imipramine has been researched along with Astrocytoma, Grade IV in 5 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastomas are the most aggressive type of brain tumour, with poor prognosis even after standard treatment such as surgical resection, temozolomide and radiation therapy." | 5.56 | Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF-κB signalling participate in anti-glioblastoma of imipramine. ( Chiang, IT; Hsu, FT; Wang, WS, 2020) |
| " However, vital safety and efficacy issues related to combined therapy with temozolomide, the first-line cytostatic in patients diagnosed with glioblastoma multiforme, and antidepressant drugs have yet to be addressed." | 3.85 | Antidepressant drugs can modify cytotoxic action of temozolomide. ( Bielecka, AM; Obuchowicz, E, 2017) |
| "Glioblastomas are the most aggressive type of brain tumour, with poor prognosis even after standard treatment such as surgical resection, temozolomide and radiation therapy." | 1.56 | Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF-κB signalling participate in anti-glioblastoma of imipramine. ( Chiang, IT; Hsu, FT; Wang, WS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chryplewicz, A | 1 |
| Scotton, J | 1 |
| Tichet, M | 1 |
| Zomer, A | 1 |
| Shchors, K | 1 |
| Joyce, JA | 1 |
| Homicsko, K | 1 |
| Hanahan, D | 1 |
| Hsu, FT | 1 |
| Chiang, IT | 1 |
| Wang, WS | 1 |
| Bielecka, AM | 1 |
| Obuchowicz, E | 1 |
| Golan, M | 1 |
| Schreiber, G | 1 |
| Avissar, S | 1 |
| Jeon, SH | 1 |
| Kim, SH | 1 |
| Kim, Y | 1 |
| Kim, YS | 1 |
| Lim, Y | 1 |
| Lee, YH | 1 |
| Shin, SY | 1 |
5 other studies available for imipramine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Topics: Animals; Antidepressive Agents, Tricyclic; Autophagy; B7-H1 Antigen; Glioblastoma; Imipramine; Immun | 2022 |
Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF-κB signalling participate in anti-glioblastoma of imipramine.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Glioblastoma; Humans; | 2020 |
Antidepressant drugs can modify cytotoxic action of temozolomide.
Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Division; | 2017 |
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents | 2011 |
The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells.
Topics: Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Apoptosis Regulatory Proteins; Aut | 2011 |