imipramine has been researched along with Disease Models, Animal in 334 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study has shown that imipramine as an inhibitor of aSMase abolishes the synergy between MetS and periodontitis on alveolar bone loss in animal model and inhibits pro-inflammatory and pro-osteoclastogenic gene expression in macrophages in vitro." | 8.12 | Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss. ( Huang, Y; Kirkwood, CL; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Zhang, L, 2022) |
| " Imipramine treatment was able to reverse depressive- and anxiety-like behaviors." | 7.91 | Imipramine treatment reverses depressive- and anxiety-like behaviors, normalize adrenocorticotropic hormone, and reduces interleukin-1β in the brain of rats subjected to experimental periapical lesion. ( Barichello, T; Ceretta, RA; Dal-Pizzol, F; Dominguini, D; Generoso, JS; Michels, M; Netto, S; Réus, GZ; Simões, LR; Valim, RF; Valvassori, SS, 2019) |
| "Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM)." | 7.91 | Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. ( Geisel, J; Happ, DF; Mikkelsen, PF; Obeid, R; Tillmann, S; Wegener, G, 2019) |
| "The aim of the present study was to investigate the effects of ketamine, imipramine, and ketamine plus imipramine on chronic depression-like behaviors of Wistar Kyoto (WKY) rats and underlying mechanism." | 7.83 | [Effects of ketamine, imipramine, and their combination on depression-like behaviors in Wistar Kyoto rats]. ( Jin, XJ; Li, QQ; Peng, LC; Ye, K, 2016) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 7.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "Outcome of imipramine (IMI) treatment was scrutinized on progression of haloperidol instigated tardive dyskinesia (TD)." | 7.83 | Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions. ( Haleem, DJ; Samad, N; Yasmin, F, 2016) |
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 7.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| "Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented." | 7.74 | Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008) |
| "The use of carbamazepine has been reported to be an effective treatment for severe depression." | 7.74 | Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? ( Akiyama, K; Araki, H; Gomita, Y; Kawasaki, H; Kitagawa, K; Kitamura, Y; Sendo, T; Shibata, K; Suemaru, K, 2008) |
| "The possibility of introducing eye-wiping test as a model of acute pain was examined in rat, and it was compared with the well-known hot plate test." | 7.73 | Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. ( Farazifard, R; Javan, M; Safarpour, F; Sheibani, V, 2005) |
| " We corroborated some previous findings that CMS, which had been used as an animal model of depression, decreased the consumption of a 1% sucrose solution and that that effect was reversed by chronic administration of imipramine." | 7.69 | The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. ( Bijak, M; Papp, M, 1995) |
| "The value of intravenous imipramine in creating a reversible model of short term heart failure was evaluated in anaesthetised dogs." | 7.68 | Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices. ( Cheriex, EC; Habets, J; Lucas, CM; Penn, OC; van der Nagel, T; van der Veen, FH; Wellens, HJ, 1992) |
| " Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 7.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 7.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 7.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 7.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 5.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "A total of 32 drug-free major depressive disorder patients and 30 healthy controls were recruited." | 5.46 | Decreased Prostaglandin D2 Levels in Major Depressive Disorder Are Associated with Depression-Like Behaviors. ( Chu, C; Shen, Y; Wei, H; Xu, Q; Zhu, W, 2017) |
| "Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics." | 5.46 | Imipramine blocks acute silicosis in a mouse model. ( Biswas, R; Harkema, JR; Holian, A; Jessop, F; Trout, KL, 2017) |
| "A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile." | 5.43 | The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Głombik, K; Kubera, M; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Spedding, M; Stachowicz, A; Trojan, E, 2016) |
| "Curcumin is a biologically active phytochemical presents in turmeric and has pharmacological actions that benefit patients with depression and anxiety." | 5.42 | The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. ( Li, J; Pan, J; Wang, R; Wu, S; Xie, X; Xu, Y; Yu, X; Yu, Y; Zheng, L, 2015) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 5.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| " Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 5.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
| "Imipramine treatment significantly increased the number of neurons in the granule cell layer (GCL) and spine synapses in the CA1 in the FSL imipramine group (treated "depressed" rats) compared with the FSL saline group." | 5.36 | Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression. ( Chen, F; Madsen, TM; Nyengaard, JR; Wegener, G, 2010) |
| "Imipramine was administrated intraperitoneally 30 min before LPS challenge." | 5.36 | Protective effects of imipramine in murine endotoxin-induced acute lung injury. ( Jiang, HN; Qu, JM; Summah, H; Yang, J; Zhang, J; Zhu, YG, 2010) |
| "Pretreatment with imipramine, MK 801 and ketamine significantly prevented the effect of shock." | 5.30 | Interaction between N-methyl-D-aspartate receptor antagonists and imipramine in shock-induced depression. ( Bapna, JS; Chandra, D; Chaturvedi, HK, 1999) |
| "This study has shown that imipramine as an inhibitor of aSMase abolishes the synergy between MetS and periodontitis on alveolar bone loss in animal model and inhibits pro-inflammatory and pro-osteoclastogenic gene expression in macrophages in vitro." | 4.12 | Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss. ( Huang, Y; Kirkwood, CL; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Zhang, L, 2022) |
| "Imipramine is a tricyclic antidepressant (TCA) drug that is sometimes used to treat neuropathic pain." | 4.02 | Synergistic effect between imipramine and citicoline upon induction of analgesic and antidepressant effects in mice. ( Khakpai, F; Ramezanikhah, M; Valizadegan, F; Zarrindast, MR, 2021) |
| "A recent review proposed four criteria for an animal model of treatment-resistant depression (TRD): a phenotypic resemblance to a risk factor for depression; enhanced response to stress; nonresponse to antidepressant drugs and response to treatments effective in TRD, such as deep brain stimulation (DBS) of the prefrontal cortex or ketamine." | 3.91 | Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression. ( Gruca, P; Lason, M; Litwa, E; Niemczyk, M; Papp, M; Tota-Glowczyk, K; Willner, P, 2019) |
| " Imipramine treatment was able to reverse depressive- and anxiety-like behaviors." | 3.91 | Imipramine treatment reverses depressive- and anxiety-like behaviors, normalize adrenocorticotropic hormone, and reduces interleukin-1β in the brain of rats subjected to experimental periapical lesion. ( Barichello, T; Ceretta, RA; Dal-Pizzol, F; Dominguini, D; Generoso, JS; Michels, M; Netto, S; Réus, GZ; Simões, LR; Valim, RF; Valvassori, SS, 2019) |
| "Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM)." | 3.91 | Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression. ( Geisel, J; Happ, DF; Mikkelsen, PF; Obeid, R; Tillmann, S; Wegener, G, 2019) |
| " We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI)." | 3.88 | Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat. ( Berk, M; Dean, OM; Harvey, BH; Holland, B; Möller, M; Oberholzer, I, 2018) |
| "Our goal was to find out the impact of two antidepressant drugs with various mechanisms of action - imipramine and fluoxetine, on the frontal cortex mitochondria-enriched fraction in an animal model of depression based on the prenatal stress procedure." | 3.88 | Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. ( Basta-Kaim, A; Chamera, K; Głombik, K; Kotarska, K; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2018) |
| " Imipramine was administered for the next 5 weeks, and it reversed anhedonia in majority of animals (imipramine-reactive); however, in some animals, it did not (imipramine-non-reactive)." | 3.88 | Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. ( Antkiewicz-Michaluk, L; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gruca, P; Kolasa, M; Kuśmider, M; Pabian, P; Papp, M; Romańska, I; Solich, J; Szlachta, M; Żurawek, D, 2018) |
| "In this study adult female Wistar and Wistar-Kyoto (WKY) rats, a putative animal model of depression, were exposed to alcohol vapor 3h daily for 10days (blood alcohol concentration ∼150mg%) followed by daily injection of 10mg/kg of imipramine (IMP, a selective norepinephrine NE/serotonin reuptake inhibitor) or nomifensine (NOMI, a selective NE/dopamine reuptake inhibitor)." | 3.85 | Role of cortical alpha-2 adrenoceptors in alcohol withdrawal-induced depression and tricyclic antidepressants. ( Csoka, AB; Getachew, B; Hauser, SR; Taylor, RE; Tizabi, Y, 2017) |
| "Depression and substance cocaine abuse are disorders with a high frequency of comorbidity." | 3.85 | Effects of escitalopram and imipramine on cocaine reinforcement and drug-seeking behaviors in a rat model of depression. ( Filip, M; Frankowska, M; Jastrzębska, J; Nowak, E; Przegaliński, E; Suder, A; Wydra, K, 2017) |
| "We measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine." | 3.83 | Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants. ( Dean, B; Gibbons, AS; Jeon, WJ; Scarr, E, 2016) |
| "We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine." | 3.83 | Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. ( Honda, S; Kawaura, K; Ogata, Y; Shirasaki, T; Soeda, F; Takahama, K, 2016) |
| "The aim of the present study was to investigate the effects of ketamine, imipramine, and ketamine plus imipramine on chronic depression-like behaviors of Wistar Kyoto (WKY) rats and underlying mechanism." | 3.83 | [Effects of ketamine, imipramine, and their combination on depression-like behaviors in Wistar Kyoto rats]. ( Jin, XJ; Li, QQ; Peng, LC; Ye, K, 2016) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 3.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| " Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravation of anhedonia spontaneously occurred especially after 20 weeks of MCAO, and it was prevented by chronic antidepressants treatment (imipramine or fluvoxamine)." | 3.83 | Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats. ( Kasahara, J; Oka, N; Tezuka, K; Uchida, H, 2016) |
| "Outcome of imipramine (IMI) treatment was scrutinized on progression of haloperidol instigated tardive dyskinesia (TD)." | 3.83 | Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions. ( Haleem, DJ; Samad, N; Yasmin, F, 2016) |
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 3.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| " Here, sucrose intake, forced swimming, immobility in the modified tail suspension test, novelty exploration, grooming, anxiety and locomotor activity were compared in naïve 3- and 18-month-old male C57BL/6 mice." | 3.78 | Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression. ( Bachurin, S; Bolkunov, A; Kubatiev, A; Malatynska, E; Redkozubova, O; Steinbusch, HW; Strekalova, T; Vignisse, J; Yeritsyan, NB, 2012) |
| "Imipramine treatment decreased anxiety levels in females, but not in males, in the normal weaning condition." | 3.78 | Effects of sex and rearing environment on imipramine response in mice. ( Kikusui, T; Mogi, K; Nagasawa, M; Shimokawa, Y, 2012) |
| " The antidepressant imipramine, which shows pro-manic properties in patients with bipolar disorder (BPD), also enhanced phospho-MARCKS in prefrontal cortex in vivo." | 3.75 | Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. ( Cirelli, C; Du, J; Falke, C; Machado-Vieira, R; Manji, HK; Szabo, ST; Tononi, G; Wang, Y; Wei, Y; Yuan, P, 2009) |
| "3 mg kg(-1), intraperitoneal [IP]) for 5 weeks corrected the reduction in body weight gain and sucrose intake induced by CMS." | 3.74 | Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. ( Arguello, O; Bortolato, M; Duranti, A; Fu, J; Kim, JH; Mangieri, RA; Mor, M; Piomelli, D; Tarzia, G; Tontini, A, 2007) |
| "Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented." | 3.74 | Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008) |
| "The use of carbamazepine has been reported to be an effective treatment for severe depression." | 3.74 | Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? ( Akiyama, K; Araki, H; Gomita, Y; Kawasaki, H; Kitagawa, K; Kitamura, Y; Sendo, T; Shibata, K; Suemaru, K, 2008) |
| "The possibility of introducing eye-wiping test as a model of acute pain was examined in rat, and it was compared with the well-known hot plate test." | 3.73 | Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. ( Farazifard, R; Javan, M; Safarpour, F; Sheibani, V, 2005) |
| "To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor (Bdnf) splice variant mRNAs (I-V) and their unique promoters in the hippocampus." | 3.73 | Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. ( Berton, O; Kumar, A; Nestler, EJ; Neve, RL; Renthal, W; Tsankova, NM, 2006) |
| "Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression." | 3.73 | Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. ( Rodrigues, AL; Santos, AR; Zomkowski, AD, 2006) |
| " The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)imidazole (TRIM) in animal models predictive of antidepressant- and anxiolytic-like activity in order to clarify the role of distinct isoforms of NOS in the regulation of depression and anxiety." | 3.72 | Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. ( Bourin, M; Vasar, E; Volke, V; Wegener, G, 2003) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| " The role played by its components, particularly hypericin and hyperforin, has been examined in different experimental models of depression." | 3.72 | Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. ( De Montis, MG; Gambarana, C; Giachetti, D; Grappi, S; Leggio, B; Nanni, G; Tolu, P; Usai, M, 2003) |
| "A standardised 50% aqueous ethanolic extract of Indian Hypericum perforatum (IHp) was investigated for its antidepressant activity on various experimental paradigms of depression, viz." | 3.70 | Antidepressant activity of Indian Hypericum perforatum Linn in rodents. ( Bhattacharya, SK; Jaiswal, AK; Kumar, V; Singh, PN, 1999) |
| " We corroborated some previous findings that CMS, which had been used as an animal model of depression, decreased the consumption of a 1% sucrose solution and that that effect was reversed by chronic administration of imipramine." | 3.69 | The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. ( Bijak, M; Papp, M, 1995) |
| "HCl), and that of imipramine in the behavioural despair model of depression." | 3.69 | Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression. ( Collu, M; D'Aquila, PS; Gessa, GL; Pani, L; Serra, G, 1994) |
| "The measurement protocol consisted of two phases: a) apnea, randomized jet ventilation (systole- and diastole-synchronized); b) postjet ventilation apnea, before and after heart failure, induced with a propranolol-imipramine-plasma expansion treatment." | 3.69 | Effect of jet ventilation on heart failure: decreased afterload but negative response in left ventricular end-systolic pressure-volume function. ( Mathru, M; Rooney, MW; Weber, A, 1996) |
| " To investigate this phenomenon as a possible animal model of obsessive-compulsive disorder (OCD), rats were treated for 5 weeks with fluoxetine, an antidepressant that relieves OCD symptoms in humans (5 mg/kg, 2." | 3.69 | Effects of serotonergic agents on food-restriction-induced hyperactivity. ( Altemus, M; Galliven, E; Glowa, JR; Leong, YM; Murphy, DL, 1996) |
| "The value of intravenous imipramine in creating a reversible model of short term heart failure was evaluated in anaesthetised dogs." | 3.68 | Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices. ( Cheriex, EC; Habets, J; Lucas, CM; Penn, OC; van der Nagel, T; van der Veen, FH; Wellens, HJ, 1992) |
| "The present study was conducted to examine whether a chronic variable stress procedure (CVS)--an animal model of depression--facilitates tumor growth, and whether this effect can be modified by concurrent administration of the antidepressant imipramine (IMI)." | 3.68 | Chronic variable stress facilitates tumoral growth: reversal by imipramine administration. ( Basso, AM; Depiante-Depaoli, M; Molina, VA, 1992) |
| " Imipramine and mianserine potentiated amphetamine-induced anorexia both after acute administration or after prolonged previous treatment with each drug." | 3.68 | Lack of tolerance to imipramine or mianserine in two animal models of depression. ( Barros, HM; Tannhauser, M; Wainstein, M, 1990) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 3.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 3.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| " The results indicate that chronic administration of imipramine or of electroshock led to the abolition of the behavioural depression and of the EEG synchronisation induced by clonidine." | 3.66 | Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat. ( Passarelli, F; Scotti de Carolis, A, 1983) |
| "To further test the new hypersensitive postsynaptic serotonin (5-HT) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block D,L-5-hydroxytryptophan (5-HTP) induced depression acting through postsynaptic rather than presynaptic mechanisms." | 3.66 | Postsynaptic action by four antidepressive drugs in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1981) |
| "Administration of imipramine plus serotonin (5-HT) to rats has been proposed as an animal model of Duchenne muscular dystrophy." | 3.65 | Skeletal muscle necrosis following membrane-active drugs plus serotonin. ( Meltzer, HY, 1976) |
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 3.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Progabide was devoid of any evident antipsychotic action." | 2.65 | The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. ( Bartholini, G; Broekkamp, C; Depoortere, H; Fournier, V; Lloyd, KG; Morselli, PL; Scatton, B; Worms, P; Zivkovic, B, 1983) |
| "Medical treatment of heart failure is associated with 50% survival at 5 years." | 2.43 | Animal models of heart failure: what is new? ( Chachques, JC; Monnet, E, 2005) |
| "Animal models of depression are important for such investigations." | 2.38 | Amygdala, depression and drug treatment. ( Fonberg, E, 1989) |
| "Oral squamous cell carcinoma (OSCC) has limited treatment options." | 1.91 | Imipramine Suppresses Tumor Growth and Induces Apoptosis in Oral Squamous Cell Carcinoma: Targeting Multiple Processes and Signaling Pathways. ( Chang, PL; Chen, YT; Hsiao, HC; Hsieh, LL; Hsu, FT; Hsu, LC; Lin, CN; Lin, KH; Tu, HF; Wang, HY, 2023) |
| "The most common features of Parkinson's disease (PD) are motor impairments, but many patients also present depression and memory impairment." | 1.62 | Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease. ( Andreatini, R; Da Cunha, C; Hocayen, PAS; Kanazawa, LKS; Miyoshi, E; Takahashi, RN; Vecchia, DD; Vital, MABF; Wendler, E, 2021) |
| "Imipramine is a kind of tricyclic antidepressant with reported anti-inflammatory and anti-oxidant effects in the brain." | 1.62 | Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. ( Ahmadiani, A; Askari, S; Dargahi, L; Ghasemi, R; Javadpour, P; Rashidi, FS, 2021) |
| "Furthermore, we analyzed human abdominal aortic aneurysm samples in support of our in vitro and in vivo results." | 1.56 | Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets. ( Brostjan, C; Eilenberg, W; Fischer, MB; Haider, P; Hengstenberg, C; Hohensinner, P; Huber, K; Kaun, C; Kral-Pointner, JB; Mayer, J; Richter, M; Speidl, WS; Wojta, J, 2020) |
| "Catalepsy was measured by the bar test." | 1.51 | Synergistic anticataleptic effect of imipramine and nicotine in a rotenone-induced rat model. ( Gorev, NP; Ionov, ID; Pushinskaya, II; Shpilevaya, LA, 2019) |
| "Depression is common and results in a significant morbidity and economic burden." | 1.51 | The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats. ( Boyko, M; Brotfain, E; Frank, D; Frenkel, A; Grinshpun, J; Gruenbaum, BF; Gruenbaum, SE; Kutz, R; Zeldetz, V; Zlotnik, A; Zvenigorodsky, V, 2019) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 1.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "On 14th day of the treatment, depression-like behaviour was induced by LPS (0." | 1.48 | Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus. ( Barua, CC; Haloi, P; Pathak, DC; Ren, X; Rizavi, H; Saikia, B; Sulakhiya, K; Tamuli, S, 2018) |
| " On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression." | 1.46 | Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Chamera, K; Głombik, K; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2017) |
| "A total of 32 drug-free major depressive disorder patients and 30 healthy controls were recruited." | 1.46 | Decreased Prostaglandin D2 Levels in Major Depressive Disorder Are Associated with Depression-Like Behaviors. ( Chu, C; Shen, Y; Wei, H; Xu, Q; Zhu, W, 2017) |
| "Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life." | 1.46 | Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice. ( Adebesin, A; Adeoluwa, OA; Eduviere, AT; Umukoro, S, 2017) |
| "Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics." | 1.46 | Imipramine blocks acute silicosis in a mouse model. ( Biswas, R; Harkema, JR; Holian, A; Jessop, F; Trout, KL, 2017) |
| "Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD)." | 1.46 | Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies. ( Brand, SJ; Harvey, BH, 2017) |
| "Lentinan (LNT) is an immune regulator and its potential and mechanism for the treatment of mood disorder is of our interest." | 1.46 | Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway. ( Bao, H; Du, J; Du, K; Gao, T; Hou, Y; Hu, W; Li, B; Nie, J; Ran, P; Shan, L; Sun, L; Xiao, C; Zheng, B; Zheng, S; Zhu, K; Zhu, Y, 2017) |
| " The role of the α2C-AR in modulating two key depression-related behaviours in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0." | 1.46 | The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat. ( Harvey, BH; Sallinen, J; Shahid, M; Uys, MM, 2017) |
| "Depression is associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and testosterone exerts suppressive effects on the HPA axis." | 1.43 | Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress. ( Chow, C; Galea, LA; Hamson, DK; Lieblich, SE; Tehrani, A; Wainwright, SR; Workman, JL, 2016) |
| " Therefore, we examined changes in the dopaminergic system in the caudate putamen (CPu), nucleus accumbens core (NAcC), and shell (NAcSh) of OBX mice and whether or not these alterations were reversed by chronic administration of imipramine." | 1.43 | Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system. ( Arai, Y; Hisamitsu, T; Nakagawasai, O; Nakajima, T; Nemoto, W; Takahashi, K; Tan-No, K, 2016) |
| "A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile." | 1.43 | The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Głombik, K; Kubera, M; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Spedding, M; Stachowicz, A; Trojan, E, 2016) |
| "Although depression is the leading cause of disability worldwide, its pathophysiology is poorly understood." | 1.43 | Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. ( Abe-Higuchi, N; Hara, K; Higuchi, F; Hobara, T; Kobayashi, A; Uchida, S; Watanabe, Y; Yamagata, H, 2016) |
| "Depression is a major comorbidity factor of diabetes and the outcome of one disorder influences the other." | 1.43 | Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes. ( Bharne, AP; Kokare, DM; Nakhate, KT; Subhedar, NK; Yedke, SU, 2016) |
| "Pneumococcal meningitis is a life-threatening infection of the central nervous system (CNS) with a high mortality rate." | 1.43 | Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants. ( Barichello, T; Dominguini, D; Generoso, JS; Jornada, LK; Quevedo, J; Sharin, VS; Simões, LR; Souza, LB; Teixeira, AL; Valvassori, SS, 2016) |
| "Curcumin is a biologically active phytochemical presents in turmeric and has pharmacological actions that benefit patients with depression and anxiety." | 1.42 | The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. ( Li, J; Pan, J; Wang, R; Wu, S; Xie, X; Xu, Y; Yu, X; Yu, Y; Zheng, L, 2015) |
| "Ferulic acid is a polyphenol that has antioxidant, anti-inflammatory and anticancer properties." | 1.42 | Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems. ( Cao, L; Chen, J; Li, G; Li, J; Lin, D; Pan, J; Pang, C; Ruan, L; Xie, X; Xu, Y; Yan, Q; Yu, X; Zhang, C; Zhang, N, 2015) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 1.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| "Dextromethorphan (DM) is an antitussive with rapid acting antidepressant potential based on pharmacodynamic similarities to ketamine." | 1.42 | Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice. ( Matsumoto, RR; Nguyen, L, 2015) |
| "Ketamine is an anesthetic with antidepressant properties." | 1.42 | The positive effect on ketamine as a priming adjuvant in antidepressant treatment. ( Dalla, C; Ferreira, C; Kokras, N; Melo, A; Pêgo, JM; Sousa, N; Ventura-Silva, AP, 2015) |
| " Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level." | 1.40 | Plurality of anxiety and depression alteration mechanism by oleanolic acid. ( Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK, 2014) |
| " The present study indicates that already a moderate lesion of dopaminergic neurons induces "depressive-like" behaviour in animals which is reversed by chronic administration of the antiparkinsonian drug, pramipexole." | 1.40 | Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease. ( Berghauzen-Maciejewska, K; Dziubina, A; Głowacka, U; Kolasiewicz, W; Kuter, K; Ossowska, K; Wardas, J, 2014) |
| " Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 1.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
| "Depression is the leading psychiatric disorder with a high risk of morbidity and mortality." | 1.40 | Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice. ( Krakowska, A; Mlyniec, K; Nowak, G; Opoka, W; Ostachowicz, B; Reczynski, W, 2014) |
| " Finally, chronic administration of imipramine significantly increased mBDNF levels, but not pro-BDNF and protease levels, indicating that the therapeutic mechanism of imipramine differs from that of ECS." | 1.39 | Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus. ( Fuchikami, M; Matsumoto, T; Morinobu, S; Segawa, M; Yamawaki, S, 2013) |
| "Treatment with imipramine in the SD rats did not induce significant differences in the number of mitochondria." | 1.39 | Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment. ( Chen, F; Madsen, TM; Nyengaard, JR; Wegener, G, 2013) |
| "Oxytocin is a neuromodulator with antidepressant-like effects." | 1.39 | Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase. ( Chai, SY; De Bundel, D; Demaegdt, H; Gard, P; Loyens, E; Michotte, Y; Smolders, I; Vanderheyden, P, 2013) |
| "Depression is one of the most common psychiatric diseases." | 1.39 | Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii. ( Han, P; Han, T; Peng, W; Wang, XR, 2013) |
| " To assess the predictive validity of this behavior as a potential marker of "despair," we tested the effects of chronic administration of two common antidepressant drugs on this measure." | 1.38 | Antidepressants reduce extinction-induced withdrawal and biting behaviors: a model for depressive-like behavior. ( Huq, Y; Huston, JP; Komorowski, M; Topic, B; van den Brink, J, 2012) |
| " On the other hand, chronic administration of NAC and IMI resulted in a significant increase in cellular antioxidant mechanisms (SOD activity) that reversed the effects of BULB in the frontal cortex, hippocampus and striatum." | 1.38 | N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: behavioral and biochemical analyses in rats. ( Filip, M; Krzyżanowska, W; Miszkiel, J; Niedzielska, E; Ogórka, A; Pomierny, B; Pomierny-Chamioło, L; Smaga, I, 2012) |
| "In an animal model of binge drinking that exhibits abstinence-induced behaviors reminiscent of negative affective states, the triple monoamine uptake inhibitor, amitifadine, produced a selective, dose dependent attenuation of binge drinking." | 1.38 | Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology. ( Basile, AS; June, HL; Kelly, T; Skolnick, P; Warnock, KT; Yang, AR; Yi, HS, 2012) |
| "Imipramine is a commonly used tricyclic antidepressant (TCA)." | 1.37 | Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice. ( Farahvar, A; Han, X; Huang, JH; Samadani, U; Smith, DH; Tong, J; Wang, E; Yang, J; Zhang, J, 2011) |
| "Imipramine treatment did not affect this factor." | 1.37 | Chronic unpredictable stress-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) gene expression is antagonized by zinc treatment. ( Cieślik, K; Legutko, B; Nowak, G; Opoka, W; Ossowska, G; Sowa-Kućma, M; Wolak, M, 2011) |
| "The treatment with imipramine reversed all the parameters described above." | 1.36 | Depressive-like parameters in sepsis survivor rats. ( Barichello, T; Cassol, OJ; Comim, CM; Constantino, LC; Constantino, LS; Dal-Pizzol, F; Kapczinski, F; Petronilho, F; Quevedo, J; Stertz, L, 2010) |
| "Imipramine significantly prevented memory deficits caused by Abeta25-35 in the water-maze and Y-maze tests, and inhibited the TNF-alpha increase in the frontal cortex." | 1.36 | Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease. ( Chavant, F; Deguil, J; Fauconneau, B; Ingrand, I; Lafay-Chebassier, C; Milin, S; Pain, S; Pérault-Pochat, MC, 2010) |
| "Imipramine treatment significantly increased the number of neurons in the granule cell layer (GCL) and spine synapses in the CA1 in the FSL imipramine group (treated "depressed" rats) compared with the FSL saline group." | 1.36 | Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression. ( Chen, F; Madsen, TM; Nyengaard, JR; Wegener, G, 2010) |
| "Imipramine was administrated intraperitoneally 30 min before LPS challenge." | 1.36 | Protective effects of imipramine in murine endotoxin-induced acute lung injury. ( Jiang, HN; Qu, JM; Summah, H; Yang, J; Zhang, J; Zhu, YG, 2010) |
| " Dose-response studies using two classes of anxiolytics (chlordiazepoxide: 2." | 1.35 | Modelling the anxiety-depression continuum in chicks. ( Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE, 2009) |
| "Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
| "Global transient cerebral ischemia was performing with the four-vessels occlusion method." | 1.35 | Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances. ( Bantsiele, GB; Bentué-Ferrer, D; Bourin, M; Laviolle, B; Reymann, JM; Saïkali, S, 2009) |
| "Harmine is a beta-carboline alkaloid that inhibits monoamine reuptake systems." | 1.35 | Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. ( Crippa, JA; Fortunato, JJ; Hallak, JE; Kapczinski, F; Kirsch, TR; Pinto, JP; Quevedo, J; Réus, GZ; Stertz, L; Stringari, RB; Zuardi, AW, 2009) |
| "In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest." | 1.35 | Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig. ( Guillaume, P; Lacroix, P; Provost, D, 2009) |
| "Treatment with desipramine or imipramine, however, was not effective at reducing immobility in the 21-day-old rats." | 1.35 | Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression. ( Bylund, DB; Happe, HK; Petty, F; Reed, AL, 2008) |
| " The effect of chronic ACTH treatment on 5-HT(2) receptor and 5-HT(2A)-receptor mRNA levels was not altered by the chronic administration of imipramine." | 1.35 | Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex. ( Akiyama, K; Fujitani, Y; Gomita, Y; Kanzaki, H; Kawasaki, H; Kimoto, S; Kitagawa, K; Kitamura, Y; Ouchida, M; Sendo, T; Shibata, K; Shimizu, K, 2008) |
| " Chronic administration of imipramine tended to attenuate the impairment of SI behavior in stressed mice, but not significantly." | 1.35 | Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders. ( Miyazaki, M; Nabeshima, T; Noda, Y; Tsunekawa, H; Wang, D; Yoneda, F, 2008) |
| " This study investigated the pharmacokinetic and pharmacological interactions between imipramine and sodium alginate in rats." | 1.35 | Pharmacokinetic and pharmacodynamic studies of drug interaction following oral administration of imipramine and sodium alginate in rats. ( Aimoto, T; Araki, H; Imai, K; Inoue, N; Suemaru, K; Watanabe, S, 2008) |
| "Major depression is a highly prevalent mental disorder and environmental factors have been strongly implicated in its pathophysiology." | 1.34 | Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. ( Hashimoto, R; Hattori, S; Kunugi, H; Maeno, H; Miyakawa, T; Wada, K; Yamanaka, H, 2007) |
| "Imipramine treatment offset all the behavioral and neurochemical stress-induced modifications." | 1.34 | Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats. ( Cassanelli, A; Danielli, B; De Montis, MG; Raone, A; Rauggi, R; Scheggi, S, 2007) |
| "Anxiety and depression are currently classified as separate clinical syndromes despite considerable similarities in their symptoms, pathophysiological substrates and response to treatment interventions." | 1.33 | Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks. ( Acevedo, EO; Cartwright, CM; Feltenstein, MW; Sufka, KJ; Warnick, JE; Webb, HE, 2006) |
| "Depression is characterized by a lack of "motivation" rather than a lack of "physical space" to move around." | 1.32 | Open space swimming test to index antidepressant activity. ( Alkon, DL; Sun, MK, 2003) |
| "Depression is highly prevalent in diabetics and is associated with poor glucose regulation and increased risk of diabetic complications." | 1.32 | Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. ( Anjaneyulu, M; Chopra, K; Kaur, I, 2003) |
| "Treatment with imipramine (3 x 30 mg/kg i." | 1.32 | Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances? ( Allain, H; Amiot, N; Bantsiele, GB; Bentué-Ferrer, D; Bourin, M; Reymann, JM, 2004) |
| " As differentiated from acute treatment, chronic administration of imipramine dose-dependently decreased the time of freezing in GC rats." | 1.32 | Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy. ( Alekhina, TA; Chugui, VF; Kolpakov, VG; Kulikov, AV; Popova, NK; Tikhonova, MA, 2004) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Imipramine (IMI) treatment normalized tT4 values." | 1.31 | Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains. ( Antoniou, K; Bekris, S; Christofidis, I; Kioukia, N; Papadopoulou-Daifoti, Z, 2000) |
| " On the 20th day after the start of TD feeding, the increased duration of immobility time induced by TD was shortened by chronic administration of the tricyclic antidepressant imipramine (10 mg/kg, i." | 1.31 | Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. ( Esashi, A; Hozumi, S; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R, 2001) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| "Pretreatment with imipramine, MK 801 and ketamine significantly prevented the effect of shock." | 1.30 | Interaction between N-methyl-D-aspartate receptor antagonists and imipramine in shock-induced depression. ( Bapna, JS; Chandra, D; Chaturvedi, HK, 1999) |
| " Moreover, long term administration of both imipramine or SKF 38393 down regulated D1 dopamine receptor number in the prefrontal cortex, while the association of the two drugs resulted in a receptor density similar to that of control rats." | 1.29 | Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine. ( Gambarana, C; Ghiglieri, O; Graziella de Montis, M, 1995) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "Fengabine (SL 79." | 1.27 | Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987) |
| " Subacute and chronic administration of imipramine (4 or 15 mg/kg) decreased immobility of rats in the behavioral despair model." | 1.27 | The effects of carbamazepine on two animal models of depression. ( Barros, HM; Leite, JR, 1987) |
| "Imipramine was administered both in an acute (3." | 1.27 | Effects of acute and chronic imipramine administration on conflict behavior in the rat: a potential "animal model" for the study of panic disorder? ( Commissaris, RL; Fontana, DJ, 1988) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| " Chronic administration of imipramine-HCl (1 and 5 mg/kg, i." | 1.27 | Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. ( Kameyama, T; Nagasaka, M; Yamada, K, 1985) |
| " Chronic administration of lithium was found to prevent the development of hyperreactivity to mild footshock, while chronic electroconvulsive shock effected a return toward normal behavior." | 1.26 | A pharmacologically pertinent animal model of mania. ( Petty, F; Sherman, AD, 1981) |
| "Treatment with imipramine (1 mg/kg) after the whiplash is able to remove these behavioral and biochemical disturbances." | 1.26 | [Memorization and central catecholamines after a craniocervical injury carried out in rats: influence of imipramine administration (author's transl)]. ( Boismare, F; Le Poncin, M; Lefrançois, J, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (14.07) | 18.7374 |
| 1990's | 31 (9.28) | 18.2507 |
| 2000's | 82 (24.55) | 29.6817 |
| 2010's | 154 (46.11) | 24.3611 |
| 2020's | 20 (5.99) | 2.80 |
| Authors | Studies |
|---|---|
| Duarte, FS | 2 |
| Codeço Martins, PR | 1 |
| Romeiro, GA | 1 |
| Monteiro De Lima, TC | 1 |
| Balavoine, F | 1 |
| Malabre, P | 1 |
| Alleaume, T | 1 |
| Rey, A | 1 |
| Cherfils, V | 1 |
| Jeanneton, O | 1 |
| Seigneurin-Venin, S | 1 |
| Revah, F | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Lewellyn, K | 1 |
| Bialonska, D | 1 |
| Loria, MJ | 1 |
| White, SW | 1 |
| Sufka, KJ | 5 |
| Zjawiony, JK | 2 |
| Valli, M | 1 |
| Betti, AH | 1 |
| Danuello, A | 1 |
| Pivatto, M | 1 |
| Centurião, F | 1 |
| Antonio, CB | 1 |
| Rates, SM | 1 |
| Bolzani, Vda S | 1 |
| Hirose, W | 1 |
| Kato, Y | 1 |
| Yamamoto, T | 1 |
| Kassai, M | 1 |
| Takata, M | 1 |
| Hayashi, S | 1 |
| Arai, Y | 2 |
| Imai, S | 1 |
| Yoshida, K | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
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| Commissaris, RL | 1 |
| Arletti, R | 1 |
| Bertolini, A | 1 |
| Golda, V | 2 |
| Petr, R | 2 |
| Baizman, ER | 1 |
| Ezrin, AM | 1 |
| Ferrari, RA | 1 |
| Luttinger, D | 1 |
| Poncelet, M | 1 |
| Martin, P | 1 |
| Danti, S | 1 |
| Simon, P | 1 |
| Soubrié, P | 1 |
| Rozsíval, V | 1 |
| Suba, P | 1 |
| Kostarczyk, E | 1 |
| Prechtl, JC | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Kameyama, T | 1 |
| Nagasaka, M | 1 |
| Yamada, K | 1 |
| Butler, SH | 1 |
| Weil-Fugazza, J | 1 |
| Godefroy, F | 1 |
| Besson, JM | 1 |
| Takahashi, R | 1 |
| Kido, A | 1 |
| Morita, T | 1 |
| Tedeschi, DH | 1 |
| Boshek, RL | 1 |
| Boston, JE | 1 |
| Geyer, H | 1 |
| Sanghvi, I | 1 |
| Gershon, S | 1 |
| Benkert, O | 1 |
| Hippius, H | 1 |
| Parker, JM | 1 |
| Mendell, JR | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Shropshire, AT | 1 |
| Rowles, G | 1 |
| Varner, LL | 1 |
6 reviews available for imipramine and Disease Models, Animal
| Article | Year |
|---|---|
[Investigation on the mechanisms for the suppression of cell proliferation in the dentate gyrus of the hippocampus in ACTH treated rats].
Topics: Adrenocorticotropic Hormone; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Dentate | 2012 |
Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of 'depression due to multiple sclerosis'.
Topics: Animals; Antidepressive Agents, Tricyclic; Cytokines; Depressive Disorder; Disease Models, Animal; E | 2002 |
Animal models of heart failure: what is new?
Topics: Animals; Blood Pressure; Cardiac Volume; Cardiomyopathy, Dilated; Disease Models, Animal; Doxorubici | 2005 |
The hyperkinetic child syndrome and brain monoamines: pharmacology and therapeutic implications.
Topics: Animals; Arousal; Attention; Brain; Child; Dextroamphetamine; Disease Models, Animal; Dopamine; Huma | 1978 |
Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport.
Topics: Amines; Androstenes; Animals; Biological Transport; Cells, Cultured; Cholesterol; Cholesterol Esters | 1991 |
Amygdala, depression and drug treatment.
Topics: Amygdala; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Imipramine; Mo | 1989 |
2 trials available for imipramine and Disease Models, Animal
| Article | Year |
|---|---|
Antidepressant effects of TNF-α blockade in an animal model of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Depression; Disease Models, Anima | 2013 |
The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials.
Topics: Adjustment Disorders; Animals; Anticonvulsants; Biogenic Amines; Brain; Clinical Trials as Topic; Co | 1983 |
326 other studies available for imipramine and Disease Models, Animal
| Article | Year |
|---|---|
Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test.
Topics: Amines; Animals; Antidepressive Agents; Cycloheptanes; Depression; Disease Models, Animal; Exercise | 2007 |
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists.
Topics: Animals; Chemistry, Pharmaceutical; Depression; Disease Models, Animal; Drug Design; Feeding Behavio | 2007 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Chickens; Depression; Disease Models, Ani | 2013 |
Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Central Nervous System Diseases; Disease Models, A | 2015 |
Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators.
Topics: Allosteric Regulation; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Ha | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; St | 2019 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Respo | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto | 2022 |
Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Disease M | 2021 |
Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Imipramine; Lipopolysaccharides; Metabolic Synd | 2022 |
Imipramine induces hyperactivity in rats pretreated with ouabain: Implications to the mania switch induced by antidepressants.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Humans; Imipramine; Mania; Ouabain; Rats; Ra | 2022 |
Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure.
Topics: Animals; Antidepressive Agents; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Humans; | 2022 |
Imipramine Suppresses Tumor Growth and Induces Apoptosis in Oral Squamous Cell Carcinoma: Targeting Multiple Processes and Signaling Pathways.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Disease Models, Animal; Head and Neck Neoplasms; Human | 2023 |
A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
MicroRNA profiling identifies a novel compound with antidepressant properties.
Topics: Animals; Antidepressive Agents; Brain Injuries, Traumatic; Computational Biology; Depression; Diseas | 2019 |
Fish Oil, but Not Olive Oil, Ameliorates Depressive-Like Behavior and Gut Microbiota Dysbiosis in Rats under Chronic Mild Stress.
Topics: Animals; Bacteria; Behavior, Animal; Depression; Disease Models, Animal; Dysbiosis; Fish Oils; Gastr | 2019 |
Effects of the adjunctive treatment of antidepressants with opiorphin on a panic-like defensive response in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Drug Th | 2020 |
Neonatal Immune Activation May Provoke Long-term Depressive Attributes.
Topics: Animals; Animals, Newborn; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; | 2019 |
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Topics: Amitriptyline; Animals; Biocatalysis; Cells, Cultured; Disease Models, Animal; Down-Regulation; Endo | 2020 |
Antidepressant-like effects of fish, krill oils and Vit B12 against exposure to stress environment in mice models: current status and pilot study.
Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Depressive Disorder; Dietary Proteins; Dis | 2019 |
Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Disease Models, Animal; Encephalitis; | 2020 |
Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets.
Topics: Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Deoxyribonuclease I; Deoxyribonucleases; Disea | 2020 |
Imipramine exerts antidepressant-like effects in chronic stress models of depression by promoting CRTC1 expression in the mPFC.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Imipramine; Male; Mice; | 2020 |
Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A
Topics: Animals; Behavior, Animal; Depression; Depressive Disorder; Disease Models, Animal; Drugs, Chinese H | 2020 |
Antidepressant treatment is associated with epigenetic alterations of Homer1 promoter in a mouse model of chronic depression.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Epigenesis, Genetic; Homer Scaff | 2021 |
Ketamine reversed short-term memory impairment and depressive-like behavior in animal model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Imipramine; Ketamine; Male; Memory, S | 2021 |
Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model.
Topics: Affect; Animals; Antidepressive Agents; Anxiety; Cell Proliferation; Depression; Disease Models, Ani | 2021 |
Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling.
Topics: Adrenergic Uptake Inhibitors; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Behavior, Ani | 2021 |
Synergistic effect between imipramine and citicoline upon induction of analgesic and antidepressant effects in mice.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Cytidine Diphosphate Choline; Depression; Dis | 2021 |
Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression.
Topics: Animals; Antidepressive Agents; Brain; Chromatography, High Pressure Liquid; Depression; Disease Mod | 2017 |
Role of cortical alpha-2 adrenoceptors in alcohol withdrawal-induced depression and tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Alcohol Content; Depression; Disease Models, Animal | 2017 |
Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression.
Topics: 14-3-3 Proteins; Animals; Antidepressive Agents; Cathepsin D; COP9 Signalosome Complex; Depression; | 2017 |
Cariprazine Exhibits Anxiolytic and Dopamine D3 Receptor-Dependent Antidepressant Effects in the Chronic Stress Model.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Aripiprazole; Chronic Disea | 2017 |
Decreased Prostaglandin D2 Levels in Major Depressive Disorder Are Associated with Depression-Like Behaviors.
Topics: Adolescent; Adult; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Brain; Chromatography, L | 2017 |
Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice.
Topics: Acetates; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; | 2017 |
The Neurotensin NTS
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Hu | 2017 |
Effects of escitalopram and imipramine on cocaine reinforcement and drug-seeking behaviors in a rat model of depression.
Topics: Animals; Citalopram; Cocaine; Cocaine-Related Disorders; Cues; Depressive Disorder; Disease Models, | 2017 |
Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide.
Topics: Animals; Benzydamine; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Imipramin | 2017 |
SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model.
Topics: Anhedonia; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Glutamic Acid; Histon | 2017 |
Elucidating the functions of brain GSK3α: Possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Glycogen Synthase Kinase | 2017 |
Imipramine blocks acute silicosis in a mouse model.
Topics: Acute Disease; Animals; Cell Survival; Cells, Cultured; Collagen; Disease Models, Animal; Imipramine | 2017 |
Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress-Induced Behavioral and Biochemical Alterations in Mouse Brain.
Topics: Acetates; Animals; Behavior, Animal; Brain; Corticosterone; Cyclopentanes; Disease Models, Animal; G | 2017 |
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cognition; Depression; Disease Models, Animal; Gar | 2018 |
Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depr | 2018 |
Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Gait; Imipramine; Ketamine; Male; Nerve Dege | 2018 |
Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; DNA Methylation; DNA Mo | 2018 |
Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Female; Flu | 2018 |
Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Bra | 2018 |
Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat.
Topics: Anhedonia; Animals; Antidepressive Agents; Autoradiography; Brain; Depression; Disease Models, Anima | 2018 |
The effect of intracerebroventricular allopregnanolone on depressive-like behaviors of rats selectively bred for high and low immobility in the forced swim test.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Genetic Predisposition | 2018 |
Rapid antidepressant effects of deep brain stimulation of the pre-frontal cortex in an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Deep Brain Stimulation; Depressive Dis | 2018 |
Validation of chronic mild stress in the Wistar-Kyoto rat as an animal model of treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder; Depre | 2019 |
Imipramine treatment reverses depressive- and anxiety-like behaviors, normalize adrenocorticotropic hormone, and reduces interleukin-1β in the brain of rats subjected to experimental periapical lesion.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; B | 2019 |
Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression.
Topics: Animals; Antidepressive Agents; Brain; Cognition; Depression; Depressive Disorder; Disease Models, A | 2019 |
Synergistic anticataleptic effect of imipramine and nicotine in a rotenone-induced rat model.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Catalepsy; Disease Models, Animal; Dos | 2019 |
Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Disease; Dentate Gyrus; D | 2019 |
The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Disease Models, A | 2019 |
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depre | 2019 |
Imipramine treatment increases cell proliferation following fluid percussion brain injury in rats.
Topics: Animals; Brain Injuries; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Fluorescent Anti | 2013 |
Depression-like behavior is dependent on age in male SAMP8 mice.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Depression; Dis | 2013 |
Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats.
Topics: Acetamides; Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Mode | 2012 |
A proposal for refining the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramin | 2013 |
Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain; Comorbidity; Corticosterone; Depressive Disorder; | 2014 |
The effect of GABAmimetics on the duration of immobility in the forced swim test in albino mice.
Topics: Alprazolam; Animals; Depression; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Arginine; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor | 2014 |
The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Colon; Curcumin; Cyclic AMP Response Element-Bi | 2015 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neur | 2014 |
Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Depression; Disease Models, Animal; Dopamine Agonist | 2014 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp | 2014 |
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
Topics: Acetamides; Animals; Antidepressive Agents; Chronic Disease; Dentate Gyrus; Depressive Disorder; Dis | 2015 |
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Aripiprazole; Chronic Disease; Depressive Disorder; Dieta | 2014 |
Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic | 2014 |
Haloperidol-induced extra pyramidal symptoms attenuated by imipramine in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Disease Models, Animal; Dyskines | 2014 |
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Mod | 2014 |
Effects of N-acetylcysteine and imipramine in a model of acute rhythm disruption in BALB/c mice.
Topics: Acetylcysteine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Circadian Rhythm; Corti | 2015 |
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine | 2015 |
Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice.
Topics: Animals; Antidepressive Agents; Bupropion; Citalopram; Copper; Depression; Disease Models, Animal; I | 2014 |
The effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Synergism; Fluoxetine; Imip | 2014 |
Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice.
Topics: Animals; Antidepressive Agents; Corticosterone; Depressive Disorder; Disease Models, Animal; Gene Kn | 2015 |
Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems.
Topics: Animals; Antidepressive Agents; Corpus Striatum; Coumaric Acids; Disease Models, Animal; Drug Evalua | 2015 |
Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Environment; Fluoxetine | 2015 |
Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules, Neuron | 2015 |
Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Dietary Sucrose; Disease | 2015 |
Analysis of dependence of antidepressant properties of TrkB receptor ligands on MAP-kinase pathway activation.
Topics: Amides; Animals; Antidepressive Agents; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell L | 2015 |
Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Dextromethorphan; | 2015 |
The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis.
Topics: Animals; Antidepressive Agents; Brain Ischemia; Depressive Disorder; Disease Models, Animal; Dose-Re | 2015 |
A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action.
Topics: Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Animal; Excitatory A | 2015 |
The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Behavior, Animal; Brain; Depression; Depress | 2015 |
Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Conserved Sequence; CpG Islands; Depress | 2015 |
Antidepressant-like effects of methanolic extract of Bacopa monniera in mice.
Topics: Animals; Antidepressive Agents; Bacopa; Behavior, Animal; Depression; Disease Models, Animal; Imipra | 2015 |
3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.
Topics: Animals; Antidepressive Agents; Benzodiazepines; Deoxyadenosines; Depressive Disorder; Disease Model | 2016 |
Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cerebral Cortex; Depressive Diso | 2016 |
The Role of Nitric Oxide in the Antidepressant Actions of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside in Insulin-Resistant Mice.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Antidepressive Agents; Combined Modality Ther | 2016 |
Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Brain; Brain-Derived Neuro | 2015 |
Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Benzazepines; Depression; Disease Model | 2016 |
Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Dentate Gyrus; Depression; Disease | 2016 |
Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system.
Topics: Animals; Apomorphine; Corpus Striatum; Depression; Disease Models, Animal; Dopamine; Dopamine Agonis | 2016 |
[Effects of ketamine, imipramine, and their combination on depression-like behaviors in Wistar Kyoto rats].
Topics: Animals; Brain; Depression; Depressive Disorder; Disease Models, Animal; Down-Regulation; Imipramine | 2016 |
Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Butyric Acid; Depression; Disease | 2016 |
Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Ex | 2016 |
The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Depression; Disease Models, Animal; Electrophoresis, Gel, | 2016 |
The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver.
Topics: Analysis of Variance; Anhedonia; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Dietary Su | 2016 |
Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzamides; Dendrites; Dentate Gyrus; Depression; Disease | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models | 2016 |
Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Cell Proliferation; Dentate Gyrus; Diseas | 2016 |
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antidepressive Agents; Central Nervous System S | 2016 |
Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Disease | 2016 |
Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Blood Glucose; Central Amygdaloid Nucleus; Depr | 2016 |
The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice.
Topics: Adrenergic Neurons; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dopaminergic | 2016 |
Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain Stem; Chronic Disease; Depressive Disorder; Disease | 2016 |
Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dis | 2016 |
Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Fluoroquinolones; Food Preferenc | 2016 |
The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Topics: Animals; Antidepressive Agents; Anxiety; Chickens; Depression; Disease Models, Animal; Imipramine; M | 2016 |
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Comorbidity; Depressiv | 2017 |
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Depressive Disorder, Treatment-Re | 2017 |
Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway.
Topics: Adjuvants, Immunologic; Animals; Antidepressive Agents, Tricyclic; Benzodiazepines; Depression; Dise | 2017 |
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Ani | 2017 |
The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Benzofura | 2017 |
Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Depression; Discrimination Learning; Disease Mo | 2017 |
Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Disease Models, Animal; Ha | 2016 |
Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine Agents; Drugs, Chinese Herbal; Fenc | 2017 |
Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Disea | 2017 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiaze | 2009 |
Anxiolytic-like effect of chronic treatment with Erythrina velutina extract in the elevated plus-maze test.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brazil; Chlordiazepox | 2008 |
Combination therapy of imipramine and melatonin: additive antidepressant effect in mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Disease Models, Animal; Dose-Response Re | 2008 |
Effects of age on susceptibility to the induction of depressive behavior and imipramine in rats.
Topics: Age Factors; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotrophic | 2008 |
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment.
Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arachidonic Acids; Bra | 2008 |
SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model.
Topics: Animals; Antidepressive Agents; Antidiuretic Hormone Receptor Antagonists; Behavior, Animal; Depress | 2009 |
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Bipolar Disorder; Cell Membrane; Central Ner | 2009 |
Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depressi | 2009 |
Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cerebral Cortex; Cluster Analysis; Dep | 2008 |
Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2009 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Role of estradiol withdrawal in 'anhedonic' sucrose consumption: a model of postpartum depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Depression, Postpartum; Disease M | 2009 |
CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Flavono | 2009 |
Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain Isc | 2009 |
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatin; Chromatin Immunoprecipitatio | 2009 |
Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; | 2009 |
Depressive-like parameters in sepsis survivor rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents, T | 2010 |
Chronic treatment with the selective NOP receptor antagonist [Nphe 1, Arg 14, Lys 15]N/OFQ-NH 2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response | 2009 |
Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition; Diseas | 2010 |
Effect of imipramine on nerve excitability in GC rats.
Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Catatonia; Cortic | 2009 |
Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Cell Count; Depression; Disease Models, Animal | 2010 |
Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cannabidiol; Cannabis; Depression | 2010 |
Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice.
Topics: Adaptation, Ocular; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antidepressive Age | 2010 |
Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; CA3 Region, Hippocampal; Cyclohex | 2010 |
Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus.
Topics: Animals; Antidepressive Agents, Tricyclic; Appetite; Chronic Disease; Dentate Gyrus; Depressive Diso | 2010 |
Protective effects of imipramine in murine endotoxin-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; C | 2010 |
Selective breeding for dominant and submissive behavior in Sabra mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Breeding; Depressive Disorder; Disease | 2010 |
Ozone modulates the effects of imipramine on immobility in the forced swim test, and nonspecific parameters of hippocampal oxidative stress in the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Animal; Hazardous Su | 2010 |
Cocaine sensitization models an anhedonia-like condition in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Cocaine; Cyclic AMP-Dependent Protein Kinas | 2011 |
Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Astrocytes; Citrates; Depression; Disease Models, Animal; | 2011 |
Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Antimanic Agents; Cell Proli | 2010 |
Exposure of mice to long-light: a new animal model to study depression.
Topics: Animals; Depression; Disease Models, Animal; Exploratory Behavior; Imipramine; Light; Male; Mice; Mi | 2010 |
Interaction between behavioral despair and addictive behaviors in rats.
Topics: Animals; Behavior, Addictive; Choice Behavior; Conditioning, Classical; Depression; Disease Models, | 2011 |
The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Cyclohexanols; Depression; D | 2011 |
Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Diazepam; Disease Models, Animal; Female; Imipramine; | 2011 |
Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Elemen | 2011 |
Neonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthood.
Topics: Affective Symptoms; Age Factors; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavi | 2011 |
Depressive-like behaviour of mice lacking cellular prion protein.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Exploratory Be | 2012 |
Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice.
Topics: Animals; Brain Injuries; Cognition Disorders; Disease Models, Animal; Hippocampus; Imipramine; Male; | 2011 |
Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.
Topics: Animals; Antidepressive Agents; Azacitidine; Behavior, Animal; Brain-Derived Neurotrophic Factor; De | 2011 |
Chronic unpredictable stress-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) gene expression is antagonized by zinc treatment.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Depression; Disease Mo | 2011 |
Pharmacological reversal of cognitive bias in the chick anxiety-depression model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Bias; Chickens; Clo | 2012 |
The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; | 2012 |
Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Adrenergic Uptake Inhibitors; Analysis of Variance; Anim | 2011 |
Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Increase in cortical pyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study.
Topics: Action Potentials; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Carrier Proteins | 2011 |
Changes in hippocampal gene expression by 7-nitroindazole in rats submitted to forced swimming stress.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Gene Expression Regulation; Hippocampus | 2012 |
[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].
Topics: Adamantane; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Depression; Disease | 2011 |
Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
Topics: Animal Husbandry; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Protocols; Digoxin | 2009 |
Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Disease Models, Animal | 2013 |
Antidepressants reduce extinction-induced withdrawal and biting behaviors: a model for depressive-like behavior.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Disease Models, Animal; Extinction, Psycholo | 2012 |
HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.
Topics: Animals; Behavior, Animal; Brain; Cells, Cultured; Corticosterone; Dexamethasone; Disease Models, An | 2012 |
Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Bromodeoxyuridine; Depressive Disorder; Diseas | 2012 |
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.
Topics: Aging; Anhedonia; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depressive D | 2012 |
NADPH oxidase mediates depressive behavior induced by chronic stress in mice.
Topics: Acetophenones; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Ascorb | 2012 |
N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: behavioral and biochemical analyses in rats.
Topics: Acetylcysteine; Animals; Antidepressive Agents; Antioxidants; Brain; Depression; Disease Models, Ani | 2012 |
Antidepressants prevent hierarchy destabilization induced by lipopolysaccharide administration in mice: a neurobiological approach to depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cytokines; Depression; Disease Models, Animal; Flu | 2012 |
Effects of sex and rearing environment on imipramine response in mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Calbindin 2; Calbindins; Disea | 2012 |
Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine.
Topics: Acute Lung Injury; Administration, Topical; Amphiregulin; Animals; Animals, Newborn; Apoptosis; Bron | 2012 |
Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology.
Topics: Affect; Alcoholism; Animals; Aza Compounds; Binge Drinking; Biogenic Monoamines; Bridged Bicyclo Com | 2012 |
The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2.
Topics: Animals; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Hippocampus; Imipramine | 2012 |
A study on evalution of antidepressant effect of imipramine adjunct with Aswagandha and Bramhi.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Helplessne | 2011 |
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment.
Topics: Animals; Antidepressive Agents, Tricyclic; CA1 Region, Hippocampal; Depressive Disorder; Disease Mod | 2013 |
Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences.
Topics: Adrenal Glands; Animals; Antidepressive Agents; Body Weight; Brain; Chronic Disease; Disease Models, | 2013 |
Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase.
Topics: Age Factors; Aminopeptidases; Angiotensin II; Animals; Antidepressive Agents; Cell Membrane; Cerebra | 2013 |
Imipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infection.
Topics: Administration, Oral; Animals; Antimony; Antiprotozoal Agents; Cricetinae; Disease Models, Animal; D | 2012 |
Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depressive | 2013 |
Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii.
Topics: Acorus; Allylbenzene Derivatives; Animals; Anisoles; Antidepressive Agents; Depression; Disease Mode | 2013 |
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Effects of imipramine on T cell subsets in olfactory bulbectomized mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Animal; Humans; Imip | 2002 |
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Argin | 2003 |
Open space swimming test to index antidepressant activity.
Topics: Alanine; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Antidepressant-like effects in various mice strains in the tail suspension test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, An | 2003 |
Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Brain Chemistry; Choice Behavior | 2003 |
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; | 2004 |
Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
Topics: Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Dose- | 2003 |
Differential effects of traumatic brain injury on the cytochrome p450 system: a perspective into hepatic and renal drug metabolism.
Topics: Animals; Brain Injuries; Cytochrome P-450 Enzyme System; Disease Models, Animal; Imipramine; Kidney; | 2003 |
Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice.
Topics: Animals; Antidepressive Agents; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2003 |
Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Models, Animal; Imi | 2004 |
Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus.
Topics: alpha-MSH; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depr | 2004 |
Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Depression; Diazepam; Disea | 2004 |
Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dos | 2005 |
Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression.
Topics: Administration, Oral; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Imipramine | 2005 |
Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy.
Topics: Animals; Antidepressive Agents, Tricyclic; Catalepsy; Disease Models, Animal; Imipramine; Male; Rats | 2004 |
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Clozapine; De | 2005 |
Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner.
Topics: Amygdala; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Bromodeoxyuridine; Cell Proli | 2006 |
Differential gender-related vulnerability to depression induction and converging antidepressant responses in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Brain-Derived Neuro | 2006 |
Eye-wiping test: a sensitive animal model for acute trigeminal pain studies.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Cornea; Data Interpretation, S | 2005 |
Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment.
Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, | 2006 |
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action.
Topics: Acetylation; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Ch | 2006 |
Immunity and emotions: lipopolysaccharide increases defensive behaviours and potentiates despair in mice.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease M | 2006 |
Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test.
Topics: Alkaloids; Animals; Antidepressive Agents; Aziridines; Behavior, Animal; Depression; Disease Models, | 2006 |
Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Imipramine; Im | 2006 |
Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behav | 2006 |
Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Chickens; | 2006 |
Genetic dissection of the tail suspension test: a mouse model of stress vulnerability and antidepressant response.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chromosome Mapping; Chromosomes, Mammalian; Crosse | 2007 |
Long-term behavioral changes after cessation of chronic antidepressant treatment in olfactory bulbectomized rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Dise | 2007 |
Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Survival; Depression; Disease Models, Animal; Enviro | 2007 |
Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Corticotropin-Releasing | 2007 |
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Topics: Amidohydrolases; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Weight; Brain; C | 2007 |
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Dentate Gyrus; Depressive Disorder; Dia | 2007 |
Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?
Topics: Adjuvants, Pharmaceutic; Amino Acids; Animals; Antidepressive Agents, Tricyclic; Bridged Bicyclo Com | 2007 |
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
Topics: Animals; Antidepressive Agents; Biological Assay; Cell Death; Cells, Cultured; Chronic Disease; Cort | 2007 |
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Diazepam; Disease Models, | 2007 |
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Bromodeoxyuridine; Cell Proliferati | 2008 |
Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2007 |
Antidepressant-like effect of agmatine is not mediated by serotonin.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2008 |
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Topics: Adolescent; Age Factors; Animals; Antidepressive Agents; Child; Citalopram; Depressive Disorder; Des | 2008 |
Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Binding Sites; | 2008 |
Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzof | 2008 |
Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors?
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Antidepressive Agents; Carbamazepine; Depression | 2008 |
Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model.
Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage; Ceramides; Disease Models, Animal; Enzyme Inhibit | 2008 |
Pharmacokinetic and pharmacodynamic studies of drug interaction following oral administration of imipramine and sodium alginate in rats.
Topics: Administration, Oral; Alginates; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Depres | 2008 |
Alprazolam in a biochemical model of depression.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Depression; Diazepam; Disease Models, Ani | 1982 |
Learned helplessness decreases [3H]imipramine binding in rat cortex.
Topics: Animals; Carrier Proteins; Depressive Disorder; Disease Models, Animal; Electroshock; Frontal Lobe; | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
A pharmacologically pertinent animal model of mania.
Topics: Affective Disorders, Psychotic; Animals; Bipolar Disorder; Disease Models, Animal; Electroshock; Hum | 1981 |
Preliminary report of a new rodent separation model of depression.
Topics: Animals; Brain; Clorgyline; Cricetinae; Depressive Disorder; Disease Models, Animal; Female; Humans; | 1984 |
Evaluation of a proposed hamster separation model of depression.
Topics: Animals; Behavior, Animal; Body Weight; Cricetinae; Depression; Disease Models, Animal; Exploratory | 1984 |
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalogra | 1983 |
Postsynaptic action by four antidepressive drugs in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Di | 1981 |
Relationship between regional distribution of imipramine and its effect on learned helplessness in the rat.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Escape Reaction; Humans; Imipramine; | 1980 |
Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant.
Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Ani | 1981 |
Tricyclic antidepressant drug action correlates with its tissue levels in anterior neocortex.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Depressive Disorder; Disease Models, Animal; Humans; Imi | 1982 |
Animal model of depression: pharmacological sensitivity of a hedonic deficit.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Drinking; Eating; Humans; Imipramine; Male; Mo | 1982 |
A further parametric study of imipramine in an animal model of depression.
Topics: Animals; Defecation; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; | 1982 |
Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Eating | 1995 |
The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression.
Topics: Animals; Depression; Disease Models, Animal; Hippocampus; Imipramine; Male; Neurons; Phenylephrine; | 1995 |
Antidepressant-like effect of selective dopamine D1 receptor agonists in the behavioural despair animal model of depression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Antidepre | 1994 |
Effects of treatment with imipramine and clonazepam on an animal model of panic disorder.
Topics: Analysis of Variance; Animals; Bicuculline; Clonazepam; Disease Models, Animal; Double-Blind Method; | 1994 |
TJS-010, a new prescription of Kampo medicine with putative antidepressive and anxiolytic properties.--A behavioral study using experimental models for depression and anxiety.
Topics: Administration, Oral; Animals; Anxiety; Depression; Disease Models, Animal; Drugs, Chinese Herbal; H | 1994 |
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice.
Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disea | 1994 |
Depletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Depression; Disease Models, Animal; Dopami | 1993 |
Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clomipramine; Depression; Disea | 1995 |
The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Depressive Disorder; Disease Models, An | 1995 |
Effect of jet ventilation on heart failure: decreased afterload but negative response in left ventricular end-systolic pressure-volume function.
Topics: Adrenergic Uptake Inhibitors; Animals; Catecholamines; Diastole; Disease Models, Animal; Dogs; Heart | 1996 |
Effects of serotonergic agents on food-restriction-induced hyperactivity.
Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Disease Models, Animal; Eating; Female; Fenc | 1996 |
Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model.
Topics: Animals; Blood Platelets; Brain; Carrier Proteins; Depressive Disorder; Dexamethasone; Disease Model | 1996 |
A genetic mouse model of helplessness sensitive to imipramine.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Female; Imipramine; Male; Mice; Mice, Inbred S | 1996 |
Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; | 1997 |
Long-term stress degenerates, but imipramine regenerates, noradrenergic axons in the rat cerebral cortex.
Topics: Adrenergic Uptake Inhibitors; Animals; Arousal; Axons; Cerebral Cortex; Depressive Disorder; Disease | 1997 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Imipramine; Ketoconaz | 1997 |
Individual differences in response to imipramine in the mouse tail suspension test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 1997 |
The depression system: preliminary studies.
Topics: Animals; Behavior, Animal; Brain Stem; Depressive Disorder; Disease Models, Animal; Functional Later | 1997 |
Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats.
Topics: Acute Disease; Animals; Appetite; Benzazepines; Chronic Disease; Disease Models, Animal; Electroshoc | 1999 |
A re-evaluation of social defeat as an animal model of depression.
Topics: Aggression; Animals; Antidepressive Agents, Tricyclic; Arousal; Depressive Disorder; Disease Models, | 1999 |
Negative affect and voluntary alcohol consumption in Wistar-Kyoto (WKY) and Sprague-Dawley rats.
Topics: Alcoholism; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Central Nervous System | 1999 |
Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chronic Disease; Disease Models, Animal | 2000 |
Antidepressant-like activity of amisulpride in two animal models of depression.
Topics: Amisulpride; Animals; Antidepressive Agents; Antipsychotic Agents; Depression; Disease Models, Anima | 2000 |
Interaction between N-methyl-D-aspartate receptor antagonists and imipramine in shock-induced depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Electroshock; Female; | 1999 |
Antidepressant activity of Indian Hypericum perforatum Linn in rodents.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Hypericum; Imipramine; M | 1999 |
Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?
Topics: Animals; Arousal; Body Temperature Regulation; Depressive Disorder; Disease Models, Animal; Dose-Res | 2001 |
Animal models for the study of antidepressant activity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
Topics: Adrenergic Uptake Inhibitors; Animals; Anxiety; Behavior, Animal; Darkness; Depression; Disease Mode | 2001 |
Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Depression; Diet; Disease | 2001 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |
Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Depression; Disease Model | 2001 |
Repeated treatment with imipramine, fluvoxamine and tranylcypromine decreases the number of escape failures by activating dopaminergic systems in a rat learned helplessness test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antidepressive Agents; Benzazep | 2001 |
Agmatine produces antidepressant-like effects in two models of depression in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Disease Mode | 2002 |
Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats.
Topics: Administration, Oral; Animals; Antidepressive Agents; Bacopa; Behavior, Animal; Depression; Disease | 2002 |
Proceedings: Methylamphetamine withdrawal as a model for the depressive state: antagonism of post-amphetamine depression by imipramine.
Topics: Animals; Brain Chemistry; Depression; Disease Models, Animal; Humans; Imipramine; Male; Methamphetam | 1975 |
Skeletal muscle necrosis following membrane-active drugs plus serotonin.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Drug Synergism; Histamine H1 Anta | 1976 |
Effects of imipramine treatment of separation-induced social disorders in rhesus monkeys.
Topics: Animals; Depression; Disease Models, Animal; Exploratory Behavior; Female; Haplorhini; Humans; Imipr | 1978 |
Sarcolemmal membrane changes related to enzyme release in the imipramine/serotonin experimental animal model.
Topics: Adenosine Triphosphatases; Aminoisobutyric Acids; Animals; Biological Transport, Active; Creatine Ki | 1976 |
Biphasic effects of imipramine in experimental models of epilepsy.
Topics: Animals; Cats; Central Nervous System; Disease Models, Animal; Electroencephalography; Electroshock; | 1976 |
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Electroshock; Humans; Imipramine | 1978 |
[Memorization and central catecholamines after a craniocervical injury carried out in rats: influence of imipramine administration (author's transl)].
Topics: Animals; Behavior, Animal; Brain Chemistry; Disease Models, Animal; Imipramine; Memory; Norepinephri | 1977 |
Experimental serotonin myopathy.
Topics: Animals; Capillaries; Disease Models, Animal; Imipramine; Male; Muscles; Muscular Diseases; Muscular | 1977 |
A reward-reduction model of depression using self stimulating rats: an appraisal.
Topics: Amphetamine; Animals; Depression; Disease Models, Animal; Humans; Imipramine; Male; Protriptyline; R | 1979 |
Non-specificity of "behavioral despair" as an animal model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Female; Humans | 1979 |
Reversal of learned helplessness by imipramine.
Topics: Animals; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reaction; Huma | 1979 |
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania.
Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypno | 1975 |
[Experimental model of depression: neurochemical changes and the effects of imipramine and citalopram].
Topics: Animals; Antidepressive Agents; Brain; Catecholamines; Citalopram; Depression; Disease Models, Anima | 1992 |
Imipramine induced heart failure in the dog: a model to study the effect of cardiac assist devices.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Echocardiography; Electrophysiology; Female; | 1992 |
Chronic variable stress facilitates tumoral growth: reversal by imipramine administration.
Topics: Animals; Cyclosporine; Depression; Disease Models, Animal; Imipramine; Immune Tolerance; Immunity; M | 1992 |
Immobility-reducing effects of antidepressants in a genetic animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Depression, Chemical; Desipramine; Disease Models, Anima | 1992 |
Social model of depression in mice of C57BL/6J strain.
Topics: Aggression; Animals; Depression; Disease Models, Animal; Exploratory Behavior; Gastric Mucosa; Gastr | 1991 |
Lack of tolerance to imipramine or mianserine in two animal models of depression.
Topics: Amphetamine; Animals; Anorexia; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response | 1990 |
Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice.
Topics: Animals; Atropine; Central Nervous System; Cimetidine; Depression; Desipramine; Disease Models, Anim | 1988 |
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl | 1987 |
The effects of carbamazepine on two animal models of depression.
Topics: Animals; Carbamazepine; Depressive Disorder; Disease Models, Animal; Haloperidol; Imipramine; Male; | 1987 |
Effects of acute and chronic imipramine administration on conflict behavior in the rat: a potential "animal model" for the study of panic disorder?
Topics: Animals; Conflict, Psychological; Disease Models, Animal; Fear; Female; Imipramine; Panic; Rats; Rat | 1988 |
Oxytocin acts as an antidepressant in two animal models of depression.
Topics: Animals; Depression; Disease Models, Animal; Drug Interactions; Escape Reaction; Female; Imipramine; | 1987 |
Animal model of depression: retention of motor depression not predictable from the threshold of reaction to the inescapable shock.
Topics: Animals; Bromocriptine; Depression; Differential Threshold; Disease Models, Animal; Electroshock; Es | 1987 |
Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models.
Topics: Animals; Antidepressive Agents; Biological Transport; Blepharoptosis; Brain; Depression; Disease Mod | 1987 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |
Animal model of depression: imipramine, bromocriptine and lisuride alleviate motor depression.
Topics: Adjustment Disorders; Animals; Bromocriptine; Disease Models, Animal; Ergolines; Female; Imipramine; | 1986 |
Changes in socio-emotional behavior under imipramine treatment in normal and amygdalo-hypothalamic dogs.
Topics: Amygdala; Animals; Depression; Disease Models, Animal; Dogs; Emotions; Hypothalamic Area, Lateral; I | 1986 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhy | 1985 |
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease M | 1985 |
An animal model of depression.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Conditioning, Classical; Depression; Disease Models | 1974 |
Proceedings: Ptosis as a model of depression.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Depression; Disease Models, Animal; Humans; Imiprami | 1974 |
Exploration of the anti-depressant potential of lithium.
Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Behavior, Animal; Bipolar Disorder; Blood | 1973 |
[Significance of pharmaco-psychiatric findings for basic biological psychiatric research].
Topics: Antidepressive Agents; Bipolar Disorder; Catecholamines; Chlorpromazine; Deficiency Diseases; Diseas | 1973 |
Proximal myopathy induced by 5-HT-imipramine simulates Duchenne dystrophy.
Topics: Animals; Disease Models, Animal; Imipramine; Male; Muscular Dystrophies; Rats; Serotonin | 1974 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |