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imidazole and Creutzfeldt-Jakob Syndrome

imidazole has been researched along with Creutzfeldt-Jakob Syndrome in 1 studies

imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.

Creutzfeldt-Jakob Syndrome: A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))

Research Excerpts

ExcerptRelevanceReference
" Long-term administration of copper significantly accelerated the onset and progression of spontaneous prion disease in TgMHu2ME199K mice and caused marked irritability and cerebellar associated tip-toe walking in PrP(0/0) mice, while wt mice were not affected."1.38Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease. ( Binyamin, O; Canello, T; Cohen, E; Frid, K; Friedman-Levi, Y; Gabizon, R; Mizrahi, M, 2012)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Canello, T1
Friedman-Levi, Y1
Mizrahi, M1
Binyamin, O1
Cohen, E1
Frid, K1
Gabizon, R1

Other Studies

1 other study available for imidazole and Creutzfeldt-Jakob Syndrome

ArticleYear
Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease.
    Neurobiology of disease, 2012, Volume: 45, Issue:3

    Topics: Age Factors; Animals; Cells, Cultured; Cerebellum; Chromatography, Affinity; Copper; Copper Sulfate;

2012
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