imipramine has been researched along with Epilepsy in 33 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 7.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Literature searches were conducted utilizing PubMed and MEDLINE databases employing combinations of search terms including, but not limited to, "epilepsy", "refractory", "seizure", and the following medications: acetazolamide, amantadine, bumetanide, imipramine, lidocaine, verapamil, and various stimulants." | 4.95 | Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. ( Perry, MS; Turner, AL, 2017) |
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 3.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Assessment of seizure risk in individuals involves consideration of predisposing factors, the antidepressant selected, and the bioavailability of the drug." | 2.38 | Seizures associated with antidepressants: a review. ( Jacobs, SC; Nelson, JC; Rosenstein, DL, 1993) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration." | 1.27 | Acute effects of antidepressants on hippocampal seizures. ( Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF, 1985) |
| "Nomifensine is a tetrahydoisoquinoline antidepressant which is chemically unrelated to the tricyclic or tetracyclic antidepressants, the monoamine oxidase inhibitors or the recently introduced agents." | 1.26 | Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
| "could increase the risk of seizures." | 1.26 | [Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (87.88) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Turner, AL | 1 |
| Perry, MS | 1 |
| KILOH, LG | 1 |
| DAVISON, K | 1 |
| OSSELTON, JW | 1 |
| CORRIOL, J | 1 |
| ZWIRN, P | 1 |
| PLOTNIKOFF, NP | 1 |
| ERALDO, O | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| BARUK, H | 1 |
| LAUNAY, J | 1 |
| KUHN, R | 1 |
| Olesen, OV | 1 |
| Small, JG | 1 |
| Small, IF | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Hess, CW | 1 |
| Lowry, MR | 1 |
| Dunner, FJ | 1 |
| Rosenstein, DL | 1 |
| Nelson, JC | 1 |
| Jacobs, SC | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Lange, SC | 2 |
| Julien, RM | 2 |
| Fowler, GW | 2 |
| Trimble, M | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Escande, M | 1 |
| Gayral, L | 1 |
| Golberger, E | 1 |
| Jarrige, A | 1 |
| Kulik, J | 1 |
| Petti, TA | 1 |
| Campbell, M | 1 |
| Perucca, E | 1 |
| Richens, A | 1 |
| Snead, OC | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Clifford, DB | 1 |
| Rutherford, JL | 1 |
| Hicks, FG | 1 |
| Zorumski, CF | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Ban, TA | 1 |
| Klein, DF | 1 |
| Greenberg, IM | 1 |
| Milner, G | 1 |
| Hills, NF | 1 |
| Weigert, S | 1 |
| Schröter, K | 1 |
| Görisch, V | 1 |
| Moccetti, T | 1 |
| Lichtlen, P | 1 |
| Albert, H | 1 |
| Meier, E | 1 |
| Imbach, P | 1 |
| Sueblinvong, V | 1 |
| Wilson, JF | 1 |
| Dallos, V | 1 |
| Heathfield, K | 1 |
7 reviews available for imipramine and Epilepsy
| Article | Year |
|---|---|
Outside the box: Medications worth considering when traditional antiepileptic drugs have failed.
Topics: Amantadine; Anticonvulsants; Bumetanide; Central Nervous System Stimulants; Epilepsy; Humans; Imipra | 2017 |
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
[5 YEARS OF DRUG THERAPY OF DEPRESSIVE STATES WITH IMINODIBENZYL DERIVATIVES].
Topics: Benzylamines; Depression; Depressive Disorder; Diabetes Mellitus; Electroconvulsive Therapy; Epileps | 1964 |
Seizures associated with antidepressants: a review.
Topics: Antidepressive Agents; Biological Availability; Causality; Depressive Disorder; Dose-Response Relati | 1993 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
Non-monoamine oxidase inhibitor antidepressants and epilepsy: a review.
Topics: Adult; Aged; Amines; Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricycl | 1978 |
The neuropharmacology of epileptic falling spells.
Topics: Anti-Anxiety Agents; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Ethosuximide; Humans; | 1987 |
3 trials available for imipramine and Epilepsy
| Article | Year |
|---|---|
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
Behavioral effects of diphenylhydantoin in severe psychiatric disorders.
Topics: Adolescent; Adult; Character; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Fem | 1967 |
A double-blind assessment of antidepressants in the treatment of 212 enuretic patients.
Topics: Clinical Trials as Topic; Desipramine; Enuresis; Epilepsy; Female; Humans; Humidity; Imipramine; Mal | 1968 |
23 other studies available for imipramine and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
An electroencephalographic study of the analeptic effects of imipramine.
Topics: Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Imipramine; Psychopharm | 1961 |
[Does RP 7162 (Surmontyl) possess a convulsive action?].
Topics: Epilepsy; Humans; Imipramine; Seizures | 1962 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
[TOFRANIL POISONING IN THE CHILD].
Topics: Child; Chloral Hydrate; Electrocardiography; Epilepsy; Humans; Imipramine; Infusions, Parenteral; Ox | 1964 |
[NEUROLEPTICS AND THE LAW OF STAGES].
Topics: Antipsychotic Agents; Catalepsy; Catatonia; Chlorpromazine; Epilepsy; Humans; Imipramine; Parkinsoni | 1964 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
EEG spikes in non-epileptic psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antisocial Personality Disorder; Barbiturates; Brain; Brain | 1967 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
[Narcolepsy--epilepsy. Differential diagnosis].
Topics: Amnesia; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Epilepsy; Halluci | 1984 |
Seizures during tricyclic therapy.
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Electroencephalography; Epilepsy; Femal | 1980 |
Biphasic effects of imipramine in experimental models of epilepsy.
Topics: Animals; Cats; Central Nervous System; Disease Models, Animal; Electroencephalography; Electroshock; | 1976 |
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.
Topics: Animals; Biogenic Amines; Brain; Depression; Epilepsy; Evaluation Studies as Topic; Humans; Imiprami | 1979 |
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography; | 1976 |
Imipramine and seizures.
Topics: Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Imipramine; Male; Mea | 1975 |
Interaction between phenytoin and imipramine.
Topics: Adult; Depression; Drug Interactions; Epilepsy; Humans; Imipramine; Phenytoin; Time Factors | 1977 |
Biphasic action of imipramine in laboratory models of epilepsy.
Topics: Anesthesia; Animals; Behavior, Animal; Cats; Electroencephalography; Electroshock; Epilepsy; Estroge | 1976 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hi | 1985 |
[Imipramine (melipramine) poisoning in childhood].
Topics: Child, Preschool; Diagnosis, Differential; Electrocardiography; Enuresis; Epilepsy; Exchange Transfu | 1972 |
[Cardiotoxicity of tricyclic antidepressive agents. (Phenothiazines and imipramines)].
Topics: Adult; Arrhythmias, Cardiac; Cardiovascular Diseases; Coronary Vessels; Electrocardiography; Epileps | 1971 |
Myocardial damage due to imipramine intoxication.
Topics: Aspartate Aminotransferases; Child, Preschool; Creatine Kinase; Electrocardiography; Electroencephal | 1969 |
Iatrogenic epilepsy due to antidepressant drugs.
Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr | 1969 |