iloprost and Vertigo

iloprost has been researched along with Vertigo* in 1 studies

Other Studies

1 other study(ies) available for iloprost and Vertigo

ArticleYear
Effects of leukotrienes and prostaglandins on cochlear blood flow in the chinchilla.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1999, Volume: 256, Issue:10

    Prostaglandins (PGs) such as PGE2 and PGI2 are vasodilators, and leukotrienes (LTs) such as LTB4 and LTC4 are vasoconstrictors. Our previous studies have shown that salicylate ototoxicity is associated with decreased levels of PGs and increased levels of LTs. We hypothesized that vasodilating PGs increase cochlear blood flow and vasoconstricting LTs decrease cochlear blood flow. PGE2, Iloprost (a PGI2 analog), LTB4, and LTC4 were applied to the round window membranes of chinchillas and cochlear blood flow was measured with a laser Doppler flowmeter. PGE2 increased cochlear blood flow, while LTC4 decreased cochlear blood flow. This findings show that vasodilating PGs may have therapeutic implications for sensorineural hearing loss and/or vertigo by increasing cochlear blood flow. Vasoconstricting LTs may cause hearing loss by decreasing cochlear blood flow.

    Topics: Animals; Chinchilla; Cochlea; Dinoprostone; Hearing Disorders; Hearing Loss, Sensorineural; Iloprost; Laser-Doppler Flowmetry; Leukotriene B4; Leukotriene C4; Random Allocation; Regional Blood Flow; Round Window, Ear; Vasoconstrictor Agents; Vasodilator Agents; Vertigo

1999