imipramine has been researched along with Alcoholism in 42 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, hypericum extracts, as well as standard antidepressants such as the tricyclic, impramine, and the selective serotonin reuptake inhibitor, fluoxetine, have been reported to be of therapeutic benefit in the treatment of alcoholism, as these compounds may reduce alcohol craving and/or intake in particular subgroups of patients." | 7.70 | Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism. ( de Beun, R; De Vry, J; Jentzsch, KR; Maurel, S; Schreiber, R, 1999) |
| "Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded with improvement in both mood and drinking behavior, and eight (13%) responded after further dosage increases or treatment with disulfiram." | 6.67 | Imipramine treatment of alcoholism with comorbid depression. ( Harrison, W; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JP; Tricamo, E, 1993) |
| " In addition, hypericum extracts, as well as standard antidepressants such as the tricyclic, impramine, and the selective serotonin reuptake inhibitor, fluoxetine, have been reported to be of therapeutic benefit in the treatment of alcoholism, as these compounds may reduce alcohol craving and/or intake in particular subgroups of patients." | 3.70 | Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism. ( de Beun, R; De Vry, J; Jentzsch, KR; Maurel, S; Schreiber, R, 1999) |
| "Imipramine treatment was safe and associated with improvement in depression in both adequately treated and intention-to-treat samples." | 2.68 | Imipramine treatment of alcoholics with primary depression: A placebo-controlled clinical trial. ( Agosti, V; Goldman, D; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JW, 1996) |
| "Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded with improvement in both mood and drinking behavior, and eight (13%) responded after further dosage increases or treatment with disulfiram." | 2.67 | Imipramine treatment of alcoholism with comorbid depression. ( Harrison, W; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JP; Tricamo, E, 1993) |
| " Determining the best dosing strategy has been the goal of recent treatment studies with alcohol-dependent patients." | 2.39 | Dosing issues in the pharmacotherapy of alcoholism. ( Mason, BJ, 1996) |
| "Patients with major depressive disorder (MDD) frequently also have alcohol use disorder (AUD) and they are more likely to experience symptomatic recurrence and resist treatment." | 1.42 | Influence of comorbid alcohol use disorder on treatment response of depressive patients. ( Hashimoto, E; Ishikawa, H; Saito, T; Tayama, M; Yamamoto, M, 2015) |
| "In an animal model of binge drinking that exhibits abstinence-induced behaviors reminiscent of negative affective states, the triple monoamine uptake inhibitor, amitifadine, produced a selective, dose dependent attenuation of binge drinking." | 1.38 | Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology. ( Basile, AS; June, HL; Kelly, T; Skolnick, P; Warnock, KT; Yang, AR; Yi, HS, 2012) |
| "These findings suggest that alcohol dependence is associated with the downregulation of the CB1 receptors, while suicide is linked to the upregulation of these receptors in the ventral striatum." | 1.36 | Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. ( Arango, V; Cooper, TB; Hungund, BL; Kassir, SA; Mann, JJ; Vinod, KY, 2010) |
| " Pharmacokinetic parameters were determined from multiple blood samples drawn over 60 hours." | 1.28 | Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls. ( Barnhill, JG; Ciraulo, AM; Ciraulo, DA; Jaffe, JH; Tarmey, MF, 1990) |
| "Desipramine clearance was affected to a lesser degree than imipramine, suggesting that from a pharmacokinetic standpoint it may be the preferred drug for the treatment of alcoholics with depression." | 1.27 | Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. ( Barnhill, JG; Ciraulo, DA; Jaffe, JH, 1988) |
| " Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment." | 1.27 | Pharmacokinetic interaction of disulfiram and antidepressants. ( Barnhill, J; Boxenbaum, H; Ciraulo, DA, 1985) |
| " These results are consistent with either a decrease in oral bioavailability of IMI in alcoholics or, assuming complete absorption, an increase in intrinsic clearance of 2." | 1.26 | Imipramine disposition in alcoholics. ( Alderson, LM; Chapron, DJ; Ciraulo, DA; Jaffe, JH; Kramer, PA; Subbarao, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (69.05) | 18.7374 |
| 1990's | 10 (23.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, E | 1 |
| Tayama, M | 1 |
| Ishikawa, H | 1 |
| Yamamoto, M | 1 |
| Saito, T | 1 |
| Vinod, KY | 1 |
| Kassir, SA | 1 |
| Hungund, BL | 1 |
| Cooper, TB | 1 |
| Mann, JJ | 1 |
| Arango, V | 1 |
| Warnock, KT | 1 |
| Yang, AR | 1 |
| Yi, HS | 1 |
| June, HL | 2 |
| Kelly, T | 1 |
| Basile, AS | 1 |
| Skolnick, P | 1 |
| STANLEY, B | 1 |
| PAL, NR | 1 |
| Olesen, OV | 1 |
| Ciraulo, DA | 4 |
| Alderson, LM | 1 |
| Chapron, DJ | 1 |
| Jaffe, JH | 3 |
| Subbarao, B | 1 |
| Kramer, PA | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Nunes, EV | 2 |
| McGrath, PJ | 2 |
| Quitkin, FM | 2 |
| Stewart, JP | 1 |
| Harrison, W | 1 |
| Tricamo, E | 1 |
| Ocepek-Welikson, K | 2 |
| Stewart, JW | 1 |
| Goldman, D | 1 |
| Agosti, V | 1 |
| Lepola, U | 1 |
| Koponen, H | 1 |
| Leinonen, E | 1 |
| Mason, BJ | 1 |
| Wilkins, JN | 1 |
| Paré, AM | 1 |
| Paré, WP | 1 |
| Kluczynski, J | 1 |
| De Vry, J | 1 |
| Maurel, S | 1 |
| Schreiber, R | 1 |
| de Beun, R | 1 |
| Jentzsch, KR | 1 |
| Rosenbaum, AH | 1 |
| Niven, RG | 1 |
| Hanson, NP | 1 |
| Swanson, DW | 1 |
| Kissin, B | 5 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Thompson, T | 1 |
| Pickens, R | 1 |
| Shaw, JA | 1 |
| Donley, P | 1 |
| Morgan, DW | 1 |
| Robinson, JA | 1 |
| Shaskan, EG | 1 |
| Becker, RE | 1 |
| Basse, P | 1 |
| Rørdam, P | 1 |
| Balant-Gorgia, AE | 1 |
| Gay, M | 1 |
| Gex-Fabry, M | 1 |
| Balant, LP | 1 |
| Barnhill, JG | 2 |
| Ciraulo, AM | 1 |
| Tarmey, MF | 1 |
| Demeter, E | 1 |
| Tekes, K | 1 |
| Majorossy, K | 1 |
| Palkovits, M | 1 |
| Soós, M | 1 |
| Magyar, K | 1 |
| Somogyi, E | 1 |
| Suranyi-Cadotte, B | 1 |
| Dongier, M | 1 |
| Lafaille, F | 1 |
| Luthe, L | 1 |
| Kranzler, HR | 1 |
| Javors, M | 1 |
| Blaisdell, G | 1 |
| Lee, J | 1 |
| Bowden, C | 1 |
| Barnhill, J | 1 |
| Boxenbaum, H | 1 |
| Ashcroft, GW | 1 |
| Crawford, TB | 1 |
| Eccleston, D | 1 |
| Sharman, DF | 1 |
| MacDougall, EJ | 1 |
| Stanton, JB | 1 |
| Binns, JK | 1 |
| Gross, MM | 1 |
| Altman, H | 1 |
| Evenson, RC | 1 |
| Sletten, IW | 1 |
| Cho, DW | 1 |
| Debus, G | 1 |
| Winokur, G | 1 |
| Chaftez, ME | 1 |
| Rosenblatt, SM | 2 |
| Machover, S | 1 |
| Charnoff, SM | 1 |
| Butterworth, AT | 1 |
| Karkalas, Y | 1 |
| Lal, H | 1 |
| Platz, A | 1 |
| Su, WH | 1 |
| Post, F | 1 |
| Dallos, V | 1 |
| Heathfield, K | 1 |
6 reviews available for imipramine and Alcoholism
| Article | Year |
|---|---|
Dosing issues in the pharmacotherapy of alcoholism.
Topics: Administration, Oral; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Comorbidity; Depressive D | 1996 |
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
An experimental analysis of behavioral factors in drug dependence.
Topics: Administration, Oral; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cannabis; Chlorpromazine; | 1975 |
Drugs in the treatment of alcoholism.
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlord | 1967 |
Prognostic factors in alcoholism.
Topics: Adult; Alcoholism; Chlordiazepoxide; Ethnicity; Follow-Up Studies; Humans; Imipramine; Male; Middle | 1968 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
6 trials available for imipramine and Alcoholism
| Article | Year |
|---|---|
Imipramine treatment of alcoholism with comorbid depression.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Comorbidity; Depressive Disorder; Disulfiram; Dose-Resp | 1993 |
Imipramine treatment of alcoholics with primary depression: A placebo-controlled clinical trial.
Topics: Adult; Alcohol Drinking; Alcoholics Anonymous; Alcoholism; Ambulatory Care; Depressive Disorder; Fem | 1996 |
Treatment of depression in alcoholics.
Topics: Adolescent; Adult; Alcoholism; Chlordiazepoxide; Counseling; Depression; Drug Evaluation; Drug Thera | 1975 |
Blood platelet monoamine oxidase activity in anergic schizophrenics.
Topics: Alcoholism; Blood Platelets; Chlorpromazine; Humans; Imipramine; Monoamine Oxidase; Schizophrenia; T | 1975 |
Drug and placebo responses in chronic alcoholics.
Topics: Achievement; Alcoholism; Antidepressive Agents; Black or African American; Chlordiazepoxide; Chronic | 1968 |
Depression associated with alcohol withdrawal. Imipramine therapy compared with placebo.
Topics: Adult; Alcoholism; Clinical Trials as Topic; Depression; Diarrhea; Humans; Imipramine; Male; Middle | 1971 |
31 other studies available for imipramine and Alcoholism
| Article | Year |
|---|---|
Influence of comorbid alcohol use disorder on treatment response of depressive patients.
Topics: Adult; Alcohol Drinking; Alcoholism; Antidepressive Agents; Depressive Disorder, Major; Female; Foll | 2015 |
Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides.
Topics: Adolescent; Adult; Aged; Alcoholism; Amidohydrolases; Analysis of Variance; Autoradiography; Basal G | 2010 |
Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology.
Topics: Affect; Alcoholism; Animals; Aza Compounds; Binge Drinking; Biogenic Monoamines; Bridged Bicyclo Com | 2012 |
FATAL HYPERPYREXIA WITH PHENELZINE AND IMIPRAMINE.
Topics: Alcoholism; Fever; Imipramine; Mental Disorders; Phenelzine; Poisoning; Toxicology | 1964 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
Imipramine disposition in alcoholics.
Topics: Administration, Oral; Adolescent; Adult; Alcoholism; Chromatography, High Pressure Liquid; Depressio | 1982 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
A naturalistic 6-year follow-up study of patients with panic disorder.
Topics: Adult; Alcoholism; Alprazolam; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Comorbidity; D | 1996 |
Pharmacotherapy of schizophrenia patients with comorbid substance abuse.
Topics: Alcoholism; Antipsychotic Agents; Cocaine; Flupenthixol; Humans; Imipramine; Marijuana Abuse; Opioid | 1997 |
Negative affect and voluntary alcohol consumption in Wistar-Kyoto (WKY) and Sprague-Dawley rats.
Topics: Alcoholism; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Central Nervous System | 1999 |
Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism.
Topics: Alcoholism; Animals; Antidepressive Agents; Depression; Drug Evaluation, Preclinical; Female; Fluoxe | 1999 |
Tardive dyskinesia: relationship with a primary affective disorder.
Topics: Adult; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Antipsychotic Agents; Chlordiazepoxide; | 1977 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
Ischemic colitis complicating imipramine overdose and alcohol ingestion. Case report.
Topics: Alcoholism; Colitis; Colon; Drug Overdose; Humans; Imipramine; Ischemia; Male; Middle Aged | 1992 |
Persistent impairment of clomipramine demethylation in recently detoxified alcoholic patients.
Topics: Adult; Alcoholism; Clomipramine; Dealkylation; Desipramine; Female; Humans; Hydroxylation; Imipramin | 1992 |
Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls.
Topics: Adult; Alcoholism; Electrocardiography; Humans; Imipramine; Infusions, Intravenous; Male; Middle Age | 1990 |
The asymmetry of 3H-imipramine binding may predict psychiatric illness.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alcoholism; Biomarkers; Brain; Carrier Proteins; | 1989 |
Platelets of alcoholics, and of subjects genetically at risk for alcoholism, share the same abnormality of imipramine binding sites.
Topics: Alcoholism; Blood Platelets; Carrier Proteins; Humans; Imipramine; Receptors, Drug; Receptors, Neuro | 1989 |
Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alcoholism; Blood Proteins; Desipramine; Humans; Imip | 1988 |
Secondary depression: treatment and outcome.
Topics: Alcoholism; Antidepressive Agents; Depressive Disorder; Drug Administration Schedule; Humans; Imipra | 1988 |
Binding of imipramine to platelet membranes is lower in alcoholics than in controls.
Topics: Adult; Aged; Alcoholism; Blood Platelets; Depression; Humans; Imipramine; Male; Membranes; Middle Ag | 1987 |
Pharmacokinetic interaction of disulfiram and antidepressants.
Topics: Adult; Alcoholism; Desipramine; Disulfiram; Drug Interactions; Half-Life; Humans; Hydroxylation; Imi | 1985 |
5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases.
Topics: Alcoholism; Bipolar Disorder; Central Nervous System Diseases; Humans; Hydroxyindoleacetic Acid; Imi | 1966 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
Patterns of psychotropic drug prescription in four midwestern state hospitals.
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Computers; Drug Utilization | 1972 |
[Self- and foreign placements of current condition in psychopharmacological longitudinal studies].
Topics: Adolescent; Aggression; Alcoholism; Antiparkinson Agents; Anxiety; Depression; Drug Evaluation; Extr | 1974 |
Genetic and clinical factors associated with course in depression. Contributions to genetic aspects.
Topics: Alcoholism; Bipolar Disorder; Chlorpromazine; Chronic Disease; Depression; Female; Humans; Imipramin | 1974 |
Jaundice following therapy with imipramine and cyproheptadine.
Topics: Adjustment Disorders; Alanine Transaminase; Alcoholism; Alkaline Phosphatase; Cyproheptadine; Drug C | 1971 |
Social and psychological factors in the treatment of chronic alcoholism.
Topics: Adult; Age Factors; Alcoholism; Ambulatory Care; Attitude of Health Personnel; Attitude to Health; C | 1970 |
Management of senile psychiatric disorders.
Topics: Adjustment Disorders; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Dementia; Depressive Diso | 1968 |
Iatrogenic epilepsy due to antidepressant drugs.
Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr | 1969 |