imipramine has been researched along with Emergencies in 9 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez, E | 1 |
| Fraile, S | 1 |
| Hidalgo, FJ | 1 |
| García, B | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Brown, K | 1 |
| Ratner, M | 1 |
| Stoll, M | 1 |
| Hui, KK | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Tribble, J | 1 |
| Weinhouse, E | 1 |
| Garland, J | 1 |
| Wendelberger, K | 1 |
| Maroncelli, RD | 1 |
| Kanarek, KS | 1 |
| Thomson, PD | 1 |
| Levin, SE | 1 |
| Berry, DJ | 1 |
| Grove, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
9 other studies available for imipramine and Emergencies
| Article | Year |
|---|---|
[Possible malignant neuroleptic syndrome associated with aripiprazole and imipramine and treated with bromocriptine].
Topics: Antipsychotic Agents; Aripiprazole; Bromocriptine; Combined Modality Therapy; Drug Therapy, Combinat | 2013 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Pheochromocytoma unmasked by imipramine in an 8-year-old girl.
Topics: Catecholamines; Child; Emergencies; Enuresis; Female; Heart Murmurs; Humans; Hypertension; Hypertrop | 2003 |
Hypertensive crisis induced by interaction of clonidine with imipramine.
Topics: Aged; Clonidine; Drug Interactions; Emergencies; Female; Humans; Hypertension; Imipramine; Time Fact | 1983 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.
Topics: Acute Disease; Desipramine; Electrocardiography; Emergencies; Female; Gastric Lavage; Humans; Imipra | 1989 |
Accidental poisoning.
Topics: Emergencies; Humans; Imipramine; Infant; Male; Parents; Pediatric Nursing; Poison Control Centers | 1986 |
The management of imipramine (Tofranil) intoxication in children.
Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Electrocardiography; Emergencies; Female; Gastric Lava | 1973 |
Emergency toxicological screening for drugs commonly taken in overdose.
Topics: Acetaminophen; Antidepressive Agents; Barbiturates; Benzazepines; Chloral Hydrate; Chromatography, T | 1973 |