imipramine has been researched along with Glial Cell Tumors in 12 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a new anti-invasive small molecule, Imipramine Blue (IB), which inhibits invasion of glioma in vitro when tested against several models." | 7.78 | Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. ( Arbiser, JL; Bellamkonda, RV; Bonner, MY; Brat, DJ; Courtneidge, SA; Diaz, B; Fried, L; Karumbaiah, L; Knaus, UG; Munson, JM; Rowson, SA, 2012) |
| "We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma cells and natural killer (NK) cell line, innate immunity." | 7.77 | Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. ( Fiserová, A; Kovaru, F; Kovárů, H; Lisá, V; Ondráčkova, P, 2011) |
| "In has been found that sphingosine, propranolol, imipramine and phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) have a stimulatory effect on phospholipase D activity in glioma C6 cells." | 7.70 | Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester. ( Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I, 2000) |
| " Imipramine increased the maximum response to 5-HT without altering the EC50 of the dose-response curve." | 5.30 | Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway. ( Kamei, K; Muneoka, K; Muraoka, S; Takigawa, M, 1998) |
| " We report a new anti-invasive small molecule, Imipramine Blue (IB), which inhibits invasion of glioma in vitro when tested against several models." | 3.78 | Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. ( Arbiser, JL; Bellamkonda, RV; Bonner, MY; Brat, DJ; Courtneidge, SA; Diaz, B; Fried, L; Karumbaiah, L; Knaus, UG; Munson, JM; Rowson, SA, 2012) |
| "Because both imipramine and citalopram have been commonly used to treat depression, which commonly occurs in glioma patients, it would be interesting to conduct large epidemiological studies to investigate the actual benefit that these two drugs would provide for malignant glioma patients when delivered during their glioma treatment." | 3.78 | Voltage-dependent K+ channels as oncotargets in malignant gliomas. ( De Witte, O; Lefranc, F; Pouleau, HB; Rynkowski, M, 2012) |
| "We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma cells and natural killer (NK) cell line, innate immunity." | 3.77 | Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. ( Fiserová, A; Kovaru, F; Kovárů, H; Lisá, V; Ondráčkova, P, 2011) |
| "In has been found that sphingosine, propranolol, imipramine and phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) have a stimulatory effect on phospholipase D activity in glioma C6 cells." | 3.70 | Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester. ( Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I, 2000) |
| "Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine)." | 3.69 | Estimation of apoptosis in C6 glioma cells treated with antidepressants. ( Kovárů, H; Lisá, V; Lukásová, E; Rittich, B; Spanová, A, 1997) |
| " We report here an early and important decrease in sphingomyelinase activity in C6 glioma cells cultured in the presence of imipramine or desipramine at final concentrations of 0." | 3.66 | Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells. ( Albouz, S; Baumann, N; Boutry, JM; Hauw, JJ; Le Saux, F; Vanier, MT, 1983) |
| " Dose-response curves for each drug, conducted at each drug's t1/2, indicated considerable differences in potency (EC50) at stimulating [3H]MPP+ release from C6-hSERT cells [3beta-(4-iodophenyl)tropane-2beta-carboxylic acid methyl ester (RTI-55) > imipramine > 1-[2-diphenylmethoxy]ethyl-4-(3-phenylpropyl)-piperazine (GBR-12935) threo-(+/-)-methylphenidate > cocaine > mazindol > 2-beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CFT) > (+)methamphetamine > amphetamine > DA > fenfluramine > norepinephrine (NE) > 5-HT]." | 1.30 | [3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux. ( Eshleman, AJ; Janowsky, A; Johnson, RA; Meyers, T; Neve, KA, 1998) |
| " Imipramine increased the maximum response to 5-HT without altering the EC50 of the dose-response curve." | 1.30 | Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway. ( Kamei, K; Muneoka, K; Muraoka, S; Takigawa, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Wang, X | 2 |
| Wu, D | 1 |
| Qi, J | 1 |
| Zhang, Y | 1 |
| Wang, K | 1 |
| Zhou, D | 1 |
| Meng, QM | 1 |
| Nie, E | 1 |
| Wang, Q | 1 |
| Yu, RT | 1 |
| Zhou, XP | 1 |
| Shchors, K | 1 |
| Massaras, A | 1 |
| Hanahan, D | 1 |
| Shipman, L | 1 |
| Kovárů, H | 2 |
| Kovaru, F | 1 |
| Ondráčkova, P | 1 |
| Lisá, V | 2 |
| Fiserová, A | 1 |
| Munson, JM | 1 |
| Fried, L | 1 |
| Rowson, SA | 1 |
| Bonner, MY | 1 |
| Karumbaiah, L | 1 |
| Diaz, B | 1 |
| Courtneidge, SA | 1 |
| Knaus, UG | 1 |
| Brat, DJ | 1 |
| Arbiser, JL | 1 |
| Bellamkonda, RV | 1 |
| Lefranc, F | 1 |
| Pouleau, HB | 1 |
| Rynkowski, M | 1 |
| De Witte, O | 1 |
| Albouz, S | 2 |
| Vanier, MT | 1 |
| Hauw, JJ | 2 |
| Le Saux, F | 2 |
| Boutry, JM | 1 |
| Baumann, N | 2 |
| Johnson, RA | 1 |
| Eshleman, AJ | 1 |
| Meyers, T | 1 |
| Neve, KA | 1 |
| Janowsky, A | 1 |
| Spanová, A | 1 |
| Lukásová, E | 1 |
| Rittich, B | 1 |
| Muraoka, S | 1 |
| Kamei, K | 1 |
| Muneoka, K | 1 |
| Takigawa, M | 1 |
| Bobeszko, M | 1 |
| Dygas, A | 1 |
| Nalepa, I | 1 |
| Barańska, J | 1 |
| Wenger, D | 1 |
12 other studies available for imipramine and Glial Cell Tumors
| Article | Year |
|---|---|
Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Disease M | 2021 |
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit.
Topics: Animals; Anticoagulants; Antidepressive Agents, Tricyclic; Antineoplastic Combined Chemotherapy Prot | 2015 |
Glioma: Repurposed drugs combined to amplify autophagy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioma; Imipramine; Ticlop | 2015 |
Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes.
Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents, Tricyclic; Brain Neoplasms; Cell | 2011 |
Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Pro | 2012 |
Voltage-dependent K+ channels as oncotargets in malignant gliomas.
Topics: Animals; Antidepressive Agents; Apoptosis; Brain Neoplasms; Cell Movement; Citalopram; Drug Resistan | 2012 |
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Culture Techniques; Desipramine; Dose-Response Relationship, Drug; | 1983 |
[3H]substrate- and cell-specific effects of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Calcium; Carrier Proteins; Cloning, Mole | 1998 |
Estimation of apoptosis in C6 glioma cells treated with antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Apoptosis; DNA Fragmentation; Fluoxetine; Glioma; Humans; Imip | 1997 |
Chronic imipramine administration amplifies the serotonin2A receptor-induced intracellular Ca2+ mobilization in C6 glioma cells through a calmodulin-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antidepressive Agents, Tricyclic; Antipsycho | 1998 |
Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester.
Topics: Animals; Brain Neoplasms; Cell Compartmentation; Drug Interactions; Enzyme Activation; Enzyme Inhibi | 2000 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel | 1986 |