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Female; Hexobarbital; Hype	1975
[Antagonism of guanethidine action and the others blocking agents by diphenychydramine, imipramine and dextroamphetamine in illation with human hypertension (author's transl)]. Archivos de farmacologia y toxicologia, 1975, Volume: 1, Issue:3 Topics: Animals; Dextroamphetamine; Diphenhydramine; Guanethidine; Hypertension; Imipramine; Male; Rats; Sti	1975
[Function of the serotoninergic system of blood platelets in patients with hypertension]. Kardiologiia, 1992, Volume: 32, Issue:11-12 Topics: Blood Flow Velocity; Blood Platelets; Female; Humans; Hypertension; Imipramine; Male; Middle Aged; R	1992
Antagonism of antihypertensive effect of guanfacine by tricyclic antidepressants. Lancet (London, England), 1991, May-11, Volume: 337, Issue:8750 Topics: Adult; Amitriptyline; Drug Interactions; Female; Guanfacine; Humans; Hypertension; Imipramine	1991
Pheochromocytoma diagnosed in an enuretic boy after imipramine-induced hypertension. Pediatric hematology and oncology, 1986, Volume: 3, Issue:3 Topics: Adolescent; Adrenal Gland Neoplasms; Enuresis; Headache; Humans; Hypertension; Imipramine; Male; Phe	1986
Hypertension in neuroblastoma induced by imipramine. The American journal of pediatric hematology/oncology, 1987,Winter, Volume: 9, Issue:4 Topics: Adrenal Gland Neoplasms; Catecholamines; Child Behavior Disorders; Child, Preschool; Female; Humans;	1987
Monoamine oxidase inhibitors. The British journal of psychiatry : the journal of mental science, 1986, Volume: 148 Topics: Humans; Hypertension; Imipramine; Monoamine Oxidase Inhibitors; Phenelzine	1986
Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:1 Topics: Adult; Bipolar Disorder; Body Weight; Erectile Dysfunction; Female; Humans; Hypertension; Imipramine	1985
Central nervous actions and screening methods of antidepressants. Folia psychiatrica et neurologica japonica, 1972, Volume: 26, Issue:4 Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Amines; Blo	1972
Ornade and anticholinergic toxicity: hypertension, hallucinations, and arrhythmias. Clinical toxicology, 1974, Volume: 7, Issue:6 Topics: Adolescent; Adult; Arrhythmias, Cardiac; Chlorpheniramine; Clomipramine; Dibenzazepines; Drug Combin	1974
Hypertension during imipramine treatment. Lancet (London, England), 1970, Jan-10, Volume: 1, Issue:7637 Topics: Depression; Female; Humans; Hypertension; Imipramine; Middle Aged	1970
Letter: Pheochromocytoma and tricyclic antidepressants. JAMA, 1974, Sep-02, Volume: 229, Issue:10 Topics: Adrenal Gland Neoplasms; Adult; Blood Vessels; Catecholamines; Depression; Epilepsy, Tonic-Clonic; F	1974
[True and false adverse effects of thymoanaleptic medications]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Dec-08, Volume: 44, Issue:51 Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio	1968
On the treatment of rapid eye movement narcolepsy. Archives of neurology, 1974, Volume: 30, Issue:1 Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalograph	1974
[Significance of enuresis. Symptomatological value in uro-nephrology]. Minerva medica, 1972, Jul-28, Volume: 63, Issue:56 Topics: Adolescent; Child; Chronic Disease; Circadian Rhythm; Enuresis; Female; Humans; Hypertension; Imipra	1972
[Enuresis as a nephrological symptom]. Munchener medizinische Wochenschrift (1950), 1971, Sep-24, Volume: 113, Issue:39 Topics: Adult; Age Factors; Child; Congenital Abnormalities; Cystitis; Diagnosis, Differential; Diazepam; En	1971
[The effect of melipramine on the clinical picture and course of manic-depressive psychosis]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1969, Volume: 69, Issue:9 Topics: Adolescent; Adult; Aged; Anxiety; Bipolar Disorder; Communicable Diseases; Craniocerebral Trauma; De	1969
[Arterial hypertension in imipramine treatment]. Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1969, Volume: 23, Issue:4 Topics: Arteries; Female; Humans; Hypertension; Imipramine; Middle Aged; Regional Blood Flow	1969
[New antihypertensive drugs. II. Debrisoquin or Declinax]. Acta clinica Belgica, 1970, Volume: 25, Issue:5 Topics: Amidines; Antihypertensive Agents; Blood; Cardiac Output; Diet; Guanethidine; Heart Rate; Humans; Hy	1970
Iatrogenic psychotic depressive reaction in hypertensive patients. The American journal of psychiatry, 1971, Volume: 127, Issue:10 Topics: Aged; Bipolar Disorder; Diuretics; Humans; Hypertension; Hyponatremia; Iatrogenic Disease; Imipramin	1971
Tricyclic antidepressants and monoamine oxidase inhibitors. Archives of general psychiatry, 1971, Volume: 24, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug	1971
[Differences on blood pressure responses to drugs in hypertensive and normotensive rats. (1)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1967, Nov-20, Volume: 63, Issue:6 Topics: Animals; Atropine; Azoles; Blood Pressure; Body Weight; Caffeine; Carbamates; Chlorothiazide; Diuret	1967

imipramine and Hypertension

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