imipramine has been researched along with Chronic Disease in 132 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 9.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| "Imipramine improved the symptoms of patients with chest pain and normal coronary angiograms, possibly through a visceral analgesic effect." | 9.07 | Imipramine in patients with chest pain despite normal coronary angiograms. ( Black, BC; Cannon, RO; Geraci, MF; Gracely, RH; Mincemoyer, R; Quyyumi, AA; Smith, WB; Stine, AM; Uhde, TW; Waclawiw, MA, 1994) |
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 7.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| "Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-months course of imipramine." | 7.77 | Imipramine for vestibular dysfunction in panic disorder: a prospective case series. ( Mathias, Kde V; Mezzasalma, MA; Nardi, AE; Nascimento, I; Valença, AM, 2011) |
| "The selective sigma2 (sigma2) ligand Lu 28-179, or 1'-[4[1-(4-fluorophenyl)-1H-indol-3-yl]-l-butyl]spiro[isobenzofuran++ +-1(3H),4'-piperidine], was studied in the chronic mild stress (CMS) model of depression." | 7.70 | The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression. ( Papp, M; Sánchez, C, 2000) |
| "A chronic mild stress (CMS) model of depression was used to study an antidepressant-like activity of alnespirone (S 20499), a selective agonist of 5-HT1A receptors." | 7.70 | Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression. ( Muñoz, C; Papp, M, 1999) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 7.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| "Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group." | 7.67 | [3H] imipramine binding sites are decreased in platelets of chronic pain patients. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Eandi, M; Magni, G, 1987) |
| ", major depression superimposed on dysthymia) were randomly assigned to 12 weeks of double-blind treatment with sertraline or with imipramine after placebo washout." | 5.09 | Gender differences in treatment response to sertraline versus imipramine in chronic depression. ( Davis, SM; Gelenberg, AJ; Harrison, WM; Keitner, GI; Keller, MB; Kornstein, SG; McCullough, JP; Schatzberg, AF; Thase, ME; Yonkers, KA, 2000) |
| "After 12 weeks of acute phase treatment in a double-blind, randomized, parallel-group, multi-center trial of sertraline or imipramine, patients with chronic depression (> or = 2 years in major depression, or major depression superimposed on dysthymia) continued study drug for 16 weeks." | 5.09 | Sertraline versus imipramine to prevent relapse in chronic depression. ( DeBattista, C; Friedman, RA; Gelenberg, AJ; Hirschfeld, RM; Howland, RH; Keller, MB; Klein, D; Kocsis, JH; Koran, LM; Kornstein, SG; LaVange, LM; Rush, AJ; Schatzberg, AF; Thase, ME, 2001) |
| "1 years; mean duration of dysthymia = 23+/-13 years) and high rates of comorbidity, 52% of patients achieved a satisfactory therapeutic response to sertraline or imipramine (by a conservative, intent-to-treat analysis)." | 5.08 | The treatment of chronic depression, part 2: a double-blind, randomized trial of sertraline and imipramine. ( Davis, SM; Fawcett, JA; Gelenberg, AJ; Harrison, WM; Hirschfeld, RM; Keller, MB; Klein, DN; Kocsis, JH; Koran, LM; Kornstein, SG; Markowitz, JC; McCullough, JP; Rush, AJ; Russell, JM; Thase, ME, 1998) |
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 5.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| "Forty Danish panic disorder patients participating in a placebo controlled study of alprazolam and imipramine (The Cross National Collaborative Panic Study, Phase II) were followed up by a telephone interview three years later, with essentially the same battery of evaluation procedures applied at baseline, end of study, and follow-up." | 5.07 | Three years follow-up of panic disorder patients: a naturalistic study. ( Rosenberg, NK; Rosenberg, R, 1994) |
| "Imipramine improved the symptoms of patients with chest pain and normal coronary angiograms, possibly through a visceral analgesic effect." | 5.07 | Imipramine in patients with chest pain despite normal coronary angiograms. ( Black, BC; Cannon, RO; Geraci, MF; Gracely, RH; Mincemoyer, R; Quyyumi, AA; Smith, WB; Stine, AM; Uhde, TW; Waclawiw, MA, 1994) |
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 3.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| "Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-months course of imipramine." | 3.77 | Imipramine for vestibular dysfunction in panic disorder: a prospective case series. ( Mathias, Kde V; Mezzasalma, MA; Nardi, AE; Nascimento, I; Valença, AM, 2011) |
| "3 mg kg(-1), intraperitoneal [IP]) for 5 weeks corrected the reduction in body weight gain and sucrose intake induced by CMS." | 3.74 | Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. ( Arguello, O; Bortolato, M; Duranti, A; Fu, J; Kim, JH; Mangieri, RA; Mor, M; Piomelli, D; Tarzia, G; Tontini, A, 2007) |
| "A chronic mild stress (CMS) model of depression was used to study an antidepressant-like activity of alnespirone (S 20499), a selective agonist of 5-HT1A receptors." | 3.70 | Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression. ( Muñoz, C; Papp, M, 1999) |
| "The selective sigma2 (sigma2) ligand Lu 28-179, or 1'-[4[1-(4-fluorophenyl)-1H-indol-3-yl]-l-butyl]spiro[isobenzofuran++ +-1(3H),4'-piperidine], was studied in the chronic mild stress (CMS) model of depression." | 3.70 | The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression. ( Papp, M; Sánchez, C, 2000) |
| "The authors evaluated high-affinity [3H]imipramine binding and [3H]serotonin uptake to platelets in eight adolescent and 10 adult patients who met DSM-III criteria for obsessive-compulsive disorder in comparison with those of normal control subjects of similar ages." | 3.67 | High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients. ( Apter, A; Carmi, M; Hermesh, H; Rehavi, M; Shahar, A; Tyano, S; Weizman, A, 1986) |
| "Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group." | 3.67 | [3H] imipramine binding sites are decreased in platelets of chronic pain patients. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Eandi, M; Magni, G, 1987) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 3.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| "imipramine." | 2.70 | Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression. ( Davis, S; Friedman, ES; Harrison, W; Hirschfeld, RM; Keller, M; Koran, LM; Rush, J; Russell, JM, 2001) |
| "Differences in recurrence rates after the switch to placebo from phenelzine and imipramine could be due to the two drugs' different mechanisms of action or to baseline differences in the two populations." | 2.68 | Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on discontinuation after 6 months' remission. ( McGrath, PJ; Quitkin, FM; Stewart, JW; Tricamo, E, 1997) |
| "Patients meeting criteria for borderline personality disorder are heterogeneous." | 2.67 | [Impact of personality factors in depression]. ( Quitkin, FM, 1993) |
| "Imipramine was associated with significantly greater pre- to posttreatment improvement of social-vocational impairments in chronic depression, suggesting that these impairments may have represented affective symptoms rather than characterologic deficits." | 2.66 | Imipramine and social-vocational adjustment in chronic depression. ( Frances, AJ; Kocsis, JH; Mann, JJ; Mason, BJ; Sweeney, J; Voss, C, 1988) |
| "Treatment with imipramine and doxepin, but not placebo, was associated with significant improvement (P less than 0." | 2.65 | Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. ( Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC, 1982) |
| "Depression is associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and testosterone exerts suppressive effects on the HPA axis." | 1.43 | Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress. ( Chow, C; Galea, LA; Hamson, DK; Lieblich, SE; Tehrani, A; Wainwright, SR; Workman, JL, 2016) |
| "We investigated the effect of chronic administration of fluoxetine "FLU" and imipramine "IMIP" on behavioral, metabolic and vascular abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS)." | 1.42 | The effects of antidepressants "fluoxetine and imipramine" on vascular abnormalities and Toll like receptor-4 expression in diabetic and non-diabetic rats exposed to chronic stress. ( Aboul-Fotouh, S; El-Gayar, N; Habib, M; Shaker, S, 2015) |
| "Depression is one of the most prevalent mental illnesses, and causes a constant feeling of sadness and lose of interest, which often leads to suicide." | 1.40 | Disrupted MEK/ERK signaling in the medial orbital cortex and dorsal endopiriform nuclei of the prefrontal cortex in a chronic restraint stress mouse model of depression. ( Jo, SA; Kim, YH; Leem, YH; Yoon, SS, 2014) |
| "Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
| "Treatment with imipramine (10mg/kg i." | 1.33 | Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. ( Antoniou, K; Bekris, S; Daskas, S; Papadopoulou-Daifoti, Z, 2005) |
| "Imipramine (IMI) treatment normalized tT4 values." | 1.31 | Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains. ( Antoniou, K; Bekris, S; Christofidis, I; Kioukia, N; Papadopoulou-Daifoti, Z, 2000) |
| " This effect can be reversed by chronic administration of various classes of antidepressant drugs." | 1.31 | The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats. ( Gentsch, C; Papp, M; Vassout, A, 2000) |
| "Imipramine treatment diminished this response enhancement in CMS exposed animals, but did not alter the proliferative responses of control subjects." | 1.30 | Effects of chronic mild stress (CMS) and imipramine administration, on spleen mononuclear cell proliferative response, serum corticosterone level and brain norepinephrine content in male mice. ( Arregi, A; Azpiroz, A; Beitia, G; Brain, PF; Cacho, R; Fano, E; Garmendia, L, 1999) |
| "3H-Imipramine binding was studied in the blood platelets of 51 unmedicated chronic schizophrenic patients." | 1.27 | 3H-imipramine binding in blood platelets of schizophrenic patients. ( Arora, RC; Locascio, JJ; Meltzer, HY, 1986) |
| " Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication." | 1.27 | Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987) |
| " A dosage schedule for in- and outpatients has been established, using imipramine (Tofranil) or chlorimipramine (Anafranil), and haloperidol (Haldol)." | 1.26 | The use of psychotropic drugs in the treatment of chronic, severe pains. ( Kocher, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (40.15) | 18.7374 |
| 1990's | 35 (26.52) | 18.2507 |
| 2000's | 21 (15.91) | 29.6817 |
| 2010's | 22 (16.67) | 24.3611 |
| 2020's | 1 (0.76) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuda, Y | 1 |
| Ozawa, N | 1 |
| Shinozaki, T | 1 |
| Aoki, K | 1 |
| Nihonmatsu-Kikuchi, N | 1 |
| Shinba, T | 1 |
| Tatebayashi, Y | 1 |
| Biala, G | 1 |
| Pekala, K | 1 |
| Boguszewska-Czubara, A | 1 |
| Michalak, A | 1 |
| Kruk-Slomka, M | 1 |
| Grot, K | 1 |
| Budzynska, B | 1 |
| Duric, V | 1 |
| Banasr, M | 1 |
| Franklin, T | 1 |
| Lepack, A | 1 |
| Adham, N | 2 |
| Kiss, B | 2 |
| Gyertyán, I | 2 |
| Duman, RS | 1 |
| Riga, D | 1 |
| Kramvis, I | 1 |
| Koskinen, MK | 1 |
| van Bokhoven, P | 1 |
| van der Harst, JE | 1 |
| Heistek, TS | 1 |
| Jaap Timmerman, A | 1 |
| van Nierop, P | 1 |
| van der Schors, RC | 1 |
| Pieneman, AW | 1 |
| de Weger, A | 1 |
| van Mourik, Y | 1 |
| Schoffelmeer, ANM | 1 |
| Mansvelder, HD | 1 |
| Meredith, RM | 1 |
| Hoogendijk, WJG | 1 |
| Smit, AB | 1 |
| Spijker, S | 1 |
| Faron-Górecka, A | 1 |
| Kuśmider, M | 2 |
| Solich, J | 2 |
| Kolasa, M | 1 |
| Gruca, P | 3 |
| Pabian, P | 1 |
| Szlachta, M | 1 |
| Dziedzicka-Wasylewska, M | 2 |
| Chen, LB | 1 |
| Qiu, FM | 2 |
| Zhong, XM | 2 |
| Hong, C | 1 |
| Huang, Z | 2 |
| Mao, QQ | 1 |
| Ismail, B | 1 |
| Aboul-Fotouh, S | 2 |
| Mansour, AA | 1 |
| Shehata, HH | 1 |
| Salman, MI | 1 |
| Ibrahim, EA | 1 |
| Hassan, OA | 1 |
| Abdel-tawab, AM | 1 |
| Patrício, P | 1 |
| Mateus-Pinheiro, A | 1 |
| Irmler, M | 1 |
| Alves, ND | 1 |
| Machado-Santos, AR | 1 |
| Morais, M | 1 |
| Correia, JS | 1 |
| Korostynski, M | 1 |
| Piechota, M | 1 |
| Stoffel, R | 1 |
| Beckers, J | 1 |
| Bessa, JM | 1 |
| Almeida, OF | 1 |
| Sousa, N | 1 |
| Pinto, L | 1 |
| Papp, M | 8 |
| Lasoń-Tyburkiewicz, M | 1 |
| Leem, YH | 1 |
| Yoon, SS | 1 |
| Kim, YH | 1 |
| Jo, SA | 1 |
| Zhao, J | 1 |
| Jung, YH | 1 |
| Jang, CG | 1 |
| Chun, KH | 1 |
| Kwon, SW | 1 |
| Lee, J | 1 |
| Habib, M | 1 |
| Shaker, S | 1 |
| El-Gayar, N | 1 |
| Le François, B | 1 |
| Soo, J | 1 |
| Millar, AM | 1 |
| Daigle, M | 1 |
| Le Guisquet, AM | 1 |
| Leman, S | 1 |
| Minier, F | 1 |
| Belzung, C | 2 |
| Albert, PR | 1 |
| Erburu, M | 1 |
| Muñoz-Cobo, I | 1 |
| Domínguez-Andrés, J | 1 |
| Beltran, E | 1 |
| Suzuki, T | 1 |
| Mai, A | 1 |
| Valente, S | 1 |
| Puerta, E | 1 |
| Tordera, RM | 1 |
| Kolisek, M | 1 |
| Montezano, AC | 1 |
| Sponder, G | 1 |
| Anagnostopoulou, A | 1 |
| Vormann, J | 1 |
| Touyz, RM | 1 |
| Aschenbach, JR | 1 |
| Wainwright, SR | 1 |
| Workman, JL | 1 |
| Tehrani, A | 1 |
| Hamson, DK | 1 |
| Chow, C | 1 |
| Lieblich, SE | 1 |
| Galea, LA | 1 |
| Kormos, V | 1 |
| Gáspár, L | 1 |
| Kovács, LÁ | 1 |
| Farkas, J | 1 |
| Gaszner, T | 1 |
| Csernus, V | 1 |
| Balogh, A | 1 |
| Hashimoto, H | 1 |
| Reglődi, D | 1 |
| Helyes, Z | 1 |
| Gaszner, B | 1 |
| Yalcin, I | 1 |
| Surget, A | 1 |
| Detanico, BC | 1 |
| Piato, AL | 1 |
| Freitas, JJ | 1 |
| Lhullier, FL | 1 |
| Hidalgo, MP | 1 |
| Caumo, W | 1 |
| Elisabetsky, E | 1 |
| Mezzasalma, MA | 2 |
| Mathias, Kde V | 2 |
| Nascimento, I | 2 |
| Valença, AM | 2 |
| Nardi, AE | 2 |
| dos Santos, L | 1 |
| de Andrade, TG | 1 |
| Graeff, FG | 1 |
| Kedracka-Krok, S | 1 |
| Fic, E | 1 |
| Jankowska, U | 1 |
| Jaciuk, M | 1 |
| Debski, J | 1 |
| Dadlez, M | 1 |
| Marston, HM | 1 |
| Martin, FD | 1 |
| Gold, L | 1 |
| Wong, EH | 1 |
| Shahid, M | 1 |
| Yu, Y | 1 |
| Wang, R | 1 |
| Chen, C | 1 |
| Du, X | 1 |
| Ruan, L | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Zhang, L | 1 |
| O'Donnell, JM | 1 |
| Pan, J | 1 |
| Xu, Y | 1 |
| Liu, X | 1 |
| Emery, CJ | 1 |
| Laude, E | 1 |
| Herget, J | 1 |
| Gill, G | 1 |
| Cope, G | 1 |
| Barer, GR | 1 |
| Fujisaki, C | 1 |
| Utsuyama, M | 1 |
| Kuroda, Y | 1 |
| Watanabe, A | 1 |
| Seidler, H | 1 |
| Watanabe, S | 1 |
| Kitagawa, M | 1 |
| Hirokawa, K | 1 |
| Russell, JM | 5 |
| Kornstein, SG | 6 |
| Shea, MT | 2 |
| McCullough, JP | 5 |
| Harrison, WM | 6 |
| Hirschfeld, RM | 7 |
| Keller, MB | 11 |
| CABRAL, CA | 1 |
| IUSKOFF DE CASAL, O | 1 |
| STRAKER, M | 1 |
| ROTH, EM | 1 |
| ARIEFF, AJ | 1 |
| ADAMS, J | 1 |
| CRAWFORD, J | 1 |
| FRYER, DG | 1 |
| TIMBERLAKE, WH | 1 |
| Bekris, S | 2 |
| Antoniou, K | 2 |
| Daskas, S | 1 |
| Papadopoulou-Daifoti, Z | 2 |
| Song, L | 1 |
| Che, W | 1 |
| Min-Wei, W | 1 |
| Murakami, Y | 1 |
| Matsumoto, K | 1 |
| Brocco, M | 1 |
| Dekeyne, A | 1 |
| Millan, MJ | 1 |
| Mathew, KK | 1 |
| Bortolato, M | 1 |
| Mangieri, RA | 1 |
| Fu, J | 1 |
| Kim, JH | 1 |
| Arguello, O | 1 |
| Duranti, A | 1 |
| Tontini, A | 1 |
| Mor, M | 1 |
| Tarzia, G | 1 |
| Piomelli, D | 1 |
| Hitoshi, S | 1 |
| Maruta, N | 1 |
| Higashi, M | 1 |
| Kumar, A | 1 |
| Kato, N | 1 |
| Ikenaka, K | 1 |
| Blaine, JD | 1 |
| Prien, RF | 1 |
| Levine, J | 1 |
| Caracci, G | 1 |
| Migone, P | 1 |
| Mukherjee, S | 1 |
| Veith, RC | 1 |
| Raskind, MA | 1 |
| Caldwell, JH | 1 |
| Barnes, RF | 1 |
| Gumbrecht, G | 1 |
| Ritchie, JL | 1 |
| Van Sweden, B | 1 |
| Dumon-Radermecker, M | 1 |
| Roth, KA | 1 |
| Katz, RJ | 1 |
| Harrison, W | 5 |
| Fawcett, JA | 3 |
| Gelenberg, A | 1 |
| Klein, D | 2 |
| Kocsis, JH | 9 |
| Rush, AJ | 5 |
| Schatzberg, A | 1 |
| Anton, SF | 1 |
| Robinson, DS | 1 |
| Roberts, DL | 1 |
| Kensler, TT | 1 |
| English, PA | 1 |
| Archibald, DG | 1 |
| Cannon, RO | 2 |
| Rosenberg, NK | 1 |
| Rosenberg, R | 1 |
| Nalepa, I | 1 |
| Vetulani, J | 1 |
| Stewart, JW | 7 |
| McGrath, PJ | 5 |
| Quitkin, FM | 7 |
| Rabkin, JG | 3 |
| Wager, S | 2 |
| Nunes, E | 1 |
| Ocepek-Welikson, K | 3 |
| Tricamo, E | 3 |
| Quyyumi, AA | 1 |
| Mincemoyer, R | 1 |
| Stine, AM | 1 |
| Gracely, RH | 1 |
| Smith, WB | 1 |
| Geraci, MF | 1 |
| Black, BC | 1 |
| Uhde, TW | 1 |
| Waclawiw, MA | 1 |
| Nunes, EV | 1 |
| Klein, DF | 3 |
| Kupfer, DJ | 2 |
| Furukawa, T | 1 |
| Awaji, R | 1 |
| Nakazato, H | 1 |
| Sumita, Y | 1 |
| Thase, ME | 8 |
| Fava, M | 1 |
| Halbreich, U | 1 |
| Koran, L | 1 |
| Davidson, J | 1 |
| Rosenbaum, J | 1 |
| Mueller, TI | 1 |
| Leon, AC | 1 |
| Solomon, DA | 1 |
| Coryell, W | 1 |
| Endicott, J | 1 |
| Finkelstein, SN | 2 |
| Berndt, ER | 2 |
| Greenberg, PE | 1 |
| Parsley, RA | 1 |
| Agosti, V | 4 |
| Minotti, V | 1 |
| De Angelis, V | 1 |
| Righetti, E | 1 |
| Celani, MG | 1 |
| Rossetti, R | 1 |
| Lupatelli, M | 1 |
| Tonato, M | 1 |
| Pisati, R | 1 |
| Monza, G | 1 |
| Fumi, G | 1 |
| Del Favero, A | 1 |
| Hyams, JS | 1 |
| Hyman, PE | 1 |
| Koran, LM | 6 |
| Markowitz, JC | 3 |
| Miceli, RJ | 2 |
| Gelenberg, AJ | 5 |
| Klein, DN | 3 |
| Schatzberg, AF | 4 |
| Davis, SM | 3 |
| Miller, IW | 2 |
| Keitner, GI | 2 |
| Schlager, DS | 1 |
| Rickels, K | 1 |
| Schweizer, E | 1 |
| Delgado, PL | 1 |
| Fawcett, J | 1 |
| Friedman, RA | 2 |
| Howland, RH | 2 |
| Connolly, MA | 1 |
| Azpiroz, A | 1 |
| Fano, E | 1 |
| Garmendia, L | 1 |
| Arregi, A | 1 |
| Cacho, R | 1 |
| Beitia, G | 1 |
| Brain, PF | 1 |
| Gambarana, C | 3 |
| Masi, F | 2 |
| Tagliamonte, A | 2 |
| Scheggi, S | 1 |
| Ghiglieri, O | 2 |
| De Montis, MG | 3 |
| Tolu, P | 1 |
| Giachetti, D | 2 |
| Bombardelli, E | 1 |
| Muñoz, C | 1 |
| Kioukia, N | 1 |
| Christofidis, I | 1 |
| Miller, IM | 1 |
| Trapp, GA | 1 |
| Sánchez, C | 1 |
| Yonkers, KA | 1 |
| Vassout, A | 1 |
| Gentsch, C | 1 |
| Rush, J | 1 |
| Friedman, ES | 1 |
| Davis, S | 1 |
| Keller, M | 1 |
| DeBattista, C | 1 |
| LaVange, LM | 1 |
| Tolu, PL | 1 |
| Rinaldi, M | 1 |
| Morazzoni, P | 1 |
| Bruins Slot, LA | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Ribet, JP | 1 |
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| Ebbutt, AF | 1 |
| Evans, CD | 1 |
| Kocher, R | 2 |
| Ellman, SJ | 1 |
| Arkin, AM | 1 |
| Nelson, WT | 1 |
| Steiner, SS | 1 |
| Kissin, B | 4 |
| Montgomery, BJ | 1 |
| Brambilla, F | 1 |
| Scarone, S | 1 |
| Ponzano, M | 1 |
| Maffei, C | 1 |
| Nobile, P | 1 |
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| Guastalla, A | 1 |
| Bennie, FH | 1 |
| Ansell, BM | 1 |
| Subrahmanyam, S | 1 |
| Herrmann, WM | 1 |
| Schärer, E | 1 |
| Wendt, G | 1 |
| Delini-Stula, A | 1 |
| Sutton, BM | 1 |
| Frances, AJ | 3 |
| Molina, VA | 1 |
| Volosin, M | 1 |
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| Keller, E | 1 |
| Murúa, VS | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pain Measurement in Healthy Volunteers[NCT00001597] | 40 participants | Observational | 1997-03-31 | Completed | |||
| Psychophysiological Interactions in Non-Cardiac Chest Pain[NCT00005575] | Phase 3 | 0 participants | Interventional | 1999-01-31 | Completed | ||
| WISE Ancillary Study Data Analyses: Efficacy of Hormone Replacement on Myocardial Ischemia in Postmenopausal Women With Normal/Minimal Coronary Artery Disease: Data Analysis[NCT00600106] | 37 participants (Actual) | Interventional | 1999-12-31 | Completed | |||
| Longitudinal Study of Individuals Presenting With a First Treated Episode of Depression of Mania (First Episode Project)[NCT01529905] | 200 participants (Anticipated) | Observational | 1999-06-30 | Recruiting | |||
| Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia[NCT01591174] | 30 participants (Actual) | Observational | 2012-05-31 | Completed | |||
| A Randomized, Double-Blind, Support-of-Concept Phase 2 Study of Single-Dose Psilocybin for Major Depressive Disorder (MDD)[NCT03866174] | Phase 2 | 104 participants (Actual) | Interventional | 2019-10-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of endothelial dysfunction.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: Baseline
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.2 |
| Placebo | 8.8 |
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: 12 weeks
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.8 |
| Placebo | 7.3 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent change in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -7.7 |
| Placebo | 1.1 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: Baseline
| Intervention | percent changed in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -13.8 |
| Placebo | -7.0 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Baseline
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -0.79 |
| Placebo | -0.79 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.8 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 5.4 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Exit at 12 weeks
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -1.05 |
| Placebo | -0.63 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 59.4 | 58.8 | 76.5 | 54.5 | 55.2 | 66.4 | 35.6 | 59.4 |
| Placebo | 44.4 | 25.0 | 66.7 | 41.5 | 57.2 | 69.3 | 41.2 | 56.1 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: Baseline
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 60.8 | 54.2 | 70.3 | 53.3 | 55.4 | 66.7 | 35.6 | 59.4 |
| Placebo | 43.8 | 37.3 | 66.7 | 42.1 | 57.4 | 65.7 | 42.9 | 53.2 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 41 | 59 | 35 | 35 | 24 |
| Placebo | 89 | 78 | 67 | 67 | 56 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: Baseline
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 89 | 76 | 50 | 44 | 39 |
| Placebo | 68 | 53 | 37 | 58 | 37 |
6 reviews available for imipramine and Chronic Disease
| Article | Year |
|---|---|
The role of antidepressants in the treatment of affective disorders.
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Clinical Trials as Topic; C | 1983 |
Management of recurrent depression.
Topics: 1-Naphthylamine; Antidepressive Agents; Chronic Disease; Combined Modality Therapy; Depressive Disor | 1993 |
Recurrent abdominal pain and the biopsychosocial model of medical practice.
Topics: Abdominal Pain; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Di | 1998 |
Panic disorder: long-term pharmacotherapy and discontinuation.
Topics: Alprazolam; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Controlled Clini | 1998 |
The long-term treatment of depression.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Combined Modality Therapy; | 1999 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
46 trials available for imipramine and Chronic Disease
| Article | Year |
|---|---|
Chronic depression and comorbid personality disorders: response to sertraline versus imipramine.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Chronic Disease; Comorbidity; Depressive Disorder; Do | 2003 |
The role of antidepressants in the treatment of affective disorders.
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Clinical Trials as Topic; C | 1983 |
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease | 1982 |
Treatment of chronic depression with sertraline or imipramine: preliminary blinded response rates and high rates of undertreatment in the community.
Topics: 1-Naphthylamine; Adult; Affective Disorders, Psychotic; Aged; Chronic Disease; Depression; Female; F | 1995 |
Long-term treatment of depression with nefazodone.
Topics: Antidepressive Agents; Chronic Disease; Depressive Disorder; Double-Blind Method; Humans; Imipramine | 1994 |
Three years follow-up of panic disorder patients: a naturalistic study.
Topics: Adult; Alprazolam; Analysis of Variance; Chronic Disease; Female; Follow-Up Studies; Humans; Imipram | 1994 |
Chronic depression: response to placebo, imipramine, and phenelzine.
Topics: Adult; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; | 1993 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
[Impact of personality factors in depression].
Topics: Antidepressive Agents; Borderline Personality Disorder; Chronic Disease; Depressive Disorder; Humans | 1993 |
A double-blind crossover trial of imipramine and phenelzine for outpatients with treatment-refractory depression.
Topics: Adult; Ambulatory Care; Chronic Disease; Depressive Disorder; Double-Blind Method; Educational Statu | 1993 |
Persistence of chronic mood disorders: a 2 year follow-up.
Topics: Adult; Antidepressive Agents; Chronic Disease; Cohort Studies; Combined Modality Therapy; Diazepam; | 1995 |
A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia.
Topics: 1-Naphthylamine; Adult; Aged; Ambulatory Care; Chronic Disease; Depressive Disorder; Double-Blind Me | 1996 |
Improvement in subjective work performance after treatment of chronic depression: some preliminary results. Chronic Depression Study Group.
Topics: 1-Naphthylamine; Antidepressive Agents; Chronic Disease; Depressive Disorder; Humans; Imipramine; Ps | 1996 |
Prophylactic efficacy of phenelzine and imipramine in chronic atypical depression: likelihood of recurrence on discontinuation after 6 months' remission.
Topics: Adult; Chronic Disease; Depressive Disorder; Drug Administration Schedule; Female; Humans; Imipramin | 1997 |
Six month follow-up of early-onset chronic depression.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; | 1996 |
Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1998 |
The treatment of chronic depression, part 1: study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Clinical Protocols; Comorbidity; Cross-Over Studi | 1998 |
The treatment of chronic depression, part 2: a double-blind, randomized trial of sertraline and imipramine.
Topics: Adult; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Chronic Disease; Comorbidity; Depres | 1998 |
The treatment of chronic depression, part 3: psychosocial functioning before and after treatment with sertraline or imipramine.
Topics: Adaptation, Psychological; Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Comorbidity; De | 1998 |
Panic disorder: long-term pharmacotherapy and discontinuation.
Topics: Alprazolam; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Controlled Clini | 1998 |
Predictors of response to acute treatment of chronic and double depression with sertraline or imipramine.
Topics: Adult; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Chronic Disease; Comorbidity; Depres | 1998 |
One year clinical and psychosocial outcomes of early-onset chronic depression.
Topics: Adult; Age Factors; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Female; | 1999 |
Lost human capital from early-onset chronic depression.
Topics: Adult; Age of Onset; Aged; Censuses; Chronic Disease; Cost of Illness; Depressive Disorder; Double-B | 2000 |
Gender differences in treatment response to sertraline versus imipramine in chronic depression.
Topics: Adult; Aged; Ambulatory Care; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder | 2000 |
Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Analysis of Variance; Anxiety Disorders; Chronic Disease; | 2001 |
Sertraline versus imipramine to prevent relapse in chronic depression.
Topics: Adult; Aged; Chronic Disease; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; D | 2001 |
Tofranil in the treatment of low back pain.
Topics: Adolescent; Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depression; Drug Evaluation | 1976 |
Psychotropic agents finding analgesic use.
Topics: Amitriptyline; Analgesics; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Fluphenazine; | 1978 |
Catecholaminergic drugs in chronic schizophrenia.
Topics: Adult; Apomorphine; Carbidopa; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; | 1979 |
Life satisfaction and psychosocial functioning in chronic depression: effect of acute treatment with antidepressants.
Topics: Activities of Daily Living; Adult; Antidepressive Agents; Chronic Disease; Depressive Disorder; Dose | 1991 |
Pharmaco-EEG profile of maroxepine: third example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.
Topics: Adult; Chlorpromazine; Chronic Disease; Dibenzazepines; Double-Blind Method; Electroencephalography; | 1991 |
Long-term follow-up of chronic depression treated with imipramine.
Topics: Adult; Chronic Disease; Comorbidity; Depressive Disorder; Female; Follow-Up Studies; Humans; Imipram | 1991 |
Relevance of DMS-III depressive subtype and chronicity of antidepressant efficacy in atypical depression. Differential response to phenelzine, imipramine, and placebo.
Topics: Adolescent; Adult; Aged; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Male; Mid | 1989 |
Social functioning in chronic depression: effect of 6 weeks of antidepressant treatment.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Adm | 1988 |
Imipramine treatment for chronic depression.
Topics: Adult; Ambulatory Care; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1988 |
Imipramine and social-vocational adjustment in chronic depression.
Topics: Adult; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Male; Middle Aged; Social A | 1988 |
Agoraphobia: relative and combined effectiveness of therapist-assisted in vivo exposure and imipramine.
Topics: Adult; Agoraphobia; Anxiety Disorders; Behavior Therapy; Chronic Disease; Clinical Trials as Topic; | 1986 |
Imipramine for treatment of chronic depression.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; | 1985 |
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
Drugs and group psychotherapy in neurotic depression.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Depression; Diazepam; Drug Evaluation; Female; Hum | 1974 |
Effect of imipramine on the rheumatoid factor titre of psychotic patients with depressive symptomatology.
Topics: Adsorption; Antigens; Chronic Disease; Clinical Trials as Topic; Depression; Erythrocytes; Humans; I | 1974 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipra | 1974 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
A comparison of melitracen and imipramine in treatment of depressed patients.
Topics: Adult; Anthracenes; Antidepressive Agents; Chronic Disease; Depression; Female; Humans; Imipramine; | 1969 |
Clinical trial of imidazoline (DH-524) as an anti-depressant.
Topics: Antidepressive Agents; Chronic Disease; Depression; Humans; Hypertension; Imidazoles; Imipramine | 1971 |
Role of antidepressants and neuroleptics in the treatment of depression.
Topics: Adult; Amitriptyline; Chronic Disease; Depression; Female; Humans; Imipramine; Male; Middle Aged; Pi | 1972 |
83 other studies available for imipramine and Chronic Disease
| Article | Year |
|---|---|
Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Electroencephalography; Fluoxetine; Humans; Imipram | 2021 |
Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.
Topics: Animals; Behavior, Animal; Choice Behavior; Chronic Disease; Conditioning, Classical; Imipramine; Ma | 2018 |
Cariprazine Exhibits Anxiolytic and Dopamine D3 Receptor-Dependent Antidepressant Effects in the Chronic Stress Model.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Aripiprazole; Chronic Disea | 2017 |
Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats.
Topics: Animals; CA1 Region, Hippocampal; Chondroitin ABC Lyase; Chondroitin Sulfate Proteoglycans; Chronic | 2017 |
Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Gene Expression; Habenula; Imipramine; M | 2018 |
Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Disease; Dentate Gyrus; D | 2019 |
Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Benzoates; Biogenic M | 2013 |
Behavioural, metabolic, and endothelial effects of the TNF-α suppressor thalidomide on rats subjected to chronic mild stress and fed an atherogenic diet.
Topics: Animals; Antidepressive Agents, Tricyclic; Aorta, Thoracic; Atherosclerosis; Chronic Disease; Depres | 2014 |
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
Topics: Acetamides; Animals; Antidepressive Agents; Chronic Disease; Dentate Gyrus; Depressive Disorder; Dis | 2015 |
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Aripiprazole; Chronic Disease; Depressive Disorder; Dieta | 2014 |
Disrupted MEK/ERK signaling in the medial orbital cortex and dorsal endopiriform nuclei of the prefrontal cortex in a chronic restraint stress mouse model of depression.
Topics: Animals; Antidepressive Agents; Chronic Disease; Depression; Imipramine; Male; Mice, Inbred C57BL; M | 2014 |
Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chronic Disease | 2015 |
The effects of antidepressants "fluoxetine and imipramine" on vascular abnormalities and Toll like receptor-4 expression in diabetic and non-diabetic rats exposed to chronic stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Blood Pressure; Blood Vessels; Body | 2015 |
Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Conserved Sequence; CpG Islands; Depress | 2015 |
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity.
Topics: Adult; Animals; Antidepressive Agents; Chronic Disease; Depressive Disorder; Fluoxetine; Histone Dea | 2015 |
PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases.
Topics: Animals; Cardiovascular Diseases; Cation Transport Proteins; Chronic Disease; Humans; Imipramine; In | 2015 |
Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Dentate Gyrus; Depression; Disease | 2016 |
Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain Stem; Chronic Disease; Depressive Disorder; Disease | 2016 |
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2008 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Chronic dizziness presenting in a patient with panic disorder: response to imipramine.
Topics: Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Dizziness; Female; Humans; Imipramine; Pan | 2009 |
Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Chronic Disease; Diazepam; | 2010 |
Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus.
Topics: Animals; Antidepressive Agents, Tricyclic; Appetite; Chronic Disease; Dentate Gyrus; Depressive Diso | 2010 |
Attenuation of chronic mild stress-induced 'anhedonia' by asenapine is not associated with a 'hedonic' profile in intracranial self-stimulation.
Topics: Anhedonia; Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chronic Disease; Dibenzocyclohepte | 2011 |
Imipramine for vestibular dysfunction in panic disorder: a prospective case series.
Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Chronic Disease; Dizziness; Female | 2011 |
Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences.
Topics: Adrenal Glands; Animals; Antidepressive Agents; Body Weight; Brain; Chronic Disease; Disease Models, | 2013 |
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise | 2002 |
An immnosuppressive drug, cyclosporine-A acts like anti-depressant for rats under unpredictable chronic stress.
Topics: Adrenal Glands; Analysis of Variance; Animals; Antidepressive Agents; Behavior; Biogenic Monoamines; | 2003 |
[Chlorpromazine and its association with imipramine in the treatment of chronic diseases].
Topics: Chlorpromazine; Chronic Disease; Imipramine; Psychopharmacology | 1961 |
Use of imipramine (tofranil) in the aged chronically ill.
Topics: Aged; Aged, 80 and over; Chronic Disease; Imipramine; Psychopharmacology | 1960 |
Treatment of recurrent mental depression with imipramine.
Topics: Chronic Disease; Depression; Depressive Disorder; Depressive Disorder, Major; Imipramine | 1961 |
A trial of imipramine (Tofranil) in depressed patients with chronic physical disease.
Topics: Chronic Disease; Depression; Depressive Disorder; Imipramine; Physical Examination | 1963 |
Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Beh | 2005 |
Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress.
Topics: Animals; Base Sequence; Brain-Derived Neurotrophic Factor; Chronic Disease; Corticosterone; Cyclic A | 2006 |
Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: mediation by dopamine D2 receptors.
Topics: Aggression; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
Imipramine in persistent vomiting.
Topics: Adult; Antidepressive Agents, Tricyclic; Antiemetics; Chronic Disease; Eating; Female; Humans; Imipr | 2006 |
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Topics: Amidohydrolases; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Weight; Brain; C | 2007 |
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
Topics: Animals; Antidepressive Agents; Biological Assay; Cell Death; Cells, Cultured; Chronic Disease; Cort | 2007 |
Phencyclidine abuse and depression.
Topics: Adult; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Male; Phencyclidine Abuse | 1983 |
The EEG in chronic psychotropic drug intoxications.
Topics: Adult; Aged; Amitriptyline; Chlorpromazine; Chlorprothixene; Chronic Disease; Drug Therapy, Combinat | 1982 |
Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant.
Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Ani | 1981 |
The sensitive heart. A syndrome of abnormal cardiac pain perception.
Topics: Angina Pectoris; Chest Pain; Chronic Disease; Diagnosis, Differential; Female; Humans; Imipramine; M | 1995 |
Reversal by imipramine of beta-adrenoceptor up-regulation induced in a chronic mild stress model of depression.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cerebral Cortex; Chronic Disease; Depressio | 1994 |
Recovery after 5 years of unremitting major depressive disorder.
Topics: Adult; Chronic Disease; Depressive Disorder; Female; Follow-Up Studies; Humans; Imipramine; Male; Ma | 1996 |
The efficacy of imipramine and psychotherapy in early-onset chronic depression: a reanalysis of the National Institute of Mental health Treatment of Depression Collaborative Research Program.
Topics: Adult; Age of Onset; Antidepressive Agents; Chronic Disease; Depressive Disorder; Humans; Imipramine | 1997 |
Effects of chronic mild stress (CMS) and imipramine administration, on spleen mononuclear cell proliferative response, serum corticosterone level and brain norepinephrine content in male mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain; Cell Division; Chronic Disease; Corticosterone; Dietar | 1999 |
A chronic stress that impairs reactivity in rats also decreases dopaminergic transmission in the nucleus accumbens: a microdialysis study.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Chronic Disease; Cocaine; Dextroamphetamine | 1999 |
Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats.
Topics: Acute Disease; Animals; Appetite; Benzazepines; Chronic Disease; Disease Models, Animal; Electroshoc | 1999 |
Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Chronic Disease; Depression; Dose-Response Relationship, Drug | 1999 |
Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chronic Disease; Disease Models, Animal | 2000 |
The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricy | 2000 |
The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Depression; Elect | 2000 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
[The treatment of chronic low back pain with psychotropic drugs (author's transl)].
Topics: Antidepressive Agents; Back Pain; Central Nervous System; Chronic Disease; Clomipramine; Drug Therap | 1977 |
Sleep-related periodic headache and imipramine.
Topics: Adult; Chronic Disease; Female; Humans; Imipramine; Male; Migraine Disorders; Sleep, REM | 1976 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
Recent advances in the drug treatment of the functional psychoses.
Topics: Acute Disease; Bipolar Disorder; Chlorpromazine; Chronic Disease; Humans; Imipramine; Lithium; Psych | 1976 |
The use of psychotropic drugs in the treatment of chronic, severe pains.
Topics: Chronic Disease; Clomipramine; Drug Evaluation; Drug Therapy, Combination; Haloperidol; Humans; Imip | 1976 |
Psyche and rheuma.
Topics: Aged; Attitude; Child; Chronic Disease; Depression; Family; Female; Humans; Imipramine; Male; Pain; | 1976 |
Role of biogenic amines in certain pathological conditions.
Topics: Acute Disease; Adult; Aggression; Biogenic Amines; Bipolar Disorder; Chlorpromazine; Chronic Disease | 1975 |
Maintenance treatment in recurrent depression: current and future directions. The first William Sargant Lecture.
Topics: Adolescent; Adult; Aged; Biomarkers; Chronic Disease; Depressive Disorder; Electroencephalography; F | 1992 |
Effect of chronic variable stress on monoamine receptors: influence of imipramine administration.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Chronic Disease; Imipramine; Male; Methoxydimethyltrypta | 1990 |
Schizophrenia and bipolar affective disorders: likenesses and differences.
Topics: Acute Disease; Bipolar Disorder; Chlorpromazine; Chronic Disease; Delusions; Depressive Disorder; Hu | 1989 |
High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients.
Topics: Adolescent; Adult; Age Factors; Blood Platelets; Carrier Proteins; Chronic Disease; Female; Humans; | 1986 |
[3H] imipramine binding sites are decreased in platelets of chronic pain patients.
Topics: Blood Platelets; Carrier Proteins; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; | 1987 |
Consequences of abrupt reduction of chronic symptoms.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chronic Disease; Female; Humans; Imipramine; M | 1987 |
Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin.
Topics: Binding Sites; Blood Platelets; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Ma | 1987 |
Imipramine in the treatment of chronic pelvic pain.
Topics: Adult; Chronic Disease; Female; Humans; Imipramine; Pain; Pelvis | 1986 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
3H-imipramine binding in blood platelets of schizophrenic patients.
Topics: Adult; Blood Platelets; Brain; Chronic Disease; Female; Humans; Imipramine; Kinetics; Macromolecular | 1986 |
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di | 1987 |
Tolerance to therapeutic effects of antidepressants.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine | 1985 |
Chronic pain: economic, psychosocial, ethical, preventive, and medical aspects.
Topics: Adolescent; Chronic Disease; Depressive Disorder; Dexamethasone; Diagnosis, Differential; Father-Chi | 1985 |
Pain patterns in the rheumatic disorders.
Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Depression; Giant Cell Arteriti | 1972 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
Genetic and clinical factors associated with course in depression. Contributions to genetic aspects.
Topics: Alcoholism; Bipolar Disorder; Chlorpromazine; Chronic Disease; Depression; Female; Humans; Imipramin | 1974 |
Rheumatology.
Topics: Acute Disease; Aged; Analgesics; Arthritis, Rheumatoid; Chronic Disease; Diazepam; Female; Gout; Hum | 1972 |
[Significance of enuresis. Symptomatological value in uro-nephrology].
Topics: Adolescent; Child; Chronic Disease; Circadian Rhythm; Enuresis; Female; Humans; Hypertension; Imipra | 1972 |
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Depression; Fema | 1971 |
Social and psychological factors in the treatment of chronic alcoholism.
Topics: Adult; Age Factors; Alcoholism; Ambulatory Care; Attitude of Health Personnel; Attitude to Health; C | 1970 |
Lithium carbonate and isocarboxazid--an effective drug approach in severe depressions.
Topics: Adult; Affect; Carbonates; Chronic Disease; Drug Synergism; Female; Humans; Imipramine; Isocarboxazi | 1971 |
The positive correlation between insulin resistance and duration of hospitalization in untreated schizophrenia.
Topics: Adult; Age Factors; Blood Glucose; Body Weight; Chronic Disease; Fatty Acids, Nonesterified; Growth | 1971 |