iloprost and Spasm

This study is planned bringing about a new choice for the prophylaxis of RA spasm which is topical iloprost and compares its efficacy with papaverine and diltiazem.. Twenty eight CABG patients with RA grafts were categorized into four groups by taking into account the topical vasodilator (papaverine, diltiazem, iloprost and saline) that was utilized during harvesting. Arterial segments were separated into four rings and were than soaked with KCL, norepinephrine, phenylephrine and serotonin. Then, acetylcholine was given to induce relaxation and the preparations were put to rest for 10 minute.. The contraction response achieved by the vasoreactive agents was most effectively inhibited by papaverine. The effectiveness of the response obtained by iloprost was similar to that of papaverine and significantly stronger than that of diltiazem. Especially at high vasoreactive substance concentrations, diltiazem had a contraction close to that of the control while the protective effect was weaker than those of papaverine and iloprost.. Iloprost can be recommended as a strong alternative to the topical agents used for preventing arterial graft spasm.

Topics: Administration, Topical; Aged; Arterial Occlusive Diseases; Coronary Artery Bypass; Diltiazem; Dose-Response Relationship, Drug; Female; Graft Occlusion, Vascular; Humans; Iloprost; Male; Middle Aged; Norepinephrine; Papaverine; Phenylephrine; Potassium Chloride; Radial Artery; Serotonin; Spasm; Tissue and Organ Harvesting; Treatment Outcome; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

Radial artery graft spasm in the perioperative or postoperative period of coronary bypass surgery necessitates urgent treatment due to risk of graft failure and mortality. Herein, we evaluated the effect of iloprost, a prostacyclin (PGI

Topics: Endothelium, Vascular; Epoprostenol; Female; Humans; Iloprost; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Radial Artery; Spasm; Vasodilation; Vasodilator Agents

Thorascopic sympathectomy is a widely used procedure for the treatment of intractable palmar hyperhidrosis.. A 24-year-old woman who underwent thorascopic sympathectomy for hyperhidrosis in 2005 presented on more than 30 occasions with recurrent right distal upper limb ischaemia secondary to repetitive episodes of vasospasm. The patient did not have preoperative symptoms consistent with Raynaud's syndrome. We observed a reduction in the symptomatic relief offered by Iloprost treatment over a period of five years.. This is the first report of distal upper limb ischaemia following thorascopic sympathectomy. We highlight the development of resistance to repeated Iloprost infusions that we observed in this case.

Topics: Drug Resistance; Female; Humans; Hyperhidrosis; Iloprost; Infusions, Parenteral; Ischemia; Radiography; Recurrence; Spasm; Sympathectomy; Thoracoscopy; Treatment Outcome; Upper Extremity; Vascular Diseases; Vasodilator Agents; Young Adult