imidapril has been researched along with Sclerosis* in 1 studies
1 other study(ies) available for imidapril and Sclerosis
| Article | Year |
|---|---|
Imidapril inhibits increased transforming growth factor-beta1 expression in remnant kidney model.
To elucidate the effect of imidapril, an angiotensin-converting enzyme inhibitor, on molecular events in progressive glomerulosclerosis, we administered imidapril to 5/6 nephrectomized rats and measured the glomerular expression of genes for transforming growth factor (TGF)-beta1, fibronectin and collagen IV. Glomerular TGF-beta1, fibronectin and collagen IV mRNAs in nephrectomized rats were significantly higher than those in sham-operated rats. Treatment with imidapril for 10 weeks significantly reduced the enhanced glomerular expression of TGF-beta1 and collagen IV mRNA in nephrectomized rats, and prevented the associated proteinuria and glomerulosclerosis. Thus, imidapril may arrest progressive glomerulosclerosis by inhibiting the expression of TGF-beta1 and collagen IV. Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Collagen; Fibronectins; Gene Expression; Imidazoles; Imidazolidines; Kidney Glomerulus; Male; Nephrectomy; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sclerosis; Transforming Growth Factor beta | 1997 |