Compounds > imipramine
Page last updated: 2024-10-29

imipramine and Chemical and Drug Induced Liver Injury

imipramine has been researched along with Chemical and Drug Induced Liver Injury in 26 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

ExcerptRelevanceReference
"We present two cases of myocarditis and hepatitis with histologic characteristics of hypersensitivity-mediated drug reactions associated with imipramine and its metabolite, desipramine."7.67Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. ( Bonadies, J; Hardin, NJ; Morrow, PL, 1989)
"We present two cases of myocarditis and hepatitis with histologic characteristics of hypersensitivity-mediated drug reactions associated with imipramine and its metabolite, desipramine."3.67Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. ( Bonadies, J; Hardin, NJ; Morrow, PL, 1989)
"Imipramine treatment hit 13 disease clusters: tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, precipitation of congestive heart failure; urinary retention, altered liver functions."1.38Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine. ( Freischmidt, A; Heilmann, J; Kelber, O; Koptina, A; Müller, J; Sadeghlar, F; Ulrich-Merzenich, G; Wagner, H; Zeitler, H, 2012)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" This case suggests that single daily dosing of tricyclic antidepressants may be more hazardous to the liver than divided doses."1.26Toxic hepatitis and single daily dosage imipramine therapy. ( DeVane, CL; Harris, R; Moskovitz, R; Stewart, RB, 1982)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199017 (65.38)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (34.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Saito, K1
Maekawa, K1
Ishikawa, M1
Senoo, Y1
Urata, M1
Murayama, M1
Nakatsu, N1
Yamada, H1
Saito, Y1
Ulrich-Merzenich, G1
Koptina, A1
Kelber, O1
Freischmidt, A1
Heilmann, J1
Müller, J1
Sadeghlar, F1
Zeitler, H1
Wagner, H1
HAEFNER, H1
KUTSCHER, I1
STROTHERS, G1
WOROBEC, T1
Kramp, JL1
Hackett, AM1
Shaw, IC1
Griffiths, LA1
Moskovitz, R1
DeVane, CL1
Harris, R1
Stewart, RB1
Weaver, GA1
Pavlinac, D1
Davis, JS1
Bui, HD1
Chaney, RH1
Morrow, PL1
Hardin, NJ1
Bonadies, J1
Fernández, G1
Villarruel, MC1
de Ferreyra, EC1
de Fenos, OM1
Castro, JA2
Powell, WJ1
Koch-Weser, J1
Williams, RA1
Lajeunesse, BS1
Piéron, R1
Marien, C1
Jagueux, M1
Fossati, C1
Wrights, N1
Prescott, LF1
Cignoli, EV1
Short, MH1
Burns, JM1
Harris, ME1

Reviews

3 reviews available for imipramine and Chemical and Drug Induced Liver Injury

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
    Arztliche Forschung, 1964, Jan-10, Volume: 18

    Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro

1964
[Liver damage due to drugs. I].
    La Clinica terapeutica, 1974, Jan-15, Volume: 68, Issue:1

    Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Re

1974

Other Studies

23 other studies available for imipramine and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 141, Issue:2

    Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp

2014
Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Feb-15, Volume: 19, Issue:3-4

    Topics: Animals; Antidepressive Agents, Tricyclic; Benzyl Alcohols; Chemical and Drug Induced Liver Injury;

2012
JAUNDICE AND ITS RELATION TO THERAPEUTIC AGENTS.
    Lancet (London, England), 1965, Feb-20, Volume: 1, Issue:7382

    Topics: Aluminum; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Hepatitis; Hydroxides; Imipramin

1965
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
    Diseases of the chest, 1965, Volume: 47

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In

1965
Glutamic pyruvic acid transaminases during treatment with amitriptyline and imipramine.
    Acta psychiatrica Scandinavica, 1967, Volume: 43, Issue:1

    Topics: Aged; Alanine Transaminase; Amitriptyline; Chemical and Drug Induced Liver Injury; Female; Humans; I

1967
The metabolism and excretion of [14C]imipramine in an experimental hepatitis.
    Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:6

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis, Animal; Imipramine;

1984
Toxic hepatitis and single daily dosage imipramine therapy.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:4

    Topics: Adult; Chemical and Drug Induced Liver Injury; Depressive Disorder; Drug Administration Schedule; Dr

1982
Hepatic sensitivity to imipramine.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:6

    Topics: Adult; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Liver

1977
Transient hepatitis due to low dose neuroleptic medication.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:5

    Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans; Imipramine; Male; Ne

1989
Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine.
    Journal of forensic sciences, 1989, Volume: 34, Issue:4

    Topics: Aged; Chemical and Drug Induced Liver Injury; Desipramine; Drug Hypersensitivity; Female; Humans; Im

1989
Imipramine prevention of carbon tetrachloride-induced liver necrosis at late states of the intoxication process.
    Journal of applied toxicology : JAT, 1986, Volume: 6, Issue:6

    Topics: Animals; Body Temperature; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C

1986
Lethal hepatic necrosis after therapy with imipramine and desipramine.
    JAMA, 1968, Oct-14, Volume: 206, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Desipramine; Drug Hypersensit

1968
[True and false adverse effects of thymoanaleptic medications].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Dec-08, Volume: 44, Issue:51

    Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio

1968
[Jaundice and rifampicin].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1971, Apr-26, Volume: 47, Issue:20

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Isoniazid; Jaundice; Liver

1971
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
    Scottish medical journal, 1973, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and

1973
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi

1971
Cholestatic jaundice during imipramine therapy.
    JAMA, 1968, Nov-18, Volume: 206, Issue:8

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Jaundice; Liver; Phenothia

1968