imidazole has been researched along with Melanoma in 8 studies
imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we determined whether or not imidazole affects B16 murine melanoma cell migration to prevent melanoma metastasis." | 7.76 | Imidazole inhibits B16 melanoma cell migration via degradation of beta-catenin. ( Baek, KJ; Jeong, YM; Kim, DS; Kim, SY; Kwon, NS; Li, H; Yun, HY, 2010) |
| "1) by imidazole was determined in cultured B16/C3 melanoma cells." | 7.67 | Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine. ( Kline, EL; Smith, TJ; Warren, JT, 1989) |
| "Investigations with mouse melanoma B16/C3 cell cultures have suggested that imidazole or a derivative thereof can facilitate expression of the tyrosinase (EC 1." | 7.67 | Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells. ( Carland, K; Kline, EL; Smith, TJ, 1986) |
| "3,3',5-L-triiodothyronine (T3) can inhibit tyrosinase activity in B16/C3 melanoma cells in culture and block the induction of that enzyme by imidazole (Endocrinol." | 7.67 | 3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells. ( Kline, EL; Smith, TJ, 1988) |
| "In the present study, we determined whether or not imidazole affects B16 murine melanoma cell migration to prevent melanoma metastasis." | 3.76 | Imidazole inhibits B16 melanoma cell migration via degradation of beta-catenin. ( Baek, KJ; Jeong, YM; Kim, DS; Kim, SY; Kwon, NS; Li, H; Yun, HY, 2010) |
| "1) by imidazole was determined in cultured B16/C3 melanoma cells." | 3.67 | Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine. ( Kline, EL; Smith, TJ; Warren, JT, 1989) |
| "Investigations with mouse melanoma B16/C3 cell cultures have suggested that imidazole or a derivative thereof can facilitate expression of the tyrosinase (EC 1." | 3.67 | Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells. ( Carland, K; Kline, EL; Smith, TJ, 1986) |
| "3,3',5-L-triiodothyronine (T3) can inhibit tyrosinase activity in B16/C3 melanoma cells in culture and block the induction of that enzyme by imidazole (Endocrinol." | 3.67 | 3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells. ( Kline, EL; Smith, TJ, 1988) |
| "1) activity of cell-free extracts (TyH) of B16 melanoma cells cultured in the presence of 5 to 10 mM ammonium chloride was considerably higher than that of cells from control cultures." | 3.66 | Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents. ( Oikawa, A; Saeki, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, TY | 1 |
| Huang, Q | 1 |
| Huang, ZS | 1 |
| Hu, MH | 1 |
| Tan, JH | 1 |
| Deleuze-Masquefa, C | 1 |
| Moarbess, G | 1 |
| Khier, S | 1 |
| David, N | 1 |
| Gayraud-Paniagua, S | 1 |
| Bressolle, F | 1 |
| Pinguet, F | 1 |
| Bonnet, PA | 1 |
| Jeong, YM | 1 |
| Li, H | 1 |
| Kim, SY | 1 |
| Yun, HY | 1 |
| Baek, KJ | 1 |
| Kwon, NS | 1 |
| Kim, DS | 1 |
| Niculescu-Duvaz, D | 1 |
| Niculescu-Duvaz, I | 1 |
| Suijkerbuijk, BM | 1 |
| Ménard, D | 1 |
| Zambon, A | 1 |
| Davies, L | 1 |
| Pons, JF | 1 |
| Whittaker, S | 1 |
| Marais, R | 1 |
| Springer, CJ | 1 |
| Saeki, H | 1 |
| Oikawa, A | 1 |
| Smith, TJ | 3 |
| Warren, JT | 1 |
| Kline, EL | 3 |
| Carland, K | 1 |
8 other studies available for imidazole and Melanoma
| Article | Year |
|---|---|
A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Cycle Checkpoints; Cell Proliferatio | 2020 |
New imidazo[1,2-a]quinoxaline derivatives: synthesis and in vitro activity against human melanoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Human | 2009 |
Imidazole inhibits B16 melanoma cell migration via degradation of beta-catenin.
Topics: Animals; Antineoplastic Agents; beta Catenin; Blotting, Western; Cell Line, Tumor; Cell Movement; Im | 2010 |
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Topics: Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Imidazoles; Melanoma; Naphthols; Protein Kinas | 2013 |
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Topics: Ammonium Chloride; Animals; Catechol Oxidase; Cell Line; Chloroquine; Cycloheximide; Ethylamines; Hy | 1983 |
Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine.
Topics: Animals; Catechol Oxidase; Cell Line; Enzyme Induction; Imidazoles; Melanoma; Mice; Monophenol Monoo | 1989 |
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Topics: Animals; Catechol Oxidase; Cell Division; Cell Line; Dactinomycin; Dose-Response Relationship, Drug; | 1986 |
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
Topics: Animals; Catechol Oxidase; Cells, Cultured; Enzyme Induction; Imidazoles; Melanoma; Mice; Monophenol | 1988 |