imidocarb-dipropionate and Hematologic-Diseases

Bobcats (Lynx rufus) are the reservoir hosts for Cytauxzoon felis, the causative agent of cytauxzoonosis. Cytauxzoonosis is a highly fatal tickborne blood protozoal disease of domestic and exotic cats. Treatment of clinically affected cats has generally been unrewarding. In our report, 6 of 7 cats had signs of illness and laboratory findings indicative of cytauxzoonosis and were successfully treated with 2 i.m. injections of diminazene aceturate or imidocarb dipropionate (2 mg/kg [0.9 mg/lb] of body weight, each). One cat died after the first injection of diminazene. Additional treatment with isotonic fluids i.v. and heparin s.c. were used as supportive care for dehydration and disseminated intravascular coagulation that were detected by laboratory testing between diminazene or imidocarb treatments. Atropine was effective in recovery and preventing adverse reactions associated with imidocarb treatment of 1 cat.

Topics: Animals; Antiprotozoal Agents; Blood; Blood Transfusion; Body Temperature; Cat Diseases; Cats; Diminazene; Erythrocyte Count; Hematocrit; Hematologic Diseases; Heparin; Imidocarb; Injections, Intramuscular; Isotonic Solutions; Leukocyte Count; Male; Piroplasmida; Protozoan Infections; Protozoan Infections, Animal; Urinalysis