imd-0354 and Osteoarthritis--Knee

imd-0354 has been researched along with Osteoarthritis--Knee* in 1 studies

Other Studies

1 other study(ies) available for imd-0354 and Osteoarthritis--Knee

Article	Year
Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone. Modern rheumatology, 2007, Volume: 17, Issue:6 Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine produced by epithelial cells and triggers dendritic cell-mediated Th2 type allergic inflammatory responses. This study investigated whether Toll-like receptor (TLR) ligands, lipopolysaccharide (LPS) and poly-IC affect TSLP production in synovial fibroblasts. Enzyme-linked immunosorbent assay showed that LPS and poly-IC upregulated TSLP production in synovial fibroblasts obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). In addition, we found that nuclear factor (NF)-kappaB inhibitor IMD-0354, dexamethasone, and interferon (IFN)-gamma inhibited the LPS- and poly-IC-induced TSLP production in RA and OA synovial fibroblasts. Thus, LPS and poly-IC can upregulate TSLP via a NF-kappaB pathway in synovial fibroblasts, which is downregulated by dexamethasone and interferon (IFN)-gamma. The current findings suggest that TSLP may be involved in the pathophysiology of inflammatory arthritis as well as allergic disease. Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Benzamides; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; Interferon-gamma; Ligands; Lipopolysaccharides; Male; NF-kappa B; Osteoarthritis, Knee; Poly I-C; Recombinant Proteins; Stromal Cells; Synovial Membrane; Thymic Stromal Lymphopoietin; Toll-Like Receptors; Up-Regulation	2007

Article

Year

Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone.

Modern rheumatology, 2007, Volume: 17, Issue:6

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine produced by epithelial cells and triggers dendritic cell-mediated Th2 type allergic inflammatory responses. This study investigated whether Toll-like receptor (TLR) ligands, lipopolysaccharide (LPS) and poly-IC affect TSLP production in synovial fibroblasts. Enzyme-linked immunosorbent assay showed that LPS and poly-IC upregulated TSLP production in synovial fibroblasts obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). In addition, we found that nuclear factor (NF)-kappaB inhibitor IMD-0354, dexamethasone, and interferon (IFN)-gamma inhibited the LPS- and poly-IC-induced TSLP production in RA and OA synovial fibroblasts. Thus, LPS and poly-IC can upregulate TSLP via a NF-kappaB pathway in synovial fibroblasts, which is downregulated by dexamethasone and interferon (IFN)-gamma. The current findings suggest that TSLP may be involved in the pathophysiology of inflammatory arthritis as well as allergic disease.

Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Benzamides; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; Interferon-gamma; Ligands; Lipopolysaccharides; Male; NF-kappa B; Osteoarthritis, Knee; Poly I-C; Recombinant Proteins; Stromal Cells; Synovial Membrane; Thymic Stromal Lymphopoietin; Toll-Like Receptors; Up-Regulation

2007