imipramine has been researched along with Benign Neoplasms, Brain in 12 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a new anti-invasive small molecule, Imipramine Blue (IB), which inhibits invasion of glioma in vitro when tested against several models." | 7.78 | Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. ( Arbiser, JL; Bellamkonda, RV; Bonner, MY; Brat, DJ; Courtneidge, SA; Diaz, B; Fried, L; Karumbaiah, L; Knaus, UG; Munson, JM; Rowson, SA, 2012) |
| "We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma cells and natural killer (NK) cell line, innate immunity." | 7.77 | Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. ( Fiserová, A; Kovaru, F; Kovárů, H; Lisá, V; Ondráčkova, P, 2011) |
| "In has been found that sphingosine, propranolol, imipramine and phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) have a stimulatory effect on phospholipase D activity in glioma C6 cells." | 7.70 | Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester. ( Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I, 2000) |
| " However, vital safety and efficacy issues related to combined therapy with temozolomide, the first-line cytostatic in patients diagnosed with glioblastoma multiforme, and antidepressant drugs have yet to be addressed." | 3.85 | Antidepressant drugs can modify cytotoxic action of temozolomide. ( Bielecka, AM; Obuchowicz, E, 2017) |
| " We report a new anti-invasive small molecule, Imipramine Blue (IB), which inhibits invasion of glioma in vitro when tested against several models." | 3.78 | Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. ( Arbiser, JL; Bellamkonda, RV; Bonner, MY; Brat, DJ; Courtneidge, SA; Diaz, B; Fried, L; Karumbaiah, L; Knaus, UG; Munson, JM; Rowson, SA, 2012) |
| "Because both imipramine and citalopram have been commonly used to treat depression, which commonly occurs in glioma patients, it would be interesting to conduct large epidemiological studies to investigate the actual benefit that these two drugs would provide for malignant glioma patients when delivered during their glioma treatment." | 3.78 | Voltage-dependent K+ channels as oncotargets in malignant gliomas. ( De Witte, O; Lefranc, F; Pouleau, HB; Rynkowski, M, 2012) |
| "We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma cells and natural killer (NK) cell line, innate immunity." | 3.77 | Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. ( Fiserová, A; Kovaru, F; Kovárů, H; Lisá, V; Ondráčkova, P, 2011) |
| "In has been found that sphingosine, propranolol, imipramine and phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) have a stimulatory effect on phospholipase D activity in glioma C6 cells." | 3.70 | Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester. ( Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I, 2000) |
| " We report here an early and important decrease in sphingomyelinase activity in C6 glioma cells cultured in the presence of imipramine or desipramine at final concentrations of 0." | 3.66 | Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells. ( Albouz, S; Baumann, N; Boutry, JM; Hauw, JJ; Le Saux, F; Vanier, MT, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shchors, K | 1 |
| Massaras, A | 1 |
| Hanahan, D | 1 |
| Shipman, L | 1 |
| Bielecka, AM | 1 |
| Obuchowicz, E | 1 |
| Golan, M | 1 |
| Schreiber, G | 1 |
| Avissar, S | 1 |
| Kovárů, H | 1 |
| Kovaru, F | 1 |
| Ondráčkova, P | 1 |
| Lisá, V | 1 |
| Fiserová, A | 1 |
| Munson, JM | 1 |
| Fried, L | 1 |
| Rowson, SA | 1 |
| Bonner, MY | 1 |
| Karumbaiah, L | 1 |
| Diaz, B | 1 |
| Courtneidge, SA | 1 |
| Knaus, UG | 1 |
| Brat, DJ | 1 |
| Arbiser, JL | 1 |
| Bellamkonda, RV | 1 |
| Lefranc, F | 1 |
| Pouleau, HB | 1 |
| Rynkowski, M | 1 |
| De Witte, O | 1 |
| KRAMER, M | 1 |
| Albouz, S | 1 |
| Vanier, MT | 1 |
| Hauw, JJ | 1 |
| Le Saux, F | 1 |
| Boutry, JM | 1 |
| Baumann, N | 1 |
| Oldendorf, WH | 1 |
| Bobeszko, M | 1 |
| Dygas, A | 1 |
| Nalepa, I | 1 |
| Barańska, J | 1 |
| von Metzler, A | 1 |
| Nitsch, C | 1 |
12 other studies available for imipramine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit.
Topics: Animals; Anticoagulants; Antidepressive Agents, Tricyclic; Antineoplastic Combined Chemotherapy Prot | 2015 |
Glioma: Repurposed drugs combined to amplify autophagy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioma; Imipramine; Ticlop | 2015 |
Antidepressant drugs can modify cytotoxic action of temozolomide.
Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Division; | 2017 |
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents | 2011 |
Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes.
Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents, Tricyclic; Brain Neoplasms; Cell | 2011 |
Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Pro | 2012 |
Voltage-dependent K+ channels as oncotargets in malignant gliomas.
Topics: Animals; Antidepressive Agents; Apoptosis; Brain Neoplasms; Cell Movement; Citalopram; Drug Resistan | 2012 |
DELIRIUM AS A COMPLICATION OF IMIPRAMINE THERAPY IN THE AGED.
Topics: Astrocytoma; Brain Neoplasms; Delirium; Geriatrics; Imipramine; Neoplasms; Temporal Lobe; Toxicology | 1963 |
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Culture Techniques; Desipramine; Dose-Response Relationship, Drug; | 1983 |
Some clinical aspects of the blood-brain barrier.
Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Capillaries; Capillary Permeability; Cell Membrane Perm | 1982 |
Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester.
Topics: Animals; Brain Neoplasms; Cell Compartmentation; Drug Interactions; Enzyme Activation; Enzyme Inhibi | 2000 |
Monoamine content in rat brain during carcinogenesis and the influence of the CNS drugs piracetam and imipramine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Brain Neoplasms; Caudate Nucleus; Female; | 1985 |