imd-0354 and Edema

imd-0354 has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for imd-0354 and Edema

ArticleYear
Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.
    Biochemical and biophysical research communications, 2020, 05-07, Volume: 525, Issue:3

    Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular disease models. Here, we examined the therapeutic effect of IMD-0354 in an experimental autoimmune uveoretinitis (EAU) model, a well-established animal model for endogenous uveitis in humans. Systemic administration of IMD-0354 significantly suppressed the clinical and histological severity, inflammatory edema, and the translocation of NF-κB p65 into the nucleus of retinas in EAU mice. Furthermore, IMD-0354 treatment significantly inhibited the levels of several Th1/Th17-mediated pro-inflammatory cytokines in vitro. Our current data demonstrate that inhibition of IKKβ with IMD-0354 ameliorates inflammatory responses in the mouse EAU model, suggesting that IMD-0354 may be a promising therapeutic agent for human endogenous uveitis.

    Topics: Animals; Autoimmune Diseases; Benzamides; Cell Nucleus; Cytokines; Edema; I-kappa B Kinase; Inflammation; Male; Mice; NF-kappa B; Retinitis; Severity of Illness Index; Th1 Cells; Th17 Cells; Uveitis

2020