imd-0354 has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for imd-0354 and Colonic-Neoplasms
| Article | Year |
|---|---|
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors.
TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4. Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Humans; Membrane Proteins; Protein Binding; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship | 2013 |