imipramine has been researched along with Drug Overdose in 29 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse." | 7.69 | Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997) |
| " We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse." | 3.69 | Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997) |
| "Imipramine has been surpassed by newer antidepressants for the treatment of depression in the past decade." | 1.42 | Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning. ( Cheung, KL; Fung, CK; Hon, KL; Lee, VW; Leung, AK; Wong, W, 2015) |
| "Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics." | 1.36 | A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man. ( Chauhan, A; Howell, BA, 2010) |
| " Mechanisms of desipramine toxicity and its dosage recommendations are discussed." | 1.32 | Excess fatality from desipramine and dosage recommendations. ( Amitai, Y; Frischer, H, 2004) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| "Paroxetine (Paxil) is a selective serotonin reuptake inhibitor, one of a new class of antidepressants used in the treatment of obsessive-compulsive disorder, panic disorder, and depression." | 1.30 | Distribution of paroxetine in three postmortem cases. ( Vermeulen, T, 1998) |
| "Nortriptyline was not detected in most cases, suggesting that it may degrade more rapidly than desipramine." | 1.29 | The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions. ( Wahba, WW; Winek, CL; Zaveri, NR, 1993) |
| " When PGF2 alpha was infused at a rate of 5 mumols kg-1 h-1, the absorption rate of water decreased from 51." | 1.28 | The effect of dinoprost on transport of water and imipramine through rat small intestinal membranes. ( Arimori, K; Deshimaru, M; Nakano, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.69) | 18.7374 |
| 1990's | 14 (48.28) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Hon, KL | 1 |
| Fung, CK | 1 |
| Lee, VW | 1 |
| Cheung, KL | 1 |
| Wong, W | 1 |
| Leung, AK | 1 |
| Howell, BA | 2 |
| Chauhan, A | 2 |
| Khandelwal, V | 1 |
| Gupta, N | 1 |
| Agarwal, A | 1 |
| Goyal, RK | 1 |
| Liu, X | 1 |
| Emery, CJ | 1 |
| Laude, E | 1 |
| Herget, J | 1 |
| Gill, G | 1 |
| Cope, G | 1 |
| Barer, GR | 1 |
| MANN, AM | 1 |
| CATTERSON, AG | 1 |
| MACPHERSON, AS | 1 |
| ARNESON, GA | 1 |
| BABIAK, W | 1 |
| LEE, FI | 1 |
| LANCASTER, NP | 1 |
| FOSTER, AR | 1 |
| NOACK, CH | 1 |
| Bateman, DN | 1 |
| Chick, J | 1 |
| Good, AM | 1 |
| Kelly, CA | 1 |
| Masterton, G | 1 |
| Amitai, Y | 1 |
| Frischer, H | 1 |
| Kinoshita, H | 1 |
| Taniguchi, T | 1 |
| Kubota, A | 1 |
| Nishiguchi, M | 1 |
| Ouchi, H | 1 |
| Minami, T | 1 |
| Utsumi, T | 1 |
| Motomura, H | 1 |
| Nagasaki, Y | 1 |
| Ameno, K | 1 |
| Hishida, S | 1 |
| Sener, EK | 1 |
| Gabe, S | 1 |
| Henry, JA | 1 |
| Chiu, TF | 1 |
| Yang, CC | 1 |
| Ger, J | 1 |
| Deng, JF | 1 |
| Bullard, MJ | 1 |
| Williams, JM | 1 |
| Hollingshed, MJ | 1 |
| Vasilakis, A | 1 |
| Morales, M | 1 |
| Prescott, JE | 1 |
| Graeber, GM | 1 |
| Zylber-Katz, E | 1 |
| Putterman, C | 1 |
| Caraco, Y | 1 |
| Winek, CL | 1 |
| Zaveri, NR | 1 |
| Wahba, WW | 1 |
| Dahlin, KL | 1 |
| Lâstbom, L | 1 |
| Blomgren, B | 1 |
| Ryrfeldt, A | 1 |
| Sandeman, DJ | 1 |
| Alahakoon, TI | 1 |
| Bentley, SC | 1 |
| Ross, JP | 1 |
| Small, TR | 1 |
| Lepage, PA | 1 |
| Vermeulen, T | 1 |
| Arimori, K | 1 |
| Deshimaru, M | 1 |
| Nakano, M | 1 |
| Basse, P | 1 |
| Rørdam, P | 1 |
| Mordel, A | 1 |
| Winkler, E | 1 |
| Almog, S | 1 |
| Tirosh, M | 1 |
| Ezra, D | 1 |
| Givens, T | 1 |
| Holloway, M | 1 |
| Wason, S | 1 |
| Rosenstein, DL | 1 |
| Takeshita, J | 1 |
| Nelson, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
29 other studies available for imipramine and Drug Overdose
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning.
Topics: Accidents, Home; Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic; Arrhythmias, Cardia | 2015 |
Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment.
Topics: Antidepressive Agents, Tricyclic; Antidotes; Dothiepin; Drug Overdose; Humans; Hydrogen-Ion Concentr | 2009 |
A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man.
Topics: Algorithms; Amitriptyline; Anesthetics, Local; Antidepressive Agents, Tricyclic; Area Under Curve; B | 2010 |
Tricyclic antidepressant overdose presenting as neuroleptic malignant syndrome.
Topics: Adult; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Imipramine; Male; Neuroleptic Malign | 2002 |
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise | 2002 |
Toxicity of imipramine: report on serious side effects and massive overdosage.
Topics: Drug Overdose; Humans; Imipramine; Suicide; Tranquilizing Agents | 1959 |
A near fatal case of imipramine overdosage.
Topics: Drug Overdose; Imipramine; Psychopharmacology | 1961 |
Case fatality due to overdosage of a combination of tranylcypromine (Parnate) and imipramine (Tofranil).
Topics: Cyclopropanes; Drug Overdose; Imipramine; Psychopharmacology; Tranylcypromine | 1961 |
Imipramine overdosage--report of a fatal case.
Topics: Drug Overdose; Imipramine; Psychopharmacology | 1961 |
Suicidal attempt by imipramine overdosage.
Topics: Drug Overdose; Imipramine; Suicide; Suicide, Attempted; Tranquilizing Agents | 1959 |
A death from overdosage of "tofranil".
Topics: Death; Death, Sudden; Drug Overdose; Humans; Imipramine; Medical Records; Psychopharmacology | 1960 |
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Ove | 2004 |
Excess fatality from desipramine and dosage recommendations.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Databases, Factual; Desipramine; Drug Overdose; Hum | 2004 |
An autopsy case of imipramine poisoning.
Topics: Antidepressive Agents, Tricyclic; Autopsy; Cause of Death; Chromatography, High Pressure Liquid; Des | 2005 |
Response to glucagon in imipramine overdose.
Topics: Adult; Diazepam; Drug Overdose; Electrocardiography; Female; Glucagon; Humans; Imipramine; Infusions | 1995 |
Adult respiratory distress syndrome and late death following imipramine overdose: a case report.
Topics: Adult; Drug Overdose; Fatal Outcome; Female; Humans; Imipramine; Respiratory Distress Syndrome | 1994 |
Extracorporeal circulation in the management of severe tricyclic antidepressant overdose.
Topics: Adult; Drug Overdose; Extracorporeal Circulation; Fatal Outcome; Female; Hemodynamics; Humans; Hypot | 1994 |
Multiple drug overdose in a kidney transplant patient.
Topics: Chromatography, Thin Layer; Cyclosporine; Depression; Drug Overdose; Half-Life; Humans; Imipramine; | 1994 |
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation S | 1993 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.
Topics: Adrenergic Agonists; Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Critical Care; | 1997 |
Imipramine overdose complicated by toxic megacolon.
Topics: Adult; Antidepressive Agents, Tricyclic; Colonic Diseases; Drug Overdose; Female; Humans; Imipramine | 1998 |
Distribution of paroxetine in three postmortem cases.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Drug | 1998 |
The effect of dinoprost on transport of water and imipramine through rat small intestinal membranes.
Topics: Animals; Biological Transport, Active; Body Water; Dinoprost; Drug Overdose; Gastrointestinal Motili | 1992 |
Ischemic colitis complicating imipramine overdose and alcohol ingestion. Case report.
Topics: Alcoholism; Colitis; Colon; Drug Overdose; Humans; Imipramine; Ischemia; Male; Middle Aged | 1992 |
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip | 1992 |
Pulmonary aspiration of activated charcoal: a complication of its misuse in overdose management.
Topics: Adolescent; Charcoal; Drug Overdose; Female; Humans; Imipramine; Malpractice; Pneumonia, Aspiration; | 1992 |
Fluoxetine-induced elevation and prolongation of tricyclic levels in overdose.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Drug Overdose; Drug Therap | 1991 |