Page last updated: 2024-09-03

imatinib mesylate and Cirrhosis

imatinib mesylate has been researched along with Cirrhosis in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	24 (40.00)	29.6817
2010's	32 (53.33)	24.3611
2020's	4 (6.67)	2.80

Authors

Authors	Studies
Anan, G; Endo, A; Hirose, T; Ito, H; Kato, T; Kimura, T; Kure, S; Matsuki, T; Mori, T; Nakamura, H; Nakayama, S; Oba-Yabana, I; Ohsaki, Y; Shimada, S; Tajima, R; Takahashi, C; Takahashi, K; Tani, J; Yamakoshi, S	1
Bu, XH; Chen, DF; Dong, B; Qin, HB; Xi, Y	1
Kim, KJ; Moon, SJ; Park, KS; Tagkopoulos, I	1
Bansod, S; Godugu, C; Saifi, MA	1
Bugyik, E; Dezső, K; Mózes, M; Nagy, P; Paku, S; Rókusz, A; Szücs, A; Veres, D	1
Chen, GX; Fan, T; Hou, J; Liang, MY; Wang, LX; Wu, ZK; Yang, X; Yue, Y	1
Abtin, F; Divekar, AA; Furst, DE; Kafaja, S; Khanna, D; Saggar, R; Singh, RR; Valera, I	1
Hirt, SW; Keil, L; Lehle, K; Schaub, AL; Schmid, C; von Suesskind-Schwendi, M	1
Asadi-Azarbaijani, B; Braber, S; Jahnukainen, K; Oskam, I; Santos, R; van Duursen, M	1
Gewin, L; Wallace, E	1
Lee, SR; Yhim, HY	1
Abraham, D; Dees, C; Denton, CP; Distler, A; Distler, O; Gay, RE; Gay, S; Hw Distler, J; Khan, K; Maurer, B; Michel, BA	1
Chang, K; Choo, EH; Ihm, SH; Jang, SW; Kim, HY; Kim, OR; Park, CS; Seung, KB	1
Demoulin, JB; Essaghir, A	1
Ahokas, RA; Chen, Y; Liu, C; Liu, H; Meng, W; Sun, Y; Zhao, T; Zhao, W	1
Fassnacht, F; Fouret, P; Kahn, JE; Lefevre, G; Levy, V; Roumier, M; Russel, S; Varnous, S	1
De Langhe, E; Hillen, A; Himmelreich, U; Lories, RJ; Poelmans, J; Vande Velde, G; Vanoirbeek, J	1
Ar, MC; Aydin, Y; Baslar, Z; Buyru, AN; Cengiz, M; Ekizoglu, S; Elverdi, T; Eskazan, AE; Ferhanoglu, B; Gulturk, E; Ongoren Aydin, S; Ozbek, U; Salihoglu, A; Senem Demiroz, A; Soysal, T; Tanrikulu Simsek, E; Tuzuner, N	1
Bernard, PL; Cinq-Mars, A; Cloutier, S; Dubois, M; Larose, É; Leblanc, MH; Sénéchal, M	1
Bibi, Y; Gottlieb, AB	1
High, WA; Kay, J	1
Akhmetshina, A; Busch, N; Dees, C; Distler, JH; Distler, O; Gay, S; Jüngel, A; Maurer, B; Schett, G; Stürzl, M; Venalis, P; Zwerina, J	1
Distler, JH; Distler, O	3
Akhmetshina, A; Busch, N; Dees, C; Distler, JH; Distler, O; Schett, G; Venalis, P; Zwerina, J	1
Bhattacharyya, S; Hinchcliff, M; Ishida, W; Leof, E; Mori, Y; Varga, J; Wilkes, M; Wu, M	1
Bacigalupo, A; Balduzzi, A; Cimminiello, M; Gabrielli, A; Gini, G; Leoni, P; Locatelli, F; Mordini, N; Olivieri, A; Raimondi, R; Sanna, A; Zecca, M	1
Fuehrer, NE; Jagirdar, J; Marchevsky, AM	1
Hirschberg, R; Leof, EB; Wang, S; Wilkes, MC	2
Baumann, M; Buck, T; Gössl, M; Heemann, U; Kribben, A; Leineweber, K; Su, S; Tewiele, M; Türk, TR; Wilde, B; Witzke, O; Wu, K	1
Beyer, C; Distler, JH; Distler, O	1
Gordon, J; Spiera, R	1
Du, W; Miharu, M; Osumi, T; Shimada, H; Takahashi, T; Tanaka, R	1
Leof, EB; Torres, VE	1
Mouthon, L	1
Beyer, C; Distler, JH	1
Chen, XX; Gu, YY; Guo, L; Ye, S; Zou, HJ	1
Dees, C; Del Galdo, F; Distler, A; Distler, JH; Distler, O; Egberts, F; Palumbo-Zerr, K; Schett, G; Spriewald, BM; Tinazzi, I; Tomcik, M; Vollath, S; Zerr, P	1
Welsh, N	1
Barcat, D; Bouchet, S; Chatelus, E; Chene, G; de Korwin-Krokowski, JD; Diot, E; Doussau, A; Durant, C; Ezzedine, K; Grandoulier, AS; Hachulla, E; Kostrzewa, E; Lepreux, S; Mahon, FX; Paul, C; Prey, S; Quemeneur, T; Schaeverbeke, T; Seneschal, J; Solanilla, A; Sparsa, A; Taïeb, A	1
Chung, EJ; Citrin, DE; Horton, JA; Hudak, KE; Mitchell, JB; Sowers, A; Thetford, A; White, AO	1
Chen, HW; Feng, KF; He, LF; Hu, H; Hua, JS; Li, Q; Ma, LK; Wang, L; Yu, H; Zhou, JL	1
Iwayama, T; Olson, LE	1
Fukada, S; Ito, T; Miyagoe-Suzuki, Y; Ogawa, R; Ohtani, T; Takeda, S; Tsujikawa, K; Uezumi, A; Watanabe, Y; Yamamoto, H	1
Akin, C; Cools, J; Gilliland, DG; Klion, AD; Law, MA; Metcalfe, DD; Noel, P; Nutman, TB	1
Druker, BJ; Frater, JL; Hrisinko, MA; Peterson, LC; Resta, D; Riley, MB; Tallman, MS; Variakojis, D	1
Nguyen, PL; Wahner, AE; Xu, Y	1
Daniels, CE; Edens, M; Kottom, TJ; Leof, EB; Limper, AH; Murphy, SJ; Wilkes, MC	1
Dobritz, M; Eckel, F; Fend, F; Hosius, C; Lersch, C; Mayr, M; Schleyer, E; Schmid, RM; Schulte-Frohlinde, E; von Delius, S	1
Baumann, M; Duisters, RF; Heymans, S; Janssen, SH; Peutz-Kootstra, CJ; Pinto, YM; Schellings, MW; Schroen, B; van Leeuwen, RE	1
Berlin, AA; Hogaboam, CM; Lukacs, NW	1
Burgin, S; Chen, S; Clapp, DW; Clegg, T; Estwick, SA; Ingram, DA; Khalaf, W; Li, X; Morgan, T; Parada, LF; Travers, J; Yang, FC; Yuan, J	1
Wollheim, FA	1
Distler, JH; Distler, O; Gay, RE; Gay, S; Hauser, T; Huber, LC; Jüngel, A; Michel, BA; Schett, G; Schulze-Horsel, U; Zwerina, J	1
Han, MK; Horowitz, JC; Moore, BB; Thannickal, VJ; Vittal, R; Zhang, H	1
Berndt, A; Böhmer, FD; Borsi, L; Buchdunger, E; Grün, K; Janik, T; Kiehntopf, M; Kosmehl, H; Leipner, C; Müller, A; Uecker, A	1
Gioni, V; Karamanos, NK; Karampinas, T; Kletsas, D; Papadopoulos, S; Roussidis, AE; Voutsinas, G	1
Apperley, JF; Boecklin, F; Chase, A; Dhar, S; Goldman, JM; Hasserjian, RP; Henry, K; Lampert, I; Olavarria, E; Parker, S; Zaiac, M	1

Reviews

9 review(s) available for imatinib mesylate and Cirrhosis

Article	Year
Imatinib: novel treatment of immune-mediated kidney injury. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:5 Topics: Animals; Autoimmune Diseases; B-Lymphocytes; Benzamides; Dendritic Cells; Fibrosis; Humans; Imatinib Mesylate; Immunologic Factors; Kidney Diseases; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; T-Lymphocytes; Transforming Growth Factor beta	2013
PDGF receptor signaling networks in normal and cancer cells. Cytokine & growth factor reviews, 2014, Volume: 25, Issue:3 Topics: Benzamides; Fibrosis; Gastrointestinal Stromal Tumors; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Infections; Leukemia; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Stroke	2014
A potential role for imatinib and other small molecule tyrosine kinase inhibitors in the treatment of systemic and localized sclerosis. Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:4 Topics: Benzamides; Fibrosis; Humans; Imatinib Mesylate; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Raynaud Disease; Scleroderma, Localized; Scleroderma, Systemic; Skin	2008
Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis. Rheumatology (Oxford, England), 2008, Volume: 47 Suppl 5 Topics: Animals; Benzamides; Clinical Trials as Topic; Dasatinib; Fibrosis; Humans; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Scleroderma, Systemic; Skin; Sulfonamides; Thiazoles	2008
Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies. Annals of the rheumatic diseases, 2010, Volume: 69 Suppl 1 Topics: Benzamides; Fibrosis; Humans; Imatinib Mesylate; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Scleroderma, Systemic	2010
Imatinib and the treatment of fibrosis: recent trials and tribulations. Current rheumatology reports, 2011, Volume: 13, Issue:1 Topics: Benzamides; Fibrosis; Humans; Imatinib Mesylate; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Scleroderma, Systemic	2011
Low-dose imatinib in the treatment of severe systemic sclerosis: a case series of six Chinese patients and literature review. Clinical rheumatology, 2012, Volume: 31, Issue:9 Topics: Adolescent; Adult; Autoimmune Diseases; Benzamides; China; Clinical Trials as Topic; Female; Fibrosis; Humans; Imatinib Mesylate; Lung; Middle Aged; Piperazines; Pyrimidines; Scleroderma, Systemic; Time Factors; Treatment Outcome	2012
Does the small tyrosine kinase inhibitor Imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis? Expert opinion on investigational drugs, 2012, Volume: 21, Issue:11 Topics: Amyloidosis; Animals; Benzamides; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Fibrosis; Humans; Imatinib Mesylate; Islets of Langerhans; Mice; Pancreatic Diseases; Piperazines; Protein Kinase Inhibitors; Pyrimidines	2012
Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities. Current rheumatology reports, 2013, Volume: 15, Issue:2 Topics: Animals; Benzamides; Fibrosis; Humans; Imatinib Mesylate; Mice; Models, Animal; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Scleroderma, Systemic	2013

Trials

5 trial(s) available for imatinib mesylate and Cirrhosis

Article	Year
Imatinib for refractory chronic graft-versus-host disease with fibrotic features. Blood, 2009, Jul-16, Volume: 114, Issue:3 Topics: Adolescent; Adult; Benzamides; Child; Female; Fibrosis; Graft vs Host Disease; Humans; Imatinib Mesylate; Intestinal Diseases; Lung Diseases; Male; Middle Aged; Pilot Projects; Piperazines; Pyrimidines; Remission Induction; Salvage Therapy; Skin Diseases; Survival Analysis; Treatment Outcome	2009
Imatinib mesylate in scleroderma-associated diffuse skin fibrosis: a phase II multicentre randomized double-blinded controlled trial. The British journal of dermatology, 2012, Volume: 167, Issue:5 Topics: Adult; Aged; Benzamides; Double-Blind Method; Female; Fibrosis; Humans; Imatinib Mesylate; Male; Middle Aged; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrimidines; Quality of Life; Scleroderma, Diffuse; Skin; Transforming Growth Factor beta; Treatment Outcome	2012
Chronic myeloid leukemia following therapy with imatinib mesylate (Gleevec). Bone marrow histopathology and correlation with genetic status. American journal of clinical pathology, 2003, Volume: 119, Issue:6 Topics: Antineoplastic Agents; Benzamides; Biopsy; Bone Marrow; Cytogenetic Analysis; Drug Resistance; Fibrosis; Fusion Proteins, bcr-abl; Histiocytes; Humans; Hyperplasia; Imatinib Mesylate; In Situ Hybridization, Fluorescence; Interferons; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocyte Count; Megakaryocytes; Piperazines; Pyrimidines; Reticulin; Reverse Transcriptase Polymerase Chain Reaction	2003
Pharmacokinetic and clinical phase II trial of imatinib in patients with impaired liver function and advanced hepatocellular carcinoma. Oncology, 2005, Volume: 69, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Benzamides; Carcinoma, Hepatocellular; Cohort Studies; Disease-Free Survival; Enzyme Inhibitors; Fibrosis; Humans; Imatinib Mesylate; Immunohistochemistry; Liver; Liver Neoplasms; Middle Aged; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Stem Cells; Time Factors; Treatment Outcome	2005
ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response. American journal of clinical pathology, 2002, Volume: 117, Issue:3 Topics: Antineoplastic Agents; Benzamides; Biopsy; Bone Marrow; Cell Count; Cell Differentiation; Cytogenetic Analysis; Fibrosis; Hematopoiesis; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Necrosis; Piperazines; Pyrimidines	2002

Other Studies

46 other study(ies) available for imatinib mesylate and Cirrhosis

Article	Year
Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion. Journal of hypertension, 2022, 10-01, Volume: 40, Issue:10 Topics: Animals; Fibrosis; Humans; Hyperemia; Imatinib Mesylate; Kidney; Kidney Diseases; Male; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley	2022
Effect of imatinib on DOCA-induced myocardial fibrosis in rats through P38 MAPK signaling pathway. European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:4 Topics: Animals; Desoxycorticosterone Acetate; Fibrosis; Imatinib Mesylate; Male; Myocardium; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction	2020
Network-based modeling of drug effects on disease module in systemic sclerosis. Scientific reports, 2020, 08-07, Volume: 10, Issue:1 Topics: Acetylcysteine; Dasatinib; Drug Repositioning; Female; Fibrosis; Genome-Wide Association Study; Humans; Imatinib Mesylate; Indoles; Male; Molecular Targeted Therapy; Protein Kinase Inhibitors; Scleroderma, Systemic; Signal Transduction	2020
Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model. Scientific reports, 2021, 06-18, Volume: 11, Issue:1 Topics: Animals; Biomarkers; Discoidin Domain Receptor 1; Discoidin Domain Receptor 2; Discoidin Domain Receptors; Disease Models, Animal; Disease Outbreaks; Disease Progression; Fibrosis; Gene Expression Regulation; Humans; Imatinib Mesylate; Immunohistochemistry; Mice; Pancreatitis, Chronic; Protein Kinase Inhibitors; Signal Transduction	2021
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models. PloS one, 2017, Volume: 12, Issue:4 Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; Fibrosis; Imatinib Mesylate; Keratin-19; Liver; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Protein Kinase Inhibitors; Thioacetamide; Transforming Growth Factor beta	2017
Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model. PloS one, 2017, Volume: 12, Issue:6 Topics: Animals; Cell Survival; Cells, Cultured; Echocardiography; Fibrosis; Gene Expression; Heart Diseases; Imatinib Mesylate; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Platelet-Derived Growth Factor; Ventricular Remodeling	2017
pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis. JCI insight, 2018, 05-03, Volume: 3, Issue:9 Topics: Adult; Animals; Antibiotics, Antineoplastic; Bleomycin; Bronchoalveolar Lavage Fluid; Case-Control Studies; CD4-Positive T-Lymphocytes; Chemokines; Chemotaxis; Dendritic Cells; Disease Models, Animal; Female; Fibrosis; Gene Expression; Humans; Imatinib Mesylate; Inflammation; Interleukin-4; Lung; Male; Mice; Protein Kinase Inhibitors; Receptors, Chemokine; Scleroderma, Systemic; Severity of Illness Index; Skin; Spleen; Transforming Growth Factor beta1; Young Adult	2018
Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats. Histology and histopathology, 2019, Volume: 34, Issue:7 Topics: Animals; Bronchiolitis Obliterans; Drug Synergism; Everolimus; Fibrosis; Graft Rejection; Imatinib Mesylate; Immunohistochemistry; Lung Transplantation; Phthalazines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Inbred F344; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; TOR Serine-Threonine Kinases; Transplantation, Homologous; Vascular Endothelial Growth Factor Receptor-2	2019
Imatinib mesylate does not counteract ovarian tissue fibrosis in postnatal rat ovary. Reproductive biology, 2019, Volume: 19, Issue:2 Topics: Actins; Animals; Female; Fibrosis; Forkhead Box Protein O3; Gene Expression Regulation; Imatinib Mesylate; Nerve Tissue Proteins; Ovarian Diseases; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vimentin	2019
Rapid left ventricular thickening and thrombus caused by FIP1L1/PDGFRA-negative hypereosinophilic syndrome. Texas Heart Institute journal, 2013, Volume: 40, Issue:3 Topics: Benzamides; Biopsy; Cerebral Infarction; Disease Progression; Echocardiography; Fibrosis; Genetic Predisposition to Disease; Hemodynamics; Humans; Hypereosinophilic Syndrome; Hypertrophy, Left Ventricular; Imatinib Mesylate; Magnetic Resonance Imaging; Male; Middle Aged; Phenotype; Piperazines; Platelet-Derived Growth Factor; Pyrimidines; Thrombosis; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left	2013
Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Annals of the rheumatic diseases, 2013, Volume: 72, Issue:12 Topics: Adult; Animals; Benzamides; Biopsy; Bleomycin; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibrosis; Fos-Related Antigen-2; Humans; Imatinib Mesylate; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-sis; Pyrimidines; Scleroderma, Systemic; Skin; Treatment Outcome	2013
Imatinib mesylate attenuates myocardial remodeling through inhibition of platelet-derived growth factor and transforming growth factor activation in a rat model of hypertension. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:6 Topics: Animals; Benzamides; Blotting, Western; Collagen Type I; Collagen Type III; Fibroblasts; Fibrosis; Gene Expression; Hypertension; Hypertrophy, Left Ventricular; Imatinib Mesylate; Male; Myocardium; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1; Ventricular Remodeling	2014
Platelet-derived growth factor blockade on cardiac remodeling following infarction. Molecular and cellular biochemistry, 2014, Volume: 397, Issue:1-2 Topics: Animals; Benzamides; Fibrosis; Imatinib Mesylate; Lymphokines; Male; Myocardial Infarction; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1	2014
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. Transplantation, 2015, Volume: 99, Issue:11 Topics: Adult; Antineoplastic Agents; Biopsy; Cardiomyopathies; Fibrosis; Heart Transplantation; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Leukemia; Magnetic Resonance Imaging; Male; mRNA Cleavage and Polyadenylation Factors; Myocardium; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Receptor, Platelet-Derived Growth Factor alpha; Treatment Outcome	2015
Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume. Disease models & mechanisms, 2016, Volume: 9, Issue:1 Topics: Animals; Biomarkers; Bleomycin; Cryptococcosis; Disease Models, Animal; Fibrosis; Imatinib Mesylate; Inflammation; Lung; Lung Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pulmonary Aspergillosis; X-Ray Microtomography	2016
Imatinib reduces bone marrow fibrosis and overwhelms the adverse prognostic impact of reticulin formation in patients with chronic myeloid leukaemia. Journal of clinical pathology, 2016, Volume: 69, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Marrow; Female; Fibrosis; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Prognosis; Reticulin; Treatment Outcome; Young Adult	2016
Management of Loeffler's Endocarditis With Bivalvular Involvement and a FIP1L1/PDGFRA-Negative Mutation. The Canadian journal of cardiology, 2016, Volume: 32, Issue:12 Topics: Adult; Bioprosthesis; Echocardiography; Fibrosis; Genetic Testing; Heart Valve Prosthesis Implantation; Heart Ventricles; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Magnetic Resonance Imaging, Cine; Male; Mitral Valve; Mitral Valve Insufficiency; Papillary Muscles; Protein Kinase Inhibitors; Thrombosis; Treatment Outcome; Tricuspid Valve	2016
Imatinib mesylate treatment of nephrogenic systemic fibrosis. Arthritis and rheumatism, 2008, Volume: 58, Issue:8 Topics: Aged; Benzamides; Fibrosis; Humans; Imatinib Mesylate; Kidney Diseases; Knee Joint; Male; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Scleroderma, Systemic; Skin; Treatment Outcome	2008
Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo. Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:10 Topics: Animals; Apoptosis; Benzamides; Biomarkers; Blood Vessels; Cell Proliferation; Cell Survival; Chemotaxis; Endothelial Cells; Fibrosis; Humans; Imatinib Mesylate; Mice; Neovascularization, Pathologic; Piperazines; Pyrimidines; Reproducibility of Results	2009
Imatinib as a novel therapeutic approach for fibrotic disorders. Rheumatology (Oxford, England), 2009, Volume: 48, Issue:1 Topics: Benzamides; Drug Evaluation, Preclinical; Fibrosis; Humans; Imatinib Mesylate; Piperazines; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrimidines; Treatment Outcome	2009
Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis. Arthritis and rheumatism, 2009, Volume: 60, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Benzamides; Bleomycin; Disease Models, Animal; Fibrillins; Fibrosis; Imatinib Mesylate; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Microfilament Proteins; Phenotype; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Scleroderma, Systemic; Skin; Skin Diseases	2009
A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate. Oncogene, 2009, Mar-12, Volume: 28, Issue:10 Topics: Animals; Benzamides; Bleomycin; Cells, Cultured; Collagen; Early Growth Response Protein 1; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Humans; Imatinib Mesylate; Mice; Mice, Inbred BALB C; NIH 3T3 Cells; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta	2009
Presence of c-KIT-positive mast cells in obliterative bronchiolitis from diverse causes. Archives of pathology & laboratory medicine, 2009, Volume: 133, Issue:9 Topics: Asthma; Benzamides; Biomarkers; Bronchioles; Bronchiolitis Obliterans; Emphysema; Fibrosis; Humans; Image Processing, Computer-Assisted; Imatinib Mesylate; Mast Cells; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines	2009
Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. American journal of physiology. Renal physiology, 2010, Volume: 298, Issue:1 Topics: Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Imatinib Mesylate; Kidney; Kidney Diseases; Male; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Smad2 Protein; Smad3 Protein; Transcription Factors; Transforming Growth Factor beta; Ureteral Obstruction	2010
Imatinib ameliorates fibrosis in uraemic cardiac disease in BALB/c without improving cardiac function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:6 Topics: Animals; Benzamides; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Imatinib Mesylate; Kidney Failure, Chronic; Male; Mice; Mice, Inbred BALB C; Nephrectomy; Oxidative Stress; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Uremia	2010
Are tyrosine kinase inhibitors promising for the treatment of systemic sclerosis and other fibrotic diseases? Swiss medical weekly, 2010, Volume: 140 Topics: Animals; Benzamides; Clinical Trials as Topic; Dasatinib; Disease Models, Animal; Drugs, Investigational; ErbB Receptors; Fibrosis; Graft vs Host Disease; Humans; Imatinib Mesylate; Mixed Connective Tissue Disease; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pulmonary Fibrosis; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Thiazoles	2010
Imatinib is effective for prevention and improvement of fibrotic fasciitis as a manifestation of chronic GVHD. Bone marrow transplantation, 2012, Volume: 47, Issue:1 Topics: Adolescent; Benzamides; Bone Marrow Transplantation; Chronic Disease; Fasciitis; Fibrosis; Graft vs Host Disease; Humans; Imatinib Mesylate; Male; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Transplantation, Homologous	2012
Fibrosis, regeneration, and aging: playing chess with evolution. Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:8 Topics: Aging; Animals; Antineoplastic Agents; Benzamides; Biological Evolution; Cytokines; Disease Progression; Fibrosis; Humans; Imatinib Mesylate; Immune System; Inflammation; Kidney Failure, Chronic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrophages; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Regeneration	2011
SSc in 2011: From mechanisms to medicines. Nature reviews. Rheumatology, 2012, Jan-10, Volume: 8, Issue:2 Topics: Benzamides; Blood Coagulation; Clinical Trials as Topic; Fibrosis; Humans; Imatinib Mesylate; Molecular Targeted Therapy; Piperazines; Platelet Activation; Protein Kinase Inhibitors; Pyrimidines; Scleroderma, Systemic; Treatment Outcome	2012
Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease. Biochimica et biophysica acta, 2013, Volume: 1832, Issue:7 Topics: Fibrosis; Genes, abl; Humans; Imatinib Mesylate; Protein-Tyrosine Kinases; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction	2013
Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host disease. The American journal of pathology, 2012, Volume: 181, Issue:5 Topics: Animals; Benzamides; Chronic Disease; Dermis; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrosis; Graft vs Host Disease; Humans; Imatinib Mesylate; Male; Mice; Mice, Inbred BALB C; Middle Aged; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Scleroderma, Systemic; Signal Transduction	2012
Inhibition of radiation-induced skin fibrosis with imatinib. International journal of radiation biology, 2013, Volume: 89, Issue:3 Topics: Animals; Benzamides; Female; Fibrosis; Imatinib Mesylate; Mice; Mice, Inbred C3H; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-kit; Pyrimidines; Radiation Injuries, Experimental; Radiation-Protective Agents; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Skin; Transforming Growth Factor beta1	2013
Imatinib attenuates myocardial fibrosis in association with inhibition of the PDGFRα activity. Arquivos brasileiros de cardiologia, 2012, Volume: 99, Issue:6 Topics: Animals; Benzamides; Blood Pressure; Blotting, Western; Desoxycorticosterone; Disease Models, Animal; Endomyocardial Fibrosis; Fibronectins; Fibrosis; Hypertension; Imatinib Mesylate; Male; Nephrectomy; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Tenascin; Treatment Outcome	2012
Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors. Neuromuscular disorders : NMD, 2013, Volume: 23, Issue:4 Topics: Animals; Benzamides; Cell Proliferation; Fibrosis; Imatinib Mesylate; Mesenchymal Stem Cells; Mice; Mice, Inbred DBA; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscle, Skeletal; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Satellite Cells, Skeletal Muscle; Signal Transduction	2013
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood, 2003, Jun-15, Volume: 101, Issue:12 Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Base Sequence; Benzamides; Biopsy; Bone Marrow; Chromosomes, Human, Pair 4; Endomyocardial Fibrosis; Eosinophils; Female; Fibrosis; Gene Deletion; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Leukocytes, Mononuclear; Lung Diseases; Male; Mast Cells; Mastocytosis; Middle Aged; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; Myeloproliferative Disorders; Oncogene Proteins, Fusion; Piperazines; Prognosis; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serine Endopeptidases; Splenomegaly; Tryptases; Vitamin B 12	2003
Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate. Archives of pathology & laboratory medicine, 2004, Volume: 128, Issue:9 Topics: Adult; Antineoplastic Agents; Benzamides; Blast Crisis; Bone Marrow; Cytogenetic Analysis; Disease Progression; Fibrosis; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Piperazines; Pyrimidines	2004
Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. The Journal of clinical investigation, 2004, Volume: 114, Issue:9 Topics: Animals; Antineoplastic Agents; Benzamides; Bleomycin; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen; Cytokines; Fibroblasts; Fibronectins; Fibrosis; Imatinib Mesylate; Immunoprecipitation; Inflammation; Luciferases; Lung; Mice; Mice, Knockout; NIH 3T3 Cells; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta2; Transgenes	2004
Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:1 Topics: Animals; Benzamides; Cell Line; Cell Proliferation; Chemotaxis; DNA-Binding Proteins; Enzyme Activation; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Imatinib Mesylate; Kidney Diseases; Macrophages; Male; Mice; p21-Activated Kinases; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Rats; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta; Ureteral Obstruction	2005
Imatinib attenuates end-organ damage in hypertensive homozygous TGR(mRen2)27 rats. Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:3 Topics: Animals; Animals, Genetically Modified; Arterioles; Benzamides; Blood Pressure; Cells, Cultured; Fibrosis; Heart Diseases; Hemodynamics; Homozygote; Hypertension; Imatinib Mesylate; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Male; Myocardium; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Renin; Signal Transduction; Transcriptional Activation	2006
Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma. Laboratory investigation; a journal of technical methods and pathology, 2006, Volume: 86, Issue:6 Topics: Administration, Intranasal; Allergens; Animals; Asthma; Benzamides; Bronchi; Bronchial Hyperreactivity; Chemokine CCL17; Chemokines, CC; Chronic Disease; Cockroaches; Eosinophils; Fibrosis; Hydroxyproline; Imatinib Mesylate; Lung; Mice; Mice, Inbred BALB C; Neutralization Tests; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Stem Cell Factor	2006
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Human molecular genetics, 2006, Aug-15, Volume: 15, Issue:16 Topics: Animals; Benzamides; Bone Marrow Cells; Cell Movement; Cell Proliferation; Collagen; Culture Media, Conditioned; Embryo, Mammalian; Fibroblasts; Fibrosis; Haplotypes; Heterozygote; Humans; Imatinib Mesylate; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurofibroma; Neurofibromatosis 1; Phenotype; Piperazines; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins p21(ras); Pyrimidines; Signal Transduction; Transforming Growth Factor beta	2006
Treatment of pulmonary fibrosis in systemic sclerosis: light at the end of the tunnel? Arthritis and rheumatism, 2007, Volume: 56, Issue:1 Topics: Animals; Benzamides; Disease Models, Animal; Fibrosis; Humans; Imatinib Mesylate; Piperazines; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrimidines; Scleroderma, Systemic	2007
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis and rheumatism, 2007, Volume: 56, Issue:1 Topics: Aged; Animals; Benzamides; Bleomycin; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Matrix Proteins; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Imatinib Mesylate; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C3H; Middle Aged; Piperazines; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrimidines; RNA, Messenger; Scleroderma, Systemic; Skin; Specific Pathogen-Free Organisms	2007
Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Benzamides; Bleomycin; Blotting, Western; Bromodeoxyuridine; Caspase 3; Cell Line, Tumor; Cells, Cultured; Collagen; DNA, Single-Stranded; Dose-Response Relationship, Drug; Epithelial Cells; Fibroblasts; Fibrosis; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunohistochemistry; Indicators and Reagents; Injections, Intraperitoneal; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lung Diseases; Mesenchymal Stem Cells; Mice; Phenotype; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction	2007
Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis. Cardiovascular research, 2008, Jul-01, Volume: 79, Issue:1 Topics: Animals; Benzamides; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Fibrosis; Heart; Imatinib Mesylate; Lymphokines; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction	2008
Imatinib mesylate inhibits proliferation and exerts an antifibrotic effect in human breast stroma fibroblasts. Molecular cancer research : MCR, 2008, Volume: 6, Issue:5 Topics: Antineoplastic Agents; Benzamides; Breast; Cell Proliferation; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Piperazines; Pyrimidines; Recombinant Proteins; RNA, Messenger; Time Factors	2008