imidazole has been researched along with Benign Neoplasms in 34 studies
imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A homotypic cancer cell membrane camouflaged zeolitic imidazolate framework (ZIF)-based nanoagent with co-loading of two inhibitors was developed, which could suppress the efflux of protons to induce intracellular acidic stress and down-regulate glutamine metabolism to reduce the energy supply." | 1.72 | A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer. ( Li, N; Lu, F; Pan, W; Tang, B; Wang, M, 2022) |
| "Recent cancer immunotherapy has attracted much attention due to high specificity and recurrence prevention of tumor." | 1.56 | pH-Sensitive Carbon Dots for Enhancing Photomediated Antitumor Immunity. ( Kim, DH; Na, K; Seo, J, 2020) |
| "Imidazole groups were present on pSCD surfaces and facilitated DOX loading via hydrophobic interactions (loading efficiency: 78." | 1.51 | Nonpolymeric pH-Sensitive Carbon Dots for Treatment of Tumor. ( Bae, SK; Lee, CB; Lee, J; Na, K; Seo, J, 2019) |
| "The anticancer activities of the complexes have been carried out towards HeLa and HCT116 cancer cells." | 1.40 | Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine. ( Arish, D; Joseph, J; Justin Dhanaraj, C; Selwin Joseyphus, R; Shiju, C, 2014) |
| "Compound 3 h showed potent anticancer efficacy against 60 human cancer cell lines, with a mean GI50 value of 0." | 1.38 | 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization. ( Addlagatta, A; Kamal, A; Kishor, C; Pal-Bhadra, M; Pushpavalli, SN; Ramaiah, MJ; Sharma, P; Srikanth, YV; Sultana, F; Viswanath, A, 2012) |
| " Lead optimization efforts which included the optimization of structure-activity relationships and drug metabolism and pharmacokinetic properties led to the identification of compound 9m, a potent, selective and orally bioavailable inhibitor of IGF-1R with in vivo efficacy in an IGF-driven mouse xenograft model." | 1.37 | Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy. ( Bittner, MA; Cooke, A; Dong, H; Foreman, K; Gokhale, PC; Ji, Q; Jin, M; Kleinberg, A; Landfair, D; Mak, G; Mulvihill, KM; Mulvihill, MJ; O'Connor, M; Pachter, JA; Rosenfeld-Franklin, M; Siu, KW; Wild, R; Yao, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 17 (50.00) | 24.3611 |
| 2020's | 6 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, M | 1 |
| Lu, F | 2 |
| Li, N | 2 |
| Pan, W | 2 |
| Tang, B | 2 |
| Huo, T | 1 |
| Nie, H | 1 |
| Li, W | 1 |
| Lin, C | 1 |
| Akhtar, M | 1 |
| Huang, R | 1 |
| Gao, L | 1 |
| Chen, Q | 1 |
| Gong, T | 1 |
| Liu, J | 1 |
| Li, C | 1 |
| Kim, DH | 1 |
| Seo, J | 2 |
| Na, K | 2 |
| Bernd, MA | 1 |
| Bauer, EB | 1 |
| Oberkofler, J | 1 |
| Bauer, A | 1 |
| Reich, RM | 1 |
| Kühn, FE | 1 |
| Koshikawa, N | 1 |
| Yasui, N | 1 |
| Kida, Y | 1 |
| Shinozaki, Y | 1 |
| Tsuji, K | 1 |
| Watanabe, T | 1 |
| Takenaga, K | 1 |
| Nagase, H | 1 |
| Cui, B | 1 |
| Wang, K | 2 |
| Shi, M | 1 |
| Li, X | 2 |
| Gao, M | 1 |
| Xin, K | 1 |
| Zhang, L | 1 |
| Ding, D | 1 |
| Kong, D | 1 |
| Wang, Z | 1 |
| Shi, Y | 1 |
| Kiessling, F | 1 |
| Lammers, T | 1 |
| Cheng, J | 1 |
| Zhao, Y | 1 |
| Hadian Rasanani, S | 1 |
| Eslami Moghadam, M | 1 |
| Soleimani, E | 1 |
| Divsalar, A | 1 |
| Ajloo, D | 1 |
| Tarlani, A | 1 |
| Amiri, M | 1 |
| Liu, K | 1 |
| Fang, L | 1 |
| Sun, H | 1 |
| Pan, Z | 1 |
| Zhang, J | 3 |
| Chen, J | 2 |
| Shao, X | 1 |
| Wang, W | 1 |
| Tan, Y | 1 |
| Ding, Z | 1 |
| Ao, L | 1 |
| Wu, C | 1 |
| Liu, X | 1 |
| Li, H | 3 |
| Wang, R | 1 |
| Su, W | 1 |
| Xu, D | 1 |
| You, Y | 1 |
| Zeng, F | 1 |
| Wang, Y | 2 |
| Liang, C | 1 |
| Feng, H | 1 |
| Ma, X | 1 |
| Akher, FB | 1 |
| Farrokhzadeh, A | 1 |
| Soliman, MES | 1 |
| Lee, J | 1 |
| Lee, CB | 1 |
| Bae, SK | 1 |
| Lin, CW | 1 |
| Tseng, SJ | 1 |
| Kempson, IM | 1 |
| Yang, SC | 1 |
| Hong, TM | 1 |
| Yang, PC | 1 |
| Gonçalves, AC | 1 |
| Morais, TS | 1 |
| Robalo, MP | 1 |
| Marques, F | 1 |
| Avecilla, F | 1 |
| Matos, CP | 1 |
| Santos, I | 1 |
| Tomaz, AI | 1 |
| Garcia, MH | 1 |
| Hiramoto, K | 1 |
| Satoh, H | 1 |
| Suzuki, T | 1 |
| Moriguchi, T | 1 |
| Pi, J | 1 |
| Shimosegawa, T | 1 |
| Yamamoto, M | 1 |
| Selwin Joseyphus, R | 1 |
| Shiju, C | 1 |
| Joseph, J | 1 |
| Justin Dhanaraj, C | 1 |
| Arish, D | 1 |
| Liu, Z | 1 |
| Zhao, S | 1 |
| Wu, Y | 1 |
| Zeng, S | 1 |
| Shalmali, N | 1 |
| Ali, MR | 1 |
| Bawa, S | 1 |
| Minoshima, M | 2 |
| Bando, T | 2 |
| Shinohara, K | 2 |
| Kashiwazaki, G | 1 |
| Nishijima, S | 1 |
| Sugiyama, H | 2 |
| Jin, M | 1 |
| Kleinberg, A | 1 |
| Cooke, A | 1 |
| Gokhale, PC | 1 |
| Foreman, K | 1 |
| Dong, H | 1 |
| Siu, KW | 1 |
| Bittner, MA | 1 |
| Mulvihill, KM | 1 |
| Yao, Y | 1 |
| Landfair, D | 1 |
| O'Connor, M | 1 |
| Mak, G | 1 |
| Pachter, JA | 1 |
| Wild, R | 1 |
| Rosenfeld-Franklin, M | 1 |
| Ji, Q | 1 |
| Mulvihill, MJ | 1 |
| Kamal, A | 1 |
| Sultana, F | 1 |
| Ramaiah, MJ | 1 |
| Srikanth, YV | 1 |
| Viswanath, A | 1 |
| Kishor, C | 1 |
| Sharma, P | 1 |
| Pushpavalli, SN | 1 |
| Addlagatta, A | 1 |
| Pal-Bhadra, M | 1 |
| Wang, S | 1 |
| Chen, C | 1 |
| Li, S | 1 |
| Qin, X | 1 |
| GORIUKHINA, TA | 1 |
| CHAMPY-HATEM, S | 1 |
| HATEM-CHAMPY, S | 1 |
| Ranchere, JY | 1 |
| Poulain, P | 1 |
| Gestin, Y | 1 |
| Petot, P | 1 |
| Beaucaire, J | 1 |
| Bellanger, JM | 1 |
| Laroye, B | 1 |
| Piombini, JL | 1 |
| Alvarez-Pérez, J | 1 |
| Ballesteros, P | 1 |
| Cerdán, S | 1 |
| Ohkanda, J | 1 |
| Strickland, CL | 1 |
| Blaskovich, MA | 1 |
| Carrico, D | 1 |
| Lockman, JW | 1 |
| Vogt, A | 1 |
| Bucher, CJ | 1 |
| Sun, J | 1 |
| Qian, Y | 1 |
| Knowles, D | 1 |
| Pusateri, EE | 1 |
| Sebti, SM | 1 |
| Hamilton, AD | 1 |
| Sasaki, S | 1 |
| Sakakibara, Y | 1 |
| Souza, GR | 1 |
| Levin, CS | 1 |
| Hajitou, A | 1 |
| Pasqualini, R | 1 |
| Arap, W | 1 |
| Miller, JH | 1 |
| Gloster, TM | 1 |
| Roberts, S | 1 |
| Perugino, G | 1 |
| Rossi, M | 1 |
| Moracci, M | 1 |
| Panday, N | 1 |
| Terinek, M | 1 |
| Vasella, A | 1 |
| Davies, GJ | 1 |
| Xue, N | 1 |
| Yang, X | 1 |
| Wu, R | 1 |
| He, Q | 1 |
| Yang, B | 1 |
| Lu, X | 1 |
| Hu, Y | 1 |
| Botha, JH | 1 |
| Robinson, KM | 1 |
| Leary, WP | 1 |
2 reviews available for imidazole and Benign Neoplasms
| Article | Year |
|---|---|
Recent advancement of imidazolate framework (ZIF-8) based nanoformulations for synergistic tumor therapy.
Topics: Antineoplastic Agents; Delayed-Action Preparations; Drug Carriers; Humans; Imidazoles; Nanocomposite | 2019 |
Imidazole: An Essential Edifice for the Identification of New Lead Compounds and Drug Development.
Topics: Anthelmintics; Antimalarials; Antineoplastic Agents; Drug Design; Helminthiasis; Humans; Imidazoles; | 2018 |
32 other studies available for imidazole and Benign Neoplasms
| Article | Year |
|---|---|
A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer.
Topics: Animals; Biomimetic Materials; Cell Survival; Enzyme Inhibitors; Glutamine; Humans; Imidazoles; Lact | 2022 |
Mitochondrial Dysfunction and Antioxidation Dyshomeostasis-Enhanced Tumor Starvation Synergistic Chemotherapy Achieved using a Metal-Organic Framework-Based Nano-Enzyme Reactor.
Topics: Antibiotics, Antineoplastic; Antioxidants; Biocompatible Materials; Doxorubicin; Glucose Oxidase; Ho | 2022 |
pH-Sensitive Carbon Dots for Enhancing Photomediated Antitumor Immunity.
Topics: Animals; Calreticulin; Carbon; Cell Death; Cell Line, Tumor; Chlorophyllides; Dendritic Cells; Hydro | 2020 |
Macrocyclic NHC complexes of group 10 elements with enlarged aromaticity for biological studies.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cisplatin; Coordination Complexe | 2020 |
A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.
Topics: Cell Survival; DNA, Mitochondrial; HeLa Cells; Humans; Imidazoles; Mitochondria; Mitophagy; Mutation | 2021 |
ATP-triggered mitochondrial cascade reactions for cancer therapy with nanoscale zeolitic imidazole framework-90.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; C | 2021 |
Singlet oxygen-responsive micelles for enhanced photodynamic therapy.
Topics: Animals; Cell Line, Tumor; Chlorophyllides; Drug Carriers; Drug Liberation; Female; Imidazoles; Ligh | 2017 |
Anticancer activity of new imidazole derivative of 1R,2R-diaminocyclohexane palladium and platinum complexes as DNA fluorescent probes.
Topics: Antineoplastic Agents; Circular Dichroism; Cisplatin; Coordination Complexes; Cyclohexanes; DNA; DNA | 2018 |
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferatio | 2018 |
Disassembly of Hydrophobic Photosensitizer by Biodegradable Zeolitic Imidazolate Framework-8 for Photodynamic Cancer Therapy.
Topics: Cell Line, Tumor; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Neoplasms; | 2018 |
Noteworthy effect of slight variation in aliphatic chain length of trisubstituted imidazole inhibitors against epidermal growth factor receptor L858R/T790M/C797S mutant in cancer therapy.
Topics: Binding Sites; Catalytic Domain; ErbB Receptors; Humans; Hydrogen Bonding; Imidazoles; Molecular Dyn | 2019 |
Nonpolymeric pH-Sensitive Carbon Dots for Treatment of Tumor.
Topics: Animals; Antibiotics, Antineoplastic; Carbon; Cell Line, Tumor; Delayed-Action Preparations; Doxorub | 2019 |
Extracellular delivery of modified oligonucleotide and superparamagnetic iron oxide nanoparticles from a degradable hydrogel triggered by tumor acidosis.
Topics: Acidosis; Cell Death; Cell Survival; Dextrans; Drug Delivery Systems; Extracellular Space; HeLa Cell | 2013 |
Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclopentanes; Cytotoxins; Humans; Imidazoles; Iron Compoun | 2013 |
Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Lineage; Gene Deletion; Imidazoles; Mice; Mice, Inbred | 2014 |
Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine.
Topics: Ampyrone; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Cell Line, T | 2014 |
Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Bcl-2-Like Protein 11; Caspase 3; Caspase 9; Ce | 2015 |
Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Chlorambucil; DNA; Humans; Imida | 2010 |
Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Imidazoles; Mice; Neoplasms; Protein Kinase Inhibito | 2011 |
3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization.
Topics: Antineoplastic Agents; Benzothiazoles; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Cell | 2012 |
Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA; Glycols; Humans; Imidazoles; Intercalating Agents; Neo | 2012 |
[Fermentative conversion of imidazole lactic acid in normal and tumor-bearing rabbits].
Topics: Animals; Biochemical Phenomena; Imidazoles; Lactic Acid; Neoplasms; Rabbits | 1954 |
[Silver cancer and tissue respiration. Reactivity of the element on imidazole. Extensive research with folic acid].
Topics: Folic Acid; Imidazoles; Metabolism; Neoplasms; Research; Silver; Silver Compounds | 1962 |
[Cancers caused by nickel and by a nickel-imidazole complex].
Topics: Carcinogens; Humans; Imidazoles; Neoplasms; Nickel | 1961 |
Preventive antibiotic therapy in surgical oncologic practice: cefotetan versus cefotaxime + imidazole.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; Cefotaxime; Cefotetan; Controll | 1989 |
Microscopic images of intraspheroidal pH by 1H magnetic resonance chemical shift imaging of pH sensitive indicators.
Topics: Animals; Glioma; Homeostasis; Humans; Hydrogen; Hydrogen-Ion Concentration; Imaging, Three-Dimension | 2005 |
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Topics: Animals; Cell Line; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase | 2006 |
Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker.
Topics: Adenine; Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Cy | 2006 |
In vivo detection of gold-imidazole self-assembly complexes: NIR-SERS signal reporters.
Topics: Animals; Gold; Imidazoles; Mice; Microscopy, Electron, Transmission; Molecular Structure; Neoplasms; | 2006 |
Structural, kinetic, and thermodynamic analysis of glucoimidazole-derived glycosidase inhibitors.
Topics: Archaeal Proteins; Bacterial Proteins; beta-Glucosidase; Enzyme Inhibitors; Glucose; Humans; Imidazo | 2006 |
Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; F | 2008 |
The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis.
Topics: Alprostadil; Aspirin; Cell Division; Cell Line; Cell Survival; gamma-Linolenic Acid; Humans; Imidazo | 1985 |