imipramine has been researched along with Aging in 56 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reboxetine is as effective as imipramine in the treatment of depression in elderly patients but is at least as well tolerated with a lower risk of hypotension and related symptoms, fewer serious adverse events, adverse event-related withdrawals and treatment-related adverse events." | 9.09 | Reboxetine versus imipramine in the treatment of elderly patients with depressive disorders: a double-blind randomised trial. ( Bercoff, E; Chiu, E; Katona, C; Tack, P; Versiani, M; Woelk, H, 1999) |
| "In 23 patients with rheumatoid arthritis the plasma protein binding of 3H-imipramine and the plasma levels of 13 proteins were measured in order to examine the significance of the proteins for the binding of imipramine." | 7.67 | Plasma protein binding of imipramine in patients with rheumatoid arthritis. ( Kristensen, CB, 1985) |
| "3H-Paroxetine (PA) binding was studied in the frontal cortex (FC) and hippocampus (H) of 4 mos (young), 15 mos (adult) and 24 mos (aged) old Fischer 344 rats." | 5.29 | Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine. ( Arora, RC; Crayton, JW; Gulati, A, 1993) |
| "The effect of aging on steady-state plasma concentrations of citalopram (CIT) and desmethylcitalopram (DCIT) was investigated in 128 depressive patients treated with 10-80 mg/day CIT." | 5.11 | Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients. ( Baumann, P; Brawand-Amey, M; Brogli, C; Cochard, N; de Mendonça Lima, CA; Eap, CB; Jacquet, S; Powell-Golay, K, 2005) |
| "Reboxetine is as effective as imipramine in the treatment of depression in elderly patients but is at least as well tolerated with a lower risk of hypotension and related symptoms, fewer serious adverse events, adverse event-related withdrawals and treatment-related adverse events." | 5.09 | Reboxetine versus imipramine in the treatment of elderly patients with depressive disorders: a double-blind randomised trial. ( Bercoff, E; Chiu, E; Katona, C; Tack, P; Versiani, M; Woelk, H, 1999) |
| " Here, sucrose intake, forced swimming, immobility in the modified tail suspension test, novelty exploration, grooming, anxiety and locomotor activity were compared in naïve 3- and 18-month-old male C57BL/6 mice." | 3.78 | Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression. ( Bachurin, S; Bolkunov, A; Kubatiev, A; Malatynska, E; Redkozubova, O; Steinbusch, HW; Strekalova, T; Vignisse, J; Yeritsyan, NB, 2012) |
| " Nevertheless, transporter function showed a substantial interaction of aging with DST: elderly DST suppressors showed a deficit in [3H]serotonin uptake capabilities and resistance to imipramine inhibition of uptake." | 3.69 | Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport. ( Carroll, BJ; Hays, JC; Nemeroff, CB; Slotkin, TA, 1997) |
| "Although the use of aging experimental animals for studying serotonergic neuronal changes is limited because of species differences, cholinergic neuronal deterioration does appear to be a feature common to mammalian aging brains." | 3.68 | Serotonergic ligand binding in aging brain of experimental animals. ( Yamagata, A; Yamaguchi, T, 1991) |
| "Aging was associated with an increase in the density of specific binding sites for [3H]imipramine in postmortem specimens of human hypothalamus, frontal cortex, and parietal cortex." | 3.67 | Elevated density of [3H]imipramine binding in aged human brain. ( Finch, CE; Marcusson, JO; Osterburg, HH; Severson, JA; Winblad, B, 1985) |
| "In 23 patients with rheumatoid arthritis the plasma protein binding of 3H-imipramine and the plasma levels of 13 proteins were measured in order to examine the significance of the proteins for the binding of imipramine." | 3.67 | Plasma protein binding of imipramine in patients with rheumatoid arthritis. ( Kristensen, CB, 1985) |
| " We found no major difference between non-elderly and elderly depressed patients as concerns efficacy, total incidence of adverse findings or safety parameters such as laboratory values and heart rate." | 2.68 | Are there any differences in the safety and efficacy of brofaromine and imipramine between non-elderly and elderly patients with major depression? ( Möller, HJ; Müller, H; Volz, HP, 1995) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| "Fluoxetine also did not increase forced swim struggle behavior in juvenile mice of all strains, but was effective in increasing struggle in adults." | 1.35 | Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains. ( Baker, KB; Davis, KW; Gerhardt, B; Lanthorn, TH; Malbari, MM; Mason, SS; Pogorelov, VM; Ritter, R; Savelieva, KV; Wray, SP, 2009) |
| "3H-Paroxetine (PA) binding was studied in the frontal cortex (FC) and hippocampus (H) of 4 mos (young), 15 mos (adult) and 24 mos (aged) old Fischer 344 rats." | 1.29 | Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine. ( Arora, RC; Crayton, JW; Gulati, A, 1993) |
| " The study shows that it is possible to obtain a good estimation of individual dosage needs from one or more serum concentrations obtained at steady state." | 1.28 | Predictive techniques applied to imipramine therapeutic drug monitoring. ( Domínguez-Gil, A; Fernandez de Gatta, MM; Garcia, MJ; Montojo, C; Ramón Gutierrez, J; Rey, F; Tamayo, M, 1989) |
| "Imipramine (IMI) was administered s." | 1.27 | Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain. ( Delongchamp, RR; Harmon, JR; Kimmel, GL; Webb, PJ, 1986) |
| "Imipramine treatment elicited a significantly greater decrease in these adrenergic sites in the aged (39." | 1.27 | The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats. ( Cooper, T; Friedman, E; Yocca, F, 1986) |
| "Imipramine receptors were studied in platelets from six healthy young subjects (age between 24 and 38 years), five newborns, and six healthy elderly persons (age between 70 and 81 years)." | 1.27 | Imipramine receptors in human platelets: effect of age. ( Giusti, P; Marazziti, D; Pacifici, GM; Placidi, GF; Rotondo, A, 1987) |
| "Imipramine binding was found to increase with age in a region-specific manner." | 1.27 | Autoradiographic analysis of [3H]imipramine binding in the human brain postmortem: effects of age and alcohol. ( Biegon, A; Gross-Isseroff, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (57.14) | 18.7374 |
| 1990's | 11 (19.64) | 18.2507 |
| 2000's | 6 (10.71) | 29.6817 |
| 2010's | 7 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrascheck, M | 1 |
| Ye, X | 1 |
| Buck, LB | 1 |
| Babenko, NA | 3 |
| Storozhenko, GV | 1 |
| Hassouneh, LK | 1 |
| Timofiychuk, OA | 1 |
| Pérez-Cáceres, D | 1 |
| Ciudad-Roberts, A | 1 |
| Rodrigo, MT | 1 |
| Pubill, D | 1 |
| Camins, A | 1 |
| Camarasa, J | 1 |
| Escubedo, E | 1 |
| Pallàs, M | 1 |
| Kharchenko, VS | 1 |
| Mason, SS | 1 |
| Baker, KB | 1 |
| Davis, KW | 1 |
| Pogorelov, VM | 1 |
| Malbari, MM | 1 |
| Ritter, R | 1 |
| Wray, SP | 1 |
| Gerhardt, B | 1 |
| Lanthorn, TH | 1 |
| Savelieva, KV | 1 |
| Rantamäki, T | 1 |
| Vesa, L | 1 |
| Antila, H | 1 |
| Di Lieto, A | 1 |
| Tammela, P | 1 |
| Schmitt, A | 1 |
| Lesch, KP | 1 |
| Rios, M | 1 |
| Castrén, E | 1 |
| Malatynska, E | 1 |
| Steinbusch, HW | 1 |
| Redkozubova, O | 1 |
| Bolkunov, A | 1 |
| Kubatiev, A | 1 |
| Yeritsyan, NB | 1 |
| Vignisse, J | 1 |
| Bachurin, S | 1 |
| Strekalova, T | 1 |
| Har'kavenko, VV | 1 |
| Storozhenko, GB | 1 |
| Krasnikova, OM | 1 |
| Babenko, NO | 1 |
| GRAUER, H | 1 |
| KRAL, VA | 1 |
| ENGELSTOFT, FH | 1 |
| HESHE, J | 1 |
| KIRK, L | 1 |
| HAASE, HJ | 1 |
| KOESTER, H | 1 |
| KOENIG, M | 1 |
| BLEKER, A | 1 |
| MAZZONI, L | 1 |
| DE PALMA, C | 1 |
| Kubera, M | 1 |
| Kenis, G | 1 |
| Bosmans, E | 1 |
| Kajta, M | 1 |
| Basta-Kaim, A | 1 |
| Scharpe, S | 1 |
| Budziszewska, B | 1 |
| Maes, M | 1 |
| de Mendonça Lima, CA | 1 |
| Baumann, P | 1 |
| Brawand-Amey, M | 1 |
| Brogli, C | 1 |
| Jacquet, S | 1 |
| Cochard, N | 1 |
| Powell-Golay, K | 1 |
| Eap, CB | 1 |
| Wilson, MA | 2 |
| Roy, EJ | 2 |
| Abernethy, DR | 1 |
| Kerzner, L | 1 |
| Cutler, NR | 1 |
| Narang, PK | 1 |
| Mocchetti, I | 1 |
| Brunello, N | 2 |
| Racagni, G | 2 |
| Langer, SZ | 1 |
| Briley, MS | 1 |
| Raisman, R | 1 |
| Henry, JF | 1 |
| Morselli, PL | 1 |
| Volz, HP | 1 |
| Müller, H | 1 |
| Möller, HJ | 1 |
| van Laar, MW | 1 |
| van Willigenburg, AP | 1 |
| Volkerts, ER | 1 |
| Arora, RC | 1 |
| Gulati, A | 1 |
| Crayton, JW | 1 |
| Slotkin, TA | 2 |
| McCook, EC | 1 |
| Ritchie, JC | 1 |
| Carroll, BJ | 2 |
| Seidler, FJ | 1 |
| Hays, JC | 1 |
| Nemeroff, CB | 1 |
| Vamvakides, A | 2 |
| Schiffman, SS | 1 |
| Graham, BG | 1 |
| Suggs, MS | 1 |
| Sattely-Miller, EA | 1 |
| Katona, C | 1 |
| Bercoff, E | 1 |
| Chiu, E | 1 |
| Tack, P | 1 |
| Versiani, M | 1 |
| Woelk, H | 1 |
| Miller, M | 1 |
| Simonds, JF | 1 |
| Bennett, AE | 1 |
| Appelbaum, PS | 1 |
| Vasile, RG | 1 |
| Orsulak, PJ | 1 |
| Schildkraut, JJ | 1 |
| Tissari, AH | 1 |
| Fujita, S | 3 |
| Yamaguchi, T | 2 |
| Yamagata, A | 1 |
| Wesemann, W | 1 |
| Weiner, N | 1 |
| Severson, JA | 1 |
| Marcusson, JO | 2 |
| Osterburg, HH | 1 |
| Finch, CE | 1 |
| Winblad, B | 2 |
| Riva, M | 1 |
| Rovescalli, AC | 1 |
| Galimberti, R | 1 |
| Demeter, E | 1 |
| Tekes, K | 1 |
| Majorossy, K | 1 |
| Palkovits, M | 1 |
| Soós, M | 1 |
| Magyar, K | 1 |
| Somogyi, E | 1 |
| Morimoto, R | 1 |
| Chiba, M | 2 |
| Kitani, K | 1 |
| Suzuki, T | 2 |
| Fernandez de Gatta, MM | 1 |
| Tamayo, M | 1 |
| Garcia, MJ | 1 |
| Montojo, C | 1 |
| Ramón Gutierrez, J | 1 |
| Rey, F | 1 |
| Domínguez-Gil, A | 1 |
| Harmon, JR | 1 |
| Webb, PJ | 1 |
| Kimmel, GL | 1 |
| Delongchamp, RR | 1 |
| Friedman, E | 1 |
| Cooper, T | 1 |
| Yocca, F | 1 |
| Marazziti, D | 1 |
| Giusti, P | 1 |
| Rotondo, A | 1 |
| Placidi, GF | 1 |
| Pacifici, GM | 1 |
| Gross-Isseroff, R | 1 |
| Biegon, A | 1 |
| Alafuzoff, I | 1 |
| Bäckström, IT | 1 |
| Ericson, E | 1 |
| Gottfries, CG | 1 |
| Yamaguchi, M | 1 |
| Rigal, JG | 1 |
| Albin, HC | 1 |
| Duchier, AR | 1 |
| D'Aulnay, JM | 1 |
| Fenelon, JH | 1 |
| Vincon, GA | 1 |
| Demotes-Mainard, FM | 1 |
| Kristensen, CB | 1 |
| Pereira, JL | 1 |
| Lipke, PR | 1 |
| Rosenthal, SH | 1 |
| Imlah, NW | 1 |
| Fahy, PT | 1 |
| Harrington, JA | 1 |
| Mackiewicz, J | 1 |
| Gershon, S | 1 |
6 reviews available for imipramine and Aging
| Article | Year |
|---|---|
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
Nocturnal polyuria in older people: pathophysiology and clinical implications.
Topics: Age Factors; Aged; Aging; Arginine Vasopressin; Atrial Natriuretic Factor; Behavior Therapy; Causali | 2000 |
Historical development of somatic therapies in affective disorders.
Topics: Affective Symptoms; Aging; Antidepressive Agents; Electroconvulsive Therapy; History, 20th Century; | 1979 |
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami | 1975 |
[Aging and drug metabolism: alteration of liver drug metabolizing ability in male rats. Is it functional deterioration or feminization of the liver?].
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Electron Transport; Female; Feminization; | 1991 |
Circadian rhythm of serotonin binding in rat brain.
Topics: Aging; Animals; Behavior, Animal; Binding Sites; Brain; Circadian Rhythm; Imipramine; Rats; Receptor | 1990 |
4 trials available for imipramine and Aging
| Article | Year |
|---|---|
Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Citalopram; Depression; Dose-Response Relatio | 2005 |
Are there any differences in the safety and efficacy of brofaromine and imipramine between non-elderly and elderly patients with major depression?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antidepressive Agents, Tricyclic; Depressive Diso | 1995 |
Acute and subchronic effects of nefazodone and imipramine on highway driving, cognitive functions, and daytime sleepiness in healthy adult and elderly subjects.
Topics: Adult; Aged; Aging; Antidepressive Agents; Automobile Driving; Cognition; Double-Blind Method; Human | 1995 |
Reboxetine versus imipramine in the treatment of elderly patients with depressive disorders: a double-blind randomised trial.
Topics: Aged; Aging; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Bl | 1999 |
46 other studies available for imipramine and Aging
| Article | Year |
|---|---|
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit | 2007 |
[Role of ceramide in reduction of the cardiolipin content in the heart during aging].
Topics: Age Factors; Aging; Animals; Cardiolipins; Ceramides; Diphosphonates; Doxorubicin; Heart; Imidazoles | 2017 |
Acid sphingomyelinase inhibitors, imipramine and zoledronic acid, increase skeletal muscle tissue sensitivity to insulin action at old age.
Topics: Aging; Animals; Ceramides; Diphosphonates; Imidazoles; Imipramine; Insulin; Male; Muscle, Skeletal; | 2018 |
Depression-like behavior is dependent on age in male SAMP8 mice.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Depression; Dis | 2013 |
Effects of inhibitors of key enzymes of sphingolipid metabolism on insulin-induced glucose uptake and glycogen synthesis in liver cells of old rats.
Topics: Aging; Aniline Compounds; Animals; Benzylidene Compounds; Ceramides; Fatty Acids, Monounsaturated; F | 2015 |
Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Fluoxetine; Hindlimb Suspension; | 2009 |
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.
Topics: Aging; Amitriptyline; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Glyc | 2011 |
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.
Topics: Aging; Anhedonia; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depressive D | 2012 |
[Correction of age-related changes in sphingolipid content in rat tissues by acid sphingomyelinase inhibition].
Topics: Aging; Animals; Ceramides; Enzyme Inhibitors; Hippocampus; Imipramine; Liver; Male; Myocardium; Rats | 2012 |
Use of imipramine (Tofranil) in psychiatric patients of a geriatric outpatient clinic.
Topics: Aged; Aged, 80 and over; Aging; Ambulatory Care Facilities; Dementia; Humans; Imipramine; Mental Dis | 1960 |
[Treatment of selected geriatric patients with imipramine (Tofranil)].
Topics: Aged; Aged, 80 and over; Aging; Bipolar Disorder; Dementia; Geriatrics; Imipramine; Mental Disorders | 1962 |
[ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)].
Topics: Aging; Antidepressive Agents; Bipolar Disorder; Body Constitution; Desipramine; Humans; Imipramine; | 1963 |
[Contribution to the study of the treatment of depressive forms in senility with a new iminodibenzilic derivative].
Topics: Aging; Dementia; Imipramine; Mental Disorders; Psychotic Disorders | 1961 |
Stimulatory effect of antidepressants on the production of IL-6.
Topics: 5-Hydroxytryptophan; Adult; Age Factors; Aging; Antidepressive Agents; Blood Cells; Cyclohexanols; D | 2004 |
Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
Topics: Aging; Animals; Carrier Proteins; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Preoptic | 1984 |
Age effects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding.
Topics: Adult; Aged; Aging; Humans; Imipramine; Immunodiffusion; Middle Aged; Orosomucoid; Protein Binding | 1984 |
Ontogenetic study of [3H]imipramine binding sites and serotonin uptake system: indication of possible interdependence.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Brain; Imipramine; Kinetics; Nerve Endings; Rats; R | 1982 |
Specific 3H-imipramine binding in human platelets. Influence of age and sex.
Topics: Adolescent; Adult; Aged; Aging; Binding Sites; Blood Platelets; Female; Humans; Imipramine; Kinetics | 1980 |
Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine.
Topics: Aging; Animals; Brain; Imipramine; Male; Paroxetine; Rats; Rats, Inbred F344; Tacrine; Tritium | 1993 |
Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Brain Mapping; Carrier Proteins; | 1997 |
Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport.
Topics: Adult; Aged; Aging; Antidepressive Agents, Tricyclic; Biological Transport; Blood Platelets; Depress | 1997 |
[D-cycloserine is active in the adult mouse and inactive in the aged mouse, in the forced swim test].
Topics: Aging; Animals; Avoidance Learning; Cycloserine; GABA Agonists; gamma-Aminobutyric Acid; Imipramine; | 1998 |
Effect of psychotropic drugs on taste responses in young and elderly persons.
Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; M | 1998 |
[Effect of amantadine or 3-cyclopentyl adamantanamine on the immobility of adult or aged mice, in the forced swim test].
Topics: Adamantane; Aging; Amantadine; Animals; Antiparkinson Agents; Brain; Imipramine; Male; Mice; Mice, I | 2000 |
Enuresis. A brief survey of current thinking with respect to pathogenesis and management.
Topics: Adolescent; Aging; Child; Child, Preschool; Conditioning, Psychological; Developmental Disabilities; | 1977 |
Clinical utility of tricyclic antidepressant blood levels: a case report.
Topics: Aged; Aging; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Phenoth | 1979 |
Serotonergic ligand binding in aging brain of experimental animals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Animals; Brain; Cell Membrane; Cerebel | 1991 |
Elevated density of [3H]imipramine binding in aged human brain.
Topics: Adolescent; Adult; Aged; Aging; Autopsy; Binding Sites; Brain; Carrier Proteins; Chlorides; Humans; | 1985 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami | 1988 |
The asymmetry of 3H-imipramine binding may predict psychiatric illness.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alcoholism; Biomarkers; Brain; Carrier Proteins; | 1989 |
Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Female; Imipramine; Immunologic Techniques | 1989 |
Predictive techniques applied to imipramine therapeutic drug monitoring.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Desipramine; False Positive Reactions; Female; Hu | 1989 |
Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain.
Topics: Aging; Animals; Body Weight; Brain; Dihydroalprenolol; Eflornithine; Female; Heart; Imipramine; Litt | 1986 |
The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats.
Topics: Aging; Animals; Brain; Desipramine; Dihydroalprenolol; Imipramine; Indoles; Male; Pineal Gland; Rats | 1986 |
Imipramine receptors in human platelets: effect of age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Platelets; Carrier Proteins; Female; Humans; Imipramine | 1987 |
Parallel pathway interactions in imipramine metabolism in rats.
Topics: Aging; Animals; Female; Imipramine; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Inbred | 1988 |
Autoradiographic analysis of [3H]imipramine binding in the human brain postmortem: effects of age and alcohol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Autoradiography; Binding Sites; Brain; Ethanol; H | 1988 |
5-Hydroxytryptamine-sensitive [3H]imipramine binding of protein nature in the human brain. II. Effect of normal aging and dementia disorders.
Topics: Aged; Aging; Alzheimer Disease; Brain; Dementia; Humans; Imipramine; Middle Aged; Nerve Tissue Prote | 1987 |
A new experimental animal for the study of age-related changes in serotonergic neuronal activity in the brain cortex.
Topics: Aging; Animals; Calcium; Cerebral Cortex; Imipramine; Models, Neurological; Rats; Serotonin; Shrews; | 1987 |
Imipramine blood levels and clinical outcome.
Topics: Adult; Aged; Aging; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; | 1987 |
Pharmacokinetics of imipramine are affected by age and sex in rats.
Topics: Aging; Animals; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Male; Preoptic Area; Rats; | 1986 |
Plasma protein binding of imipramine in patients with rheumatoid arthritis.
Topics: Aging; Arthritis, Rheumatoid; Blood Proteins; Humans; Imipramine; Protein Binding | 1985 |
[Treatment of depressive status of senile involution. Use of monochloro-imipramine].
Topics: Adjustment Disorders; Aged; Aging; Chlorides; Female; Humans; Imipramine; Middle Aged | 1969 |
Recognition of depression.
Topics: Aged; Aging; Amitriptyline; Brain Damage, Chronic; Depression; Humans; Imipramine; Social Isolation; | 1968 |
A comparison of two antidepressant drugs.
Topics: Adult; Aging; Depression; Female; Humans; Imipramine; Male; Middle Aged; Phenelzine; Sex | 1964 |
An experimental study of the neuropathological effects of imipramine in animals of different ages.
Topics: Aging; Animals; Brain; Cerebellum; Female; Guinea Pigs; Heart; Imipramine; In Vitro Techniques; Kidn | 1965 |