imipramine has been researched along with Heart Failure in 18 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The value of intravenous imipramine in creating a reversible model of short term heart failure was evaluated in anaesthetised dogs." | 7.68 | Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices. ( Cheriex, EC; Habets, J; Lucas, CM; Penn, OC; van der Nagel, T; van der Veen, FH; Wellens, HJ, 1992) |
| " During a double-blind drug and dose selection phase, investigators were permitted to change drug or dosage to achieve greater than or equal to 70% suppression in VPC frequency and greater than 90% suppression of runs of VPC with the exception of patients assigned to placebo, who continued receiving it." | 6.66 | Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS. ( , 1988) |
| "Bupropion is a new antidepressant of the aminoketone class which is structurally unrelated to the tricyclics and which is relatively free of cardiac side effects in healthy depressed patients." | 6.66 | Cardiovascular effects of imipramine and bupropion in depressed patients with congestive heart failure. ( Bigger, JT; Giardina, EG; Glassman, AH; Johnson, LL; Roose, SP; Walsh, BT, 1987) |
| "The physician must watch carefully for orthostatic hypotension when using imipramine in depressed patients with impaired LVP." | 5.27 | The use of imipramine in depressed patients with congestive heart failure. ( Bigger, JT; Cooper, TB; Giardina, EG; Glassman, AH; Johnson, LL; Roose, SP; Walsh, BT, 1983) |
| "The measurement protocol consisted of two phases: a) apnea, randomized jet ventilation (systole- and diastole-synchronized); b) postjet ventilation apnea, before and after heart failure, induced with a propranolol-imipramine-plasma expansion treatment." | 3.69 | Effect of jet ventilation on heart failure: decreased afterload but negative response in left ventricular end-systolic pressure-volume function. ( Mathru, M; Rooney, MW; Weber, A, 1996) |
| "A case report is presented of an adolescent male who developed hypothyroidism and cardiomyopathy 6 months after he began taking lithium and imipramine for a severe conduct disorder." | 3.68 | Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy. ( Dietrich, A; Mortensen, ME; Wheller, J, 1993) |
| "Only two goats showed an increase in aortic and left and right ventricular pressures concomitant with increased aortic flow during latissimus dorsi muscle stimulation both before and after induction of cardiac failure using imipramine." | 3.68 | Long-term follow-up (12 to 35 weeks) after dynamic cardiomyoplasty. ( Cheriex, EC; Havenith, M; Lorusso, R; Lucas, CM; Penn, OC; Van der Veen, FH; Wellens, HJ, 1993) |
| "The value of intravenous imipramine in creating a reversible model of short term heart failure was evaluated in anaesthetised dogs." | 3.68 | Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices. ( Cheriex, EC; Habets, J; Lucas, CM; Penn, OC; van der Nagel, T; van der Veen, FH; Wellens, HJ, 1992) |
| " In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline." | 3.66 | Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. ( Oei, LS; Rodstein, M, 1979) |
| " During a double-blind drug and dose selection phase, investigators were permitted to change drug or dosage to achieve greater than or equal to 70% suppression in VPC frequency and greater than 90% suppression of runs of VPC with the exception of patients assigned to placebo, who continued receiving it." | 2.66 | Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS. ( , 1988) |
| "Bupropion is a new antidepressant of the aminoketone class which is structurally unrelated to the tricyclics and which is relatively free of cardiac side effects in healthy depressed patients." | 2.66 | Cardiovascular effects of imipramine and bupropion in depressed patients with congestive heart failure. ( Bigger, JT; Giardina, EG; Glassman, AH; Johnson, LL; Roose, SP; Walsh, BT, 1987) |
| "Medical treatment of heart failure is associated with 50% survival at 5 years." | 2.43 | Animal models of heart failure: what is new? ( Chachques, JC; Monnet, E, 2005) |
| "The physician must watch carefully for orthostatic hypotension when using imipramine in depressed patients with impaired LVP." | 1.27 | The use of imipramine in depressed patients with congestive heart failure. ( Bigger, JT; Cooper, TB; Giardina, EG; Glassman, AH; Johnson, LL; Roose, SP; Walsh, BT, 1983) |
| "Imipramine was infused at 1 mg/kg/min until cardiac failure and vascular collapse terminated the experiment at 21 +/- 2." | 1.27 | Treatment of haemodynamic and electrocardiographic side-effects resulting from imipramine toxicity in rats and dogs. ( Fiedler, VB; Göbel, H; Kettenbach, B; Nitz, RE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BESSON, H | 1 |
| Monnet, E | 1 |
| Chachques, JC | 1 |
| Glassman, AH | 2 |
| Johnson, LL | 2 |
| Giardina, EG | 2 |
| Walsh, BT | 2 |
| Roose, SP | 2 |
| Cooper, TB | 1 |
| Bigger, JT | 2 |
| Dietrich, A | 1 |
| Mortensen, ME | 1 |
| Wheller, J | 1 |
| Lucas, CM | 2 |
| Van der Veen, FH | 2 |
| Cheriex, EC | 2 |
| Lorusso, R | 1 |
| Havenith, M | 1 |
| Penn, OC | 2 |
| Wellens, HJ | 2 |
| Weber, A | 1 |
| Mathru, M | 1 |
| Rooney, MW | 1 |
| Rodstein, M | 1 |
| Oei, LS | 1 |
| Ramanathan, KB | 1 |
| Davidson, C | 1 |
| Habets, J | 1 |
| van der Nagel, T | 1 |
| Greene, HL | 1 |
| Richardson, DW | 1 |
| Hallstrom, AP | 1 |
| McBride, R | 1 |
| Capone, RJ | 1 |
| Barker, AH | 1 |
| Roden, DM | 1 |
| Echt, DS | 1 |
| Fiedler, VB | 1 |
| Kettenbach, B | 1 |
| Göbel, H | 1 |
| Nitz, RE | 1 |
| Eggermont, E | 1 |
| Raveschot, J | 1 |
| Deneve, V | 1 |
| Casteels-van Daele, M | 1 |
| Moccetti, T | 1 |
| Lichtlen, P | 1 |
| Bain, DJ | 1 |
| Turner, T | 1 |
| Greeff, K | 1 |
| Wagner, J | 1 |
| Bismuth, C | 1 |
| Bodin, F | 1 |
| Pebay-Peroula, F | 1 |
| Frejaville, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000504] | Phase 2 | 0 participants | Interventional | 1982-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for imipramine and Heart Failure
| Article | Year |
|---|---|
Animal models of heart failure: what is new?
Topics: Animals; Blood Pressure; Cardiac Volume; Cardiomyopathy, Dilated; Disease Models, Animal; Doxorubici | 2005 |
3 trials available for imipramine and Heart Failure
| Article | Year |
|---|---|
Congestive heart failure after acute myocardial infarction in patients receiving antiarrhythmic agents for ventricular premature complexes (Cardiac Arrhythmia Pilot Study).
Topics: Anilides; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Double-Blind Method; Encainide; Fema | 1989 |
Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Metho | 1988 |
Cardiovascular effects of imipramine and bupropion in depressed patients with congestive heart failure.
Topics: Aged; Angiocardiography; Antidepressive Agents; Blood Pressure; Bupropion; Clinical Trials as Topic; | 1987 |
14 other studies available for imipramine and Heart Failure
| Article | Year |
|---|---|
[THE HEART AND POISONINGS].
Topics: Chloroquine; Diagnosis; Digitalis Glycosides; Heart; Heart Failure; Imipramine; Prognosis; Quinidine | 1964 |
The use of imipramine in depressed patients with congestive heart failure.
Topics: Aged; Depressive Disorder; Electrocardiography; Female; Heart Failure; Heart Ventricles; Humans; Hyp | 1983 |
Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy.
Topics: Adolescent; Cardiac Complexes, Premature; Cardiomyopathies; Child; Child Behavior Disorders; Drug Th | 1993 |
Long-term follow-up (12 to 35 weeks) after dynamic cardiomyoplasty.
Topics: Animals; Biopsy; Cardiac Pacing, Artificial; Cardiac Surgical Procedures; Echocardiography, Doppler; | 1993 |
Effect of jet ventilation on heart failure: decreased afterload but negative response in left ventricular end-systolic pressure-volume function.
Topics: Adrenergic Uptake Inhibitors; Animals; Catecholamines; Diastole; Disease Models, Animal; Dogs; Heart | 1996 |
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; | 1979 |
Cardiac arrhythmia and imipramine therapy.
Topics: Arrhythmias, Cardiac; Female; Heart Failure; Humans; Imipramine; Middle Aged | 1975 |
Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Echocardiography; Electrophysiology; Female; | 1992 |
Treatment of haemodynamic and electrocardiographic side-effects resulting from imipramine toxicity in rats and dogs.
Topics: Animals; Arrhythmias, Cardiac; Chromonar; Coumarins; Dipyridamole; Dogs; Electrocardiography; Female | 1985 |
The adverse influence of imipramine on the adaptation of the newborn infant to extrauterine life.
Topics: Cyanosis; Depression; Female; Fetal Diseases; Fetus; Heart Failure; Humans; Imipramine; Infant, Newb | 1972 |
[Changes in the heart due to phenothiazines and imipramine derivatives].
Topics: Aged; Anticonvulsants; Arrhythmias, Cardiac; Death, Sudden; Electrocardiography; Heart Diseases; Hea | 1971 |
Imipramine poisoning.
Topics: Amitriptyline; Child; Enzymes; Female; Heart Failure; Humans; Imipramine; Poisoning | 1971 |
[Animal experiments to study the cardiotoxic effect of thymoleptics].
Topics: Amitriptyline; Animals; Blood Pressure; Cats; Desipramine; Drug Synergism; Epinephrine; Heart; Heart | 1971 |
[Imipramine poisoning and acute cardiac failure. Value of sodium lactate].
Topics: Adult; Arrhythmias, Cardiac; Barbiturates; Chlormethiazole; Electric Countershock; Heart Conduction | 1968 |