imipramine has been researched along with Aura in 33 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 7.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Literature searches were conducted utilizing PubMed and MEDLINE databases employing combinations of search terms including, but not limited to, "epilepsy", "refractory", "seizure", and the following medications: acetazolamide, amantadine, bumetanide, imipramine, lidocaine, verapamil, and various stimulants." | 4.95 | Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. ( Perry, MS; Turner, AL, 2017) |
| "In a variety of laboratory models of experimental epilepsy, imipramine exerts a biphasic action on the CNS as manifested by antiepileptic properties at low doses and convulsant effects at higher doses." | 3.65 | Biphasic effects of imipramine in experimental models of epilepsy. ( Fowler, GW; Julien, RM; Lange, SC, 1976) |
| "Assessment of seizure risk in individuals involves consideration of predisposing factors, the antidepressant selected, and the bioavailability of the drug." | 2.38 | Seizures associated with antidepressants: a review. ( Jacobs, SC; Nelson, JC; Rosenstein, DL, 1993) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration." | 1.27 | Acute effects of antidepressants on hippocampal seizures. ( Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF, 1985) |
| "Nomifensine is a tetrahydoisoquinoline antidepressant which is chemically unrelated to the tricyclic or tetracyclic antidepressants, the monoamine oxidase inhibitors or the recently introduced agents." | 1.26 | Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1979) |
| "could increase the risk of seizures." | 1.26 | [Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (87.88) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Turner, AL | 1 |
| Perry, MS | 1 |
| KILOH, LG | 1 |
| DAVISON, K | 1 |
| OSSELTON, JW | 1 |
| CORRIOL, J | 1 |
| ZWIRN, P | 1 |
| PLOTNIKOFF, NP | 1 |
| ERALDO, O | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| BARUK, H | 1 |
| LAUNAY, J | 1 |
| KUHN, R | 1 |
| Olesen, OV | 1 |
| Small, JG | 1 |
| Small, IF | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Hess, CW | 1 |
| Lowry, MR | 1 |
| Dunner, FJ | 1 |
| Rosenstein, DL | 1 |
| Nelson, JC | 1 |
| Jacobs, SC | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Lange, SC | 2 |
| Julien, RM | 2 |
| Fowler, GW | 2 |
| Trimble, M | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Escande, M | 1 |
| Gayral, L | 1 |
| Golberger, E | 1 |
| Jarrige, A | 1 |
| Kulik, J | 1 |
| Petti, TA | 1 |
| Campbell, M | 1 |
| Perucca, E | 1 |
| Richens, A | 1 |
| Snead, OC | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Clifford, DB | 1 |
| Rutherford, JL | 1 |
| Hicks, FG | 1 |
| Zorumski, CF | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Ban, TA | 1 |
| Klein, DF | 1 |
| Greenberg, IM | 1 |
| Milner, G | 1 |
| Hills, NF | 1 |
| Weigert, S | 1 |
| Schröter, K | 1 |
| Görisch, V | 1 |
| Moccetti, T | 1 |
| Lichtlen, P | 1 |
| Albert, H | 1 |
| Meier, E | 1 |
| Imbach, P | 1 |
| Sueblinvong, V | 1 |
| Wilson, JF | 1 |
| Dallos, V | 1 |
| Heathfield, K | 1 |
7 reviews available for imipramine and Aura
| Article | Year |
|---|---|
Outside the box: Medications worth considering when traditional antiepileptic drugs have failed.
Topics: Amantadine; Anticonvulsants; Bumetanide; Central Nervous System Stimulants; Epilepsy; Humans; Imipra | 2017 |
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
[5 YEARS OF DRUG THERAPY OF DEPRESSIVE STATES WITH IMINODIBENZYL DERIVATIVES].
Topics: Benzylamines; Depression; Depressive Disorder; Diabetes Mellitus; Electroconvulsive Therapy; Epileps | 1964 |
Seizures associated with antidepressants: a review.
Topics: Antidepressive Agents; Biological Availability; Causality; Depressive Disorder; Dose-Response Relati | 1993 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
Non-monoamine oxidase inhibitor antidepressants and epilepsy: a review.
Topics: Adult; Aged; Amines; Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricycl | 1978 |
The neuropharmacology of epileptic falling spells.
Topics: Anti-Anxiety Agents; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Ethosuximide; Humans; | 1987 |
3 trials available for imipramine and Aura
| Article | Year |
|---|---|
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
Behavioral effects of diphenylhydantoin in severe psychiatric disorders.
Topics: Adolescent; Adult; Character; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Fem | 1967 |
A double-blind assessment of antidepressants in the treatment of 212 enuretic patients.
Topics: Clinical Trials as Topic; Desipramine; Enuresis; Epilepsy; Female; Humans; Humidity; Imipramine; Mal | 1968 |
23 other studies available for imipramine and Aura
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
An electroencephalographic study of the analeptic effects of imipramine.
Topics: Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Imipramine; Psychopharm | 1961 |
[Does RP 7162 (Surmontyl) possess a convulsive action?].
Topics: Epilepsy; Humans; Imipramine; Seizures | 1962 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
[TOFRANIL POISONING IN THE CHILD].
Topics: Child; Chloral Hydrate; Electrocardiography; Epilepsy; Humans; Imipramine; Infusions, Parenteral; Ox | 1964 |
[NEUROLEPTICS AND THE LAW OF STAGES].
Topics: Antipsychotic Agents; Catalepsy; Catatonia; Chlorpromazine; Epilepsy; Humans; Imipramine; Parkinsoni | 1964 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
EEG spikes in non-epileptic psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antisocial Personality Disorder; Barbiturates; Brain; Brain | 1967 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
[Narcolepsy--epilepsy. Differential diagnosis].
Topics: Amnesia; Cataplexy; Clomipramine; Diagnosis, Differential; Electroencephalography; Epilepsy; Halluci | 1984 |
Seizures during tricyclic therapy.
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Electroencephalography; Epilepsy; Femal | 1980 |
Biphasic effects of imipramine in experimental models of epilepsy.
Topics: Animals; Cats; Central Nervous System; Disease Models, Animal; Electroencephalography; Electroshock; | 1976 |
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.
Topics: Animals; Biogenic Amines; Brain; Depression; Epilepsy; Evaluation Studies as Topic; Humans; Imiprami | 1979 |
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography; | 1976 |
Imipramine and seizures.
Topics: Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Imipramine; Male; Mea | 1975 |
Interaction between phenytoin and imipramine.
Topics: Adult; Depression; Drug Interactions; Epilepsy; Humans; Imipramine; Phenytoin; Time Factors | 1977 |
Biphasic action of imipramine in laboratory models of epilepsy.
Topics: Anesthesia; Animals; Behavior, Animal; Cats; Electroencephalography; Electroshock; Epilepsy; Estroge | 1976 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hi | 1985 |
[Imipramine (melipramine) poisoning in childhood].
Topics: Child, Preschool; Diagnosis, Differential; Electrocardiography; Enuresis; Epilepsy; Exchange Transfu | 1972 |
[Cardiotoxicity of tricyclic antidepressive agents. (Phenothiazines and imipramines)].
Topics: Adult; Arrhythmias, Cardiac; Cardiovascular Diseases; Coronary Vessels; Electrocardiography; Epileps | 1971 |
Myocardial damage due to imipramine intoxication.
Topics: Aspartate Aminotransferases; Child, Preschool; Creatine Kinase; Electrocardiography; Electroencephal | 1969 |
Iatrogenic epilepsy due to antidepressant drugs.
Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr | 1969 |