imipramine has been researched along with Acute Liver Injury, Drug-Induced in 26 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present two cases of myocarditis and hepatitis with histologic characteristics of hypersensitivity-mediated drug reactions associated with imipramine and its metabolite, desipramine." | 7.67 | Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. ( Bonadies, J; Hardin, NJ; Morrow, PL, 1989) |
| "We present two cases of myocarditis and hepatitis with histologic characteristics of hypersensitivity-mediated drug reactions associated with imipramine and its metabolite, desipramine." | 3.67 | Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine. ( Bonadies, J; Hardin, NJ; Morrow, PL, 1989) |
| "Imipramine treatment hit 13 disease clusters: tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, precipitation of congestive heart failure; urinary retention, altered liver functions." | 1.38 | Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine. ( Freischmidt, A; Heilmann, J; Kelber, O; Koptina, A; Müller, J; Sadeghlar, F; Ulrich-Merzenich, G; Wagner, H; Zeitler, H, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " This case suggests that single daily dosing of tricyclic antidepressants may be more hazardous to the liver than divided doses." | 1.26 | Toxic hepatitis and single daily dosage imipramine therapy. ( DeVane, CL; Harris, R; Moskovitz, R; Stewart, RB, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (65.38) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Saito, K | 1 |
| Maekawa, K | 1 |
| Ishikawa, M | 1 |
| Senoo, Y | 1 |
| Urata, M | 1 |
| Murayama, M | 1 |
| Nakatsu, N | 1 |
| Yamada, H | 1 |
| Saito, Y | 1 |
| Ulrich-Merzenich, G | 1 |
| Koptina, A | 1 |
| Kelber, O | 1 |
| Freischmidt, A | 1 |
| Heilmann, J | 1 |
| Müller, J | 1 |
| Sadeghlar, F | 1 |
| Zeitler, H | 1 |
| Wagner, H | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| STROTHERS, G | 1 |
| WOROBEC, T | 1 |
| Kramp, JL | 1 |
| Hackett, AM | 1 |
| Shaw, IC | 1 |
| Griffiths, LA | 1 |
| Moskovitz, R | 1 |
| DeVane, CL | 1 |
| Harris, R | 1 |
| Stewart, RB | 1 |
| Weaver, GA | 1 |
| Pavlinac, D | 1 |
| Davis, JS | 1 |
| Bui, HD | 1 |
| Chaney, RH | 1 |
| Morrow, PL | 1 |
| Hardin, NJ | 1 |
| Bonadies, J | 1 |
| Fernández, G | 1 |
| Villarruel, MC | 1 |
| de Ferreyra, EC | 1 |
| de Fenos, OM | 1 |
| Castro, JA | 2 |
| Powell, WJ | 1 |
| Koch-Weser, J | 1 |
| Williams, RA | 1 |
| Lajeunesse, BS | 1 |
| Piéron, R | 1 |
| Marien, C | 1 |
| Jagueux, M | 1 |
| Fossati, C | 1 |
| Wrights, N | 1 |
| Prescott, LF | 1 |
| Cignoli, EV | 1 |
| Short, MH | 1 |
| Burns, JM | 1 |
| Harris, ME | 1 |
3 reviews available for imipramine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Re | 1974 |
23 other studies available for imipramine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp | 2014 |
Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzyl Alcohols; Chemical and Drug Induced Liver Injury; | 2012 |
JAUNDICE AND ITS RELATION TO THERAPEUTIC AGENTS.
Topics: Aluminum; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Hepatitis; Hydroxides; Imipramin | 1965 |
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In | 1965 |
Glutamic pyruvic acid transaminases during treatment with amitriptyline and imipramine.
Topics: Aged; Alanine Transaminase; Amitriptyline; Chemical and Drug Induced Liver Injury; Female; Humans; I | 1967 |
The metabolism and excretion of [14C]imipramine in an experimental hepatitis.
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Galactosamine; Hepatitis, Animal; Imipramine; | 1984 |
Toxic hepatitis and single daily dosage imipramine therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Depressive Disorder; Drug Administration Schedule; Dr | 1982 |
Hepatic sensitivity to imipramine.
Topics: Adult; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Liver | 1977 |
Transient hepatitis due to low dose neuroleptic medication.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans; Imipramine; Male; Ne | 1989 |
Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Desipramine; Drug Hypersensitivity; Female; Humans; Im | 1989 |
Imipramine prevention of carbon tetrachloride-induced liver necrosis at late states of the intoxication process.
Topics: Animals; Body Temperature; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1986 |
Lethal hepatic necrosis after therapy with imipramine and desipramine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Desipramine; Drug Hypersensit | 1968 |
[True and false adverse effects of thymoanaleptic medications].
Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio | 1968 |
[Jaundice and rifampicin].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Isoniazid; Jaundice; Liver | 1971 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
Cholestatic jaundice during imipramine therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Imipramine; Jaundice; Liver; Phenothia | 1968 |