imd-0354 has been researched along with Prostatic-Neoplasms--Castration-Resistant* in 1 studies
1 other study(ies) available for imd-0354 and Prostatic-Neoplasms--Castration-Resistant
| Article | Year |
|---|---|
Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.
Although enzalutamide (ENZ) has been widely used to treat. We selected several ENZ-resistant cell lines that replicated clinical characteristics of the majority of patients with ENZ-resistant disease. A high-throughput pharmacologic screen was utilized to identify compounds with greater cytotoxic effect for ENZ-resistant cell lines, compared with parental ENZ-sensitive cells. We validated the potential hits. Our findings identify BCL-2 and IKKB dependencies in clinically relevant ENZ-resistant prostate cancer cells Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Humans; I-kappa B Kinase; Male; Nitriles; Phenylthiohydantoin; Prostate; Prostatectomy; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Xenograft Model Antitumor Assays | 2021 |