imidazole has been researched along with Alzheimer Disease in 8 studies
imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The characteristic of Alzheimer's disease (AD) is the accumulation and aggregation of amyloid-β (Aβ)." | 1.48 | Imidazole improves cognition and balances Alzheimer's-like intracellular calcium homeostasis in transgenic Drosophila model. ( He, Q; Li, M; Qin, X; Wang, W; Wu, T; Yin, M; Zhang, T; Zhang, W, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yawson, GK | 1 |
| Huffman, SE | 1 |
| Fisher, SS | 1 |
| Bothwell, PJ | 1 |
| Platt, DC | 1 |
| Jones, MA | 1 |
| Ferrence, GM | 1 |
| Hamaker, CG | 1 |
| Webb, MI | 1 |
| Masuoka, N | 1 |
| Lei, C | 1 |
| Li, H | 1 |
| Hisatsune, T | 1 |
| Li, M | 1 |
| Zhang, W | 1 |
| Wang, W | 1 |
| He, Q | 1 |
| Yin, M | 1 |
| Qin, X | 1 |
| Zhang, T | 1 |
| Wu, T | 1 |
| Xu, YX | 1 |
| Wang, H | 1 |
| Li, XK | 1 |
| Dong, SN | 1 |
| Liu, WW | 1 |
| Gong, Q | 1 |
| Wang, TD | 1 |
| Tang, Y | 1 |
| Zhu, J | 1 |
| Li, J | 1 |
| Zhang, HY | 1 |
| Mao, F | 1 |
| Gurjar, AS | 1 |
| Darekar, MN | 1 |
| Yeong, KY | 1 |
| Ooi, L | 1 |
| Qin, J | 1 |
| Cho, M | 1 |
| Lee, Y | 1 |
| Brodney, MA | 1 |
| Auperin, DD | 1 |
| Becker, SL | 1 |
| Bronk, BS | 1 |
| Brown, TM | 1 |
| Coffman, KJ | 1 |
| Finley, JE | 1 |
| Hicks, CD | 1 |
| Karmilowicz, MJ | 1 |
| Lanz, TA | 1 |
| Liston, D | 1 |
| Liu, X | 1 |
| Martin, BA | 1 |
| Nelson, RB | 1 |
| Nolan, CE | 1 |
| Oborski, CE | 1 |
| Parker, CP | 1 |
| Richter, KE | 1 |
| Pozdnyakov, N | 1 |
| Sahagan, BG | 1 |
| Schachter, JB | 1 |
| Sokolowski, SA | 1 |
| Tate, B | 1 |
| Van Deusen, JW | 1 |
| Wood, DE | 1 |
| Wood, KM | 1 |
| Shin, BK | 1 |
| Saxena, S | 1 |
1 review available for imidazole and Alzheimer Disease
| Article | Year |
|---|---|
Influence of Imidazole-Dipeptides on Cognitive Status and Preservation in Elders: A Narrative Review.
Topics: Aged; Alzheimer Disease; Animals; Anserine; Brain; Carnosine; Cognition; Cognitive Dysfunction; Diet | 2021 |
7 other studies available for imidazole and Alzheimer Disease
| Article | Year |
|---|---|
Ruthenium(III) complexes with imidazole ligands that modulate the aggregation of the amyloid-β peptide via hydrophobic interactions.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coordination Complexes; Humans; Imidazoles; Protein Aggreg | 2021 |
Imidazole improves cognition and balances Alzheimer's-like intracellular calcium homeostasis in transgenic Drosophila model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Brain; Calcium; Co | 2018 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosensing Techniques; Electrochemical Techniques; Ferrous | 2019 |
Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; | 2011 |
Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Binding Sites; Copper; Electron Spin | 2011 |