imipramine has been researched along with Bradycardia in 10 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 5.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| " Activities of the compounds in antagonizing reserpine-induced ptosis in rabbits and prolongation of alcohol hypnosis in mice give good correlation with their clinical actions, whilst their activities in augmenting excitation of rats by amphetamine and yohimbine toxicity in mice, and in reversing reserpine-induced bradycardia in rats offer further evidence for drug-induced sensitization to adrenergic or tryptaminic mechanisms, which is not however specific for antidepressant agents." | 3.64 | A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE. ( HALLIWELL, G; QUINTON, RM; WILLIAMS, FE, 1964) |
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 1.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| FEKETE, M | 2 |
| BORSY, J | 1 |
| HALLIWELL, G | 1 |
| QUINTON, RM | 1 |
| WILLIAMS, FE | 1 |
| LOEW, D | 1 |
| TAESCHLER, M | 1 |
| Pentel, P | 1 |
| Peterson, CD | 1 |
| Gouffault, J | 1 |
| Van den Driessche, J | 1 |
| Pony, JC | 1 |
| Courgeon, P | 1 |
| Thomas, R | 1 |
| Burda, CD | 1 |
| Viana, AP | 1 |
| Osswald, W | 1 |
| Smolarz, W | 1 |
| Kośmider, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 trial available for imipramine and Bradycardia
| Article | Year |
|---|---|
[Conduction disorders induced by piperazine; clinical and experimental study].
Topics: Adult; Antipsychotic Agents; Bradycardia; Bundle-Branch Block; Cerebral Hemorrhage; Clinical Trials | 1973 |
9 other studies available for imipramine and Bradycardia
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE.
Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervou | 1964 |
[RESEARCH ON ANTICHOLINERGIC EFFECTS OF ANTIDEPRESSIVE SUBSTANCES IN THE RABBIT].
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Bradycardia; Cholinergic Antagonists; Desip | 1964 |
Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bradycardia; Electroca | 1980 |
Cardiotoxic effects of Mellaril.
Topics: Amitriptyline; Bradycardia; Electrocardiography; Humans; Imipramine; Tachycardia; Thioridazine | 1970 |
Antiarrhythmic effects of proadifen hydrochloride (SKF 525-A).
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Barb | 1970 |
[Disorders of heart rhythm in the course of lethal poisoning with imipramine].
Topics: Adult; Bradycardia; Electrocardiography; Female; Humans; Imipramine | 1969 |
A possible role of cholinergic effects in the noradrenaline potentiating action of imipramine.
Topics: Animals; Arrhythmias, Cardiac; Bradycardia; Cats; Dogs; Electrocardiography; Female; Hexamethonium C | 1966 |