imetelstat and Pancreatitis

Gallbladder toxicity was reported in most motesanib studies with varying frequency and at variable times after initiation of treatment.. A 44-year-old man was admitted due to severe epigastric pain. The patient was diagnosed with non-small cell lung cancer 9 months ago and received 6 cycles of chemotherapy with motesanib, paclitaxel, and carboplatin. Ultrasonography showed a large amount of sludge within gallbladder. Computed tomography scan demonstrated diffuse dilatation of biliary tree with distended gallbladder without evidence of stone and mild pancreatic swelling. Endoscopic retrograde cholangiopancreatography showed yellowish viscous mucoid plug impacting ampullary orifice and dilated bile duct with amorphous filling defect at distal half of common duct. Endoscopic sphincterotomy was performed to prevent biliary obstruction and recurrent pancreatitis after removal of mucoid material.. To the best of our knowledge, this is the first report of obstructive cholangitis and acute pancreatitis associated with sludge formation during motesanib therapy. Endoscopic sphincterotomy appears to be useful to treat and prevent biliary obstruction caused by motesanib-induced biliary sludge.

Topics: Adult; Antineoplastic Agents; Bile; Carcinoma, Non-Small-Cell Lung; Cholangitis; Fatal Outcome; Humans; Indoles; Lung Neoplasms; Male; Niacinamide; Oligonucleotides; Pancreatitis; Sphincterotomy, Endoscopic