imipramine has been researched along with Adverse Drug Event in 16 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present the case of a 35-year-old woman who developed serotonin syndrome after receiving a single dose of the cyclic antidepressant imipramine (Tofranil)." | 3.69 | Serotonin syndrome: case report and review of the literature. ( McKay, CA; Tilden, FF; Weiner, AL, 1997) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Since pulmonary fibrosis is a recognized, if rare, complication of certain drug exposures, including antidepressants, betablockers, antibiotics, anticonvulsants, and nonsteroidal antiinflammatory drugs (NSAIDs), we tested the hypothesis that exposure to these drugs might contribute to the etiology of cryptogenic fibrosing alveolitis." | 1.30 | Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study. ( Britton, J; Cooper, M; Hubbard, R; Johnston, I; Smith, C; Venn, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Shephard, EA | 1 |
| Phillips, IR | 1 |
| ENGLISH, HL | 1 |
| DOMINIKOVICH, EG | 1 |
| LONGMIRE, WT | 1 |
| DAVIS, HK | 1 |
| LEON, CA | 1 |
| Weiner, AL | 1 |
| Tilden, FF | 1 |
| McKay, CA | 1 |
| Hubbard, R | 1 |
| Venn, A | 1 |
| Smith, C | 1 |
| Cooper, M | 1 |
| Johnston, I | 1 |
| Britton, J | 1 |
| Wilson, JG | 1 |
| Fossati, C | 1 |
| Hall, P | 1 |
| Hall, NA | 1 |
3 reviews available for imipramine and Adverse Drug Event
| Article | Year |
|---|---|
The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Genetic Va | 2010 |
Present status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; | 1973 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Re | 1974 |
13 other studies available for imipramine and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
An alarming side-effect of tofranil.
Topics: Drug-Related Side Effects and Adverse Reactions; Equipment Failure; Humans; Iatrogenic Disease; Imip | 1959 |
Drug toxicity.
Topics: Drug-Related Side Effects and Adverse Reactions; Imipramine; Promethazine; Quinine | 1962 |
ACUTE IMIPRAMINE INTOXICATION.
Topics: Drug-Related Side Effects and Adverse Reactions; Imipramine; Poisoning; Psychoses, Substance-Induced | 1963 |
A non-reported side effect of imipramine.
Topics: Drug-Related Side Effects and Adverse Reactions; Imipramine | 1961 |
Serotonin syndrome: case report and review of the literature.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Synergism; Drug-Related Side Effe | 1997 |
Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1998 |
Differential diagnosis and treatment of depression in the elderly.
Topics: Adjustment Disorders; Aged; Antidepressive Agents; Circadian Rhythm; Dementia; Depression; Diagnosis | 1974 |
The other edge.
Topics: Aged; Aspirin; Atropine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Imipramine | 1970 |