imidazole has been researched along with Leukemia in 2 studies
imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The imidazole N3 position was then methylated with methyl iodine, whereupon the synthesis was terminated by complexation of the imidazolium salt with silver(I) oxide." | 5.42 | 4-Alkylated Silver-N-Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells. ( Bedringaas, SL; Bjørsvik, HR; Gjertsen, BT; Leitch, C; Sandtorv, AH, 2015) |
| " Our previous study reported that nitroxoline, an FDA approved antibiotic, showed potential BRD4 inhibitory activity and antiproliferation activity against leukemia cell lines." | 3.91 | Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors. ( Chen, K; Hu, T; Jiang, H; Jiang, X; Luo, C; Luo, X; Qiao, G; Shen, J; Wang, J; Wang, X; Xing, J; Yang, F; Zhang, R; Zheng, M, 2019) |
| "The imidazole N3 position was then methylated with methyl iodine, whereupon the synthesis was terminated by complexation of the imidazolium salt with silver(I) oxide." | 1.42 | 4-Alkylated Silver-N-Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells. ( Bedringaas, SL; Bjørsvik, HR; Gjertsen, BT; Leitch, C; Sandtorv, AH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, J | 1 |
| Zhang, R | 1 |
| Jiang, X | 1 |
| Hu, T | 1 |
| Wang, X | 1 |
| Qiao, G | 1 |
| Wang, J | 1 |
| Yang, F | 1 |
| Luo, X | 1 |
| Chen, K | 1 |
| Shen, J | 1 |
| Luo, C | 1 |
| Jiang, H | 1 |
| Zheng, M | 1 |
| Sandtorv, AH | 1 |
| Leitch, C | 1 |
| Bedringaas, SL | 1 |
| Gjertsen, BT | 1 |
| Bjørsvik, HR | 1 |
2 other studies available for imidazole and Leukemia
| Article | Year |
|---|---|
Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Computer-Aided Design; Drug Design; Human | 2019 |
4-Alkylated Silver-N-Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Screening Assays, Ant | 2015 |