imipramine and Gelineau Syndrome studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Research Excerpts

Excerpt	Relevance	Reference
" The course of the patient's symptomatology and the favourable response of his symptoms to stimulants and imipramine support the theory that his intermittent loss of sphincter control is part of his narcolepsy-cataplexy."	3.69	Narcolepsy-cataplexy and loss of sphincter control. ( Bixler, EO; Kales, A; Sollenberger, SE; Vela-Bueno, A; Vgontzas, AN, 1996)
"Narcolepsy is a disorder of sleep with uncontrolled sleepiness and cataplexy."	2.40	[Narcolepsy]. ( Shimizu, T, 1998)
"Saudi patients with narcolepsy have the same clinical presentation as reported in the Western literature."	1.33	Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder. ( Alenezi, AM; BaHammam, AS, 2006)
" The serum concentration-versus-time curve for each horse was analyzed separately to estimate pharmacokinetic values."	1.31	Pharmacokinetics of imipramine in narcoleptic horses. ( Hines, MT; Mealey, KL; Mealey, RH; Peck, KE, 2001)
"Narcolepsy may affect as many as 250,000 Americans."	1.26	The treatment of narcolepsy and cataplexy. ( Campbell, RK, 1981)
"Narcolepsy may affect as many as 200,000 Americans."	1.26	Narcolepsy. Diagnosis and treatment. ( Carskadon, MA; Dement, WC; Guilleminault, C; Zarcone, VP, 1976)
" Side effects were common and almost half these patients became tolerant, needing higher dosage to control symptoms."	1.25	Natural history, symptoms and treatment of the narcoleptic syndrome. ( Asselman, P; Baraitser, M; Marsden, CD; Parkes, JD, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (78.26)	18.7374
1990's	7 (15.22)	18.2507
2000's	3 (6.52)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Parkes, JD	1
Baraitser, M	1
Marsden, CD	1
Asselman, P	1
Tonokura, M	1
Fujita, K	1
Morozumi, M	1
Yoshida, Y	1
Kanbayashi, T	1
Nishino, S	1
PECK, RE	1
MOUSSONG-KOVACS, E	2
TAKACS, L	2
BaHammam, AS	1
Alenezi, AM	1
Suzuki, J	1
Hess, CW	1
Strain, GM	1
Olcott, BM	1
Archer, RM	2
McClintock, BK	1
Chuman, MA	1
Sweeney, CR	1
Hendricks, JC	2
Beech, J	1
Morrison, AR	1
Soldatos, CR	1
Kales, A	2
Cadieux, RJ	1
Hagel, K	1
Campbell, RK	1
Linnoila, M	1
Simpson, D	1
Skinner, T	1
Parkes, D	1
Lunn, DP	1
Cuddon, PA	1
Shaftoe, S	1
Helbing-Zwanenburg, B	1
Kamphuisen, HA	1
Mourtazaev, MS	1
Vgontzas, AN	1
Sollenberger, SE	1
Bixler, EO	1
Vela-Bueno, A	1
Shimizu, T	1
Peck, KE	1
Hines, MT	1
Mealey, KL	1
Mealey, RH	1
Autret, A	1
Minz, M	1
Beillevaire, T	1
Degos, C	1
Cathala, HP	1
Dement, WC	4
Darke, PG	1
Jessen, V	1
Montplaisir, J	1
Pfefferbaum, A	1
Berger, PA	1
Mitler, MM	1
Soave, O	1
Carskadon, MA	1
Guilleminault, C	2
Zarcone, VP	1
Lange, KW	1
Egeler-Peerdeman, SM	1
Visscher, F	1
Taphoorn, MJ	1
Hughes, C	1
Karacan, I	1
Cunha, UV	1
Roth, B	4
Faber, J	4
Nevsímalová, S	4
Tosovský, J	3
Kuhlo, W	1
Zarcone, V	1
Kendel, K	1
Rüther, E	1
Beck, U	1
Meier-Ewert, K	1
Carskadon, M	1
Sigwald, J	1
Julou, L	1
Bouttier, D	1
Thomas, J	1
Pearlman, CA	1
Greenberg, R	1
Gottschalk, LA	1
Gleser, GC	1
Wylie, HW	1
Kaplan, SM	1
Passouant, P	1
Baldy-Moulinier, M	1
Aussilloux, C	1
Bourdillon, JL	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial[NCT02832336]			Phase 1/Phase 2	16 participants (Actual)	Interventional	2016-10-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Introduction to the mechanism of action of different treatments of narcolepsy. Sleep, 1994, Volume: 17, Issue:8 Suppl Topics: Amphetamine; Brain; Clomipramine; Drug Therapy, Combination; Humans; Imipramine; Narcolepsy	1994
[Narcolepsy]. Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56, Issue:2 Topics: Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Clomipramine; Diagnosis, Differ	1998
[Narcolepsy]. Deutsche medizinische Wochenschrift (1946), 1990, Aug-17, Volume: 115, Issue:33 Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Clomipramine; Diagnosis, Differential; Female; Hum	1990
[Nacolepsy an its therapy]. Deutsche medizinische Wochenschrift (1946), 1971, Jul-30, Volume: 96, Issue:31 Topics: Amphetamine; Barbiturates; Cataplexy; Drug Tolerance; Electroencephalography; Humans; Imipramine; Mo	1971
Narcolepsy. The New England journal of medicine, 1973, May-31, Volume: 288, Issue:22 Topics: Adolescent; Adult; Amphetamine; Cataplexy; Child; Diagnosis, Differential; Female; Hallucinations; H	1973
Medical-psychological implications of recent sleep research. Psychiatry in medicine, 1970, Volume: 1, Issue:4 Topics: Adaptation, Psychological; Amphetamine; Barbiturates; Central Nervous System Stimulants; Chloral Hyd	1970

Article	Year
Clinical and polygraphic effects of d.1 5 HTP on narcolepsy-cataplexy. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1977, Volume: 27, Issue:5 Topics: 5-Hydroxytryptophan; Cataplexy; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Fema	1977
Effects of imipramine on anxiety and hostility levels. Psychopharmacologia, 1965, Mar-30, Volume: 7, Issue:4 Topics: Adult; Anxiety; Clinical Trials as Topic; Fear; Guilt; Hate; Humans; Hypochondriasis; Imipramine; Ma	1965

imipramine and Gelineau Syndrome

Research Excerpts

Research

Studies (46)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Natural history, symptoms and treatment of the narcoleptic syndrome. Acta neurologica Scandinavica, 1975, Volume: 52, Issue:5 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Clomipr	1975
Narcolepsy in a hypocretin/orexin-deficient chihuahua. The Veterinary record, 2003, Jun-21, Volume: 152, Issue:25 Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Dog Diseases; Dogs; Imipramine; Intracellul	2003
Imipramine hydrochloride in the treatment of narcolepsy--a case report. The American journal of psychiatry, 1961, Volume: 117 Topics: Health Services; Humans; Imipramine; Narcolepsy; Psychopharmacology; Sleep Wake Disorders	1961
Treatment of narcolepsy with imipramin. Therapia Hungarica (English edition), 1963, Volume: 11 Topics: Humans; Imipramine; Narcolepsy; Sleep Wake Disorders	1963
[Imipramine in the treatment of narcolepsy. (Preliminary communication)]. Orvosi hetilap, 1962, Aug-19, Volume: 103 Topics: Communication; Health Services; Humans; Imipramine; Narcolepsy; Sleep Wake Disorders	1962
Narcolepsy in Saudi Arabia. Demographic and clinical perspective of an under-recognized disorder. Saudi medical journal, 2006, Volume: 27, Issue:9 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Antidepressive Agents, Second-Generation; Ant	2006
Narcoleptic syndrome and paradoxical sleep. Folia psychiatrica et neurologica japonica, 1966, Volume: 20, Issue:2 Topics: Adolescent; Adult; Child; Chlorpromazine; Electroencephalography; Eye Movements; Female; Humans; Imi	1966
[Narcolepsy--epilepsy. Differential diagnosis]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, Jun-12, Volume: 73, Issue:24 Topics: Amnesia; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Epilepsy; Halluci	1984
Narcolepsy in a Brahman bull. Journal of the American Veterinary Medical Association, 1984, Sep-01, Volume: 185, Issue:5 Topics: Animals; Cattle; Cattle Diseases; Electroencephalography; Electromyography; Electrooculography; Huma	1984
The neurological basis of sleep. Heart & lung : the journal of critical care, 1983, Volume: 12, Issue:2 Topics: Brain Stem; Electroencephalography; Eye Movements; Humans; Hypothalamus; Imipramine; Narcolepsy; Nor	1983
Narcolepsy in a horse. Journal of the American Veterinary Medical Association, 1983, Jul-01, Volume: 183, Issue:1 Topics: Animals; Atropine; Cataplexy; Female; Horse Diseases; Horses; Humans; Imipramine; Narcolepsy; Neosti	1983
Treatment of sleep disorders II: narcolepsy. Rational drug therapy, 1983, Volume: 17, Issue:3 Topics: Cataplexy; Female; Humans; Imipramine; Male; Methylphenidate; Narcolepsy	1983
[Narcolepsy (morbus Gélineau) (author's transl)]. Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1980, Volume: 48, Issue:2 Topics: Electroencephalography; Female; Hallucinations; Humans; Imipramine; Male; Methylphenidate; Narcoleps	1980
The treatment of narcolepsy and cataplexy. Drug intelligence & clinical pharmacy, 1981, Volume: 15, Issue:4 Topics: Cataplexy; Female; Humans; Imipramine; Methylphenidate; Middle Aged; Narcolepsy; Pharmacists; Sleep	1981
Characteristics of therapeutic response to imipramine in cataplectic men. The American journal of psychiatry, 1980, Volume: 137, Issue:2 Topics: Cataplexy; Drug Tolerance; Humans; Imipramine; Male; Middle Aged; Narcolepsy; Pilot Projects	1980
Familial occurrence of narcolepsy in miniature horses. Equine veterinary journal, 1993, Volume: 25, Issue:6 Topics: Animals; Atropine; Breeding; Electroencephalography; Female; Horse Diseases; Horses; Imipramine; Mal	1993
The origin of excessive daytime sleepiness in the Prader-Willi syndrome. Journal of intellectual disability research : JIDR, 1993, Volume: 37 ( Pt 6) Topics: Adolescent; Adult; Catalepsy; Clomipramine; Female; Humans; Hypoventilation; Imipramine; Male; Middl	1993
Narcolepsy-cataplexy and loss of sphincter control. Postgraduate medical journal, 1996, Volume: 72, Issue:850 Topics: Adult; Antidepressive Agents, Tricyclic; Cataplexy; Central Nervous System Stimulants; Fecal Inconti	1996
Pharmacokinetics of imipramine in narcoleptic horses. American journal of veterinary research, 2001, Volume: 62, Issue:5 Topics: Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Chromatography, High Pressure Liquid; F	2001
Narcolepsy--not as rare as we believed! Medical times, 1979, Volume: 107, Issue:6 Topics: Adult; Child; Humans; Imipramine; Methamphetamine; Methylphenidate; Narcolepsy	1979
Narcolepsy in a dog. The Veterinary record, 1977, Aug-06, Volume: 101, Issue:6 Topics: Animals; Dog Diseases; Dogs; Humans; Imipramine; Male; Narcolepsy	1977
[Hypersomnias. 1. Narcolepsy]. L'union medicale du Canada, 1977, Volume: 106, Issue:12 Topics: Amphetamines; Clomipramine; Humans; Imipramine; Methylphenidate; Monoamine Oxidase Inhibitors; Narco	1977
Narcolepsy, paranoid psychosis, and tardive dyskinesia: a pharmacological dilemma. The Journal of nervous and mental disease, 1977, Volume: 164, Issue:4 Topics: Chlorpromazine; Dyskinesia, Drug-Induced; Fluphenazine; Humans; Imipramine; Male; Middle Aged; Narco	1977
Narcolepsy in seven dogs. Journal of the American Veterinary Medical Association, 1976, Jun-01, Volume: 168, Issue:11 Topics: Animals; Catalepsy; Dog Diseases; Dogs; Eating; Female; Humans; Imipramine; Male; Narcolepsy; Play a	1976
Narcolepsy. Diagnosis and treatment. Primary care, 1976, Volume: 3, Issue:4 Topics: Adolescent; Adult; Behavior; Cataplexy; Child; Diagnosis, Differential; Female; Humans; Hypoglycemia	1976
[Too weak with laughing]. Nederlands tijdschrift voor geneeskunde, 1990, Mar-10, Volume: 134, Issue:10 Topics: Adult; Cataplexy; Clomipramine; Emotions; Female; Humans; Imipramine; Male; Methylphenidate; Middle	1990
Treatment of cataplexy in a dog with narcolepsy. Journal of the American Veterinary Medical Association, 1989, Mar-15, Volume: 194, Issue:6 Topics: Animals; Cataplexy; Dog Diseases; Dogs; Electrocardiography; Female; Imipramine; Narcolepsy; Parasym	1989
Erectile dysfunction in narcoleptic patients. Sleep, 1986, Volume: 9, Issue:1 Pt 2 Topics: Adult; Cataplexy; Erectile Dysfunction; Humans; Imipramine; Male; Methylphenidate; Middle Aged; Narc	1986
Antidepressants: their uses in nonpsychiatric disorders of aging. Geriatrics, 1986, Volume: 41, Issue:10 Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr	1986
[Effect of imipramine, dexphenmetrazine and amphetamine sulfate on synchronous and paradoxical sleep in narcolepsy-cataplexy. A polygraphic study]. Ceskoslovenska neurologie, 1970, Volume: 33, Issue:1 Topics: Amphetamine; Cataplexy; Electroencephalography; Humans; Imipramine; Narcolepsy; Phenmetrazine; Sleep	1970
The influence of imipramine, dexphenmetrazine and amphetaminsulphate upon the clinical and polygraphic picture of narcolepsy-cataplexy. Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1971, Volume: 108, Issue:2 Topics: Amphetamine; Cataplexy; Electrocardiography; Electroencephalography; Electromyography; Electrooculog	1971
A clinical and polygraphic study of the effect of a new imidazo-quinazoline derivative in narcolepsy-cataplexy. The relationship between the antidepressant and anticataplectic effects of the drug. Activitas nervosa superior, 1972, Volume: 14, Issue:1 Topics: Antidepressive Agents; Cataplexy; Humans; Imipramine; Narcolepsy; Quinazolines; Sleep, REM	1972
[L-dopa therapy of narcolepsy. Observation of clinical course and polygraphic EEG night sleep and day leads]. Der Nervenarzt, 1973, Volume: 44, Issue:8 Topics: Adult; Brain; Dihydroxyphenylalanine; Drug Combinations; Electroencephalography; Female; Humans; Imi	1973
On the treatment of rapid eye movement narcolepsy. Archives of neurology, 1974, Volume: 30, Issue:1 Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalograph	1974
[Therapy of hypersomnia]. Revue neurologique, 1967, Volume: 116, Issue:6 Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Centra	1967
The influence of imipramine, dexphenmetrazine and amphetamine-sulphate on the composition of diurnal sleep of narcoleptics. Activitas nervosa superior, 1974, Volume: 16, Issue:1 Topics: Amphetamine; Humans; Imipramine; Narcolepsy; Phenmetrazine; Sleep Stages; Time Factors	1974
[Cataplexy associated with Gélineau's disease; effect of clomipramine]. Revue neurologique, 1970, Volume: 123, Issue:1 Topics: Cataplexy; Hallucinations; Humans; Hypnosis; Imipramine; Male; Middle Aged; Narcolepsy; Paralysis; S	1970
Treatment of narcolepsy. British medical journal, 1971, Mar-20, Volume: 1, Issue:5750 Topics: Adult; Cataplexy; Humans; Imipramine; Male; Narcolepsy	1971