imipramine has been researched along with Dementia in 33 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of paroxetine and imipramine prospectively in patients with coexisting depression and dementia." | 9.08 | A double-blind comparison of the efficacy and safely of paroxetine and imipramine in the treatment of depression with dementia. ( Bray, J; Hunter, BN; Katona, CL, 1998) |
| "To compare the efficacy of paroxetine and imipramine prospectively in patients with coexisting depression and dementia." | 5.08 | A double-blind comparison of the efficacy and safely of paroxetine and imipramine in the treatment of depression with dementia. ( Bray, J; Hunter, BN; Katona, CL, 1998) |
| "Depression is a highly prevalent concomitant of dementia." | 2.40 | Depression and dementia: comorbidities, identification, and treatment. ( Meyers, BS, 1998) |
| "Acute anticholinergic delirium has been reported to occur following ingestion of antidepressants, neuroleptics and antiparkinsonian drugs in toxic and therapeutic doses." | 1.27 | Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia. ( Banno, V; Jones, BD; Moreau, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (69.70) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (12.12) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Kołaczkowski, M | 4 |
| Marcinkowska, M | 3 |
| Bucki, A | 4 |
| Pawłowski, M | 3 |
| Mitka, K | 1 |
| Jaśkowska, J | 1 |
| Kowalski, P | 1 |
| Kazek, G | 2 |
| Siwek, A | 4 |
| Wasik, A | 2 |
| Wesołowska, A | 4 |
| Mierzejewski, P | 3 |
| Bienkowski, P | 2 |
| Śniecikowska, J | 2 |
| Jastrzębska-Więsek, M | 3 |
| Partyka, A | 3 |
| Więckowski, K | 1 |
| Głuch-Lutwin, M | 2 |
| Gryboś, A | 1 |
| Pytka, K | 1 |
| Zagórska, A | 1 |
| Mordyl, B | 1 |
| Jaromin, A | 1 |
| Walczak, M | 1 |
| Nardi, M | 1 |
| Anwander, M | 1 |
| Rüegger-Frey, B | 1 |
| Bopp-Kistler, I | 1 |
| GRAUER, H | 1 |
| KRAL, VA | 1 |
| ENGELSTOFT, FH | 1 |
| HESHE, J | 1 |
| KIRK, L | 1 |
| LELOUET, JM | 1 |
| BLATRIX, C | 1 |
| JACQUIN, M | 1 |
| SOMMER, A | 1 |
| HAUSNER, M | 1 |
| DOLEZAL, V | 1 |
| LECOMTE, G | 1 |
| ALCALAY, R | 1 |
| MAZZONI, L | 1 |
| DE PALMA, C | 1 |
| Herbert, ME | 1 |
| Jacobson, S | 1 |
| Werner, V | 1 |
| Diehl, LW | 1 |
| Bowen, DM | 1 |
| Allen, SJ | 1 |
| Benton, JS | 1 |
| Goodhardt, MJ | 1 |
| Haan, EA | 1 |
| Palmer, AM | 1 |
| Sims, NR | 1 |
| Smith, CC | 1 |
| Spillane, JA | 1 |
| Esiri, MM | 1 |
| Neary, D | 1 |
| Snowdon, JS | 1 |
| Wilcock, GK | 1 |
| Davison, AN | 1 |
| Mellerup, ET | 1 |
| Plenge, P | 1 |
| Rosenberg, R | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Klein, DF | 1 |
| Sparks, DL | 2 |
| Danner, FW | 1 |
| Davis, DG | 1 |
| Hackney, C | 1 |
| Landers, T | 1 |
| Coyne, CM | 1 |
| Katona, CL | 1 |
| Hunter, BN | 1 |
| Bray, J | 1 |
| Meyers, BS | 1 |
| Shraberg, D | 1 |
| Husain, MM | 1 |
| Knight, DL | 1 |
| Doraiswamy, PM | 1 |
| Figiel, GS | 1 |
| McDonald, WM | 1 |
| Boyko, OB | 1 |
| Krishnan, KR | 1 |
| Nemeroff, CB | 1 |
| Markesbery, WR | 1 |
| Marcusson, JO | 1 |
| Alafuzoff, I | 1 |
| Bäckström, IT | 1 |
| Ericson, E | 1 |
| Gottfries, CG | 1 |
| Winblad, B | 1 |
| Moreau, A | 1 |
| Jones, BD | 1 |
| Banno, V | 1 |
| Wamboldt, MZ | 1 |
| Kalin, NH | 1 |
| Weiler, SJ | 1 |
| Hall, P | 1 |
| Bertolotti, P | 1 |
| Spaggiari, G | 1 |
| Junod, JP | 1 |
| Webb, WL | 1 |
| Radzuweit, H | 1 |
| Knorr, W | 1 |
| Post, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Controlled, Randomized, Double-Blind Trial of Sertraline in Patients With Frontal Lobe Dementia (FLD)[NCT00001777] | Phase 1 | 30 participants | Interventional | 1997-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for imipramine and Dementia
| Article | Year |
|---|---|
[The state of psychopharmacotherapy in geriatrics 2].
Topics: Actihaemyl; Aged; Amitriptyline; Bencyclane; Cerebrovascular Circulation; Clorazepate Dipotassium; D | 1980 |
Depression and dementia: comorbidities, identification, and treatment.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cog | 1998 |
1 trial available for imipramine and Dementia
| Article | Year |
|---|---|
A double-blind comparison of the efficacy and safely of paroxetine and imipramine in the treatment of depression with dementia.
Topics: Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Dementia; Depressi | 1998 |
30 other studies available for imipramine and Dementia
| Article | Year |
|---|---|
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; C | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indol | 2015 |
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
Topics: Affect; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Dementia; Dopamine Agonist | 2017 |
Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.
Topics: Animals; Antipsychotic Agents; Dementia; Humans; Ligands; Mice; Phosphoric Diester Hydrolases; Serot | 2022 |
[There's not only Alzheimer's disease].
Topics: Accidental Falls; Aged; Alzheimer Disease; Antidepressive Agents; Cognition Disorders; Comorbidity; | 2012 |
Use of imipramine (Tofranil) in psychiatric patients of a geriatric outpatient clinic.
Topics: Aged; Aged, 80 and over; Aging; Ambulatory Care Facilities; Dementia; Humans; Imipramine; Mental Dis | 1960 |
[Treatment of selected geriatric patients with imipramine (Tofranil)].
Topics: Aged; Aged, 80 and over; Aging; Bipolar Disorder; Dementia; Geriatrics; Imipramine; Mental Disorders | 1962 |
[New indications for tofranil in geriatrics, and especially in diffuse cerebral sclerosis].
Topics: Dementia; Diffuse Cerebral Sclerosis of Schilder; Geriatrics; Humans; Imipramine; Mental Disorders; | 1962 |
[Study of tofranil 10 in gerontological psychiatry].
Topics: Dementia; Geriatrics; Imipramine; Mental Disorders; Psychiatry; Psychotic Disorders | 1962 |
EFFECTS OF IMIPRAMINE UPON VARIOUS MENTAL SYNDROMES IN AMBULATORY TREATMENT.
Topics: Anxiety; Anxiety Disorders; Autonomic Nervous System Diseases; Dementia; Depression; Humans; Imipram | 1963 |
[DISAPPEARANCE OF RECURRENCES IN A PERIODIC SUBJECT (INTERMITTENT MELANCHOLIA) UNDER THE EFFECT OF A CONTINUOUS IMIPRAMINE TREATMENT].
Topics: Dementia; Depressive Disorder; Geriatrics; Humans; Imipramine; Mental Disorders; Periodicity; Psycho | 1963 |
[Contribution to the study of the treatment of depressive forms in senility with a new iminodibenzilic derivative].
Topics: Aging; Dementia; Imipramine; Mental Disorders; Psychotic Disorders | 1961 |
Late paraphrenia.
Topics: Aged; Chlorpromazine; Dementia; Diagnosis, Differential; Electroconvulsive Therapy; Female; Hearing | 1967 |
Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Atrophy; Brain; Carrier Proteins; Cerebral Cortex; Dementia; | 1983 |
3H-imipramine binding sites in platelets from psychiatric patients.
Topics: Antidepressive Agents; Binding, Competitive; Bipolar Disorder; Blood Platelets; Carrier Proteins; De | 1982 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Clinical and biological aspects of depression in the elderly.
Topics: Aged; Dementia; Depression; Doxepin; Humans; Imipramine; Methylphenidate; Middle Aged; Trazodone | 1980 |
Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual.
Topics: Acetylcholinesterase; Aged; Brain; Carrier Proteins; Choline O-Acetyltransferase; Cognition; Coronar | 1994 |
The myth of pseudodementia: depression and the aging brain.
Topics: Aged; Dementia; Depression; Diagnosis, Differential; Humans; Imipramine; Male | 1978 |
Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.
Topics: Aged; Aged, 80 and over; Blood Platelets; Brain; Carrier Proteins; Dementia; Depressive Disorder; Fe | 1991 |
Altered serotonergic and cholinergic synaptic markers in Pick's disease.
Topics: Acetylcholinesterase; Aged; Brain; Choline O-Acetyltransferase; Dementia; Female; Frontal Lobe; Huma | 1991 |
5-Hydroxytryptamine-sensitive [3H]imipramine binding of protein nature in the human brain. II. Effect of normal aging and dementia disorders.
Topics: Aged; Aging; Alzheimer Disease; Brain; Dementia; Humans; Imipramine; Middle Aged; Nerve Tissue Prote | 1987 |
Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia.
Topics: Aged; Amitriptyline; Benztropine; Bipolar Disorder; Central Nervous System Diseases; Dementia; Diagn | 1986 |
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia.
Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocor | 1985 |
Differential diagnosis and treatment of depression in the elderly.
Topics: Adjustment Disorders; Aged; Antidepressive Agents; Circadian Rhythm; Dementia; Depression; Diagnosis | 1974 |
[Note on the use of dihydrogenated derivatives of ergotoxin (Hydergine) and their association with psychopharmacology in the treatment of aged neuropsychiatric patients].
Topics: Aged; Barbiturates; Butyrophenones; Dementia; Ergoloid Mesylates; Female; Humans; Imipramine; Male; | 1966 |
[The use of psychotropic drugs in geriatrics].
Topics: Aged; Antidepressive Agents; Behavior; Dementia; Depression; Humans; Imipramine; Mental Disorders; T | 1972 |
The use of psychopharmacological drugs in the aged.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Anxiety; Barbiturates; Butyrophenones; Dementia; De | 1971 |
[Influencing of biological and immunologic pregnancy reactions by psychotropic drugs].
Topics: Adolescent; Adult; Aged; Butyrophenones; Chlorpromazine; Dementia; Depressive Disorder, Major; Dysau | 1969 |
Management of senile psychiatric disorders.
Topics: Adjustment Disorders; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Dementia; Depressive Diso | 1968 |