imidazolone has been researched along with Neoplasms* in 2 studies
2 other study(ies) available for imidazolone and Neoplasms
| Article | Year |
|---|---|
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.
In the presented work, we report the synthesis of a series of 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides 7a-fvia the Erlenmeyer-Plöchl reaction. All the prepared imidazolones 7a-f were evaluated as inhibitors of human (h) carbonic anhydrases (CA, EC 4.2.1.1) cytosolic isoforms hCA I and II, as well as transmembrane tumor-associated isoforms hCA IX and XII. All the tested hCA isoforms were inhibited by the prepared imidazolones 7a-f in variable degrees with the following K Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Cell Proliferation; HCT116 Cells; Humans; Imidazoles; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Neoplasms; Structure-Activity Relationship; Sulfonamides | 2019 |
Synthesis and anti-cancer activity of chalcone linked imidazolones.
A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and 8) showed good anti-cancer activity with GI(50) values ranging from 1.26 to 13.9 microM. When breast carcinoma cells (MCF-7) were treated with 10 microM concentration of compounds TMAC, CA-4, 6 and 8 cell cycle arrest was observed in G2/M phase. Surprisingly, the increased concentration of the same compound to 30 microM caused accumulation of cells in G0/G1 phase of the cell cycle. Topics: Antineoplastic Agents; Cell Line, Tumor; Chalcone; Drug Screening Assays, Antitumor; Humans; Imidazoles; Neoplasms | 2010 |